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Comprehensive analysis of the gut microbiome and posttranslational modifications elucidates the route involved in microbiota-host interactions

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Zoological Research 2024年第1期45卷 95-107页

作者： Hai-Yang wang Lan-Xiang Liu Xue-Yi Chen Yang-Dong Zhang wen-Xia Li wen-wen Li Lian wang Xiao-Long Mo Hong Wei Ping Ji Peng Xie NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China College of Stomatology and Affiliated Stomatological Hospital of Chongqing Medical University Chongqing 401147China Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Chongqing 401147China Department of Neurology Yongchuan Hospital of Chongqing Medical UniversityChongqing 402160China Department of Pathology Faculty of Basic MedicineChongqing Medical UniversityChongqing 400016China Department of Neurology First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Yu-Yue Pathology Scientific Research Center Chongqing 401329China

The gut microbiome interacts with the host to maintain body homeostasis,with gut microbial dysbiosis implicated in many ***,the underlying mechanisms of gut microbe regulation of host behavior and brain functions remain *** study aimed to elucidate the influence of gut microbiota on brain functions via post-translational modification mechanisms in the presence or absence of bacteria without any *** conducted succinylome analysis of hippocampal proteins in germ-free(GF)and specific pathogen-free(SPF)mice and metagenomic analysis of feces from SPF *** results were integrated with previously reported hippocampal acetylome and phosphorylome data from the same batch of *** bioinformatics analyses revealed 584 succinylation sites on 455 proteins,including 54 up-regulated succinylation sites on 91 proteins and 99 down-regulated sites on 51 proteins in the GF mice compared to the SPF *** constructed a panoramic map of gut microbiota-regulated succinylation,acetylation,and phosphorylation,and identified cross-talk and relative independence between the different types of post-translational modifications in modulating complicated intracellular *** correlation analysis indicated that 13 taxa,predominantly belonging to the Bacteroidetes phylum,were correlated with the biological functions of post-translational *** correlations between these taxa and succinylation and negative correlations between these taxa and acetylation were identified in the modulation of intracellular *** study highlights the hippocampal physiological changes induced by the absence of gut microbiota,and proteomic quantification of succinylation,phosphorylation,and acetylation,contributing to our understanding of the role of the gut microbiome in brain function and behavioral phenotypes.

关键词： Gut microbiota Hippocampal protein Post-translational modifications Succinylation Acetylation Phosphorylation

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Mn single-atoms decorated CNT electrodes for high-performance supercapacitors

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Nano Research 2024年第5期17卷 4039-4046页

作者： Qian Rong Chao Yuwen Yingkai Liu Yuanrong Liu Chunyang wang Yang wang Ding Zhang Zhen wen Yunnan Key Laboratory of Opto-Electronic Information Technology Institute of Physics and Electronic InformationYunnan Normal UniversityKunming 650500China Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650093China Department of Physics and Astronomy University of CaliforniaIrvineCA 92697USA School of Materials Science and Engineering National Institute for Advanced MaterialsSmart Sensing Interdisciplinary Science CenterNankai UniversityTianjin 300350China Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Institute of Functional Nano and Soft Materials(FUNSOM)Soochow UniversitySuzhou 215123China

Developing highly robust and efficient electrode materials is of critical importance to promoting the energy density of current supercapacitors for ***,we report an efficient catalyst with monodispersed Mn single-atoms embedded in carbon nanotubes(Mn-CNTs)for enhancing the electrode performance of supercapacitors.A high specific capacitance(1523.6 F·g^(-1) at 1.0 A·g^(-1))can be achieved,which is about twice as high as the specific capacitance of the electrode material without the introduction of Mn ***,the asymmetric electrochemical capacitor created with Mn-CNT and activated carbon exhibits a high energy density of 180.8 Wh·kg^(-1) at a power density of 1.4 kW·kg^(-1),much higher than most reported *** study shows that the integration of Mn atoms into the CNT can enhance the charge transport capacity and the number of polar active sites of Mn-CNT and then facilitate chemical interactions between Mn-CNT and OH-.This work provides a novel strategy to enable high-energy storage in supercapacitors by introducing single-atoms into carbon nanotubes to improve electrodes’energy density and cycle life.

