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Predicting cholecystocholedochal fistulas in patients with Mirizzi syndrome undergoing endoscopic retrograde cholangiopancreatography

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World Journal of Gastroenterology 2020年第40期26卷 6241-6249页

作者： chi-Huan Wu Nai-Jen Liu Chun-Nan yeh Shang-Yu Wang Yi-Yin Jan Department of Gastroenterology and Hepatology Linkou Medical CenterChang Gung Memorial HospitalChang Gung UniversityCollege of MedicineTaoyuan 333Taiwan Department of General Surgery Linkou Medical CenterChang Gung Memorial HospitalChang Gung UniversityCollege of MedicineTaoyuan 333Taiwan

BACKGROUND Mirizzi syndrome(MS) is defined as an extrinsic compression of the extrahepatic biliary system by an impacted stone in the gallbladder or the cystic duct leading to obstructive jaundice. Endoscopic retrograde cholangiopancreatography(ERCP) could serve diagnostic and therapeutic purposes in patients with MS in addition to revealing the relationships between the cystic duct, the gallbladder, and the common bile duct(CBD). Cholecystectomy is a challenging procedure for a laparoscopic surgeon in patients with MS, and the presence of a cholecystocholedochal fistula renders preoperative diagnosis important during *** To evaluate cholecystocholedochal fistulas in patients with MS during ERCP before *** From 2004 to 2018, all patients diagnosed with MS during ERCP were enrolled in this study. Patients with associated malignancy or those who had already undergone cholecystectomy before ERCP were excluded. In total, 117 patients with MS diagnosed by ERCP were enrolled in this study. Among them, 21 patients with MS had cholecystocholedochal fistulas. MS was further confirmed during cholecystectomy to check if cholecystocholedochal fistulas were present. The clinical data, cholangiography, and endoscopic findings during ERCP were recorded and *** Gallbladder opacification on cholangiography is more frequent in patients with MS complicated by cholecystocholedochal fistulas(P < 0.001). Pus in the CBD and stricture length of the CBD longer than 2 cm were two additional independent factors associated with MS, as demonstrated by multivariate analysis(odds ratio 5.82, P = 0.002;0.12, P = 0.008, respectively).CONCLUSION Gall bladder opacification is commonly seen in patients with MS with cholecystocholedochal fistulas during pre-operative ERCP. Additional findings such as pus in the CBD and stricture length of the CBD longer than 2 cm may aid the diagnosis of MS with cholecystocholedochal fistulas.

关键词： Cholecystectomy Cholecystocholedochal fistula Common bile duct Endoscopic retrograde cholangiopancreatography Mirizzi syndrome

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Dynamic Gain-Clamped Amplifier with Backward-Injection of a Fabry-Perot Laser

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光学学报 2003年第S1期23卷 499-500页

作者： chien-Hung yeh chih-Yang Chen chien-Chung Lee Sien chi Institute of Electro-Optical Engineering Chiao-Tung University 1001 Ta Hsueh Road Hsinchu Taiwan 300

We have been experimentally demonstrated an active control technique of dynamic gain-clamped spectra for theerbium-doped fiber amplifiers (EDFA's) by a backward-injected Fabry-Perot (F-P) laser into this EDFA. In addition, employing a short length erbium-doped fiber (EDF) that not cause any gain saturation for preamplification in front of this amplifier module, it can reduce the noise figure degradation and simultaneously achieve gain variation from 11.1 dB to 0.5 dB for 10 dB input power level change.

关键词： control technique fiber amplifiers noise figure input power

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Risk factors and metabolic abnormality of patients with non-alcoholic fatty liver disease: Either non-obese or obese chinese population

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Hepatobiliary & Pancreatic Diseases International 2018年第1期17卷 45-48页

作者： Shou-Wu Lee Teng-Yu Lee Sheng-Shun Yang Chun-Fang Tung Hong-Zen yeh chi-Sen Chang Division of Gastroenterology Department of Internal Medicine Taichung Veterans General Hospital

Background: Non-alcoholic fatty liver disease(NAFLD) occurs not only in obese individuals but also in non-obese ones. The aim of this study was to focus on the association between NAFLD and metabolic events in a non-obese or obese chinese ***: Data collected from subjects registered at Taichung Veterans General Hospital from January to December 2009 were analyzed. The exclusion criteria were alcoholics, chronic hepatitis B or C. Patients included in analyses were assigned to four groups according to sonography of their liver(normal or NAFLD), and body mass index(BMI) levels(non-obese if BMI < 25 kg/m~2 or obese if BMI ≥ 25 kg/m~2).Results: There were 745, 208, 770 and 285 patients enrolled in four groups labeled non-obese normal liver(group A), non-obese NAFLD(group B), obese normal liver(group C) and obese NAFLD(group D),respectively. The highest ratio of metabolic syndrome existed in the group B(26.9%), followed by group A(11.7%), group D(10.9%) and finally the group C(5.2%). The positive association with NAFLD in non-obese individuals was significant in triglyceride(OR = 1.01; 95% CI: 1.01–1.02) and glucose(OR = 1.02; 95% CI:1.01–1.03), while the positive association with NAFLD in obese subjects was only significant in triglyceride(OR = 1.01; 95% CI: 1.01–1.02). The positive association was most significant in all cases(adjusted OR = 2.41; 95% CI: 1.78–3.24), especially in non-obese individuals(OR = 2.81; 95% CI: 1.92–4.12).Conclusions: Non-obese NAFLD subjects displayed a higher proportion of metabolic abnormality. Hyperlipidemia and hyperglycemia had the most positive strength association with NAFLD.

