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Chinese Medical Journal 2022年第19期135卷 2378-2379页

作者： Taotao Lyu Zhifeng Liu Tianyuan Yu Mengqian Lu Yingqi Zhang Yi Jiao hourong wang Yajing Xu Qian Guan School of Acupuncture Moxibustion and TuinaBejing University of Chinese MedicineBeijing 100029China Tuina Research Center of Beijing University of Chinese Medicine Bejing 100029China

To the Editor:Peripheral nerve injury(PNI)refers to the injury of the peripheral nerve plexus,nerve trunk,or its branches undertheaction of externalforces.Skeletal muscle-derived cells servea strong secretory,function while they can differentiate into Schwann cell-like cells or other ceil types,so that it can,effectively promote regeneration'of peripheral nerves.llUsing some specific acupuncture points with mild mechanical stimulation on the surface can have a positive effect on nerve repair.2i Tuina helps relieve symptoms such as muscle spasms and pain caused by nerve damage.There are three points belonging to the Bladder meridian of foot Taiyang(BL)and the Gallbladder meridian of foot Shaoyang(GB),which usually are selected to carry out Tuina.According to the anatomical nerve position,Yinmen(BL37)is on the sciatic nerve trunk,Chengshan(BL57)is on the tibial nerve,and Yanglingquan(GB34)is on the common peroneal nerve;meanwhile,the three points are on the sciatic nerve or its branches.The three points are on the biceps femoris,gastrocnemius,and tibial anterior muscles.

关键词： meridian gastro acupuncture

An investigation of the influence of intestinal flora in external traditional Chinese medicine therapy

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Journal of Traditional Chinese Medical Sciences 2023年第1期10卷 10-18页

作者： hourong wang Zhifeng Liu Tianyuan Yu Yingqi Zhang Yi Jiao Di Liu Yajing Xu Qian Guan Mengqian Lu School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 102488China Dongzhimen Hospital Beijing University of Chinese MedicineBeijing 100700China Dongfang Hospital Beijing University of Chinese MedicineBeijing 100078China

External therapy,which has been used for millennia to treat disease,has now become the newest member of complementary and alternative therapies.A growing number of clinical studies and animal experiments have shown that external therapy exerts a positive effect on the intestinal flora.In this paper,we review the research related to external therapy on various systemic diseases and focus on changes in the intestinal flora.We found that studies on external therapy are dominated by acupuncture and tuina,primarily aimed at the treatment of digestive and neurological diseases.However,the deeper mechanism of regulation of the intestinal flora by external therapy has not yet been experimentally confirmed.

关键词： Traditional Chinese medicine External therapy Intestinal flora Digestive diseases Neurological diseases Acupoint Mechanism

Effect of pediatric tuina on hypothalamic metabolites in young rabbits using liquid chromatography-mass spectrometry

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Journal of Traditional Chinese Medical Sciences 2022年第2期9卷 188-196页

作者： Zhifeng Liu Yi Jiao Tianyuan Yu Yingqi Zhang Di Liu hourong wang Yajing Xu Qian Guan Taotao Lv Jian Shu School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing102488China Department of Acupuncture Dongfang Hospital Beijing University of Chinese MedicineBeijing100078China Shu Acupuncture Clinic FayettevilleNY13066USA