关键词： carbon nanotube(CNT) supercapacitor single-atoms power density energy density

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Pathologic assessment of hepatocellular carcinoma in the era of immunotherapy:a narrative review

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Hepatobiliary Surgery and Nutrition 2024年第3期13卷 472-493页

作者： Han wang You-wen Qian Hui Dong wen-Ming Cong Department of Pathology Shanghai Eastern Hepatobiliary Surgery HospitalNaval Medical UniversityShanghaiChina

Background and Objective:Immune checkpoint inhibitor(ICI)-based therapy has achieved impressive success in various cancer *** ICIs have been unprecedentedly approved as the treatment regimens for advanced hepatocellular carcinoma(HCC)in recent ***,numerous clinical trials are being performed to exploit more ICIs into initially unresectable HCC and postoperative HCC to expectantly induce adequate tumor downstaging for further resection or implement adjuvant treatment for relapse-free survival,*** this review,we aim to summarize some pragmatic histomorphologic,immunohistochemical,and molecular pathologic parameters which promisingly indicate the response of neoadjuvant/conversion ICI-related therapy and predict the efficacy of adjuvant/therapeutic ICI-related therapy for ***:We searched PubMed using the terms hepatocellular carcinoma,immunotherapy,immune checkpoint inhibitor,immune checkpoint blockade,conversion therapy,neoadjuvant therapy,adjuvant therapy,biomarker,pathologic evaluation,pathologic assessment till February *** Content and Findings:Although there is no consensus regarding the pathologic evaluation of relevant HCC specimens,it is encouraging that a few of studies have concentrated on this field,and moreover,the methods and parameters noted on other cancer types are also worthy of *** the pathologic assessment of HCC specimens underwent immunotherapy,a suitable sampling scheme,identifying immunotherapy-related pathologic response,and quantification of pathologic response rate should be *** the patients of HCC who are scheduled to receive immunotherapy,tumor-infiltrating lymphocyte,intratumoral tertiary lymphoid structure,programmed cell death ligand 1,Wnt/β-catenin,microsatellite instability and mismatch repair,tumor mutational burden and tumor neoantigen,as well as some other signaling pathways are the potential predictive biomarkers of treatment response of ***:The managem

关键词： Hepatocellular carcinoma(HCC) immune checkpoint blockade pathologic evaluation neoadjuvant therapy conversion therapy adjuvant therapy

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Quantitative prediction model for the depth limit of oil accumulation in the deep carbonate rocks:A case study of Lower Ordovician in Tazhong area of Tarim Basin

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Petroleum Science 2024年第1期21卷 115-124页

作者： wen-Yang wang Xiong-Qi Pang Ya-Ping wang Zhang-Xin Chen Fu-Jie Jiang Ying Chen State Key Laboratory of Lithospheric Evolution Institute of Geology and GeophysicsChinese Academy of SciencesBeijing100029China State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Research Institute of Exploration and Development PetroChina Southwest Oil&Gas Field CompanyChengdu610041SichuanChina Chemical and Petroleum Engineering Schulich School of EngineeringUniversity of CalgaryCalgaryT2N 1N4Canada

With continuous hydrocarbon exploration extending to deeper basins,the deepest industrial oil accumulation was discovered below 8,200 m,revealing a new exploration ***,the extent to which oil exploration can be extended,and the prediction of the depth limit of oil accumulation(DLOA),are issues that have attracted significant attention in petroleum *** it is difficult to characterize the evolution of the physical properties of the marine carbonate reservoir with burial depth,and the deepest drilling still cannot reach the ***,the DLOA cannot be predicted by directly establishing the relationship between the ratio of drilling to the dry layer and the *** this study,by establishing the relationships between the porosity and the depth and dry layer ratio of the carbonate reservoir,the relationships between the depth and dry layer ratio were obtained *** depth corresponding to a dry layer ratio of 100%is the *** on this,a quantitative prediction model for the DLOA was finally *** results indicate that the porosity of the carbonate reservoir,Lower Ordovician in Tazhong area of Tarim Basin,tends to decrease with burial depth,and manifests as an overall low porosity reservoir in deep *** critical porosity of the DLOA was 1.8%,which is the critical geological condition corresponding to a 100%dry layer ratio encountered in the *** depth of the DLOA was 9,000 *** study provides a new method for DLOA prediction that is beneficial for a deeper understanding of oil accumulation,and is of great importance for scientific guidance on deep oil drilling.

关键词： Deep layer Tarim Basin Hydrocarbon accumulation Depth limit of oil accumulation Prediction model

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Transition-metal free trifluoromethylimination of alkenes enabled by direct activation of N-unprotected ketimines

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Chinese Chemical Letters 2024年第9期35卷 155-159页

作者： Boqiang wang Yongzhuo Xu Jiajia wang Muyang Yang Guo-Jun Deng wen Shao Key Laboratory for Green Organic Synthesis and Application of Hunan Province Key Laboratory of Environmentally Friendly Chemistry and Application of Ministry of EducationCollege of ChemistryXiangtan UniversityXiangtan 411105China Department School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

A highly site-selective intermolecular trifluoromethylimination of activated and unactivated olefins was reported under transition-metal-and photosensitizer-free *** newly developed strategy provides straightforward and efficient access to diverse value-added vicinal trifluoromethyl amines without resorting to the pre-functionalized *** experiments demonstrate that the approach proceeded through CF_(3)and iminyl two-radicals process,which were generated directly from commercially available benzophenone imine in a novel electron-donor mode via a SET process activated by the bifunctional hypervalent iodine *** synthetic potential of the protocols was further showcased via the condensation/amination sequential cascade,and transformations to accessβ-CF_(3)primary amines.

