检索结果-南通市图书馆

Michael Acceptor Pyrrolidone Derivatives and Their Activity against Diffuse Large B-cell Lymphoma

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2024年第5期44卷 890-901页

作者： Bi-qiong zhang Feng-qing wang Jie yin Xiao-tan YU Zheng-xi hu liang-hu GU Qing-yi TONG yong-hui zhang hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of PharmacyTongji Medical CollegeHuazhong University of Science and TechnologyWuhan430030China

Objective This study aimed to design and evaluate the efficacy of pyrrolidone derivatives as potential therapeutic agents against diffuse large B-cell lymphoma(DLBCL),a common and heterogeneous malignancy of the adult lymphohematopoietic *** the limitations of current therapies,there is a pressing need to develop new and effective drugs for DLBCL *** A series of pyrrolidone derivatives were synthesized,and their antitumor activities were assessed,particularly against DLBCL cell ***-activity relationship(SAR)analysis was conducted to identify key structural components essential for *** most promising compound,referred to as compound 7,was selected for further mechanistic *** expression levels of relevant mRNA and protein were detected by RT-qPCR and Western blotting,and the expression of mitochondrial membrane potential and ROS was detected using flow cytometry for further assessment of cell cycle arrest and *** The compound 7 exhibited good antitumor activity among the synthesized derivatives,specifically in DLBCL cell *** analysis highlighted the critical role ofα,β-unsaturated ketones in the antitumor efficacy of these ***,compound 7 was found to induce significant DNA damage,trigger an inflammatory response,cause mitochondrial dysfunction,and disrupt cell cycle progression,ultimately leading to apoptosis of DLBCL *** The compound 7 has good antitumor activity and can induce multiple cellular mechanisms leading to cancer cell *** findings warrant further investigation of the compound 7 as a potential therapeutic agent for DLBCL.

关键词： pyrrolidone analogs Michael acceptor DNA damage mitochondrial dysfunction apoptosis

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于模型的汽油机电子节气门控制器设计

上海交通大学学报 2015年第2期49卷 245-249页

作者：张虎张勇梁俊毅殷承良上海交通大学汽车电子控制技术国家工程实验室上海200240

建立了电子节气门系统模型,并通过系统辨识方法得出模型参数.根据被控电子节气门的摩擦力和非线性回位弹簧模型,设计了前馈非线性补偿控制器.将经过前馈非线性补偿后的电子节气门系统简化成线性系统,并对该线性系统进行H无穷控制器的设... 详细信息

建立了电子节气门系统模型,并通过系统辨识方法得出模型参数.根据被控电子节气门的摩擦力和非线性回位弹簧模型,设计了前馈非线性补偿控制器.将经过前馈非线性补偿后的电子节气门系统简化成线性系统,并对该线性系统进行H无穷控制器的设计.对设计的H无穷控制器进行离散化,并加入比例控制环节来弥补控制器离散化导致的性能下降.经过试验验证,在前馈非线性补偿器、H无穷控制器和比例控制的作用下,被控电子节气门的性能达到了设计需求.

关键词：汽油机电子节气门非线性系统 H无穷控制

The 8×10 GHz Receiver Optical Subassembly Based on Silica Hybrid Integration Technology for Data Center Interconnection

在线全文

学校读者我要写书评

暂无评论

Chinese Physics Letters 2017年第10期34卷 39-43页

作者： Chao-yi Li jun-Ming An Jiu-Qi wang liang-liang wang Jia-Shun zhang Jian-Guang Li Yuan-Da Wu Yue wang Xiao-Jie yin yong Li Fei Zhong State Key Laboratory on Integrated Optoelectronics Institute of Semiconductors Chinese Academy of Sciences College of Material Science and Optoelectronic Technology University of Chinese Academy of Sciences Beijing 100049 College of Software Beihang University Beijing 100191 4Henan Shi Jia Photons Technology Co. Ltd Hebi 458030

