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Computer Modeling in Engineering & Sciences 2025年第1期142卷 385-404页

作者： Chongzhen Zhang Zhichen Liu Xiangrui Xu Fuqiang hu Jiao Dai Baigen cai Wei Wang School of Automation and Intelligence Beijing Jiaotong UniversityBeijing100044China Shuohuang Railway Development Co. Ltd.National Energy GroupCangzhou062350China Beijing Key Laboratory of Security and Privacy in Intelligent Transportation School of Computer Science and TechnologyBeijing Jiaotong UniversityBeijing100044China

In the realm of Intelligent Railway Transportation Systems,effective multi-party collaboration is crucial due to concerns over privacy and data *** Federated Learning(VFL)has emerged as a promising approach to facilitate such collaboration,allowing diverse entities to collectively enhance machine learning models without the need to share sensitive training ***,existing works have highlighted VFL’s susceptibility to privacy inference attacks,where an honest but curious server could potentially reconstruct a client’s raw data from embeddings uploaded by the *** vulnerability poses a significant threat to VFL-based intelligent railway transportation *** this paper,we introduce SensFL,a novel privacy-enhancing method to against privacy inference attacks in ***,SensFL integrates regularization of the sensitivity of embeddings to the original data into the model training process,effectively limiting the information contained in shared *** reducing the sensitivity of embeddings to the original data,SensFL can effectively resist reverse privacy attacks and prevent the reconstruction of the original data from the *** experiments were conducted on four distinct datasets and three different models to demonstrate the efficacy of *** results show that SensFL can effectively mitigate privacy inference attacks while maintaining the accuracy of the primary learning *** results underscore SensFL’s potential to advance privacy protection technologies within VFL-based intelligent railway systems,addressing critical security concerns in collaborative learning environments.

关键词： Vertical federated learning privacy defenses

Gene mining and efficient biosynthesis of a fungal peptidyl alkaloid

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Chinese Herbal Medicines 2021年第1期13卷 98-104页

作者： Chen Zhang Bing-yu Liu Jia-wang Liu Dao-jiang Yan Jian Bai Ya-long Zhang Yan-hua Mou You-cai hu State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100050China School of Life Science and Biopharmaceutics Shenyang Pharmaceutical UniversityShenyang 110016China

Objective: Peptidyl alkaloids, a series of important natural products can be assembled by fungal nonribosomal peptide synthetases(NRPSs). However, many of the NRPSs associated gene clusters are silent under laboratory conditions, and the traditional chemical separation yields are low. In this study, we aim to discovery and efficiently prepare fungal peptidyl alkaloids assembled by fungal ***: Bioinformatics analysis of gene cluster containing NRPSs from the genome of Penicillium thymicola, and heterologous expression of the putative gene cluster in Aspergillus nidulans were ***, structural identification, and biological evaluation of the product from heterologous expression were carried ***: The putative tri-modular NRPS Anc A was heterologous-expressed in A. nidulans to give anacine(1) with high yield, which showed moderate and selective cytotoxic activity against A549 cell ***: Heterologous expression in A. nidulans is an efficient strategy for mining fungal peptidyl alkaloids.

关键词： anacine biosynthesis non-ribosomal peptide synthetase peptidyl alkaloid

上海国际旅游度假区景观开发新技术应用——种植土项目及容器苗培育项目的实践

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中国园林 2017年第7期33卷 17-21页

作者：蔡虎上海申迪园林投资建设有限公司

主要阐述了上海迪士尼乐园乃至整个上海国际旅游度假区在景观开发中采用的完全不同于国内传统做法的先进理念和实践,一个是种植土项目,另一个是容器苗培育项目。种植土项目中,首先分析了上海本地的土壤状况,然后因地制宜开发出改良配方... 详细信息

主要阐述了上海迪士尼乐园乃至整个上海国际旅游度假区在景观开发中采用的完全不同于国内传统做法的先进理念和实践,一个是种植土项目,另一个是容器苗培育项目。种植土项目中,首先分析了上海本地的土壤状况,然后因地制宜开发出改良配方及生产方案,最后生产换填的全过程。容器苗培育项目中,从控根容器板的应用、苗木土球控制、苗木分枝质量控制、苗木整形等角度自下而上阐述了迪士尼带来的先进苗木培育理念和实践。最后从这2个项目实践中,总结了一些值得国内绿化行业参考的一些先进理念。

关键词：风景园林上海国际旅游度假区种植土容器苗

Metal-Free,Site-Selective C-H Fluorination of Heteroarenes Under Visible Light

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CCS Chemistry 2024年第7期6卷 1681-1688页

作者： Cheng huang Chang-Ming You Yu-Shu Qin Rui-Nan Ci Peng Xiao Sheng Tang Bin Liu Zhenhong Wei Li-Zhu Wu hu cai School of Chemistry and Chemical Engineering Nanchang UniversityNanchangJiangxi 330031 Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryUniversity of Chinese Academy of SciencesChinese Academy of SciencesBeijing 100190 School of Future Technology University of Chinese Academy of SciencesBeijing 100049

The site-selective C-H fluorination of heteroarenes is a straightforward approach to accessing valuable heteroaryl fluorides but remains a formidable ***,we report a general strategy for visible-light-induced C-H fluorination of heteroarenes via the merger of N-F fluorinating reagents and *** paramagnetic resonance experiments provide evidence for the homolytic cleavage of the N-F bond under blue light-emitting diode irradiation,which is the key step in the *** transformation is metal-free,photocatalysts-free,and site-selective under mild reaction conditions(ambient temperature,visible-light irradiation,tolerant to H2O).The robustness of this protocol has also been highlighted by late-stage modification of complex and medicinally relevant molecules.

