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Clinical manifestation and humoral immuno-function of myasthenia gravis patients with abnormal and normal thymus gland

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Neural Regeneration Research 2006年第2期1卷 190-192页

作者： Fuhua Peng Yongqiang Dai Wei Qiu xueqiang hu Department of Neurology Third Affiliated Hospital of SunYat-sen University Guangzhou 510630 Guangdong ProvinceChina

BACKGROUND： Myasthenia gravis （MG） is an autoimmune disease which mainly affects neuromuscular junctions. The ages, modified Osserman classification and clinical manifestation and humoral immunol function of MG with and without thymic abnormality are different. OBJECTIVE： To explore the clinical manifestation and humoral immuno-function of MG with abnormal and normal thymus gland. DESIGN ： Contrast observation SETTTNG ： Department of Neurology, the Third Affiliated Hospital of Sun Yat-sen University PARTZCZPANTS ： A total of 49 inpatients with MG were selected from the Third Affiliated Hospital of Sun Yat-sen University from March 2000 to August 2005. All the patients had typical clinical manifestation of MG and positive neostigmine test. All the patients knew and agreed the laboratory examinations. There were 22 males and 27 females of 2-69 years old. Chest MRI or CT scan were performed to reveal thymus gland abnormality. According to whether there was tumor in superior mediastinum, all patients were divided into 2 groups, abnormal and normal groups. Normal thymus gland group （n=30） contained 16 males and 14 females of 6-43 years old. Abnormal thymus gland group （n=19） contained 6 male and 13 female of 2-69 years old, METHODS： ① All patients were questioned about initial symptoms. Meanwhile, main clinical manifestations were recorded at hospital admission. ② 7180A automatic biochemical analyzer and automatic microplate reader were used in detecting seroimmunity index. The levels of C3, C4, IgG, IgA, IgM and CH50 in blood serum were analyzed by nephelometry. ③ Clinical classification is based on modified Osserman classification. The patients with MG were divided into six types： I （Ocular myasthenia）, Ⅱ a （Mild generalized myasthenia）, Ⅱb （Moderately severe generalized myasthenia）, Ⅲ （Acute fulminating myasthenia）, Ⅳ（Late se- vere myasthenia）. MAZN OUTCOME MEASURES： ① Differences of initial symptoms and clinical manifestation of two group patients. ② Differ

关键词： Clinical manifestation and humoral immuno-function of myasthenia gravis patients with abnormal and normal thymus gland IgA than IgM

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Effects of dendritic cell and subgroup changes on bone marrow transplantation treatment of multiple sclerosis

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Neural Regeneration Research 2009年第11期4卷 874-878页

作者： Fuhua Peng Xiufeng Zhong xueqiang hu Zhiyang Zhou Yu Yang Wei Qiu XuhuiDeng Department of Neurology Third Affiliated Hospital of Sun Yat-sen University Guangzhou 510630 Guangdong Province China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center of Sun Yat-sen University Guangzhou 510060 Guangdong Province China Department of Neurology Sixth Affiliated Hospital of Sun Yat-sen University Guangzhou 510655 Guangdong Province China

BACKGROUND： Bone marrow transplantation is an effective treatment for severe forms of various autoimmune disorders. Dendritic cell reconstitution is thought to be one factor contributing to host immune recovery and therapeutic efficacy. OBJECTIVE： To assess the effects of bone marrow transplantation on an animal model of experimental autoimmune encephalomyelitis （EAE）, and to investigate changes in dendritic cells and subgroups following bone marrow transplantation. DESIGN, TIME AND SETTING： This experimental, neuroimmunological study was performed in Sun Yat-sen University between August 2006 and May 2007. MATERIALS： A total of 30 female C57BL/6 mice, aged 6-8 weeks, served as recipients, and 20 female adult C57BL/6 served as donors. Myelin oligodendrocyte glycoprotein 35-55 amino acid peptide （MOG35-55） of mudne origin was synthesized by Bio-Scientific （Xi＇an, China, purity 〉 95%）. Complete Freund＇s adjuvant was purchased from Difco Laboratories, Detroit, MI; pertussis vaccine was purchased from Alexis, San Diego, CA; radiation device and flow cytometry for FACS analysis were purchased from Theratron 780-C, Canada and Coulter, Fullerton, CA, respectively. METHODS： The C57BL/6 mice, aged 6-8 weeks, were immunized by subcutaneous injection of MOG35-55 peptide emulsified in complete Freund＇s adjuvant, which contained 500 μg Mycobacterium tuberculosis H37RA. The mice were subsequently intravenously injected with pertussis vaccine to induce EAE. The mice were randomly assigned to transplantation and EAE model groups （n = 12 for each）. Bone marrow cells [（5-10） × 10^6] were transplanted into EAE mice via the tail vein 4-6 hours following total body irradiation, and the model group was not treated. MAIN OUTCOME MEASURES： Mouse behavioral changes following EAE were evaluated daily. Injured spinal cord tissue sections were stained with hematoxylin and eosin 20 days after the initial immunization to observe inflammatory infiltration using light microscopy. Flow cytometry wa