关键词： Fatty liver Non-alcoholic fatty liver disease Obese chinese population

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The association of non-alcoholic fatty liver disease and metabolic syndrome in a chinese population

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Hepatobiliary & Pancreatic Diseases International 2017年第2期16卷 176-180页

作者： Shou-Wu Lee Teng-Yu Lee Sheng-Shun Yang Yen-Chun Peng Hong-Zen yeh chi-Sen Chang Division of Gastroenterology Department of Internal Medicine Taichung Veterans General Hospital Taichung Taiwan China

BACKGROUND： Non-alcoholic fatty liver disease（NAFLD） is associated with features of metabolic syndrome. The aim of this study was to investigate the association between NAFLD and metabolic syndrome in a chinese population. METHODS： Data from subjects were retrospectively collected from 2006 to 2009. The exclusion criteria included significant consumption of alcohol and chronic hepatitis B and C. The patients were assigned to two groups according to ultrasound findings： normal group and fatty liver group. The liver function of patients was determined by assessing serum alanine aminotransferase（ALT）. Metabolic syndrome was diagnosed based on the 2005 International Diabetes Federation criteria. RESULTS： A total of 7568 subjects were enrolled and 5736（75.8%） and 1832（24.2%） patients were assigned to the normal and fatty liver groups, respectively. The fatty liver group had significant male predominance（69.7% vs 56.0%）, higher body mass index（mean, 26.67 vs 23.55 kg/m^2） compared with the normal group. There were 441（7.7%） and 377（20.6%） cases with metabolic syndrome in the normal and fatty liver groups, respectively, with significant difference（P=0.001）, and the subgroup of 385 cases with fatty liver and elevated ALT had higher prevalence（28.8%） of metabolic syndrome. The strongest association of an individual component of metabolic syndrome with NAFLD was hyperlipidemia（adjusted OR=2.55, 95% CI： 2.22-2.94）.CONCLUSION： The individuals with NAFLD had a higher ratio of metabolic syndrome. Hyperlipidemia had the strongest positive association with NAFLD.

关键词： fatty liver hyperlipidemia metabolic syndrome

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On the number of matchings of graphs formed by a graph operation

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Science china Mathematics 2006年第10期49卷 1383-1391页

作者： yeh Yeong-Nan Institute of Mathematics Academia Sinica

Let G be a simple graph. Define R(G) to be the graph obtained from G by adding a new vertex e* corresponding to each edge e = (a, b) of G and by joining each new vertex e* to the end vertices a and b of the edge e corresponding to it. In this paper, we prove that the number of matchings of R(G) is completely determined by the degree sequence of vertices of G.

关键词： matching, Hosoya index, matching polynomial, oriented incident matrix,skew adjacency matrix.

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Knowledge discovery for geographical cellular automata

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Science china Earth Sciences 2005年第10期48卷 1758-1767页

作者： Anthony Gar-On yeh Centre of Urban Planning and Environmental Management The University of Hong Kong Hong Kong SAR China

This paper proposes a new method for geographical simulation by applying data mining techniques to cellular automata. CA has strong capabilities in simulating complex systems. The core of CA is how to define transition rules. There are no good methods for defining these transition rules. They are usually defined by using heuristic methods and thus subject to uncer-tainties. Mathematical equations are used to represent transition rules implicitly and have limita-tions in capturing complex relationships. This paper demonstrates that the explicit transition rules of CA can be automatically reconstructed through the rule induction procedure of data mining. The proposed method can reduce the influences of individual knowledge and preferences in de-fining transition rules and generate more reliable simulation results. It can efficiently discover knowledge from a vast volume of spatial data.

关键词： knowledge discovery, cellular automata, geographical simulation, geographical information systems.