An 8×10 GHz receiver optical sub-assembly （ROSA） consisting of an 8-channel arrayed waveguide grating （AWG） and an 8-channel PIN photodetector （PD） array is designed and fabricated based on silica hybrid integration technology. Multimode output waveguides in the silica AWG with 2% refractive index difference are used to obtain fiat-top spectra. The output waveguide facet is polished to 45° bevel to change the light propagation direction into the mesa-type PIN PD, which simplifies the packaging process. The experimentM results show that the single channel I dB bandwidth of AWG ranges from 2.12nm to 3.06nm, the ROSA responsivity ranges from 0.097 A/W to 0.158A/W, and the 3dB bandwidth is up to 11 GHz. It is promising to be applied in the eight-lane WDM transmission system in data center interconnection.

关键词： AWG GHz Receiver Optical Subassembly Based on Silica Hybrid Integration Technology for Data Center Interconnection The 8 PD

Development of a High-throughput Sequencing Platform for Detection of Viral Encephalitis Pathogens Based on Amplicon Sequencing

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2024年第3期37卷 294-302页

作者： zhang Ya Li SU Wen Zhe wang Rui Chen LI Yan zhang jun Feng LIU Sheng hui hu Dan He XU Chong Xiao yin Jia Yu yin Qi Kai HE ying LI Fan FU Shi Hong NIE Kai liang Guo Dong TAO yong XU Song Tao MA Chao Feng wang huan Yu Shaanxi University of Chinese Medicine Xianyang 712000ShaanxiChina National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China Guangzhou Center for Disease Control and Prevention Guangzhou 510000GuangdongChina Shandong Center for Disease Control and Prevention Jinan 250000ShandongChina Department of Ophthalmology Beijing Chaoyang HospitalCapital Medical UniversityBeijing 100020China Xi'an Center for Disease Control and Prevention Xi’an 710054ShaanxiChina

Objective Viral encephalitis is an infectious disease severely affecting human *** is caused by a wide variety of viral pathogens,including herpes viruses,flaviviruses,enteroviruses,and other *** laboratory diagnosis of viral encephalitis is a worldwide ***,high-throughput sequencing technology has provided new tools for diagnosing central nervous system ***,In this study,we established a multipathogen detection platform for viral encephalitis based on amplicon *** We designed nine pairs of specific polymerase chain reaction(PCR)primers for the 12 viruses by reviewing the relevant *** detection ability of the primers was verified by software simulation and the detection of known positive *** sequencing was used to validate the samples,and consistency was compared with Sanger *** The results showed that the target sequences of various pathogens were obtained at a coverage depth level greater than 20×,and the sequence lengths were consistent with the sizes of the predicted *** sequences were verified using the National Center for Biotechnology Information BLAST,and all results were consistent with the results of Sanger *** Amplicon-based high-throughput sequencing technology is feasible as a supplementary method for the pathogenic detection of viral *** is also a useful tool for the high-volume screening of clinical samples.

关键词： Viral encephalitis Amplicon sequencing High-throughput sequencing Multipathogen detection

Observation and mitigation of image distortion in high-energy electron radiography

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2023年第6期34卷 69-77页

作者： Hao-Qing Li liang Sheng Chang-Qing zhang ying-Chao Du Zheng Zhou Xiu-Feng Weng Jia-Hao Xiao Hong-Qiao yin Bin Sun Kun Wei Yang Li Bao-jun Duan yong-Tang Liu Yan-Hong zhang Mei zhang Yan Song Xiao-Dong zhang jun Liu Zhu-Ming Fu Qing Xu Xue Du Jian-Peng Gao Xin-yi wang Xin-Jian Tan Dong-Wei Hei Department of Engineering Physics Tsinghua UniversityBeijing100084China State Key Laboratory of Intense Pulsed Radiation Simulation and Effect Northwest Institute of Nuclear TechnologyXi’an710024China Institute of Applied Electronics China Academy of Engineering PhysicsMianyang621900China Institute of Intelligent Machines Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei230031China Zhongke Hefei Institutes of Collaborative Research and Innovation for Intelligent Agriculture Hefei231131China