关键词： Transition-metal free Alkenes difunctionalization Amination Trifluoromethylation Single-electron transfer

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UBE2T mediates the stemness properties of breast cancer cells through the mTOR signaling pathway

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BIOCELL 2024年第6期48卷 959-970页

作者： JIAWEI YIN YONGSHENG wang GUANGWEI WEI MINGXIN wen Department of Traumatology The Second Hospital of Shandong UniversityJinan250033China Department of Pathology Weifang People’s HospitalWeifang261000China Department of Human Anatomy Shandong University School of MedicineJinan250012China Department of Cell Biology and Key Laboratory of Experimental Teratology Shandong University School of MedicineJinan250012China

Objectives:This study aimed to reveal the role and possible mechanism of the ubiquitin-conjugating enzyme 2T(UBE2T)in the biological activities of breast cancer stem cells(BCSCs).Methods:The specific protein and gene expression were quantified by Western blotting and quantitative real-time polymerase chain reaction,the proportion of BCSCs was examined by flow cytometry,and the self-renewal and proliferation of BCSCs were verified by serial sphere formation and soft ***:Increasing expression of UBE2T was drastically found in breast cancer than that in adjacent ***,UBE2T overexpression significantly increased the proportion of BCSCs in breast cancer cells and promoted their self-renewal and *** UBE2T exhibited the opposite ***2T increased the levels of the mammalian target of rapamycin and the phosphorylated mammalian target of *** target of rapamycin(mTOR)inhibitor rapamycin inhibited the function of UBE2T in ***:UBE2T plays a role in BCSCs through mTOR pathway and may suggest a novel therapeutic strategy for breast cancer.

关键词： UBE2T Breast cancer Breast cancer stem cell mTOR

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Sea-level change in coastal areas of China:Status in 2021

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Advances in Climate Change Research 2024年第3期15卷 515-524页

作者： wen-Shan LI Hui wang wen-Xi XIANG Ai-Mei wang Wei-Qing XU Yu-Xi JIANG Xin-Hui WU Meng-Yuan QUAN National Marine Data and Information Service Tianjin 300171China Ocean University of Chin1 Qingdao 266100China University of Michigan‒Shanghai Jiao Tong University Joint Institute Shanghai 200030China

The sea level in coastal areas of China reached the second highest in 2021,just after that recorded in *** force and dynamic analyses based on tide gauges,satellite observations,reanalysis data and regional numerical outputs were conducted to understand these abnormally high sea levels and determine their possible *** show that the coastal sea level of China had increased at an annual rate of 3.4±0.3 mm during 1980-2021,with an acceleration of 0.06±0.02 mm per *** superposition of significant oscillations of quasi-2,3-7,quasi-9,quasi-11,quasi-19 and 20-30 years contributed to the anomalously high sea *** negative-phased El Nino/Southern Oscillation was correlated with the anomalously high sea level and the north-south anti-phase pattern of the coastal sea level in ***,phase lags of 1-4 months occurred with the sea-level *** a decadal timescale,the Pacific Decadal Oscillation(PDO)was negatively correlated with the anomalous mean sea level(MSL),and the negative-phased PDO contributed to the anomalous sea-level change in ***,the monthly MSL peaked in April and July,and the contribution of wind stress to the anomalously high sea level was 38.5%in the south of the Taiwan Strait in April and 30%along the coast of China in *** results were consistent with the tide gauge and satellite *** agreement was also observed between the coastal sea-level fingerprint and the air and sea surface temperatures.

