Phytochemicals targeting NF-kB signaling:Potential anti-cancer interventions
作者机构：Amity Institute of Physiology&Allied SciencesAmity UniversityNoidaUttar PradeshIndia Centre for Interdisciplinary Research in Basic SciencesJamia Millia IslamiaNew DelhiIndia Amity Institute of Virology&ImmunologyAmity UniversityNoidaUttar PradeshIndia
出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)
年 卷 期：2022年第12卷第3期
页 面：394-405页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100706[医学-药理学] 1002[医学-临床医学] 100214[医学-肿瘤学] 100602[医学-中西医结合临床] 10[医学]
主 题：Cancer Transcription factor Phytochemicals Inflammation Chemoprevention
摘 要：Nuclear factor kB(NF-kB)is a ubiquitous regulator of the signalome and is indispensable for various biological cell ***-kB consists of five transcription factors that execute both cytoplasmic and nuclear signaling processes in ***-kB is the only signaling molecule that governs both pro-and antiapoptotic,and pro-and anti-inflammatory *** is due to the canonical and non-canonical components of the NF-kB signaling ***,these pathways orchestrate cancer-related inflammation,hyperplasia,neoplasia,and ***-canonical NF-kB pathways are particularly involved in the chemoresistance of cancer *** view of its pivotal role in cancer progression,NF-kB represents a potentially significant therapeutic target for modifying tumor cell *** phytochemicals are known to modulate NF-kB pathways through the stabilization of its inhibitor,IkB,by inhibiting phosphorylation and ubiquitination *** natural pharmacophores are known to inhibit the nuclear translocation of NF-kB and associated pro-inflammatory responses and cell survival *** view of this and the high degree of specificity exhibited by various phytochemicals for the NF-kB component,we herein present an in-depth overview of these phytochemicals and discuss their mode of interaction with the NF-kB signaling pathways for controlling the fate of tumor cells for cancerdirected interventions.
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