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Chinese Journal of Chemistry 2024年第13期42卷 1474-1480页

作者： Ke-Lan Xu Yu-Heng Wang Xi-Rui Wang pan hu Bo-Wen pan Wen-Jing Zhang Zi-Yue Chen Ying Zhou Xiong-Li Liu National&Local Joint Engineering Research Center for the Exploitation of Homology Resources of Southwest Medicine and Food Guizhou UniversityGuiyangGuizhou 550025China College of Pharmaceutical Sciences Guizhou University of Traditional Chinese MedicineGuiyangGuizhou 550025China Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhouHenan 450001China

The privileged C_(2)-symmetric rigid phenol-type ligand is more attractive but challenging in asymmetric ***,we designed and synthesized a class of rigid-featured chiral tridentate Phenol-2NO ligands,that incorporate the advantages of both the phenol skeleton and pyrroloimidazolone-based N-oxide moiety,from readily available L-prolinamides in operationally simple two steps and up to 44%overall *** importantly,using an achiral quinoline derivative as an additive,the newly developed Phenol-2NO ligand could serve as the anioic ligand upon deprotonative activation to coordinate to Zn(II)to form a highly enantioselective catalyst for the asymmetric Michael-type Friedel-Crafts alkylation reaction of indoles with 2,*** yields(up to 90%)and high enantioselectivities(up to 99%ee)are obtained for a wide range of substrates under mild *** and DFT calculations revealed the reaction mechanism and the origins of the *** also represented the first activation of phenol-type ligand/metal complex by an achiral organic base as the additive in asymmetric catalysis.

关键词： Phenol-2NO C_(2)-Symmetric Rigid-featured Tridentate ligand Asymmetric catalysis Alkylation Synthesis design Heterocycles

Remodeling the immune microenvironment for gastric cancer therapy through antagonism of prostaglandin E2 receptor 4

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Genes & Diseases 2024年第4期11卷 411-425页

作者： Mengmeng Guo pan hu Jiayi Xie Kefu Tang Shixiu hu Jialiang Sun Yundong He Jing Li Weiqiang Lu huirong Liu Mingyao Liu Zhengfang Yi Shihong Peng Shanghai Key Laboratory of Regulatory Biology School of Life SciencesEast China Normal UniversityShanghai 200241China Prenatal Diagnosis Center Department of Clinical LaboratoryChangning Maternity and Infant Health HospitalEast China Normal UniversityShanghai 200051China Key Laboratory of Acupuncture and Immunological Effects Shanghai University of Traditional Chinese MedicineShanghai 201203China Fengxian Hospital Affiliated to Southern Medical University Shanghai 201400China Shanghai Yuyao Biotech Co. Ltd.Shanghai 200241China

Gastric cancer is highly prevalent among digestive tract *** to the intri-cate nature of the gastric cancer immune microenvironment,there is currently no effective treatment available for advanced gastric ***,there is promising potential for immunotherapy targeting the prostaglandin E2 receptor subtype 4(EP4)in gastric *** our previous study,we identified a novel small molecule EP4 receptor antagonist called *** with YY001 alone demonstrated a significant reduction in gastric cancer growth and inhibited tumor metastasis to the lungs in a mouse ***,adminis-tration of YYo01 stimulated a robust immune response within the tumor microenvironment,characterized by increased infiltration of antigen-presenting cells,T cells,and M1 ***,our research revealed that YYo01 exhibited remarkable synergistic ef-fects when combined with the PD-1 antibody and the clinically targeted drug apatinib,rather than *** findings suggest that YYo01 holds great promise as a potential therapeutic strategy for gastric cancer,whether used as a standalone treatment or in combination with other drugs.

关键词： EP4 Immunomodulation Synergy Tumor microenvironment YY001

The dynamic catalysis of Ga/ZSM-5 catalysts for propane-CO_(2) coupling conversion to aromatics and syngas

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Journal of Energy Chemistry 2024年第10期97卷 513-519,I0011页

