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Bidirectional regulation of the brain-gut-microbiota axis following traumatic brain injury

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Neural Regeneration Research 2025年第8期20卷 2153-2168页

作者： Xinyu You lin Niu Jiafeng fu Shining Ge Jiangwei Shi Yanjun Zhang Pengwei Zhuang National Key Laboratory of Chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina Haihe Laboratory of Modern Chinese Medicine Tianjin University of Traditional Chinese MedicineTianjinChina First Teaching Hospital of Tianjin University of Traditional Chinese Medicine TianjinChina National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion TianjinChina

Traumatic brain injury is a prevalent disorder of the central nervous *** addition to primary brain parenchymal damage,the enduring biological consequences of traumatic brain injury pose long-term risks for patients with traumatic brain injury;however,the underlying pathogenesis remains unclear,and effective intervention methods are *** dysfunction is a significant consequence of traumatic brain *** the most densely innervated peripheral tissue in the body,the gut possesses multiple pathways for the establishment of a bidirectional“brain-gut axis”with the central nervous *** gut harbors a vast microbial community,and alterations of the gut niche contribute to the progression of traumatic brain injury and its unfavorable prognosis through neuronal,hormonal,and immune pathways.A comprehensive understanding of microbiota-mediated peripheral neuroimmunomodulation mechanisms is needed to enhance treatment strategies for traumatic brain injury and its associated *** comprehensively reviewed alterations in the gut microecological environment following traumatic brain injury,with a specific focus on the complex biological processes of peripheral nerves,immunity,and microbes triggered by traumatic brain injury,encompassing autonomic dysfunction,neuroendocrine disturbances,peripheral immunosuppression,increased intestinal barrier permeability,compromised responses of sensory nerves to microorganisms,and potential effector nuclei in the central nervous system influenced by gut ***,we reviewed the mechanisms underlying secondary biological injury and the dynamic pathological responses that occur following injury to enhance our current understanding of how peripheral pathways impact the outcome of patients with traumatic brain *** review aimed to propose a conceptual model for future risk assessment of central nervous system-related diseases while elucidating novel insights into the bidirectional effec

关键词： traumatic brain injury brain-gut-microbiome axis gut microbiota neuroimmune immunosuppression host defense vagal afferents bacterial infection dorsal root ganglia nociception neural circuitry

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A bio-inspired optical imaging method for robotic perception in turbid water

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Science China Technological Sciences 2025年第1期 79-81页

作者： Xudong SUN Yafeng LI Peng lin Xiaodi SHANG Xianping fu School of Information Science and Technology Dalian Maritime University College of Computer Science and Technology Qingdao University

In the realm of underwater robotics, optical imaging plays a pivotal role in many scientific researches. Due to the effects of absorption and scattering,images captured in turbid water are severely degraded. Therefore, enhancing the quality of underwater optical images stands paramount in ensuring the continued advancement and efficacy of underwater robots across its multifarious applications.

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Engineering N3C vacancies in hierarchical porous carbon nitride nanosheets for room temperature ultradeep photocatalytic aerobic oxidative desulfurization

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Science China Chemistry 2025年

作者： Yina Nie Weijie Yang Xin Wang Xiang Li Lele Wei Xiaolin Bai lin Liu Feng fu Jun Wan College of Chemistry & Chemical Engineering Research Institute of Comprehensive Energy Industrial Technology Shaanxi Key Laboratory of Chemical Reaction Engineering Yan'an University Anhui Engineering Research Center of Carbon Neutrality College of Chemistry and Materials Science Anhui Normal University

The production of ultra-low sulfur clean fuels holds global significance for improving energy efficiency and reducing environmental pollution. Photocatalytic aerobic oxidative desulfurization（PODS） offers an attractive approach to efficiently remove refractory heterocyclic aromatic sulfur compounds under mild conditions. However, the sluggish charge dynamics,insufficient molecule activation, and slow mass transfer within photocatalysts restrict the overall desulfurization efficiency,hindering the widespread application of this technology. Herein, we developed a defective g-C3N4（M1U3CN） photocatalyst with bridged N3Cvacancies and hierarchical porous structures to address these limitations. This catalyst not only demonstrates outstanding dibenzothiophene（DBT） removal efficiency of 99.6% for model oil with high conversion and selectivity but also achieves complete sulfur removal from gasoline as well as 96.7% sulfur removal for distilled diesel at room temperature,successfully achieving ultradeep aerobic oxidative desulfurization. The introduction of rich N3Cvacancies and abundant micromeso-macroporous distribution in M1U3CN enhances kinetic efficiencies by promoting charge carrier separation, mass transfer,and molecular activation simultaneously; resulting in exceptional PODS performance. This work provides a collaborative strategy to overcome kinetic challenges in aerobic oxidative desulfurization via defect and structural engineering of the catalyst.

