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Security-Enhanced Directional Modulation Based on Two-Dimensional M-WFRFT

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China Communications 2024年第5期21卷 229-248页

作者： Zhou Zhuang Luo Junshan Wang shilian Xia Guojiang School of Electronic Science National University of Defense TechnologyChangsha 410073China Beijing Institute of Astronautical Systems Engineering Beijing 100076China

Directional modulation(DM)is one of the most promising secure communication ***,when the eavesdropper is co-located with the legitimate receiver,the conventional DM has the disadvantages of weak anti-scanning capability,anti-deciphering capability,and low secrecy *** response to these problems,we propose a twodimensional multi-term weighted fractional Fourier transform aided DM scheme,in which the legitimate receiver and the transmitter use different transform terms and transform orders to encrypt and decrypt the confidential *** order to further lower the probability of being deciphered by an eavesdropper,we use the subblock partition method to convert the one-dimensional modulated signal vector into a twodimensional signal matrix,increasing the confusion of the useful *** results demonstrate that the proposed DM scheme not only provides stronger anti-deciphering and anti-scanning capabilities but also improves the secrecy rate performance of the system.

关键词： bit error rate directional modulation phased array secrecy rate weighted fractional Fourier transform

Beamforming design for covert broadcast communication with hidden adversary

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Science China(Information Sciences) 2024年第6期67卷 384-398页

作者： Weiyu CHEN Haiyang DING shilian WANG Junshan LUO Fengkui GONG College of Electronic Science and Technology National University of Defense Technology College of Information and Communication National University of Defense Technology State Key Laboratory of Integrated Service Networks Xidian University

This paper explores covert broadcast communication in a challenging situation in which the transmitter, Alice, faces uncertainty regarding the position of the passive adversary, Willie. In this situation,controlling the signal exposure becomes difficult. Specifically, this paper focuses on the cases where Alice can delimit the suspicious areas where Willie may be located. The suspicious areas can have arbitrary number and shapes. Under the Rician fading model, the analytical expression of Willie's detection performance is derived. Then, the transmit power, the beamforming direction, and the number of channel uses are jointly designed to minimize the optimal Willie's detection performance among all the possible positions of Willie, on the premise of satisfying receivers' quality-of-service requirements. To tackle the formulated knotty problem with an infinite number of irregular and discontinuous Willie's possible positions, the continuous nature of the antenna pattern is exploited to convert the original problem into the one with a finite number of possible positions, by sampling the suspicious areas. Then, different algorithms are developed to address the resultant non-convex optimization problem for single-antenna Willie and multi-antenna Willie, respectively. Numerical results demonstrate significant performance gains of the proposed scheme over the widely-adopted maximum ratio transmission scheme, which indicates that simply adjusting the main lobe towards the receiver is indeed far away from optimum and shows the importance of leveraging Alice's limited knowledge of Willie's position.

关键词： low-probability-of-detection communication multiple antennas covertness performance uncertain position parameters optimization

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A WNT7B-m^(6)A-TCF7L2 positive feedback loop promotes gastric cancer progression and metastasis

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Signal Transduction and Targeted Therapy 2021年第3期6卷 571-573页

作者： Qian Gao Liuyang Yang Aolin Shen Yang Li Yongxiang Li shilian hu Runhuai Yang Xiangting Wang Xuebiao Yao Guodong Shen Department of Geriatrics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui 230001China Department of Genetics School of Life ScienceAnhui Medical UniversityHefeiAnhui 230032China Anhui Provincial Key Laboratory of Tumor Immunotherapy and Nutrition Therapy HefeiAnhui 230001China Department of General Surgery First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui 230022China School of Biomedical Engineering Anhui Medical UniversityHefeiAnhui 230032China M0E Key Laboratory for Membrane-less Organelles and Cellular Dynamics University of Science and Technology of ChinaHefeiAnhui 230027China

Dear Editor,Signal transduction takes the responsibility of translating extracellular information into specific cellular activities,enabling cells,including cancer cells,to respond exquisitely to extracellular guidance cues.N6-methyladenosine(m^(6)A),the most pervasive and abundant modification within eukaryotic mRNAs,is known to have specific effects on cellular activities relevant to cancer.1 Despite the fact that m^(6)A methylation is a dynamic event involving a series of enzymes,it remains unknown whether signal transduction,much less extracellular signaling molecules,uses m^(6)A methylation as an effector mechanism in cancer.

