Lower limb pain in sympathetic-sensory coupling

作     者：Hongjun Yang Kairun Peng Sanjue Hu Li Xuan 

作者机构：Department of Neurology Guangzhou Military Command General Hospital Guangzhou 510010 Guangdong Province China Institute of Neuroscience Fourth Military Medical University Xi'an 710032 Shaanxi Province China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第2期

页      面：125-130页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 07[理学] 071006[理学-神经生物学] 

基　　金：the Natural Science Foundation of Guangdong Province No. 05300503 

主　　题：dorsal root ganglion spontaneous activity neuropathic pain sympathetic stimulation chemical lumbar sympathectomy sympathetic-sensory coupling 

摘      要：Previous studies have shown that sympathetic nerves are related to certain types of pain, and this phenomenon is referred to as sympathetic-sensory coupling. Chronic pain resulting from nerve injury can be exacerbated by sympathetic stimulation or relieved by sympathetic inhibition. In the present study, the correlation between pain and sympathetic nerves was analyzed in patients with severe pain in lower limbs, as we^l as in a chronically compressed dorsa~ root ganglion ~CCD） rat model （model of low back pain and sciatica）. Patients with severe pain in the lower limbs underwent chemical lumbar sympathectomy （CLS）, and the analgesic effects of CLS were compared with painkillers. Results demonstrated significantly relieved lower limb pain following CLS, and the analgesic effects of CLS were superior to those seen with painkillers. In the CCD rat model, dorsal root ganglion neuronal activity significantly increased as a result of electrical stimulation to the sympathetic nerves. These results suggest that sympathetic nerves are closely associated with pain and sympathetic-sensory coupling is likely in lower limb pain in both patients and rat models of CCD.