Image distortion caused by the angular misalignment of quadrupole magnets in high-energy electron radiography has been studied *** propose that the distortion originates from the coupling of the electron motions in the transverse directions,based on a theoretical analysis and the transfer-matrix *** relative angular rotation between the second and third magnetic quadrupoles was identified as the main contributor to image *** was verified by both a beam-dynamics simulation and *** strategies to mitigate this image distortion are also explored,including magnets online tuning,higher beam energy and larger magnification *** study provides criteria for designing experiments and paves the way for achieving higher image precision.

关键词： Misalignment Angular rotation Russian quadruplet Transfer matrix

South Galactic Cap u-band Sky Survey(SCUSS):Project Overview

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2016年第4期16卷 133-144页

作者： Xu Zhou Xiao-hui Fan Zhou Fan Bo-liang He Lin-hua Jiang Zhao-Ji Jiang yi-Peng Jing Michael Lesser jun Ma jun-Dan Nie Shi-yin Shen Jia-Li wang Zhen-Yu Wu Tian-Meng zhang Zhi-Min Zhou hu Zou Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100012China Steward Observatory University of ArizonaTucsonAZ 85721USA Center for Astronomy and Astrophysics Department of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Kavli Institute for Astronomy and Astrophysics Peking UniversityBeijing 100871China

The South Galactic Cap u-band Sky Survey （SCUSS） was established in 2009 in order to provide a photometric input catalog for target selection of the Large Sky Area Multi-Object Fiber Spectroscopic Telescope （LAMOST） project. SCUSS is an international cooperative project between National Astronomical Observatories, Chinese Academy of Sciences, and Steward Observatory at the University of Arizona, using the 90 inch （2.3 m） Bok telescope on Kitt Peak. The telescope is equipped with a prime focus camera that is composed of a mosaic of four 4096 × 4096 CCDs and has a field of view of about 1 deg2. From 2009 to 2013, SCUSS performed a sky survey of an approximately 5000 deg2 field of the South Galactic Cap in u band, including the Galactic anticenter area and the SDSS-IV extended imaging area. The limiting magnitude of SCUSS is deeper than 23 mag （at a signal-to-noise ratio of 5）. In this paper, we briefly describe the goals of this project, method of observations and data reduction, and we also introduce current and potential scientific activities related to the SCUSS project.

关键词： observation: sky survey -- techniques: data reduction -- objects: stars and galaxies

Chinese expert consensus on organ protection of transplantation(2022 edition)