关键词： metastasis cancer 6

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论中华文化传统的创造性转化

湖南师范大学社会科学学报 2024年第1期53卷 1-12页

作者：单世联上海交通大学媒体与传播学院上海200240

中华文化传统的“创造性转化”是近年来中国文化理论与实践的核心议题。就其概念内涵与实践效果而言,创造性转化也是中华文化传统之一,是近代中国文化变迁和发展的基本经验。合理地锚定转化的对象和内容,应当区分“传统文化”与“文化... 详细信息

中华文化传统的“创造性转化”是近年来中国文化理论与实践的核心议题。就其概念内涵与实践效果而言,创造性转化也是中华文化传统之一,是近代中国文化变迁和发展的基本经验。合理地锚定转化的对象和内容,应当区分“传统文化”与“文化传统”两个概念,需要转化也可以转化的是“文化传统”而不是“传统文化”。根据文化传统的民族性、时代性和开放性的特征,创造性转化的基本方式是“接着”传统并以“层累式”创作来延展传统,以“接合”“去接合”的方式拓展传统,以释放被排斥、压抑的内容和实践来优化传统。应予强调的是,文化传统的“创造性转化”重在创造,重在探索。作为中华民族精神自由舒展、自我实现的过程,创造性转化有丰富的历史经验而没有刻板的程式,有明确的方向也需要民族的集体实践。

关键词：创造性转化传统文化文化传统接着接合重组

发现“文化”——启蒙运动与现代文化理论的起源

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天津社会科学 2024年第4期 21-35,174,175页

作者：单世联上海交通大学媒体与传播学院

文化与人类俱生,但意识到有一个相对独立的“文化”领域,意识到需要一门相对独立的“新科学”也即文化科学来研究这个领域,却是重大的思想事件和文化行动。西方的文化自觉发生在启蒙时代。启蒙塑造了西方现代文化,也激活了对自身的质疑... 详细信息

文化与人类俱生,但意识到有一个相对独立的“文化”领域,意识到需要一门相对独立的“新科学”也即文化科学来研究这个领域,却是重大的思想事件和文化行动。西方的文化自觉发生在启蒙时代。启蒙塑造了西方现代文化,也激活了对自身的质疑、反思和批判。当代研究更多将苏格兰启蒙运动的“人的科学”而不是法国传统的“理性至上”作为启蒙运动的核心原则。但只要“人的科学”还是以自然科学为典范,它就仍然是不充分、不真实的。维柯、卢梭、赫尔德和柏克更鲜明、更直接地坚持人造物与自然界的不同并以此为论述的起点,反对以自然科学的方法来研究“人”并探索了独立的人文研究方法,他们的理论是启蒙运动“人的科学”的扩展版。经过浪漫主义的集聚和马克思、韦伯等人的推动,维柯等人所奠定的文化理论在当代已经是一个显赫的学术思想论域,但面临两个根本性挑战:如何在广泛论题之中确立文化理论的统一性?如何在世界文化化、文本化的同时维护并面向自然和物质?维柯等人的“发现”依然有着解决当代问题的理论潜力。

关键词：文化文化科学启蒙运动人的科学维柯卢梭赫尔德柏克

Establishment and application of a detection kit for human carcinoembryonic antigen mRNA by real-time RT-PCR

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Establishment and application of a detection kit for human c...

2020长三角老年医学高峰论坛、浙江省老年医学学术大会、华东老年医学中心联盟会议、浙江省老年医学联盟会议、浙江省老年病专科联盟会议

作者： Yang Wenwen Cheng Min hu shilian

Background Progress in gastric cancer is hampered by the lack of diagnostic markers useful for clinical *** study aims to establish a quantitative method for human carcino-embryonic antigen(CEA) mRNA by real-time *** application was further evaluated by detecting circulating tumor cells in the peripheral blood of gastric cancer *** and Results The concentration of each component in the detection kit was optimized;the stability,sensitivity,and specificity were *** expression level of CEA mRNA was detected in the samples of peripheral *** primers and probes were obtained,and setting standards were successfully *** establishing the positive and negative control materials,the specificity,sensitivity,accuracy and quality control were determined for the detection *** specificity and accuracy were both more than 95%,and the sensitivity was of 100 copies/ml(whole peripheral blood).The detection results of CEA mRNA in peripheral blood samples showed that all the samples were positive for 15 gastric cancer patients clinically diagnosed with metastasis;and 12 samples were positive and other 13 samples were negative among 25 gastric cancer patients without clinically diagnosed with metastasis or not;all the samples were negative for 10 gastric ulcer patients;and all the samples were negative for 10 healthy *** The quantitative RT-PCR assay for CEA mRNA could be used for the detection of circulating tumor cells in peripheral blood of gastric cancer patients,which would be valuable for the diagnosis and clinicaldecision making for gastric cancer patients.

