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Bupi Hewei decoction ameliorates 5-fluorouracil-induced intestinal dysbiosis in rats through T helper 17/T regulatory cell signaling pathway

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Journal of Traditional Chinese Medicine 2020年第1期40卷 38-48页

作者： Sun Zhigao hu yazhuo Wang Yuguo Feng Jian Dou Yongqi Department of Traditional Chinese Medicine Chinese PLA General HospitalBeijing 100853China&Department of Traditional Chinese MedicineHainan Branch of Chinese PLA General HospitalSanya 572013China Institute of Gerontology Chinese PLA General HospitalBeijing 100853China Department of Traditional Chinese Medicine Chinese PLA General HospitalBeijing 100853China

OBJECTIVE:To observe the effects of the Bupi Hewei(BPHW)decoction on diarrhea and intestinal flora disorder induced by 5-fluorouracil(5-FU)and investigate the possible mechanism underlying these ***:Thirty-five male Sprague-Dawley rats were randomly divided into four groups:normal control,5-FU,5-FU+BPHW decoction(10.5 g/kg for 5 consecutive days),and 5-FU+Bacillus licheni-formis capsule groups(0.2 g/kg for 5 consecutive days).Animal models were established via the intraperitoneal injection of 5-FU(30 mg/kg for 5 consecutive days).At the end of the treatment period,diarrhea was assessed,and the change of the intestinal flora was examined using 16 S r DNA highthroughput ***(IL)-17,IL-21,IL-6,IL-10,RAR-related orphan receptor gamma(RORγt),and forkhead box P3(Foxp3)expression in the jejunum was detected using immunohistochemistry,quantitative real-time polymerase chain reaction(PCR),Western blotting,and enzymelinked immuno sorbent ***:In this study,the BPHW decoction effectively lowered the diarrhea score,increased the proportions of Bacteroidetes and Prevotellaceae-Alloprevotella species,and reduced the proportions of Proteobacteria,Escherichia-Shigella,Ruminococcaceae NK4 A214,and Ruminococcaceae UCG-005 species in the rat intestine after 5-FU *** addition,the BPHW decoction significantly suppressed the expression of IL-17,IL-21,IL-6,IL-10,RORγt,and Foxp3 in the ***:Our findings suggest that the BPHW decoction can improve the intestinal immune balance and reduce intestinal inflammation by targeting T helper cell/T regulatory cell-associated factors.

关键词： Gastrointestinal microbiome Fluorouracil Drug therapy T-Lymphocytes,regulatory Th17 cells Bupi Hewei decoction

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Effects of bone morphogenetic protein-4 on spatial memory and cholinergic expression in the dentate gyrus after fornix-fimbria transection in rats

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Neural Regeneration Research 2008年第1期3卷 1-4页

作者： Lei Liu Yilong Xue Jingkun Pan yazhuo hu Yuhong Gao Yun Luo Department of Neurosurgery General Hospital of Chinese PLA Beijing 100853 China Laboratory for Cell Biology Institute of Geriatrics General Hospital of Chinese PLA Beijing 100853 China

BACKGROUND： Previous experiments have confirmed bone morphogenetic proteins （BMPs） upregulate cholinergic expression in neurons isolated from the embryonic rat hippocampus and cerebral cortex. Therefore, BMPs could be useful for treating Alzheimer＇s disease and other neurodegenerative diseases. OBJECTIVE： BMP-4 was infused into the hippocampal dentate gyrus of fomix-fimbria transected rats to test the effects of BMP-4 on cholinergic expression in dentate gyrus neurons, and to observe changes in spatial memory behavior. DESIGN： A randomized controlled animal experiment. SETTING： Department of Neurosurgery and Laboratory for Cell Biology, Institute of Geriatrics, General Hospital of Chinese PLA. MATERIALS： Twenty-seven healthy adult male Sprague Dawley （SD） rats, weighing 250-300 g, were provided by the Laboratory Animal Center of the General Hospital of Chinese PLA. Reagents： BMP-4 （B-2680, Sigma Company） and choline acetyl transferase （CHAT） antibody （AB5042, Chemicon Company） were used in this study. Equipments： a rat stereotaxic instrument （type： SN-2N, Narushige Group, Japan） and Image-prog-plus image analysis software （Media Cybernetics company, USA） were used in this study. The protocol was carried out in accordance with ethical guidelines for the use and care of animals. METHODS： This experiment was performed in the Institute of Geriatrics, General Hospital of Chinese PLA between July 2004 and March 2005. Rats were randomly divided into 4 groups： Alzheimer＇s disease group （n = 7）, normal control group （n = 5）, BMP-4-Alzheimer＇s disease group （n = 8）, and model group （n = 7）. In the Alzheimer＇s disease group, the left hippocampal fomix-fimbria of rats was transected to mimic Alzheimer＇s disease symptoms. In the BMP-4-Alzheimer＇s disease group, 1 μt L BMP-4 （10 mg/L） was perfused into the left dentate gyrus with a microinjector at 1 μ L/min. In the model group, 1 μ L saline was perfused into the same position by the same method. Twenty-eight days after injection