关键词： experimental autoimmune encephalomyelitis dendritic cells bone marrow transplantation

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Glacial debris flow susceptibility mapping based on combined models in the Parlung Tsangpo Basin,China

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Journal of Mountain Science 2024年第4期21卷 1231-1245页

作者： ZHOU Yonghao hu Xiewen XI Chuanjie WEN Hong CAO Xichao JIN Tao ZHOU Ruichen ZHANG Yu GONG xueqiang Faculty of Geosciences and Engineering Southwest Jiaotong UniversityChengdu 611756China School of Architecture and Civil Engineering Xihua UniversityChengdu 610039China

Machine learning(ML)-based prediction models for mapping hazard(e.g.,landslide and debris flow)susceptibility have been widely developed in recent ***,in some specific areas,ML models have limited application because of the uncertainties in identifying negative *** Parlung Tsangpo Basin exemplifies a region prone to recurrent glacial debris flows(GDFs)and is characterized by a prominent landform featuring deep *** the limitations of the ML model,we developed and compared two combined statistical models(FA-WE and FA-IC)based on factor analysis(FA),weight of evidence(WE),and the information content(IC)*** final GDF susceptibility maps were generated by selecting 8 most important static factors and considering the influence of *** results show that the FA-IC model has the best *** areas with a very high susceptibility to GDFs are primarily located in the narrow valley section upstream,on both sides of the valley in the middle and downstream of the Parlung Tsangpo River,and in the narrow valley section of each *** areas encompass 86 gullies and are characterized as"narrow and steep".

关键词： Parlung Tsangpo Basin Glacial debris flow Factor analysis Susceptibility mapping Weight of evidence Information content method.

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Scenarios analysis and performance assessment of blockchain integrated in 6G scenarios

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Science China(Information Sciences) 2024年第7期67卷 5-26页

作者： Bo LI Guanjie CHENG Honghao GAO xueqiang YAN Shuiguang DENG College of Computer Science and Technology Zhejiang University College of Computer Science and Technology Shanghai University 2012 Lab Huawei Technologies Co. Ltd.

Emerging applications such as smart city infrastructures and virtual reality landscapes are setting rigorous benchmarks for 6G mobile networks, requiring elevated levels of confidentiality, integrity, nonrepudiation, authentication, and stringent access controls. Blockchain technology is heralded as a transformative enabler for meeting 6G standards, owing to its intrinsic attributes. However, a gap exists in the holistic investigation of blockchain's applicability in 6G realms, particularly addressing the “whether”, “when”, and“how” of its deployment. Present research trails in developing robust methodologies to gauge blockchain's efficacy within 6G use cases. Addressing this, our study introduces a novel confluence of blockchain with 6G networks, where data resides in distributed Hash tables(DHTs) while their hashes are secured in distributed ledger technology(DLT), harnessing blockchain's core strengths-immutability, traceability, and fortified security. We delineate seven specific 6G use cases poised for enhancement through blockchain integration,and scrutinize the rationale, nature, and timing of this convergence. Furthermore, we devise a comprehensive methodology for assessing blockchain's performance metrics and scalability in 6G environments. Our extensive experimental analyses evaluate the synergistic performance of this integration, revealing that the Quorum blockchain satisfactorily supports 80% of 6G scenarios. The findings suggest that, with appropriate configurations, consortium blockchains are well-equipped to fulfill the demanding performance and scalability requisites of 6G networks.

关键词： blockchain distributed ledger technology (DLT) 6G performance assessment 6G scenarios analysis transaction arrival rate

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Stability of dimensionally stable anode for chlorine evolution reaction

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Nano Research 2024年第3期17卷 949-959页

作者： Ziliang Deng Shuying Xu Chuhao Liu xueqiang Zhang Mufan Li Zipeng Zhao Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications Experimental Center of Advanced MaterialsSchool of Materials Science and EngineeringBeijing Institute of TechnologyBeijing 100081China Beijing National Laboratory for Molecular Sciences College of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China Laser Micro/Nano-Fabrication Laboratory School of Mechanical EngineeringBeijing Institute of TechnologyBeijing 10081China