关键词： Gastric cancer Genetic marker Carcino-embryonic antigen mRNA RT-PCR

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CHFR基因与胃癌关系研究新进展

中国肿瘤临床 2009年第17期36卷 1016-1019页

作者：程昭栋胡世莲安徽医科大学附属省立医院合肥市230001

CHFR(Checkpoint with FHA and ring finger),是Scolnick和Halazonetis于2000年新发现的一种能够检测分裂期正常细胞的分裂情况及控制分裂进行的基因,是一个新的有丝分裂前期检查点基因,同时也是一种新发现的抑癌基因。CHFR编码一种具有... 详细信息

CHFR(Checkpoint with FHA and ring finger),是Scolnick和Halazonetis于2000年新发现的一种能够检测分裂期正常细胞的分裂情况及控制分裂进行的基因,是一个新的有丝分裂前期检查点基因,同时也是一种新发现的抑癌基因。CHFR编码一种具有FHA和RING区的蛋白,当微管抑制剂诱发有丝分裂应激时,这种蛋白具有延迟染色体的浓集、阻止细胞进入有丝分裂中前期的作用,在正常人组织中普遍表达,而在多种肿瘤组织中发现其表达缺失,而CpG岛的甲基化是导致CHFR表达缺失或沉默的重要机制。胃癌是世界上发病率最高的肿瘤之一,在肿瘤引起的死亡原因中占第二位。胃癌的发生过程涉及到许多基因和复杂的步骤,相关基因包括癌基因,抑癌基因,DNA修复基因,抑癌基因的功能由于基因突变、启动子的甲基化而丢失。甲基化发生于基因的启动子区时会导致基因的沉默,由此而引发肿瘤的发生。启动子区异常甲基化已经作为细胞恶变的一个独立的途径而被许多文献所报道,有研究显示胃癌的发生发展过程中也涉及许多抑癌基因的甲基化现象,其中包括CHFR基因。本文对CHFR基因的结构、编码蛋白的功能及其与胃癌关系的研究进展作一综述。

关键词：有丝分裂前期 CHFR基因胃癌甲基化抑癌基因

The ErbB2-overexpression tumor metastasis suppression by humanized antibody chA21 with new recognition epitope

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The ErbB2-overexpression tumor metastasis suppression by hum...

中国居民主要致死性慢性病的人口死亡趋势及应对策略

细胞—生命的基础——中国细胞生物学学会2013年全国学...

作者： Guodong Shen Siyi hu Zhao Zha Geng Bian hu shilian Jing Liu School of Life Science University of Science and Technology of China Gerontology Institute Anhui Provincial Hospital

It is widely known that ErbB2(HER2/p185) overexpression in human malignant cancers correlates with poor prognosis and the resistance against radiotherapy,chemotherapy and endocrine *** antibody drug trastuzumab(herceptin) is used in the treatment of clinical tumors with considerable success,but the insensitivity or resistant phenomenon in tumor therapy is increasingly *** a tumor-inhibitory anti-ErbB2 monoclonal antibody A21 and its

关键词： antibody drug ErbB2/Her2 trastuzumab chA21 breast cancer

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中国临床保健杂志 2022年第3期25卷 297-302页

作者：胡世莲王静方向程翠中国科学技术大学附属第一医院(安徽省立医院) 安徽省老年医学研究所肿瘤免疫与营养治疗安徽省重点实验室合肥230001

慢性病是我国居民的主要致死原因,随着我国人口老龄化趋势进一步加重,慢性病的死亡占比必将进一步升高。该文就近年来我国居民的主要致死性慢性病,如卒中、缺血性心肌病、呼吸系统肿瘤、慢性阻塞性肺疾病、消化系统肿瘤、阿尔茨海默病... 详细信息

慢性病是我国居民的主要致死原因,随着我国人口老龄化趋势进一步加重,慢性病的死亡占比必将进一步升高。该文就近年来我国居民的主要致死性慢性病,如卒中、缺血性心肌病、呼吸系统肿瘤、慢性阻塞性肺疾病、消化系统肿瘤、阿尔茨海默病及其他痴呆症等进行分析;了解其近几十年来的总体死亡趋势及流行病学特点,并提出相应的应对策略。

关键词：慢性病健康状况死亡率流行病学研究中国