关键词： senile dementia bone morphogenetic-protein-4 hippocampus dentate gyrus cholinergicneuron Alzheimer's disease

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Effects of Shuyusan on monoamine neurotransmitters expression in a rat model of chronic stress-induced depression

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Neural Regeneration Research 2011年第33期6卷 2582-2588页

作者： Yuanyuan Zhang Jianjun Jia Liping Chen Zhitao Han Yulan Zhao Honghong Zhang yazhuo hu Department of Neurology South Building of Chinese PLA General Hospital Beijing 100853 China

Shuyusan, a traditional Chinese medicine, was shown to improve depression symptoms and behavioral scores, as well as increase 5-hydroxytryptamine （5-HT）, 5-hydroxyindoleacetic acid, and 5-hydroxytryptophan levels, in a rat model of chronic stress-induced depression. However, dopamine, noradrenalin, and 3-methoxy-4-hydroxyphenylglycol expressions remained unchanged following Shuyusan treatment. Compared with the model group, the number of 5-HT-positive neurons in layers 4-5 of the frontal cortex, as well as hippocampal CA1 and CA3 regions, significantly increased following Shuyusan treatment. These results suggested that Shuyusan improved symptoms in a rat model of chronic stress-induced depression with mechanisms that involved 5-HT, 5-HT metabolite, 5-HT precursor expressions.

关键词： 5-hydroxytryptamine chronic stress depression neurotransmitter Shuyusan traditional Chinese medicine

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Protective effects of baicalin on amyloid beta 25-35-induced apoptosis in human neuroblastoma SH-SY5Y cells

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Neural Regeneration Research 2010年第22期5卷 1739-1744页

作者： Miao Geng Hongyan Chen Jianhua Wang yazhuo hu Jianwei Liu Jing Liu Jingkun Pan Yuhong Gao Institute of Geriatrics Division of South Building Chinese PLA General Hospital Beijing 100853 China

Baicalin, a type of flavanoid, effectively prevents cellular apoptosis induced by various factors. However, little evidence is available regarding its role on amyloid β （Aβ） -induced neuronal apoptosis. The present study investigated the protective mechanisms of baicalin on Aβ-induced neuronal apoptosis. Flow cytometry and cation dye 5, 5＇, 6, 6＇-tetrachloro-1, 1＇, 3, 3＇-tetraethyl- benzimidazoly lcarbocyanine iodide （JC-1） were employed to measure mitochondrial membrane potential, and nitric oxide secretion and apoptotic-related factors, such as caspase-3, were comprehensively analyzed. Results demonstrated a protective effect of baicalin on Aβ-treated SH-SY5Y cell viability; the rate of apoptosis decreased, nitric oxide generation and expression of caspase-3 were effectively inhibited, and mitochondrial membrane potential was effectively protected. Baicalin inhibited Aβ-induced neuronal apoptosis via multiple targets and multiple pathways, such as the inhibition of free radical damage, reduction of caspase-3 expression, and protection of normal mitochondrial functions.

关键词： baicalin neuron apoptosis traditional Chinese medicine caspase-3 amyloid β neural regeneration

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Neuroglobin expression in rats after traumatic brain injury

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Neural Regeneration Research 2012年第25期7卷 1960-1966页

作者： Xin Lin Min Li Aijia Shang yazhuo hu Xiao Yang Ling Ye Suyan Bian ZhongfengWang Dingbiao Zhou Department of Surgery Division of Nanlou General Hospital of Chinese PLA Beijing 100853 China Department of Traumatic-Aesthetic Surgery Huangsi Aesthetic Surgery Hospital Beijing 100120 China Department of Neurosurgery Division of Surgery General Hospital of Chinese PLA Beijing 100853 China Institute of Geriatrics General Hospital of Chinese PLA Beijing 100853 China Institute of Microbiology and Epidemiology Academy of Military Medical Sciences Beijing 100071 China Department of Cardiology Division of Nanlou General Hospital of Chinese PLA Beijing 100853 China Institute of Brain Science and State Key Laboratory of Medical Neurobiology Fudan University Shanghai 200032 China