在线全文

学校读者我要写书评

暂无评论

Hepatobiliary & Pancreatic Diseases International 2022年第6期21卷 516-526页

作者： Jian-hui Li Xiao Xu Yan-Feng wang Hai-Yang Xie Jing-Yu Chen Nian-Guo Dong Mitesh Badiwala Li-Ming Xin Roberto Vanin Pinto Ribeiro Hao yin Hao zhang Jian-Zheng zhang Feng huo Jia-yin Yang Hong-Ji Yang hui Pan Shao-Guang Li yin-Biao Qiao Jia Luo Hao-Yu Li jun-jun Jia Hao Yu Han liang Si-Jia Yang Hao wang Zhong-Yang Liu Li-cheng zhang Xiao-yi hu Hao Wu yi-Qing hu Pei-Fu Tang Qi-Fa Ye Shu-Sen Zheng Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Department of Hepatobiliary and Pancreatic Surgery Hangzhou First People’s HospitalZhejiang University School of MedicineHangzhou 310000China Zhongnan Hospital of Wuhan University Institute of Hepatobiliary Diseases of Wuhan UniversityTransplant Center of Wuhan UniversityHubei Key Laboratory of Medical Technology on TransplantationWuhan 430062China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Wuxi Lung Transplantation Center Wuxi People’s Hospital Affiliated with Nanjing Medical UniversityWuxi 214023China Department of Cardiovascular Surgery Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Peter Munk Cardiac Centre Toronto General Hospital-University Health NetworkTorontoCanada School of Computer Engineering and Science Shanghai UniversityShanghai 200444China Organ Transplant Center Shanghai Changzheng HospitalShanghai 200003China Department of Orthopedics Chinese PLA General HospitalBeijing 100039China National Clinical Research Center for Orthopedics Sports Medicine&RehabilitationBeijing 100039China Department of Surgery General Hospital of Guangzhou Military Command of PLAGuangzhou 510040China Department of Liver Surgery Liver Transplantation CenterWest China Hospital of Sichuan UniversityChengdu 610041China Organ Transplantation Center Sichuan Provincial People’s Hospital and School of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072China Department of Lung Transplantation The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Division of Hepatobiliary Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Introduction Organ transplantation increases survival and improves qual-ity of life to many patients with end-stage organ ***-gan shortage is a worldwide problem that restricts organ trans-plantation[1].Organ procurement and preservation as well as ischemia-reperfusion injury(IRI)after transplantation are the im-portant factors affecting prognosis of *** the de-velopment of organ transplantation technology in the 20th cen-tury,organ protection technology has been a most promising con-cept in this *** preservation solutions such as the Collins solution,University of Wisconsin(UW)solution,and histidine-tryptophan-ketoglutarate(HTK)solution were developed sequen-tially[2],which developed rapidly in static cold storage(SCS)*** remains the standard preservation technique for organ transplantation[2].

关键词： organ preservation transplantation

Metformin accelerates bone fracture healing by promoting type H vessel formation through inhibition of YAP1/TAZ expression

在线全文

学校读者我要写书评

暂无评论

Bone Research 2023年第3期11卷 625-637页

作者： Zhe Ruan Hao yin Teng-Fei Wan Zhi-Rou Lin Shu-Shan Zhao Hai-Tao Long cheng Long Zhao-hui Li Yu-Qi Liu Hao Luo liang cheng Can Chen Min Zeng zhang-Yuan Lin Rui-Bo Zhao Chun-Yuan Chen Zhen-Xing wang Zheng-Zhao Liu Jia Cao yi-yi wang Ling Jin yi-Wei Liu Guo-Qiang Zhu Jing-Tao Zou Jiang-Shan Gong yi Luo yin hu yong Zhu hui Xie Department of Orthopedics Xiangya HospitalCentral South UniversityChangshaHunan 410008China Movement System Injury and Repair Research Center Xiangya HospitalCentral South UniversityChangshaHunan 410008China hunan Key Laboratory of Angmedicine ChangshaHunan 410008China Angmedicine Research Center of Central South University ChangshaHunan 410008China The First Affiliated Hospital Department of Metabolism and EndocrinologyHengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China

Due to increasing morbidity worldwide,fractures are becoming an emerging public health *** study aimed to investigate the effect of metformin on the healing of osteoporotic as well as normal *** H vessels have recently been identified as a bone-specific vascular subtype that supports ***,we show that metformin accelerated fracture healing in both osteoporotic and normal ***,metformin promoted angiogenesis in vitro under hypoxia as well as type H vessel formation throughout fracture ***,metformin increased the expression of HIF-1α,an important positive regulator of type H vessel formation,by inhibiting the expression of YAP1/TAZ in calluses and hypoxia-cultured human microvascular endothelial cells(HMECs).The results of HIF-1αor YAP1/TAZ interference in hypoxia-cultured HMECs using si RNA further suggested that the enhancement of HIF-1αand its target genes by metformin is primarily through YAP1/TAZ ***,overexpression of YAP1/TAZ partially counteracted the effect of metformin in promoting type H vessel-induced angiogenesis-osteogenesis coupling during fracture *** summary,our findings suggest that metformin has the potential to be a therapeutic agent for fractures by promoting type H vessel formation through YAP1/TAZ inhibition.

