检索结果-南通市图书馆

Journal of Environmental Sciences 2005年第2期17卷 256-258页

作者： JIXiu-ling YANGLiu SHENZhe-min CHENGJin-ping JINGui-wen QULi-ya WANGWen-hua SchoolofEnvironmentalScienceandEngineering ShanghaiJiaotongUniversityShanghai200240China GuizhouInstituteforEnvironmentalProtection Guiyang550002China

The neurotransmitter level changes of ducks exposed 8-month in a mercury-polluted site(Wanshan, China) and a reference site(Shanghai, China) were examined. Chemical analyses showed both higher mercury and selenium concentrations in the organ of Wanshan ducks. An increased content of acetylcholine(ACh) in brain and blood and a decreased activity of acetylcholinesterase(AChE) in blood were observed. Moreover, there was an increasing trend for nitric oxide synthase(NOS) activity and nitric oxide(NO) production in duck brain, but a reduction of NOS activity in duck serum. The possible explanations were due to the interactive effect of selenium accumulation and the sublethal exposure level of mercury in Wanshan area. The present study showed that AChE and NOS were sensitive to mercury contamination of real circumstance, suggesting that these two indexes have the potential to be biomarkers in assessment of health effects by mercury contamination.

关键词： mercury neurotransmitter long-term exposure Wanshan area

A review of the neurotransmitter system associated with cognitive function of the cerebellum in Parkinson's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第2期19卷 324-330页

作者： Xi Chen Yuhu Zhang Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Shantou University Medical College ShantouGuangdong ProvinceChina

The dichotomized brain system is a concept that was generalized from the‘dual syndrome hypothesis’to explain the heterogeneity of cognitive impairment,in which anterior and posterior brain systems are independent but partially *** dopaminergic system acts on the anterior brain and is responsible for executive function,working memory,and *** contrast,the cholinergic system acts on the posterior brain and is responsible for semantic fluency and visuospatial *** from dopaminergic/cholinergic imaging or functional neuroimaging has shed significant insight relating to the involvement of the cerebellum in the cognitive process of patients with Parkinson’s *** research has reported evidence that the cerebellum receives both dopaminergic and cholinergic ***,whether these two neurotransmitter systems are associated with cognitive function has yet to be fully ***,the precise role of the cerebellum in patients with Parkinson’s disease and cognitive impairment remains ***,in this review,we summarize the cerebellar dopaminergic and cholinergic projections and their relationships with cognition,as reported by previous studies,and investigated the role of the cerebellum in patients with Parkinson’s disease and cognitive impairment,as determined by functional *** findings will help us to understand the role of the cerebellum in the mechanisms underlying cognitive impairment in Parkinson’s disease.

关键词： anterior brain system cerebellum cholinergic cognitive impairment dopaminergic dual syndrome hypothesis neuroimage neurotransmitter Parkinson’s disease posterior brain system therapeutic targets

Effects of Paranosema locustae(Microsporidia) on the development and morphological phase transformation of Locusta migratoria(Orthoptera: Acrididae) through modulation of the neurotransmitter taurine

在线全文

学校读者我要写书评

暂无评论

Journal of Integrative Agriculture 2020年第1期19卷 204-210页

作者： LI Ao-mei YIN Yue ZHANG Yu-xin ZHANG Liu ZHANG Kai-qi SHEN Jie TAN Shu-qian SHI Wang-peng Department of Entomology and MOA Key Lab of Pest Monitoring and Green Management College of Plant ProtectionChina Agricultural University

neurotransmitters are important in the maintenance of phase transformation of Locusta migratoria(Arthropoda: Orthoptera). Here, the effects of the entomopathogen Paranosema locustae on the neurotransmitter taurine in migratory locusts were studied using biochemical methods. After inoculation with P. locustae, the taurine content of infected locusts significantly declined, but F/C values(ratio between the length of hind femur and the width of the head of locust) increased significantly, compared to healthy locusts. Meanwhile, F/C values of infected locusts that were injected with 2 μg of taurine showed no significant differences from those of healthy locusts, demonstrating that supplemental taurine inhibited the changes in morphological phase caused by P. locustae. Paranosema locustae infection also caused longer developmental durations and lower body weights of locusts, but these changes were unaffected after injection with taurine. These results provided new insights into the mechanisms by which microsporidian parasites affected their locust hosts.