In this study, we used a rat model of severe closed traumatic brain injury to explore the relationship between neuroglobin, brain injury and neuronal apoptosis. Real-time PCR showed that neuroglobin mRNA expression rapidly increased in the rat cerebral cortex, and peaked at 30 minutes and 48 hours following traumatic brain injury. Immunohistochemical staining demonstrated that neuroglobin expression increased and remained high 2 hours to 5 days following injury. The rate of increase in the apoptosis-related Bax/Bcl-2 ratio greatly decreased between 30 minutes and 1 hour as well as between 48 and 72 hours post injury. Expression of neuroglobin and the anti-apoptotic factor Bcl-2 greatly increased, while that of the proapoptotic factor decreased, in the cerebral cortex post severe closed traumatic brain injury. It suggests that neuroglobin might protect neurons from apoptosis after traumatic injury by regulating Bax/Bcl-2 pathway.

关键词： neuroglobin traumatic brain injury neuron apoptosis cerebral cortex Bax Bcl-2 neuralregeneration

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Emperipolesis is a potential histological hallmark associated with chronic hepatitis B

Emperipolesis is a potential histological hallmark associate...

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中华医学会第七次全国艾滋病、丙型肝炎学术会议

作者： Zhao Jingmin hu yazhuo Jiang Lina Zhou Guangde Liu Shuhong Liu Yuan Wu Liyuan Sun Qiang Wang Xiaoning Department of Pathology and Hepatology Beijing 302 Hospital Beijing Key Laboratory for Aging and Geriatrics Institute of GeriatricsGeneral Hospital of Chinese PLA Laboratory of Cell Engineering Institute of Biotechnology

Although emperipolesis exists in infectious liver diseases,the diagnostic value of emperipolesis in chronic hepatitis B is not exactly *** aim of this study was to evaluate the histological characteristics and laboratory parameters of emperipolesis in chronic hepatitis *** 402 patients with hepatitis B and other liver diseases were processed in a retrospective *** severity

关键词： CHB Emperipolesis is a potential histological hallmark associated with chronic hepatitis B

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琴键堰在水利界的研究与应用现状

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灌溉排水学报 2020年第S1期39卷 143-148页

作者：胡亚卓拾兵中国海洋大学工程学院山东青岛266100

本文将国内外对琴键堰的流态特征、水力特性、影响水力特性的各重要参数、结构设计及施工等问题的研究成果及应用情况作了系统的归纳和详细的评述,并对琴键堰上游淤积、下游消能冲刷影响及在大坝河谷中修建琴键堰等问题作了讨论。总结... 详细信息

本文将国内外对琴键堰的流态特征、水力特性、影响水力特性的各重要参数、结构设计及施工等问题的研究成果及应用情况作了系统的归纳和详细的评述,并对琴键堰上游淤积、下游消能冲刷影响及在大坝河谷中修建琴键堰等问题作了讨论。总结了琴键堰的发展趋势,希望找出琴键堰合适的适用条件,为以后的工程建设提供参考,具有实用价值。迄今为止,所有已建的琴键堰均采用了物理比例模型进行研究,数值模拟能够以可接受的精度再现琴键堰下游的复杂流动条件,从而用于验证下游结构设计或研究能量消散。然而,因缺乏系统的试验研究,目前琴键堰下游流动条件的详细数据明显不知,影响了数值模型的开发和验证。建议在该领域开展进一步的研究工作。

关键词：琴键堰流态特征水力特性超泄比消能防冲

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乳腺病变剪切波弹性模量与胶原纤维的相关性

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中国医学影像学杂志 2014年第10期22卷 721-724页

作者：王知力孙璐胡亚卓李晔解放军总医院超声诊断科北京100853 解放军总医院病理科北京100853 解放军总医院老年病研究所北京100853

目的探讨乳腺良恶性病变剪切波弹性模量及胶原纤维含量的差异,分析乳腺病变剪切波弹性模量与胶原纤维的相关性。资料与方法对解放军总医院的116例拟进行手术或穿刺活检的乳腺病变患者进行剪切波弹性检查,并对手术或穿刺活检病理标本行Va... 详细信息

目的探讨乳腺良恶性病变剪切波弹性模量及胶原纤维含量的差异,分析乳腺病变剪切波弹性模量与胶原纤维的相关性。资料与方法对解放军总医院的116例拟进行手术或穿刺活检的乳腺病变患者进行剪切波弹性检查,并对手术或穿刺活检病理标本行Van Gieson(VG)染色,采用Image-Pro Plus 5.1软件进行胶原纤维的定量分析。结果乳腺恶性病变弹性模量最大值、平均值及病灶与周围组织弹性模量比值(140.43±70.16)kPa、(63.11±33.68)kPa、3.49±1.95明显高于良性病变的(54.64±48.53)kPa、(34.52±25.23)kPa、2.25±1.48(t=5.329、4.382、4.487,P<0.01)。恶性病变胶原纤维面积明显大于良性病变(t=8.437,P<0.01)。弹性模量最大值与胶原纤维含量呈线性正相关(r=0.746,P<0.05)。结论乳腺病变的弹性模量与胶原纤维含量密切相关,胶原纤维在乳腺癌的发生发展过程中可能发挥重要作用。