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Lipomatous ependymoma with ZFTA:RELA fusion-positive:A case report

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World Journal of Clinical Cases 2025年第1期13卷 48-55页

作者： Xiao-Yu Zhao Juan-Han Yu Yi-Hua Wang Yi-Xin Liu Lu Xu lin fu Ning Yi China Medical University The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Department of Pathology The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina Anshan Cancer Hospital Anshan 114000Liaoning ProvinceChina

BACKGROUND Ependymoma with lipomatous differentiation is a rare type of *** ZFTA fusion-positive supratentorial ependymoma is a novel tumor type in the 2021 World Health Organization classification of central nervous system *** fusion-positive lipomatous ependymoma has not been reported to *** SUMMARY We reported a case of a 15-year-old Chinese male who had a sudden convulsion lasting approximately six *** resonance imaging showed a round cystic shadow of approximately 1.9 cm×1.5 cm×1.9 cm under the right parieto-occipital *** examination showed characteristic perivascular pseudorosettes and adipose differentiation in the ***-chemical staining showed that the tumor cells were negative for cytokeratin,NeuN,Syn and p53,but positive for GFAP,vimentin and S-100 ***-ficant punctate intracytoplasmic EMA immunoreactivity was *** level of Ki-67 was about 5%.Genetic analysis revealed ZFTA:RELA fusion.A cranio-tomy with total excision of the tumor was *** follow-up time was 36 months,no evidence of disease recurrence was found in magnetic resonance *** Based on these findings,the patient was diagnosed as a ependymoma with ZFTA fusion and lipomatous *** case report provides information on the microscopic morphological features of ependymoma with ZFTA fusion and lipomatous differentiation,which can help pathologists to make a definitive diagnosis of this tumor.

关键词： Ependymoma Lipomatous Molecular classification Supratentorial ZFTA:RELA fusion Case report

Incorporating Variation and Quality of the Underlying Effects in Meta-Analysis

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Journal of Systems Science & Complexity 2022年第6期35卷 2381-2397页

作者： fu Jinyu lin Jinguan School of Mathematics Southeast UniversityNanjing 210096China School of Statistics and Data Science Nanjing Audit UniversityNanjing 211815China

This paper proposes a model to further explore the effects of the quality information and variation of the underlying effects on the summary effect measure in meta-analysis.A shape parameter is used in this model to quantify the asymmetry of the effect sizes of studies that are *** of the proposed model parameters is carried out by the Bayesian MCMC *** of the resultant estimates are examined in the simulations and empirical case with data obtained from a total of 22 meta-analyses taken from three different designs.A conclusion would be drawn that it is advisable to take the proposed model,when quality information becomes available,in particular with a situation where the underlying effects approximately follow a normal ***,however,the quality information is absent,the skew-normal distribution for random effect model should be adopted.

关键词： Bayesian estimation heterogeneity overall effect size quality score skew-normal distribution

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Surfing the nano-wave:Emerging trends in cancer diagnostics and therapy

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Nano Research 2025年第1期18卷 520-544页

作者： Genping fu Yuting Weng Yunfan Li Carl Ho Yiyu fu Wenxuan Wang Songbin fu Wenjing Sun Jie lin Xiaoyu Fan Binbin Jia Mengdi Cai linlin Li Laboratory of Medical Genetics Harbin Medical UniversityHarbin 150081China Key Laboratory of Preservation of Human Genetics Resources and Disease Control in China(Harbin Medical University) Ministry of EducationHarbin 150081China Beijing Key Laboratory for Optical Materials and Photonic Devices Department of ChemistryCapital Normal UniversityBeijing 100048China College of Materials and Chemical Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion MaterialsChina Three Gorges UniversityYichang 443002China Washington University School of Medicine in St.Louis St.LouisMO 63110USA Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Aix-Marseille College Wuhan University of TechnologyWuhan 430070China

Facing the growing global challenge posed by cancer,the quest for more accurate and potent cancer diagnostic and therapeutic strategies continues to require a multidisciplinary integration *** review firstly summarizes various types of nanoparticles in cancer ***,it offers a comprehensive overview of signalenhancing techniques for visualizing in situ tumors,along with multimodal diagnostic methods for detecting *** for tumor therapy,cutting-edge drug delivery methods that can cross biological barriers and the pinpoint targeting of tumor lesions for precise medical intervention are *** the domain of therapeutic diagnostics,we elucidate the theoretical underpinnings and structural paradigms that underlie a spectrum of advanced diagnostic and therapeutic ***,we present a compendium of publications delineating the clinical applications of each nano-based theragnostic integration ***,this comprehensive review discusses the safety concerns pertaining to the clinical application of nanoparticles and proposes some strategic recommendations to enhance the precision and safety of theragnostic-guided,nanotechnology-based clinical practices.A deeper understanding of nanomaterials,together with intimate interdisciplinary collaborations,nano-wave will most probably guide human beings to win the battle against cancers.