Objective: To investigate the changes in the hypothalamic metabolites of lipopolysaccharide(LPS) febrile young rabbits after the treatment with pediatric tuina.Methods: A total of 30 young rabbits were randomly assigned into three groups: the normal group, the model group, and the tuina group. Both the model group and the tuina group were injected intravenously with LPS. “Six antipyretic manipulations”(pushing Tianmen, pushing Kangong, kneading Taiyang,kneading Erhougaogu, clearing Tianheshui, and pushing Jizhu) were administered 1 h after the LPS injection in the tuina group. The rectal temperatures of the young rabbits were monitored during the experiment to explore the antipyretic effect. Three hours after the injection, the content of interleukin-1β(IL-1β), tumor necrosis factor(TNF)-a, and prostaglandin E;(PGE;) in the serum was detected. In addition, liquid chromatography-mass spectrometry(LC-MS) was used for the hypothalamus metabolomics.Results: Compared with the model group, the rectal temperature of the tuina group was decreased at 2 h and 3 h after the LPS injection(P =.04, P =.03, respectively), and the content of IL-1β, TNF-a, and PGE2was decreased(P =.03, P =.003, and P =.008, respectively). The metabolomics results showed that there were 23 potential biomarkers after the tuina intervention, enriching 27 pathways. Lipid metabolites,especially glycerophospholipids, were a majority of the altered metabolites. The primary metabolic pathways affected by tuina included the arachidonic acid metabolism, the GABAergic synapse, D-glutamine and D-glutamate metabolism, and the glutamatergic synapse.Conclusion: Pediatric tuina reduced the temperature of the febrile rabbits and downregulated the expression of IL-1β, TNF-a, and PGE2, and the antipyretic mechanism may be related to changes in metabolites and metabolic pathways in the hypothalamus.

关键词： Fever Pediatric tuina Metabolomics Liquid chromatography coupled with mass spectrometry Hypothalamus Interleukin-1b Tumor necrosis factor-a Prostaglandin E_(2)

Protective mechanisms of Tuina therapy against lipopolysaccharide-induced fever in young rabbits based on untargeted metabolomics analysis

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中医杂志:英文版 2023年第4期43卷 725-733页

作者： LIU Di ZHANG Yingqi YU Tianyuan LIU Zhifeng JIAO Yi wang hourong XU Yajing GUAN Qian CHEN Lulu HU Hui School of Acupuncture-Moxibustion and Tuina Beijing University of Chinese MedicineBeijing 102401China Department of Acupuncture-Moxibustion Beijing Massage HospitalBeijing 100035China Department of Acupuncture-Moxibustion Dongfang HospitalBeijing University of Chinese MedicineBeijing 100078China

OBJECTIVE:To investigate the effect of Tuina on the plasma metabolites of lipopolysaccharide-induced febrile in infant rabbits.METHODS:Twenty-four infant New Zealand rabbits were selected and randomly divided into three groups:saline,model,and Tuina.The fever model was established by injecting LPS intravenously through the ear margin vein in the model group and Tuina group,respectively.The modeling was considered successful when the anal temperature increased by 0.5℃or above within 1 h.In the Tuina group,six Tuina techniques(i.e.,opening Tianmen/the heaven gate,pushing Kangong/the superciliary arch,kneading Taiyang and the prominent bone behind the ears,clearing Tianheshui,spine pinching)that alleviate fever were performed on the young rabbits 1 h after the modeling,whereas the model and saline groups were not given Tuina treatment,with the real-time anal temperature monitored during the experiment.The plasma was taken 3 h after the modeling for liquid chromatography-mass spectrometry(LC-MS)untargeted metabolomics study.RESULTS:Our results showed a fever-reducing effects of Tuina therapy on lipopolysaccharide-induced fever in young rabbits,as indicated by a significantly lower anal temperature,maximum rise in body temperature,and body response index at 2 and 3 h after modeling in the Tuina group compared to the model group,with reductions in the PGE2 expression observed in the blood and hypothalamus.The differential metabolites including riboflavin,nicotinamide N-oxide,porphobilinogen,5-hydroxyindoleacetic acid,gamma-aminobutyric acid,and lysoPC(16:1(9Z)/0:0)were found following the Tuina intervention.Tuina primarily involves glycine-serinethreonine,arginine-proline,porphyrin-chlorophyll,pyrimidine,primary bile acid biosynthesis,and cyanoamino acid metabolic pathways.CONCLUSION:Tuina therapy has proven to be effective in reducing body temperature and down-regulating PGE2 expression in LPS-induced febrile young rabbits,with its mechanism of fever-reducing action possibly associated with the changes in plasma metab

关键词： fever pediatrics metabolomics Lipopolysaccharides riboflavin glycine Tuina therapy

基于IL-17F/IL-17RC信号通路及M1小胶质细胞探讨“三法三穴”推拿手法即刻镇痛作用的机制

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北京中医药大学学报 2024年第1期47卷 116-123页