作者： Yonggui Song Zhong-pan hu Haohao Feng Enze Chen Le Lv Yimo Wu Zhen Liu Yong Jiang Xiaozhi Su Feifei Xu Mingchang Zhu Jingfeng Han Yingxu Wei Svetlana Mintova Zhongmin Liu The Key Laboratory of the Inorganic Molecule-Based Chemistry of Liaoning Province and Laboratory of Coordination Chemistry Shenyang University of Chemical TechnologyShenyang110142LiaoningChina National Engineering Research Center of Lower-Carbon Catalysis Technology Dalian National Laboratory for Clean EnergyiChEM(Collaborative Innovation Center of Chemistry for Energy Materials)Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201203China Normandie University Laboratory of Catalysis and Spectrochemistry(LCS)NSICAENUNICAENCNRSCaen 1450France

Alkane coupling with CO_(2) by metal-containing zeolites catalysis is found to be a promising way to produce aromatics and syngas in recent years,but the real active sites and the role of CO_(2) are still unclear owing to the quick evolution of the metallic active sites and the complex reaction processes including direct propane aromatization,CO_(2) hydrogenation,reverse water-gas shift reaction,and propane-CO_(2) coupling ***,Ga/ZSM-5 catalysts were constructed to study the dynamic evolution of the metallic active sites and the role of CO_(2) during the propane and CO_(2) coupling *** optimizing the reaction conditions,a notable propane conversion rate of 97.9%and an impressive aromatics selectivity of 80.6%in hydrocarbons can be achieved at the conditions of 550℃and CO_(2)/C_(3)H_(8) of 4.^(13)CO_(2)isotope experiments illustrate that C-atoms of CO_(2) can enter into CO(86.5%)and aromatics(10.8%)during the propane-CO_(2) coupling reaction *** situ XANES and FTIR spectroscopies at 550℃and H_(2)/C_(3)H_(8) atmosphere reveal that GaO_(x) species can be gradually dispersed into[GaH_(2)]^(+)/[GaH]^(2+)on the Bronsted acid sites of ZSM-5 zeolite during H_(2) and/or C_(3)H_(8) treatment,which are the real active sites for propane-CO_(2) coupling *** situ CO_(2)-FTIR experiments demonstrate that the[GaH_(2)]^(+)/[GaH]^(2+)species can react with CO_(2) and accelerate the propane and CO_(2) coupling *** work not only presents a cost-effective avenue for CO_(2) utilization,but also contributes to the active site design for improved alkane and CO_(2) activation in coupling reaction system.

关键词： Carbon dioxide Propane aromatization Ga/ZSM-5 Gallium hydride Spectroscopy

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基于双向思维培养的中学生物学教学实践探索

生物学教学 2024年第6期49卷 19-21页

作者：胡攀广东省广州市西关外国语学校广州510176

就课堂教学中培养学生的正向和逆向双向思维、聚合和发散双向思维、纵向和横向双向思维的策略做了具体的阐述,旨在通过提升学生双向思维能力,使其主动分析、思考和解决各种生物学问题,进而成为生物学知识的探知者。

关键词：双向思维核心素养高中生物学

Fatal multiple acyl-CoA dehydrogenase deficiency caused by ETFDH gene mutation:A case report

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World Journal of Clinical Cases 2024年第23期12卷 5422-5430页

作者： Xue-Xia Li Xiao-Nan Yang hu-Dan pan Liang Liu State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and TechnologyMacao 999078China State Key Laboratory of Traditional Chinese Medicine Syndrome The Second Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510006Guangdong ProvinceChina

BACKGROUND Multiple acyl-CoA dehydrogenase deficiency(MADD)is a disease of rare autosomal recessive *** are three types of *** I is a neonatalonset form with congenital *** II is a neonatal-onset form without congenital *** III is considered to a milder form and usually responds to ***,late-onset form could also be fatal and not responsive to *** SUMMARY We report a severe case of a young man with onset type III MADD induced by drugs and strenuous exercise characterized by rhabdomyolysis and liver *** analysis indicated 12 out of 70 kinds of organic acids like glutaric acid-2 were *** analysis in genetic metabolic diseases revealed 24 out of 43 tested items were abnormal,revealing the elevation of several acylcarnitines and the reduction of carnitine in the *** next generation sequencing technology for gene sequencing related to fatty acid oxidation and carnitine cycle defects,a rare ETFDH gene variant was identified:NM_004453:4:C.1448C>T(***483 Leu).The patient was diagnosed with lateonset *** was not responsive to riboflavin and progressively worsened into multiple organ failure that finally led to *** Type III MADD can also be fatal and not responsive to treatments.