关键词： Locusta migratoria Paranosema locustae neurotransmitter taurine morphological characteristics

Ion Transport Signal Pathways Mediated by neurotransmitter(Biogenic Amines) of Litopenaeus vannamei Under Low Salinity Challenge

在线全文

学校读者我要写书评

暂无评论

Journal of Ocean University of China 2019年第1期18卷 210-218页

作者： PAN Luqing SI Lingjun HU Dongxu The Key Laboratory of Mariculture of Ministry of Education Ocean University of China

The Pacific white shrimp, Litopenaeus vannamei, is widely farmed in China. Salinity is a major environmental factor that affects its growth and distribution. Crustacean hyperglycemic hormone is verified to participate in ion transport in response to the salinity challenge mediated by endocrine neurotransmitters(biogenic amines, BAs). In the present study, the contents of BAs and expressions of their receptors were detected in gills of Litopenaeus vannamei exposed to low salinity. The intracellular signaling molecules such as cyclic adenosine monophosphate(cAMP), protein kinase A(PKA), 14-3-3 protein, FXYD2 protein and cAMP response element-binding protein(CREB) were detected. The effects of low salinity on the expressions of Na^+-K^+-ATPase, Na^+/K^+/2 Cl-co-transporter and Cl-transporter and activity of Na^+-K^+-ATPase were also analyzed. The results showed that dopamine and epinephrine concentrations and their receptor expressions were significantly affected by low salinity. The changes of c AMP and PKA were obvious and the expressions of 14-3-3 and FXYD2 peaked at early stages. However, the expression of CREB was only significantly up-regulated on day 9. The activity and expression of Na^+-K^+-ATPase(α subunit) reached a peak on day 1. The expressions of Na^+/K^+/2 Cl-co-transporter and Cl-transporter up-regulated obviously. It suggests that BAs can activate the cAMP-PKA pathway, which further acts on the 14-3-3 and FXYD2 proteins, and ultimately improve the activity of Na^+-K^+-ATPase. Furthermore, after BAs stimulate the cAMP-PKA pathway, PKA phosphorylates the transcription factor CREB and regulates the expressions of ion transport enzymes/transporters. The results in this study are helpful for understanding the response mechanism of endocrine neurotransmitters on osmoregulation in crustaceans.

关键词： ion regulation Litopenaeus vannamei low salinity neurotransmitter BA receptor

The Relationship between Problem Behavior and neurotransmitter Deficiency in Adolescents

在线全文

学校读者我要写书评

暂无评论

Journal of Huazhong University of Science and Technology(Medical Sciences) 2010年第6期30卷 714-719页

作者：宋晓琴王红星郑雷谌丁艳王增珍 Department of Epidemiology and Health Statistics School of Public HealthTongji Medical CollegeHuazhong University of Science and Technology Ingenious Targeting Laboratory Inc.25New York 11790-3350USA

This study examined the association of problem behavior with neurotransmitter deficiency in adolescents,which would provide new insights into behavioral problems.A total of 1259 students of the seventh grade from 4 middle schools in Wuhan city located in the central China were *** the approval of school and parents,they were invited to complete the Youth Self-Report (YSR) questionnaire and Symptom Scale of neurotransmitter Deficiency (SSND) ***’s bivariate correlation analysis showed that the correlation coefficients between each subscale of YSR and SSND ranged from 0.24 to 0.61 with all Pneurotransmitter deficiency may cause a series of behavioral and mental problems.

关键词： problem behavior neurotransmitter Youth Self-Report canonical correlation analysis

Influence of mesenteric lymph reperfusion on neurotransmitter expression in brain tissue of a superior mesenteric artery occlusion shock rat model

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2010年第11期5卷 859-863页

作者： Chunyu Niu Zigang Zhao Aimin Shang Jiaming Tian Chunhui Zhang Rui Han Yuping Zhang Jing Zhang Institution of Microcirculation Hebei North University Zhangjiakou 075029 Hebei Province China