关键词： Sealevel La Nina PDO Wind stress

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Transcriptome analysis reveals steroid hormones biosynthesis pathway involved in abdominal fat deposition in broilers

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Journal of Integrative Agriculture 2024年第9期23卷 3118-3128页

作者： Yuting Zhu Yongli wang Yidong wang Guiping Zhao Jie wen Huanxian Cui State Key Laboratory of Animal Nutrition/Key Laboratory of Animal(Poultry)Genetics Breeding and Reproduction Ministry of Agriculture and Rural Affairs/Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193China

Excessive abdominal fat deposition reduces the feed efficiency and increase the cost of production in ***,it is an important task for poultry breeders to breed broilers with low abdominal *** fat deposition is a highly complex biological process,and its molecular basis remains *** this study,we performed transcriptome analysis to compare gene expression profiles at different stages of abdominal fat deposition to identify the key genes and pathways involved in abdominal fat *** found that abdominal fat weight(AFW)increased gradually from day 35(D35)to 91(D91),and then decreased at day 119(D119).Accordingly,after detecting differentially expressed genes(DEGs)by comparing gene expression profiles at D35 vs.D63 and D35 vs.D91,and identifying gene modules associated with fat deposition by weighted gene co-expression network analysis(WGCNA),we performed intersection analysis of the detected DEGs and WGCNA gene modules and identified 394 and 435 intersecting genes,*** results of the Gene Ontology(GO)functional enrichment analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analyses showed that the steroid hormone biosynthesis and insulin signaling pathways were co-enriched in all intersecting genes,steroid hormones have been shown that regulated insulin signaling pathway,indicating the importance of the steroid hormone biosynthesis pathway in the development of broiler abdominal *** then identified 6 hub genes(ACTB,SOX9,RHOBTB2,PDLIM3,NEDD9,and DOCK4)related to abdominal fat *** analysis also revealed that there were direct interactions between 6 hub ***9 has been shown to bind to proteins required for steroid hormone receptor binding,and RHOBTB2 indirectly regulates the steroid hormones biosynthesis through cyclin factor,and ultimately affect fat *** results suggest that the genes RHOBTB2 and SOX9 play an important role in fat deposition in broilers,by regul

关键词： broilers abdominal fat deposition transcriptome analysis hub genes steroid hormones biosynthesis pathway

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Reactive oxygen species:Multidimensional regulators of plant adaptation to abiotic stress and development

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Journal of Integrative Plant Biology 2024年第3期66卷 330-367页

作者： Pengtao wang wen-Cheng Liu Chao Han Situ wang Ming-Yi Bai Chun-Peng Song State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475004China The Key Laboratory of Plant Development and Environmental Adaptation Biology Ministry of EducationSchool of Life SciencesShandong UniversityQingdao 266237China Faculty of Science McGill UniversityMontreal H3B1X8Canada

Reactive oxygen species(ROS)are produced as undesirable by-products of metabolism in various cellular compartments,especially in response to unfavorable environmental conditions,throughout the life cycle of *** ROS production disrupts normal cellular function and leads to oxidative *** cope with excessive ROS,plants are equipped with a sophisticated antioxidative defense system consisting of enzymatic and non-enzymatic components that scavenge ROS or inhibit their harmful effects on ***,when maintained at relatively low levels,ROS act as signaling molecules that regulate plant growth,development,and adaptation to adverse ***,we provide an overview of current approaches for detecting *** also discuss recent advances in understanding ROS signaling,ROS metabolism,and the roles of ROS in plant growth and responses to various abiotic stresses.

关键词： abiotic stress growth and development plant reactive oxygen species

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Embedded Majorana islands

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Science China(Physics,Mechanics & Astronomy) 2024年第9期67卷 154-164页

作者： Jin-Xing Hou Alex Weststrom Rui wang wen-Li Yang Jian Li Institute of Modern Physics Northwest UniversityXi’an 710127China Department of Physics School of ScienceWestlake UniversityHangzhou 310030China Shaanxi Key Laboratory for Theoretical Physics Frontiers Xi’an 710127China Institute of Natural Sciences Westlake Institute for Advanced StudyHangzhou 310024China National Laboratory of Solid State Microstructures and Department of Physics Nanjing UniversityNanjing 210093China Collaborative Innovation Center for Advanced Microstructures Nanjing 210093China Peng Huanwu Center for Fundamental Theory Xi’an 710127China

Mesoscopic superconducting islands hosting Majorana zero modes(MZMs),or Majorana islands in short,offer a prototype of topological *** this work we investigate theoretically the model of a generic Majorana island tunneling-coupled to a singlepiece metallic substrate,hence an embedded Majorana *** show the crucial consequences of an interplay between the topological ground states nonlocally addressed by the MZMs and the metallic bath with coherent electron propagation:on the one hand,the topological degeneracy on the Majorana island can be preserved,by virtue of the particle-hole symmetry,despite the apparent bath-induced coupling between MZMs;on the other hand,the electronic interference in the metallic bath may lead to profound alterations to the renormalization group behavior of the hybrid system towards low energy/temperature compared with conventional Kondo *** work serves to establish the model of embedded Majorana islands as an experimentally relevant and theoretically intriguing problem particularly in the direction of topological quantum computation.

关键词： topological quantum computation Majorana zero modes topological qubit mesoscopic superconductor topological Kondo effect

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