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Phytochemicals targeting NF-kB signaling:Potential anti-cancer interventions

Journal of Pharmaceutical Analysis 2022年第3期12卷 394-405页

作者： Akansha Chauhan Asim Ul Islam hridayesh prakash Sandhya Singh Amity Institute of Physiology&Allied Sciences Amity UniversityNoidaUttar PradeshIndia Centre for Interdisciplinary Research in Basic Sciences Jamia Millia IslamiaNew DelhiIndia Amity Institute of Virology&Immunology Amity UniversityNoidaUttar PradeshIndia

Nuclear factor kB(NF-kB)is a ubiquitous regulator of the signalome and is indispensable for various biological cell ***-kB consists of five transcription factors that execute both cytoplasmic and nuclear signaling processes in ***-kB is the only signaling molecule that governs both pro-and antiapoptotic,and pro-and anti-inflammatory *** is due to the canonical and non-canonical components of the NF-kB signaling ***,these pathways orchestrate cancer-related inflammation,hyperplasia,neoplasia,and ***-canonical NF-kB pathways are particularly involved in the chemoresistance of cancer *** view of its pivotal role in cancer progression,NF-kB represents a potentially significant therapeutic target for modifying tumor cell *** phytochemicals are known to modulate NF-kB pathways through the stabilization of its inhibitor,IkB,by inhibiting phosphorylation and ubiquitination *** natural pharmacophores are known to inhibit the nuclear translocation of NF-kB and associated pro-inflammatory responses and cell survival *** view of this and the high degree of specificity exhibited by various phytochemicals for the NF-kB component,we herein present an in-depth overview of these phytochemicals and discuss their mode of interaction with the NF-kB signaling pathways for controlling the fate of tumor cells for cancerdirected interventions.

关键词： Cancer Transcription factor Phytochemicals Inflammation Chemoprevention

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