Chlorine(Cl2)is one of the most important chemicals produced by the electrolysis of brine solutions and is a key raw material for many areas of industrial *** nearly half a century,dimensionally stable anode(DSA)made from a mixture of RuO_(2) and TiO_(2) solid oxides coated on Ti substrate has been the most widely used electrode for chlorine evolution reaction(CER).In harsh operating environments,the stability of DSAs remains a major challenge greatly affecting their *** deactivation of DSAs significantly increases the cost of the chlor-alkali industry due to the corrosion of Ru and the formation of the passivation layer TiO_(2).Therefore,it is urgent to develop catalysts with higher activity and stability,which requires a thorough understanding of the deactivation mechanism of DSA *** paper reviews existing references on the deactivation mechanisms of DSA catalysts,including both experimental and theoretical *** on how CER selectivity affects electrode stability are also ***,studies on the effects of the preparation process,elemental composition,and surface/interface structures on the DSA stability and corresponding improvement strategies are *** development of other non-DSA-type catalysts with comparable stability is also reviewed,and future opportunities in this exciting field are also outlined.

关键词： chlorine evolution reaction(CER) dimensionally stable anode(DSA) RuO_(2)-TiO_(2) metal oxide anode stability

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多发性硬化的诊断和鉴别诊断

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中华神经科杂志 2022年第9期55卷 1019-1024页

作者：胡学强钟晓南中山大学附属第三医院神经内科广州510630

多发性硬化(MS)是以中枢神经系统炎性脱髓鞘病变为主要特点的免疫介导性疾病,是青壮年人群神经功能残疾的最常见原因之一。明确MS的诊断和临床分型,对于MS患者的尽早治疗和治疗策略选择至关重要。临床医师可充分收集患者客观的临床证据... 详细信息

多发性硬化(MS)是以中枢神经系统炎性脱髓鞘病变为主要特点的免疫介导性疾病,是青壮年人群神经功能残疾的最常见原因之一。明确MS的诊断和临床分型,对于MS患者的尽早治疗和治疗策略选择至关重要。临床医师可充分收集患者客观的临床证据,排除其他鉴别诊断后,参考目前的诊断标准对MS的时间多发性和空间多发性进行全面评估,并依据其临床分型标准指导治疗策略选择。目前针对MS诊断的检查技术和评估方式多处于研究探索阶段,相信未来MS诊断的敏感度和特异度将得到进一步提升。

关键词：多发性硬化诊断鉴别诊断指南

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抗水通道蛋白4抗体阴性视神经脊髓炎/视神经脊髓炎谱系疾病的再认识

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中华神经科杂志 2016年第6期49卷 425-429页

作者：钟晓南胡学强中山大学附属第三医院神经内科广州510630

视神经脊髓炎（neuromyelitis optica,NMO）和NMO谱系疾病（NMO spectrum disorders,NMOSD）是一类以视神经炎和（或）急性横贯性脊髓炎为典型临床表现的自身免疫性炎性脱髓鞘疾病.水通道蛋白4（aquaporin-4,AQP4）抗体（AQP4-IgG）的... 详细信息

视神经脊髓炎（neuromyelitis optica,NMO）和NMO谱系疾病（NMO spectrum disorders,NMOSD）是一类以视神经炎和（或）急性横贯性脊髓炎为典型临床表现的自身免疫性炎性脱髓鞘疾病.水通道蛋白4（aquaporin-4,AQP4）抗体（AQP4-IgG）的发现使其有别于多发性硬化（multiple sclerosis,MS）成为独立的疾病实体.目前认为AQP4-IgG是NMO/NMOSD最具特异性的生物学标志物,但仍存在部分NMO/NMOSD患者血清AQP4-IgG阴性.另外,在NMO/NMOSD患者中发现了另一些自身免疫抗体,提示还有AQP4-IgG以外的其他免疫因素参与NMO/NMOSD的发病机制.

关键词：炎性脱髓鞘疾病视神经脊髓炎水通道蛋白4 抗体阴性谱系急性横贯性脊髓炎生物学标志物自身免疫抗体

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Recent Advances in Electrochemical-Based Silicon Production Technologies with Reduced Carbon Emission

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Research 2024年第1期2023卷 209-236页

作者： Feng Tian Zhongya Pang Shen hu xueqiang Zhang Fei Wang Wei Nie Xuewen Xia Guangshi Li Hsien-Yi Hsu Qian Xu Xingli Zou Li Ji Xionggang Lu State Key Laboratory of Advanced Special Steel&Shanghai Key Laboratory of Advanced Ferrometallurgy&School of Materials Science and Engineering Shanghai University99#Shangda RoadShanghai 200444China Center for Hydrogen Metallurgy Technology Shanghai UniversityShanghai 200444China State Key Laboratory of ASIC and System School of MicroelectronicsFudan University220#Handan RoadShanghai 200433China School of Energy and Environment Department of Materials Science and EngineeringCity University of Hong KongKowloon TongHong KongChina