关键词： Electron transfer flavoprotein dehydrogenase mutation Multiple acyl-CoA dehydrogenase deficiency Multiple organ failure Case report

杜仲泛应激蛋白基因EuUSP1的克隆和功能分析

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植物生理学报 2024年第1期60卷 130-140页

作者：胡盼赵德刚贵州大学生命科学学院农业生物工程研究院山地植物资源保护与种质创新教育部重点实验室贵阳550025 贵州省农业科学院贵州省农业生物技术重点实验室植物保育技术应用工程研究中心贵阳550006

泛应激蛋白(universal stress protein,USP)是植物抵抗胁迫的保护蛋白。为探究杜仲泛应激蛋白基因EuUSP1的分子结构和功能,本研究以杜仲组培苗为材料,通过RT-PCR和RACE克隆EuUSP1 cDNA,进行生物信息学分析,构建了过表达载体遗传转化三... 详细信息

泛应激蛋白(universal stress protein,USP)是植物抵抗胁迫的保护蛋白。为探究杜仲泛应激蛋白基因EuUSP1的分子结构和功能,本研究以杜仲组培苗为材料,通过RT-PCR和RACE克隆EuUSP1 cDNA,进行生物信息学分析,构建了过表达载体遗传转化三星烟草进行功能分析,并利用qPCR技术进行时空表达特征分析。结果表明,该基因转录cDNA全长782 bp,ORF长495 bp,5′UTR 149 bp,3′UTR 138 bp,编码蛋白164个氨基酸残基。EuUSP1在杜仲幼茎的表达量高于幼叶和幼根,且在7月表达显著高于其他时期。过表达EuUSP1对烟草植株形态没有明显影响,但在干旱胁迫下,转EuUSP1基因植株缓解干旱引起的萎蔫。在干旱胁迫10 d时转基因烟草植株叶片的CAT、SOD和POD活性显著高于野生型,分别为237.3、533.65和8800 U·g^(-1)。干旱胁迫前转基因植株MDA含量显著低于野生型,为6.99 nmol·g^(-1)。综上说明EuUSP1有助于增强抗旱性。

关键词：杜仲 EuUSP1基因抗逆性

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阳离子改性木质素混凝剂污泥脱水性能研究

环境化学 2024年第5期43卷 1719-1731页

作者：潘宇蒋大鹏孙亿倍胡潘杨琥南京大学环境学院污染控制与资源化研究国家重点实验室南京210023 泉州南京大学环保产业技术研究院泉州362000

混凝调理是一种成本低廉、操作方便的污泥调理方法.而传统无机盐混凝剂和合成有机高分子混凝剂在使用过程中存在金属离子及高毒性单体残留等问题.本文以自然界中来源广泛的一种可再生资源——木质素为原材,以丙烯酰胺和甲基丙烯酰氧乙... 详细信息

混凝调理是一种成本低廉、操作方便的污泥调理方法.而传统无机盐混凝剂和合成有机高分子混凝剂在使用过程中存在金属离子及高毒性单体残留等问题.本文以自然界中来源广泛的一种可再生资源——木质素为原材,以丙烯酰胺和甲基丙烯酰氧乙基三甲基氯化铵为改性单体,采用接枝共聚技术,制得一系列电荷密度(CD)不同的阳离子改性木质素混凝剂(LN-CD).以南京仙林某市政污水处理厂活性污泥为研究对象,测定了活性污泥经系列LN-CD调理后的泥饼含水率(FCMC)、污泥比阻(SRF)、毛细吸水时间(CST)和压缩系数(s),系统考察了LN-CD污泥调理性能;结合污泥絮体结构、泥饼表面形貌和污泥中胞外聚合物(EPS)不同形态及成分含量与分布变化情况,详细讨论了LN-CD混凝剂的污泥脱水机理.研究结果表明,LN-CD具有良好的污泥调理效果,CD是影响LN-CD脱水性能的重要因素,CD越高污泥脱水效果越佳,其中经CD最高的LN-CD1调理后,FCMC、SRF、CST和s分别为:68.91%、0.89×10^(12)m·kg^(−1)、15.0 s及0.81;且获得的污泥絮体尺寸最大结构也最为紧密,污泥中不同形态EPS含量及蛋白质与多糖组分也均有效下降.这是由于LN-CD通过电中和及粘结架桥作用有效聚集污泥颗粒,对EPS结构造成破坏,释放出结合水;此外,木质素本身特有的芳环结构不仅可利用其刚性结构特征起到骨料支撑作用有利于改善泥饼可压缩性,增强其泥饼渗透性,同时其疏水性能还可通过疏水缔合作用与EPS中疏水片段结合有效压缩EPS,从而进一步提高其污泥脱水性能.综上所述,LN-CD制备简单,绿色环保,污泥调理性能优良,其在污泥脱水中应具有良好的应用前景.

