Effects of Shuyusan on monoamine neurotransmitters expression in a rat model of chronic stress-induced depression

作     者：Yuanyuan Zhang Jianjun Jia Liping Chen Zhitao Han Yulan Zhao Honghong Zhang Yazhuo Hu 

作者机构：Department of Neurology South Building of Chinese PLA General Hospital Beijing 100853 China 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2011年第6卷第33期

页      面：2582-2588页

核心收录：

学科分类：090603[农学-临床兽医学] 0710[理学-生物学] 07[理学] 09[农学] 0906[农学-兽医学] 071006[理学-神经生物学] 

基　　金：a grant from Science and Technology Bureau of Beijing  No.Z090507017709030 

主　　题：5-hydroxytryptamine chronic stress depression neurotransmitter Shuyusan traditional Chinese medicine 

摘      要：Shuyusan, a traditional Chinese medicine, was shown to improve depression symptoms and behavioral scores, as well as increase 5-hydroxytryptamine （5-HT）, 5-hydroxyindoleacetic acid, and 5-hydroxytryptophan levels, in a rat model of chronic stress-induced depression. However, dopamine, noradrenalin, and 3-methoxy-4-hydroxyphenylglycol expressions remained unchanged following Shuyusan treatment. Compared with the model group, the number of 5-HT-positive neurons in layers 4-5 of the frontal cortex, as well as hippocampal CA1 and CA3 regions, significantly increased following Shuyusan treatment. These results suggested that Shuyusan improved symptoms in a rat model of chronic stress-induced depression with mechanisms that involved 5-HT, 5-HT metabolite, 5-HT precursor expressions.