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Discovery of transition rules for geographical cellular automata by using ant colony optimization

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Science china Earth Sciences 2007年第10期50卷 1578-1588页

作者： Anthony Gar-On yeh Center of Urban Planning and Environmental Management The University of Hong Kong Hong Kong SAR China

A new intelligent algorithm of geographical cellular automata (CA) based on ant colony optimization (ACO) is proposed in this paper. CA is capable of simulating the evolution of complex geographical phenomena, and the core of CA models is how to define transition rules. However, most of the transition rules are defined by mathematical equations, and are hence not explicit. When the study area is complicated, it is much more difficult to extract parameters for geographical CA. As a result, ACO is applied to geographical CA to automatically and intelligently obtain transition rules in this paper. The transition rules extracted by ACO are defined as logical expressions rather than implicit mathematical equations to describe the complex relationships of the nature, and easy for people to understand. The ACO-CA model was applied to simulating rural-urban land conversions in Guangzhou City, china, and appropriate simulation results were generated. Compared with See5.0 decision tree model, ACO-CA is more suitable to discovering transition rules for geographical CA.

关键词： ant colony optimization, CA, geographical simulation, artificial intelligence

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Multi-agent systems for simulating spatial decision behaviors and land-use dynamics

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Science china Earth Sciences 2006年第11期49卷 1184-1194页

作者： Anthony Gar-On yeh Center of Urban Planning and Environmental Management The University of Hong Kong Hong Kong SAR China

A new method to simulate urban land-use dynamics is proposed based on multi-agent systems (MAS). The model consists of a series of environmental layers and multi-agent layers, which can interact with each other. It attempts to explore the interactions between different players or agents, such as residents, property developers, and governments, and between these players and the envi- ronment. These interactions can give rise to urban macro-spatial patterns. This model is used to simulate the land-use dynamics of the Haizhu district of Guangzhou City in 1995―2004. Cellular automata (CA) were also used for the simulation of land use changes as a comparison. The study indicates that MAS has better performance for simulating complex cities than CA.

关键词： multi-agent systems, cellular automata, complex systems, cities, land use.

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Heartburn and regurgitation have different impacts on life quality of patients with gastroesophageal reflux disease

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World Journal of Gastroenterology 2014年第34期20卷 12277-12282页

作者： Shou-Wu Lee Han-Chung Lien Teng-Yu Lee Sheng-Shun Yang Hong-Jeh yeh chi-Sen Chang Division of Gastroenterology and Hepatology Department of Internal MedicineTaichung Veterans General Hospital Department of Medicine Chung Shan Medical University Department of Medicine Yang Ming University School of Medicine

AIM: To investigate the impact of heartburn and regurgitation on the quality of life among patients with gastroesophageal reflux disease (GERD).

关键词： Erosive esophagitis Gastroesophageal reflux disease Gender Life quality Non-erosive reflux disease

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The roles of bone remodeling in normal hematopoiesis and age-related hematological malignancies

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Bone Research 2023年第2期11卷 273-291页

作者： Hengwei Zhang Jane LLiesveld Laura MCalvi Brea CLipe Lianping Xing Michael WBecker Edward MSchwarz Shu-chi A.yeh Center for Musculoskeletal Research University of Rochester Medical Center601 Elmwood AveBox 665RochesterNY14642USA Department of Pathology and Laboratory Medicine University of Rochester Medical CenterRochesterNYUSA Wilmot Cancer Center University of Rochester Medical CenterRochesterNYUSA Department of Medicine Division of Hematology/Oncology and Bone Marrow Transplantation ProgramUniversity of Rochester Medical CenterRochesterNYUSA Department of Medicine Division of Endocrinology/MetabolismUniversity of Rochester Medical CenterRochesterNYUSA Department of Orthopaedics University of Rochester Medical CenterRochesterNYUSA Department of Medicine Division of Allergy/Immunology/RheumatologyUniversity of Rochester Medical CenterRochesterNYUSA Department of Biomedical Engineering University of RochesterNYUSA Department of Physiology/Pharmacology University of Rochester Medical CenterRochesterNYUSA

Prior research establishing that bone interacts in coordination with the bone marrow microenvironment(BMME)to regulate hematopoietic homeostasis was largely based on analyses of individual bone-associated cell *** advances in intravital imaging has suggested that the expansion of hematopoietic stem cells(HSCs)and acute myeloid leukemia cells is restricted to bone marrow microdomains during a distinct stage of bone *** findings indicate that dynamic bone remodeling likely imposes additional heterogeneity within the BMME to yield differential clonal responses.A holistic understanding of the role of bone remodeling in regulating the stem cell niche and how these interactions are altered in age-related hematological malignancies will be critical to the development of novel *** advance this understanding,herein,we provide a synopsis of the cellular and molecular constituents that participate in bone turnover and their known connections to the hematopoietic ***,we elaborate on the coupling between bone remodeling and the BMME in homeostasis and age-related hematological malignancies and after treatment with bone-targeting *** then discuss unresolved questions and ambiguities that remain in the field.

关键词： remodeling homeostasis likely

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