关键词： selective C-H fluorination heteroaryl fluorides C(sp^(2))-F bond formation photochemistry radical chemistry

Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins

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Neural Regeneration Research 2025年第1期20卷 242-252页

作者： Daiyu hu Yuanqing Cao Chenglin cai Guangming Wang Min Zhou Luying Peng Yantao Fan Qiong Lai Zhengliang Gao Fundamental Research Center Shanghai Yangzhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Center)School of MedicineTongji UniversityShanghaiChina Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)Shanghai University School of MedicineNantongJiangsu ProvinceChina Shanghai Engineering Research Center of Organ Repair Shanghai University School of MedicineShanghaiChina Key Laboratory of Arrhythmias Ministry of EducationShanghai East HospitalSchool of MedicineTongji UniversityShanghaiChina

human brain development is a complex process,and animal models often have significant *** address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-like organoids,to more accurately model early human brain development and *** enable more consistent and intuitive reproduction of early brain development,in this study,we incorporated forebrain organoid culture technology into the traditional unguided method of brain organoid *** involved embedding organoids in matrigel for only 7 days during the rapid expansion phase of the neural epithelium and then removing them from the matrigel for further cultivation,resulting in a new type of human brain organoid *** cerebral organoid system replicated the temporospatial characteristics of early human brain development,including neuroepithelium derivation,neural progenitor cell production and maintenance,neuron differentiation and migration,and cortical layer patterning and formation,providing more consistent and reproducible organoids for developmental modeling and toxicology *** a proof of concept,we applied the heavy metal cadmium to this newly improved organoid system to test whether it could be used to evaluate the neurotoxicity of environmental *** organoids exposed to cadmium for 7 or 14 days manifested severe damage and abnormalities in their neurodevelopmental patterns,including bursts of cortical cell death and premature *** exposure caused progressive depletion of neural progenitor cells and loss of organoid integrity,accompanied by compensatory cell proliferation at ectopic *** convenience,flexibility,and controllability of this newly developed organoid platform make it a powerful and affordable alternative to animal models for use in neurodevelopmental,neurological,and neurotoxicological studies.

关键词： cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells neurogenesis neurotoxicology organoids stem cells

Carboxylic Acid as Traceless Directing Group for Pd/Cu-Catalyzed Decarboxylative ortho-halogenation of Aryl Carboxylic Acids with NaX

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Carboxylic Acid as Traceless Directing Group for Pd/Cu-Catal...

论城市文化空间及其主体层次结构与高等教育国际化的互动

中国化学会第十六届全国均相催化学术会议

作者： Yongqing Jiang Shuiliang Wang 付拯江 hu cai College of Chemistry Nanchang University 南昌大学化学学院

＜正＞Transition-metal catalyzed C-H bond halogenation of aromatics has been a state-of-the-art strategy from the standpoint of the atom- and step-economy, and considerable efforts has been put forward into transition... 详细信息

关键词： Decarboxylation C-H activation Halogenations Traceless directing group

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湘潭大学学报（哲学社会科学版） 2009年第3期33卷 153-157页

作者：胡亮才湖南城市学院国际交流处湖南益阳413000

现代空间理论认为,空间与社会通过主体相互建构。在现代城市,主体以时空方式存在于城市文化之中。主体通过建构具有层级性的社会文化空间影响着高等教育国际化的文化语境建设,并促使高等教育物质基础日趋国际化,高等教育的发展又反作用... 详细信息

现代空间理论认为,空间与社会通过主体相互建构。在现代城市,主体以时空方式存在于城市文化之中。主体通过建构具有层级性的社会文化空间影响着高等教育国际化的文化语境建设,并促使高等教育物质基础日趋国际化,高等教育的发展又反作用于城市文化空间的形成及城市主体的层级性形成。同时,现代技术的发展使空间得以拓展,"人"得以全面延伸。在媒介和各种教育技术的运用下,高等教育国际化的公共性空间得以形成。这种城市文化空间及主体层次结构与高等教育国际化互动模式理论框架的形成,为其实证研究提供了可供借鉴的思路。

关键词：城市文化空间高等教育国际化主体结构

基于振动控制的微小物体释放操作方法与实验研究

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兵工学报 2017年第4期38卷 802-809页

作者：胡俊峰蔡建阳江西理工大学机电工程学院江西赣州341000

针对微夹持器在夹持微小物体过程中的黏着问题,提出了一种基于压电振动控制的释放操作方法。应用弹性黏着理论证明了可利用压电振动效应产生的惯性力克服微夹持器与微小物体之间的黏着力,说明了该释放操作方法的可行性。采用实验方法建... 详细信息

针对微夹持器在夹持微小物体过程中的黏着问题,提出了一种基于压电振动控制的释放操作方法。应用弹性黏着理论证明了可利用压电振动效应产生的惯性力克服微夹持器与微小物体之间的黏着力,说明了该释放操作方法的可行性。采用实验方法建立反映压电微夹持器振动特性的动态模型,基于该模型得出稳定释放微小物体时驱动器输入电压幅值和频率应满足的条件。以一种微夹持器为对象搭建实验平台进行微小物体的释放实验,结果表明:所提出的释放操作方法是可行的;同时微小物体的尺寸越小、释放越困难,需要越大的惯性力克服其受到的黏着力。

关键词：机械学微夹持器释放操作黏着振动

Two coordinated geometries of Mn2+ ions in one single molecule:organic–inorganic hybrids constructed with tris(2-aminoethyl)amine and manganese halide

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Two coordinated geometries of Mn2+ ions in one single molecu...