BACKGROUND： Previous studies have shown that mesenteric lymph reperfusion （MLR） exacerbates brain injury in a rat model of superior mesenteric artery occlusion （SMAO） shock. However, little is known about the influence of MLR on neurotransmitter expression in brain tissue. OBJECTIVE： To observe the effect of MLR on brain tissue injury by measuring monoamine and cholinergic neurotransmitter levels. DESIGN, TIME AND SETTING： A randomized, controlled, animal experiment was performed at the Institute of Microcirculation, Hebei North University, China; Research Room of Microcirculation and Laboratory of Biochemistry, Department of Pathophysiology, Basic Medical College, Hebei North University between December 2007 and March 2009. MATERIALS： Choline acetyltransferase （CHAT） and acetylcholine esterase （ACHE） kits were provided by Nanjing Jiancheng Bioengineering Institute, China; dopamine （DA） and noradrenalin （NE） standards were provided by the National Institute for the Control of Pharmaceutical and Biological Products; HP1100 chromatograph of liquid was provided by Agllent, USA. METHODS： A total of 24 male, Wistar rats were randomly assigned to 4 groups： sham-surgery, MLR SMAO, and MLR ＋ SMAO groups, with 6 rats in each group. In the MLR or SMAO groups, the mesenteric lymph duct or superior mesenteric artery was blocked for 1 hour. In the MLR ＋ SMAO group, the mesenteric lymph duct and superior mesenteric artery were occluded for 1 hour, followed by 2-hour repeffusion. ChAT and AChE levels were measured using the synthesized and hydrolyzed acetylcholine method, respectively. Liquid chromatography was employed to quantitatively analyze DA and NE levels, using relative retention time and the external standard method. MAIN OUTCOME MEASURES： CHAT, ACHE, DA, and NE levels. RESULTS： AChE levels were significantly increased, but ChAT levels were significantly decreased in the MLR and MLR ＋ SMAO groups following 2-hour repeffusion （P〈 0.01）. However, AChE activity in the MLR ＋

关键词： mesenteric lymph reperfusion shock superior mesenteric artery occlusion brain neurotransmitter neural regeneration

Evolution of neurotransmitter gamma-aminobutyric acid, glutamate and their receptors

在线全文

学校读者我要写书评

暂无评论

Zoological Research 2012年第S03期33卷 I0013-I0019页

作者： Zhiheng GOU Xiao WANG Wen WANG CAS-Max Planck Junior Research Group State Key Laboratory of Genetic Resources and EvolutionKunming Institute of Zoologythe Chinese Academy ofSciences(CAS)Kunming 650223China Graduate School of the Chinese Academy of Sciences Beijing 100049China

Gamma-aminobutyric acid （GABA） and glutamate are two important amino acid neurotransmitters widely present in the nervous systems of mammals, insects, round worm, and platyhelminths, while their receptors are quite diversified across different animal phyla. However, the evolutionary mechanisms between the two conserved neurotransmitters and their diversified receptors remain elusive, and antagonistic interactions between GABA and glutamate signal transduction systems, in particular, have began to attract significant attention. In this review, we summarize the extant results on the origin and evolution of GABA and glutamate, as well as their receptors, and analyze possible evolutionary processes and phylogenetic relationships of various GABAs and glutamate receptors. We further discuss the evolutionary history of Excitatory/Neutral Amino Acid Transporter （EAAT）, a transport protein, which plays an important role in the GABA-glutamate ＂yin and yang＂ balanced regulation. Finally, based on current advances, we propose several potential directions of future research.

关键词： Gamma-aminobutyric acid Glutamate neurotransmitter Receptor Evolution Yin and yang regulation

Correlation of blood uric acid level with the degree of anxiety as well as the neurotransmitter and cytokine secretion in young and middle-aged patients with anxiety disorder

维普期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Hainan Medical University 2019年第2期25卷 62-65页

作者： Xiao-Bei Liu Xiao-Jun Hou Neurology Department Shanghai Changhai HospitalShanghai200433

Objective:To study the correlation of blood uric acid level with the degree of anxiety as well as the neurotransmitter and cytokine secretion in young and middle-aged patients with anxiety ***: The young and middle-aged patients diagnosed with generalized anxiety disorder in our hospital between March 2015 and February 2018 were selected as the anxiety group, and the healthy subjects receiving physical examination during the same period were selected as the control group. Peripheral blood was collected to determine the contents of uric acid, neurotransmitters and cytokines, and Hamilton Anxiety Scale (HAMA) was adopted to judge the degree of ***: The blood uric acid level of anxiety group was obviously higher than that of control group and the higher the HAMA scores, the more significant the rising of blood uric acid levels;serum 5-hydroxytryptamine (5-HT), norepinephrine (NE), dopamine (DA), interleukin-1α (IL-1α), IL-17 and interferon-γ (IFN-γ) contents of anxiety group were significantly higher than those of control group whereas neuropeptide Y (NPY), IL-4 and transforming growth factor-β (TGF-β) contents were significantly lower than those of control group;blood uric acid level of the anxiety group was positively correlated with 5-HT, NE, DA, IL-1 , IL-17 and IFN-γ contents, and negatively correlated with NPY, IL-4 and TGF-β ***: The rise of blood uric acid level in young and middle-aged patients with anxiety disorder is related to the aggravation of anxiety degree as well as the abnormal secretion of neurotransmitters and cytokines.