关键词： YAP1 healing fracture

A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus(2019-nCoV) infected pneumonia(standard version)

在线全文

学校读者我要写书评

暂无评论

Military Medical Research 2020年第1期7卷 1-22页

作者： ying-hui Jin Lin Cai Zhen-Shun cheng Hong cheng Tong Deng yi-Pin Fan cheng Fang Di huang Lu-Qi huang Qiao huang yong Han Bo hu Fen hu Bing-hui Li yi-Rong Li Ke liang Li-Kai Lin Li-Sha Luo Jing Ma Lin-Lu Ma Zhi-yong Peng Yun-Bao Pan Zhen-Yu Pan Xue-Qun Ren hui-Min Sun ying wang Yun-Yun wang Hong Weng Chao-Jie Wei Dong-Fang Wu Jian Xia yong Xiong Hai-Bo Xu Xiao-Mei Yao Yu-Feng Yuan Tai-Sheng Ye Xiao-Chun zhang ying-Wen zhang yin-Gao zhang hua-Min zhang Yan Zhao Ming-Juan Zhao Hao Zi Xian-Tao Zeng yong-Yan wang Xing-huan wang 无 Center for Evidence-Based and Translational Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Hospital Management Wuhan UniversityWuhan 430071China Department of Respiratory Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Pharmacy Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Evidence-Based Medicine and Knowledge Translation Henan UniversityKaifeng 475000China China Academy of Chinese Medical Sciences Beijing 100700China China Center for Evidence Based Traditional Chinese Medicine(CCEBTCM) Beijing 100700China Department of Critical Care Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Clinical Laboratory Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Infectious Diseases Zhongnan Hospital of Wuhan UniversityWuhan 430071China Division of Medical Affairs Zhongnan Hospital of Wuhan UniversityWuhan 430071China Division of Nursing Affairs Zhongnan Hospital of Wuhan UniversityWuhan 430071China Office of Nosocomial Infection Control Zhongnan Hospital of Wuhan UniversityWuhan 430071China Emergency Center Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Radiology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Department of Health Research Methods Evidenceand ImpactMcMaster UniversityHamiltonON L8S 4L8Canada Department of Traditional Chinese Medicine Zhongnan Hospital of Wuhan UniversityWuhan 430071China Global Health Institute Wuhan UniversityWuhan 430072China the Zhongnan Hospital of Wuhan University Novel Coronavirus Management and Research Team Evidence-Based Medicine Chapter of China International Exchange and Promotive Association for Medical and Health Care(CPAM)

In December 2019, a new type viral pneumonia cases occurred in Wuhan, hubei Province;and then named "2019 novel coronavirus(2019-nCoV)" by the World Health Organization(WHO) on 12 January 2020. For it is a never been experienced respiratory disease before and with infection ability widely and quickly, it attracted the world’s attention but without treatment and control manual. For the request from frontline clinicians and public health professionals of 2019-nCoV infected pneumonia management, an evidence-based guideline urgently needs to be developed. Therefore, we drafted this guideline according to the rapid advice guidelines methodology and general rules of WHO guideline development;we also added the first-hand management data of Zhongnan Hospital of Wuhan University. This guideline includes the guideline methodology, epidemiological characteristics, disease screening and population prevention, diagnosis, treatment and control(including traditional Chinese Medicine), nosocomial infection prevention and control, and disease nursing of the 2019-nCoV. Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. This rapid advice guideline is suitable for the first frontline doctors and nurses, managers of hospitals and healthcare sections, community residents, public health persons, relevant researchers, and all person who are interested in the 2019-nCoV.

关键词： 2019 novel coronavirus 2019-nCoV Respiratory disease Pneumonia Infectious diseases Rapid advice guideline Clinical practice guideline Evidence-based medicine