作者：陈金平刘志凤于天源王厚融张英琦官乾徐亚静杨震杰萨出拉张润龙张汉钰刘家玥孙佳伟北京中医药大学针灸推拿学院北京100029 北京中医药大学东直门医院北京医院

目的通过观察“三法三穴”推拿手法对轻型慢性压迫性损伤(minor CCI)模型大鼠脊髓背角中白细胞介素-17F(IL-17F)、白细胞介素-17受体C(IL-17RC)、核转录因子-κB激活剂1(Act1)、肿瘤坏死因子受体相关因子6(TRAF6)及M1型小胶质细胞表达... 详细信息

目的通过观察“三法三穴”推拿手法对轻型慢性压迫性损伤(minor CCI)模型大鼠脊髓背角中白细胞介素-17F(IL-17F)、白细胞介素-17受体C(IL-17RC)、核转录因子-κB激活剂1(Act1)、肿瘤坏死因子受体相关因子6(TRAF6)及M1型小胶质细胞表达的影响,探讨推拿对周围神经病理性疼痛的即刻镇痛机制。方法将36只SD大鼠按随机数字表法分为假手术组、模型组、推拿组,12只/组,结扎右侧坐骨神经复制minor CCI模型。推拿组使用按摩推拿手法模拟仪在大鼠患侧殷门、承山、阳陵泉依次进行点法、拨法、揉法,假手术组及模型组仅抓握束缚,干预1次。采用机械痛实验与冷板实验评价即刻干预后大鼠对机械刺激、冷刺激的反应情况;采用蛋白质印迹法检测各组大鼠脊髓背角中IL-17F、TRAF6的蛋白表达情况;采用实时荧光PCR(RT-PCR)法检测各组大鼠脊髓背角中IL-17F、IL-17RC、Act1、TRAF6的mRNA表达情况;采用免疫荧光法检测各组大鼠脊髓背角中M1型小胶质细胞平均荧光强度。结果行为学结果显示,干预前,与假手术组比较,模型组、推拿组大鼠机械缩足反射阈值(PMWT)降低,冷敏阈值升高;推拿手法干预后,与模型组比较,推拿组大鼠PMWT升高,冷敏阈值降低;与干预前比较,干预后推拿组大鼠PMWT升高,冷敏阈值降低(均P<0.05)。RT-PCR结果显示,与假手术组比较,模型组大鼠脊髓背角中IL-17F、IL-17RC、TRAF6、Act1的mRNA表达均升高;与模型组比较,推拿组大鼠上述指标mRNA表达均降低(均P<0.05)。蛋白质印迹法结果显示,与假手术组比较,模型组大鼠脊髓背角中IL-17F、TRAF6蛋白表达升高;与模型组比较,推拿组大鼠IL-17F、TRAF6蛋白表达降低(均P<0.05)。免疫荧光结果显示,与假手术组比较,模型组大鼠脊髓背角分化簇40(CD40)平均荧光强度增强;与模型组比较,推拿组大鼠CD40平均荧光强度减弱(均P<0.05)。结论“三法三穴”推拿手法干预1次,其机制可能是通过抑制脊髓背角中IL-17F、IL-17RC、Act1、TRAF6的表达及M1型小胶质细胞的活化实现的,从而有即刻镇痛的作用。

关键词：推拿小胶质细胞殷门承山阳陵泉大鼠

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推拿干预神经根型颈椎病镇痛机制的研究进展

环球中医药 2024年第4期17卷 752-758页

作者：张汉钰王厚融于天源刘家玥张英琦孙佳伟陈金平张润龙杨震杰萨出拉官乾徐亚静北京中医药大学针灸推拿学院 102488 北京医院

神经根型颈椎病(cervical spondylotic radiculopathy, CSR)是颈椎病最常见的临床证型,严重影响了人们的日常生活。推拿作为临床上治疗颈椎病的常用中医外治法之一,疗效肯定。本文对推拿治疗CSR机制进行综述,发现:(1)通过改善颈部的受... 详细信息