关键词： Anxiety disorder in the young and middle-aged Blood uric acid neurotransmitter Cytokine

The dopaminergic system and Alzheimer's disease

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2495-2512页

作者： Yuhan Zhang Yuan Liang Yixue Gu International Medical College Chongqing Medical UniversityChongqingChina College of Pharmacy Chongqing Medical UniversityChongqingChina Department of Neurology The First Affiliated Hospital of Chongqing Medical UniversityChongqing Key Laboratory of NeurologyChongqingChina

Alzheimer's disease is a common neurodegenerative disorder in older *** its prevalence,its pathogenesis remains unclea *** addition to the most widely accepted causes,which in clude excessive amyloid-beta aggregation,tau hyperphosphorylation,and deficiency of the neurotransmitter acetylcholine,numerous studies have shown that the dopaminergic system is also closely associated with the occurrence and development of this *** is a crucial catecholaminergic neurotransmitter in the human ***-associated treatments,such as drugs that target dopamine receptor D and dopamine analogs,can improve cognitive function and alleviate psychiatric symptoms as well as ameliorate other clinical *** r,therapeutics targeting the dopaminergic system are associated with various adverse reactions,such as addiction and exacerbation of cognitive *** review summarizes the role of the dopaminergic system in the pathology of Alzheimer's disease,focusing on currently available dopamine-based therapies for this disorder and the common side effects associated with dopamine-related *** aim of this review is to provide insights into the potential connections between the dopaminergic system and Alzheimer's disease,thus helping to clarify the mechanisms underlying the condition and exploring more effective therapeutic options.

关键词： adverse drug reaction Alzheimer's disease catecholamine dopamine receptor dopamine receptor heterodimers dopaminergic system neurodegenerative disease neurotransmitter signaling pathways traditional Chinese medicine treatment

Nerve root magnetic stimulation regulates the synaptic plasticity of injured spinal cord by ascending sensory pathway

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第12期20卷 3564-3573页

作者： Ya Zheng Lingyun Cao Dan Zhao Qi Yang Chunya Gu Yeran Mao Guangyue Zhu Yulian Zhu Jing Zhao Dongsheng Xu Department of Rehabilitation Medicine Huashan HospitalFudan UniversityShanghaiChina School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Department of Rehabilitation Medicine Ruijin HospitalShanghai Jiaotong UniversityShanghaiChina Rehabilitation Medical Center Tongji Hospital Affiliated to Tongji University School of MedicineShanghaiChina Department of Rehabilitation Baoshan BranchShuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghaiChina National Center for Neurological Disorders ShanghaiChina Department of Neurology Minhang Hospital Affiliated to Fudan UniversityShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Institute of Rehabilitation Medicine Shanghai Academy of Traditional Chinese MedicineShanghaiChina

Promoting synaptic plasticity and inducing functional reorganization of residual nerve fibers hold clinical significance for restoring motor function following spinal cord *** stimulation targeting the nerve roots has been shown to improve motor function by enhancing nerve conduction in the injured spinal cord and restoring the synaptic ultrastructure of both the sensory and motor ***,our understanding of the neurophysiological mechanisms by which nerve root magnetic stimulation facilitates motor function recovery in the spinal cord is limited,and its role in neuroplasticity remains *** this study,we established a model of spinal cord injury in adult male Sprague–Dawley rats by applying moderate compression at the T10 *** then performed magnetic stimulation on the L5 nerve root for 3 weeks,beginning on day 3 *** day 22 post-injury,we observed that nerve root magnetic stimulation downregulated the level of interleukin-6 in the injured spinal cord tissue of ***,this treatment reduced neuronal damage and glial scar formation,and increased the number of neurons in the injured spinal ***,nerve root magnetic stimulation decreased the levels of acetylcholine,norepinephrine,and dopamine,and increased the expression of synaptic plasticity-related m RNA and proteins PSD95,GAP43,and Synapsin *** together,these results showed that nerve root magnetic stimulation alleviated neuronal damage in the injured spinal cord,regulated synaptic plasticity,and suppressed inflammatory *** findings provide laboratory evidence for the clinical application of nerve root magnetic stimulation in the treatment of spinal cord injury.

关键词： dendrite inflammation magnetic stimulation nerve root neurological function neuronal damage neurotransmitter spinal cord injury synaptic plasticity synaptic transmission