关键词：阳离子改性木质素混凝剂电荷密度污泥脱水性能胞外聚合物脱水机制

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面向片上信息处理的集成拓扑光子器件研究进展(特邀)

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光学学报 2024年第15期44卷 421-436页

作者：胡攀孙璐王洪炜张永苏翼凯上海交通大学区域光纤通信网与新型光通信系统国家重点实验室上海200240

集成拓扑光子器件以光为信息载体,为光的传播过程提供拓扑保护,在下一代面向片上信息处理的光子芯片中具有巨大的应用潜力。通过引入拓扑的概念,集成光子系统得以拥有全新的特性,包括单向传播的边界态以及对结构缺陷免疫等。随着对拓扑... 详细信息

集成拓扑光子器件以光为信息载体,为光的传播过程提供拓扑保护,在下一代面向片上信息处理的光子芯片中具有巨大的应用潜力。通过引入拓扑的概念,集成光子系统得以拥有全新的特性,包括单向传播的边界态以及对结构缺陷免疫等。随着对拓扑光子学理论的深入研究,提出和验证了许多基于拓扑光子学原理的器件,展示了拓扑光子学在构建高性能光信息处理芯片方面的广阔前景。本文详细介绍了集成拓扑光子器件的研究进展:首先,从不同的拓扑相或拓扑机制出发,介绍一维、二维拓扑光子集成器件及其在片上光信息处理中的应用;然后,进一步对非厄米、合成维度、非线性以及连续谱束缚态中的拓扑现象及集成光子器件展开讨论;最后,对集成拓扑光子器件面临的问题和发展趋势进行总结和展望。

关键词：集成光学拓扑光子学拓扑相拓扑边界态集成光子器件

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云服务提供者避风港规则适用的研究

法学（汉斯） 2024年第6期12卷 3687-3693页

作者：胡盼湖北大学法学院湖北武汉

传统避风港规则的适用在面对以飞速发展的云计算为技术支撑的云服务提供者时已显力不从心,具体表现为云服务提供者的主体地位模糊、难以实施删除、屏蔽和断开链接以及无法将转通知作为必要措施的问题。对于云计算的进步带来的冲击和挑战... 详细信息

传统避风港规则的适用在面对以飞速发展的云计算为技术支撑的云服务提供者时已显力不从心,具体表现为云服务提供者的主体地位模糊、难以实施删除、屏蔽和断开链接以及无法将转通知作为必要措施的问题。对于云计算的进步带来的冲击和挑战,我们可以对云服务提供者进行分层治理,同时借鉴“合理审慎原则”对必要措施进行合理限制,利用“技术过滤”进行适当的事前审查,借鉴“三振出局”进行逐级预警。

关键词：云计算云服务提供者避风港规则

次分数环境下标的股票有分红和配股的亚式期权定价

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乐山师范学院学报 2024年第4期39卷 8-14页

作者：胡攀四川文理学院数学学院四川达州635000

针对次分数环境下标的股票有连续分红且配、送股次数随机的几何平均亚式期权的定价问题,利用随机分析方法得到了几何平均亚式看涨、看跌期权的定价公式及其平价关系。数值模拟结果表明,几何平均亚式看涨、看跌期权的价格与配、送股比例... 详细信息

针对次分数环境下标的股票有连续分红且配、送股次数随机的几何平均亚式期权的定价问题,利用随机分析方法得到了几何平均亚式看涨、看跌期权的定价公式及其平价关系。数值模拟结果表明,几何平均亚式看涨、看跌期权的价格与配、送股比例,配股价和除权除息前股价呈不同的变化趋势,但均与hurst指数成反比。该研究对丰富期权定价模型具有理论意义,同时为我国金融市场的期权投资者提供了参考依据。

关键词：次分数布朗运动连续分红配股几何平均亚式期权数值模拟