关键词：乳腺肿瘤超声检查,乳房弹性成像技术胶原病理学,外科

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肌阵挛失神癫痫临床和电生理研究

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中国神经精神疾病杂志 2020年第10期46卷 577-581页

作者：胡亚卓樊新红王晓丽王碧胡小静朱江刘永红空军军医大学西京医院神经内科脑电监测中心西安710032 兵器工业五二一医院神经内科

目的探讨肌阵挛失神癫痫(epilepsy with myoclonic absences,EMA)的临床和电生理特点。方法对我院脑电监测中心2018-2019年收治的3例EMA患者临床和电生理特点进行总结和随访研究。结果3例患者均为男性。2例儿童期起病,1例成年起病。1例... 详细信息

目的探讨肌阵挛失神癫痫(epilepsy with myoclonic absences,EMA)的临床和电生理特点。方法对我院脑电监测中心2018-2019年收治的3例EMA患者临床和电生理特点进行总结和随访研究。结果3例患者均为男性。2例儿童期起病,1例成年起病。1例表现为肌阵挛失神和全面性强直阵挛发作,2例表现为肌阵挛失神发作。3例发作期脑电图异常放电均不是标准3Hz棘慢复合波,发作期棘慢复合波频率波动在2.5~3.5 Hz。2例间断闪光刺激诱发试验阳性,其中1例表现为光阵发性反应(1~60 Hz阳性),1例表现为光阵发性反应及光惊厥性反应。睁闭眼试验3例均为阴性。过度换气试验2例阳性,1例阴性。治疗给予丙戊酸钠缓释片,2例有效,1例仍有发作。结论EMA多见于儿童,但也有较大年龄发病者。以肌阵挛失神为主要发作类型。EMA发作期脑电图可以是2.5~3.5 Hz棘慢复合波。EMA患者光敏性可为低频、高频均敏感。其肌阵挛失神发作容易被过度换气所诱发。治疗使用丙戊酸钠或丙戊酸钠联合拉莫三嗪,通常有效,存在认知功能损害,或伴随其他发作,特别是全面性强直阵挛发作的患者,可能预后不良。

关键词：肌阵挛失神癫痫视频脑电监测肌电图描计术间断性闪光刺激

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美育教育渗透文化类综艺节目的路径选择探究

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新闻研究导刊 2024年第7期15卷 12-14页

作者：孙杨胡雅卓钭亚萍山西传媒学院视听学院山西太原030012

近年来,文化类综艺节目市场百花齐放,一大批口碑出圈的优质作品横空出世。文化类综艺节目是守护和弘扬中华优秀传统文化的重要窗口,通过创新叙事模式、镜头语言、艺术形象、舞台表现等方面的内容,能够映射出我国五千年来深厚的历史底蕴... 详细信息

近年来,文化类综艺节目市场百花齐放,一大批口碑出圈的优质作品横空出世。文化类综艺节目是守护和弘扬中华优秀传统文化的重要窗口,通过创新叙事模式、镜头语言、艺术形象、舞台表现等方面的内容,能够映射出我国五千年来深厚的历史底蕴,激发观众审美兴趣,提升大众审美水平。文化类综艺节目的广泛传播,有利于坚定文化自信,增强民族文化认同。而美育作为一种思想与艺术相结合的教育,对文化类综艺节目的艺术语言、艺术形象和艺术意蕴等方面具有深远影响,可培养大众形成高雅的审美品位、正确的价值取向。美育教育则是审美教学与美感教学的结合,可培养出德智体美劳全面发展的社会主义建设者和接班人,对文化类综艺节目的制播和思想内核具有重要影响。用美学理念包装节目,以美育教育功能反哺受众,实现对时代精神的追寻,促进大众综合素质的提高,有利于社会主义精神文明建设。文章以文化类综艺节目为核心,分析美育在舞台美学、叙事结构、价值引领等方面对文化类综艺节目样态的影响,挖掘美育教育培育大众审美趣味和情操,提升综合素质的功能,推动该类型节目实现对精神价值的追求及引领,促进社会美育的建设与发展。

关键词：传统文化美育教育文化类综艺节目价值文化自信

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