Sustainable and low-carbon-emission silicon production is currently one of the main focuses for the metallurgical and materials science ***,considered a promising strategy,has been explored to produce silicon due to prominent advantages:(a)high electricity utilization efficiency;(b)low-cost silica as a raw material;and(c)tunable morphologies and structures,including films,nanowires,and *** review begins with a summary of early research on the extraction of silicon by *** has been placed on the electro-deoxidation and dissolution–electrodeposition of silica in chloride molten salts since the 21st century,including the basic reaction mechanisms,the fabrication of photoactive Si films for solar cells,the design and production of nanoSi and various silicon components for energy conversion,as well as storage ***,the feasibility of silicon electrodeposition in room-temperature ionic liquids and its unique opportunities are *** this basis,the challenges and future research directions for silicon electrochemical production strategies are proposed and discussed,which are essential to achieve large-scale sustainable production of silicon by electrochemistry.

关键词： directions electrodeposition electricity

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On-line Determination of Rare Earth Distribution by Energy Dispersive X-ray Fluorescence Spectrometry

On-line Determination of Rare Earth Distribution by Energy D...

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第十六届全国稀土分析化学学术研讨会

作者： Qu huayang hu Shaocheng Lu Mingbo Wang Chaogang hu xueqiang Chen Jiwen NCS Testing Technology Co. Ltd. China Iron and Steel Research Institute Group

Rare earth elements（REEs） have been widely used in metallurgical machinery, electronic information, petrochemical, energy and other fields due to their unique physical and chemical properties. The REEs with enhanced optical, electrical and magnetic properties can be used to prepare advanced materials, such as fluorescent, polishing, catalytic and permanent magnetic materials. The indispensible REEs in the advanced materials, despite with trace amount, are known as "industrial vitamins". The preparation of unitary REE with high purity is fundamental to the industry of new rare earth material. The unitary REE is separated by hydrometallurgical process from rare earth concentrate with more than ten kinds of rare earth elements. The continuous separation process is evaluated by REE distributions. At present, most of the REE distributions in factories are obtained via artificial sampling coupled with ICP OES. The detection lags behind the production, resulting in unstable qualities of products. In order to determine the distributions of REEs on line, a XOR-50 rare earth distribution on-line analytical equipment was developed based on ED-XRF. A on-line determination of REE in rare earth separation process was established. The excitation voltage, current and filter were optimized according to the characteristics of REEs. The influence of the salinity was corrected by mathematical technique. The absorption enhancement effect was calculated by fundamental parameter method. The results of on-line detection are consistent with ICP OES. The relative standard deviation（n=11） of the main REEs（w＞ 1%） is less than 0.6%. The equipment can carry out automatically from the extraction solution in 1 minute. The measurement intervals can be set by the operator. Combining on-line introduction of the rare earth material, simultaneous analysis of multi elements, rapid detection in 1 minute, on-line analysis with self-starting and real-time transmission of the results, the method meets the r

关键词： ED-XRF Rare Earth Element Distribution On-line

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The interventional effect of Polygonatum cyrtonema hua polysaccharide on atherosclerosis in mice of different sexes

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Food Science and human Wellness 2024年第1期13卷 370-380页

作者： Anjun Guo Xueying Li Lihua Pan Qiangming Li Jianping Luo xueqiang Zha Engineering Research Centre of Bioprocess of Ministry of Education Hefei University of TechnologyHefei 230009China School of Food and Biological Engineering Hefei University of TechnologyHefei 230009China Key Laboratory of Metabolism and Regulation for Major Disease of Anhui Higher Education Institutes Hefei University of TechnologyHefei 230009China

In the present study,we investigated the intervention effects of a purified Polygonatum cyrtonema polysaccharide(PCP)on high-fat diet(HFD)-induced atherosclerosis in male and female LDLr-/-*** showed that HFD caused severe dyslipidemia,atherosclerotic lesions,oxidative damages and inflammation in male and female mice,and these effects seemed to be more pronounced in males than in ***,the above variations could be dose-dependently reversed by PCP treatment,and the intervention effects on males were greater than those on *** factor kappa-B(NF-κB),mitogen-activated protein kinase(MAPKs)and protein kinase B(Akt)are 3 pivotal signaling pathways mediating the development of ***,PCP was also found to significantly decrease the phosphorylation of p65,p38,extracellular-regulated kinase 1/2(ERK1/2)and Akt,and increase the protein expression of inhibitor of NF-κB(IκB)in the aortas of male and female mice induced by *** together,these findings indicated that PCP could be effective for the prevention of atherosclerosis,and the intervention effect of PCP on male mice was more obvious than that of female mice.

关键词： Polygonatum cyrtonema polysaccharide Anti-atherosclerosis Sex

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