神经根型颈椎病(cervical spondylotic radiculopathy, CSR)是颈椎病最常见的临床证型,严重影响了人们的日常生活。推拿作为临床上治疗颈椎病的常用中医外治法之一,疗效肯定。本文对推拿治疗CSR机制进行综述,发现:(1)通过改善颈部的受力结构缓解颈椎失稳、减轻椎间关节的错位及紊乱从而缓解机械压迫,纠正病变解剖结构改善疼痛;(2)通过降低肿瘤细胞坏死因子-α(tumor necrosis factor-α, TNF-α)、白细胞介素-1α(interleukin-1α, IL-1α)、白细胞介素-6(interleukin-6, IL-6)等促炎因子表达,上调白细胞介素-4(interleukin-4, IL-4)、白细胞介素-10(interleukin-10, IL-10)、转化生长因子(transforming growth factor, TGF)-β1等抗炎因子的表达,缓解炎性浸润产生镇痛作用;(3)通过调节外周及中枢β-EP等神经递质的表达,发挥镇痛效果;(4)恢复胸腺T细胞、分化抗原(cluster of differentiation, CD)4^(+)免疫细胞的平衡,以缓解疼痛反应。可见,推拿可通过“多水平—多途径—多靶点”从而发挥对CSR的镇痛作用。本文通过回顾推拿治疗CSR的相关文献,以期为日后临床应用或实验研究提供参考依据。

关键词：推拿神经根型颈椎病镇痛疼痛炎症神经递质细胞免疫

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肩部摇法在历版推拿教材中的演变

辽宁中医药大学学报 2024年第2期26卷 91-94页

作者：陈金平刘志凤于天源王厚融杨震杰萨出拉张英琦官乾徐亚静张润龙张汉钰刘家玥孙佳伟北京中医药大学针灸推拿学院北京100029 北京中医药大学东直门医院北京100007 北京医院北京100730

肩部摇法是临床常用的一种治疗肩关节疾病的推拿手法,该文通过梳理1959年至今各高校推拿学系列教材及特色教材中肩部摇法的发展脉络,对肩部摇法的概念、归类、分型、动作要领、注意事项、作用及应用进行整理。经过历版教材的不断演变,... 详细信息

肩部摇法是临床常用的一种治疗肩关节疾病的推拿手法,该文通过梳理1959年至今各高校推拿学系列教材及特色教材中肩部摇法的发展脉络,对肩部摇法的概念、归类、分型、动作要领、注意事项、作用及应用进行整理。经过历版教材的不断演变,肩部摇法内容逐渐丰富,手法操作由简入繁,种类由单一到多样,名称由繁杂到统一,操作逐渐趋于规范化。

关键词：肩部摇法推拿手法教材演变

“三法三穴”推拿手法干预早期对Minor CCI模型大鼠脊髓背角IL-17A/RA、C/EBPβ信号通路影响的研究

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环球中医药 2024年第3期17卷 401-406页

作者：陈金平刘志凤于天源王厚融张英琦杨震杰萨出拉官乾徐亚静张润龙张汉钰刘家玥孙佳伟北京中医药大学针灸推拿学院 100029 北京中医药大学东直门医院推拿疼痛科北京医院针灸按摩科