关键词： nanoparticles drug delivery gastric cancer glioma glioblastoma

Pretrained Models and Evaluation Data for the Khmer Language

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Tsinghua Science and Technology 2022年第4期27卷 709-718页

作者： Shengyi Jiang Sihui fu Nankai lin Yingwen fu School of Information Science and Technology Guangdong University of Foreign StudiesGuangzhou 510000China Guangzhou Key Laboratory of Multilingual Intelligent Processing Guangdong University of Foreign StudiesGuangzhou 510000China

Trained on a large corpus,pretrained models(PTMs)can capture different levels of concepts in context and hence generate universal language representations,which greatly benefit downstream natural language processing(NLP)*** recent years,PTMs have been widely used in most NLP applications,especially for high-resource languages,such as English and ***,scarce resources have discouraged the progress of PTMs for low-resource ***-based PTMs for the Khmer language are presented in this work for the first *** evaluate our models on two downstream tasks:Part-of-speech tagging and news *** dataset for the latter task is *** demonstrate the effectiveness of the Khmer *** addition,we find that the current Khmer word segmentation technology does not aid performance *** aim to release our models and datasets to the community in hopes of facilitating the future development of Khmer NLP applications.

关键词： pretrained models Khmer language word segmentation part-of-speech(POS)tagging news categorization

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Performance of the combination of decarbonisation policy instruments and implications for carbon neutrality in China

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Advances in Climate Change Research 2022年第6期13卷 923-937页

作者： lin fu Can WANG School of Environment Tsinghua UniversityBeijing 100084China National Center for Climate Change Strategy and International Cooperation Beijing 100035China

Decarbonisation is a complex systemic issue that involves multiple market ***,the integrated application of multiple policy instruments is *** study used the fuzzy-set qualitative comparative analysis(fsQCA)method to explore the causality relationship between decarbonisation policies with reference to the Intergovernmental Panel on Climate Change(IPCC)and the decoupling elasticity of Tapio from a configuration *** found that taxation and regulation are the critical drivers of decoupling,while information and public goods and services are *** decoupled policy mixes were tabled,each focusing on a)taxation,b)taxation and economic instruments,and c)trading system and *** contrast,the execution of information and voluntary instruments,as well as the non-implementation of the tax,are essential to *** combinations that are negative for decoupling were also introduced:a)trade and economic incentives,b)trade,information and voluntary instruments,and c)information,public goods and services,and voluntary *** most valuable policy mix for China is the implementation of taxes,trade,economic and regulations with the provision of auxiliary decarbonised information and public goods and *** following processes are involved:a)integrate regulations with economic policies for more flexibility;b)introduce the carbon tax and a tax rebate policy to complement the carbon market policy based on research into the feasibility and cost-effectiveness;c)provide information and public services mainly on the consumption side;and d)recommend voluntary policies for innovative *** the basis of more cases and a configuration perspective,this study offers various policy mixes that are conducive or not to decoupling and suggestions for optimising China’s decarbonisation *** also offered a way to measure the intensity of the decarbonisation policy with respect to the carbon emission structure of sect

关键词： Policy instrument Qualitative comparative analysis Configuration Tapio decoupling

Coherent Control of a Simple Quantum System

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Chinese Physics Letters 1997年第6期14卷 417-420页

作者： lin fu-cheng Shanghai Institute of Optics and Fine Mechanics Chinese Academy of SciencesShanghai 201800

The quantum dynamics of a three-level Vee-system can be controlled by using two single-mode cw *** dc component of the probability for finding a specific state in laser fields can be obtained by matching the intensities,phases and detunings of the lasers to relevant eigenvalues of the quantum *** selectivity of control does not depend strongly on the laser intensities but the absolute amount of the product does *** are generally three paths to reach such a dc component control and,at some points,two of them cross each other causing a near 100%*** stability of the process to the fluctuation of the experiment was analyzed.

关键词： tuning quantum Quantum