目的通过观察“三法三穴”推拿手法干预早期对轻度坐骨神经慢性压迫性损伤(Minor chronic compression injury of sciatic nerve, Minor CCI)模型大鼠脊髓背角中白介素-17A(interleukin-17A,IL-17A)、白介素-17A受体(interleukin-17A receptor, IL-17RA)、转录因子CCAAT增强子结合蛋白β(transcription factor CCAAT/enhancer binding protein β, C/EBPβ)表达的影响,明确推拿对周围神经病理性疼痛(peripherally neuropathic pain, pNP)的即刻镇痛机制。方法 SD大鼠随机分为假手术组、模型组、推拿组,8只/组,模型组、推拿组复制Minor CCI模型。使用按摩推拿手法模拟仪模拟点法、拨法、揉法,对推拿组大鼠患侧殷门、承山、阳陵泉进行定时、定性、定量干预1次,通过机械缩足反射阈值(paw mechanical withdraw threshold, PMWT)与冷敏阈值(cold sensitivity threshold, CST)评价干预后即刻对大鼠机械痛觉、温度觉敏化情况变化;通过蛋白免疫印迹法(Western Bolt, WB)检测脊髓背角中IL-17A、C/EBPβ表达;通过荧光定量聚合酶链式反应(real time-polymerase chain reaction, RT-PCR)检测脊髓背角中IL-17A、IL-17RA、C/EBPβ表达。结果与假手术组、模型组相比,推拿干预1次后可提高Minor CCI模型大鼠PMWT与CST(P<0.01);WB结果显示,与模型组相比,推拿可降低IL-17A、C/EBPβ在脊髓背角中蛋白的表达(P<0.05);RT-PCR结果显示,与模型组相比,推拿可降低IL-17A、IL-17RA、C/EBPβ在脊髓背角中mRNA的表达(P<0.05)。结论推拿干预1次后,可通过抑制脊髓背角中IL-17A、IL-17RA、C/EBPβ信号通路的表达,改善机械痛觉及冷刺激敏化情况,从而实现即刻镇痛的作用。

关键词：推拿周围神经病理性疼痛脊髓背角白介素-17A 白介素-17A受体转录因子CCAAT增强子结合蛋白β

基于改进PSO算法的无人机城域三维路径规划

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电光与控制 2024年第2期31卷 41-45,76页

作者：黄晋李云飞王圣淳刘厚荣中国民用航空飞行学院四川广汉618000

粒子群优化(PSO)算法得益于其原理简单、易实现等优点,被广泛应用于路径规划。针对传统PSO算法搜索精度不佳、容易陷入局部最优解等问题,提出一种改进的PSO算法用于无人机在城市环境下的三维路径规划。为了改善粒子的搜索效率和精度,采... 详细信息

粒子群优化(PSO)算法得益于其原理简单、易实现等优点,被广泛应用于路径规划。针对传统PSO算法搜索精度不佳、容易陷入局部最优解等问题,提出一种改进的PSO算法用于无人机在城市环境下的三维路径规划。为了改善粒子的搜索效率和精度,采用混沌序列初始化粒子群,使得初始粒子分布更均匀;引入分段自适应惯性权重和自适应指数学习因子,以平衡粒子的全局和局部搜索能力;在速度更新公式中增添加速度因子,以增加粒子离开较差区域的能力;引入自适应调整系数对粒子位置更新公式进行优化;选取4种测试函数进行测试并进行仿真实验,对比遗传算法和传统PSO算法,结果表明改进算法所求结果的质量更好。

关键词：无人机路径规划粒子群算法城市空间

国际话语权视阈下的针灸研究——基于近10年来Web of Science核心合集载文的计量分析

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中国针灸 2018年第5期38卷 555-561页

作者：王厚融孙贵平郑博阳袁恺云南中医学院针灸推拿康复学院昆明650500 浙江大学教育学院浙江大学心理与行为科学系

为客观反映2007至2017年间国际学术舞台上针灸疗法的研究成果,探查中国针灸研究的学术话语权构筑状况,采用文本分析软件对近10年5668篇针灸研究主题文献进行计量分析。结果表明:国际性的针灸研究已经形成,研究力量以"中国—美国"为轴心... 详细信息

为客观反映2007至2017年间国际学术舞台上针灸疗法的研究成果,探查中国针灸研究的学术话语权构筑状况,采用文本分析软件对近10年5668篇针灸研究主题文献进行计量分析。结果表明:国际性的针灸研究已经形成,研究力量以"中国—美国"为轴心向世界各地发散,研究视域集中,中外互动良好。在国际话语权视阈下,针灸研究的权威传播平台建设、学术中心和研究场域的培育、与国际研究力量互动的同时提升中国针灸研究的质量,成为增强中国针灸研究国际话语权的重要任务。

关键词：国际话语权计量分析针灸研究期刊文献出版文献研究热点