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Journal of Bionic Engineering 2022年第2期19卷 547-553页

作者： Caroline fradin francois Orange Sonia Amigoni frédéric Guittard Thierry darmanin NICE Lab UniversitéCote d’Azur06100 NiceFrance Centre Commun de Microscopie Appliquée(CCMA) UniversitéCote d’Azur06100 NiceFrance

Here,using a bioinspired approach,the soft-template electropolymerization of naphtho[2,3-b]thieno[3,4-e][1,4]dioxine(NaphdOT)was conducted in dichloromethane with different water content,and using different supporting *** role of the electrolytes in the formation of reverse micelles that constitutes the soft template is *** reverse micelles stabilized by the electrolyte and the monomer were observed by TEM and related to the various porous nanostructures of the obtained polymer *** show that the nature of the electrolyte is not only fundamental for the formation of reverse micelles and thus porous nanostructures,but also plays a huge role in the good deposition of the oligomers upon the soft *** with nanostructures such as nanotubes,nanorings or nanomembranes were realized.

关键词： Electropolymerization Soft template Reverse micelles Porous nanostructures

Ways and waves of MALT1 paracaspase activation

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Cellular & Molecular Immunology 2018年第1期15卷 8-11页

作者： Laura Israël frédéric Bornancin Novartis Institutes for BioMedical Research Novartis CampusBaselCH-4002Switzerland

Mucosa-associated lymphoid tissue lymphoma translocation protein 1(MALT1),also known as paracaspase 1,is a ubiquitous protease with homology to caspases.1 The function of MALT1 is best understood in immune cells,in particular lymphocytes,in which MALT1 controls signaling downstream of antigen receptors,for example,nuclear-factor-kappa-B(NF-κB)and mitogen-activated protein kinase *** of MALT1 paracaspase activity has been shown to require the assembly of a tripartite signaling complex termed CBM(CARd11/BCL10/MALT1),which is formed following the phosphorylation and conformational change of caspase recruitment domain 11(CARd11)that is induced by antigen-receptor stimulation.

关键词： MALT1 caspase lymphocytes

Lattice Boltzmann Simulation of Mixed Convection Heat Transfer in a driven Cavity with Non-uniform Heating of the Bottom Wall

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Communications in Theoretical Physics 2015年第1期63卷 91-100页

作者： Soufiene Bettaibi Ezeddine Sediki frdric Kuznik Sauro Succi UR: Rayonnement Thermique Facult des Sciences de Tunis Universit de Tunis El Manar 2092 Tunis Tunisia INSA-Lyon CETHIL F-69621 Villeurbanne France Universit de Lyon CNRS UMR5008 F-69622 Villeurbanne France Research director IAC-CNR Rome Via dei Taurini 19 00185 Roma

The goal of this article is to study numerically the mixed convection in a differentially heated rid-driven cavity with non-uniform heating of the bottom wall. The velocity field is solved by a hybrid scheme with multiple relaxation time Lattice Boltzmann （MRT-LBM） model, while the temperature field is obtained by resolution of the energy balance equation using the finite difference method （FdM）. First, the model is checked and validated using data from the riterature. Validation of the present resuJts with those available in the literature shows a good agreement. A good efficiency in time simulation is confirmed. Thereafter, the model has been applied to mixed convection in a driven cavity with non-uniform heating wall at the fixed Grashof number Gr = 106. It is found that, the heat transfer is weakened as the richardson number is augmented. For Gr = 106, we note the appearance of secondary vortices at different positions of the cavity corners.

关键词： lattice Boltzmann method (LBM) finite difference method (FdM) heated Lid-driven cavity mixed convection non-uniform heating wall

Feed supplementation with arginine and zinc on antioxidant status and inflammatory response in challenged weanling piglets

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Animal Nutrition 2017年第3期3卷 236-246页

作者： Nadia Bergeron Claude Robert frédéric Guay département des sciences animales Université Laval

Although supplementing the diet with zinc oxide and arginine is known to improve growth in weanling piglets, the mechanism of action is not well understood. We measured the antioxidant status and inflammatory response in 48 weanling castrated male piglets fed diets supplemented with or without zinc oxide(2,500 mg Zn oxide per kg) and arginine(1%) starting at the age of 20 days. The animals were injected with lipopolysaccharide(100 μg/kg) on day 5. Half of them received another injection on day *** samples were taken just before and 6, 24 and 48 h after injection and the mucosa lining the ileum was recovered following euthanizing on days 7 and 14. Zinc supplementation increased reduced and total glutathione(GSH)(reduced and total) during days 5 to 7 and arginine decreased oxidized GSH measured on days 5 and 12 and the ratio of total antioxidant capacity to total oxidative status during days12 to 14. Zinc decreased plasma malondialdehyde measured on days 5 and 12 and serum haptoglobin measured on day 12 and increased both metallothionein-1 expression and total antioxidant capacity measured in the ileal mucosa on day 14. Tumour necrosis factor a concentration decreased from days 5 to12(all effects were significant at P dy shows that the zinc supplement reduced lipid oxidation and lipopolysaccharide-induced inflammation during the post-weaning period, while the arginine supplementation had only a limited effect.

关键词： Antioxidant Inflammation Zinc Arginine Piglet Weanling

Filtered Backprojection Reconstruction with depth-dependent Filtering

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Tsinghua Science and Technology 2010年第1期15卷 17-24页

作者： frank dennerlein Holger Kunze frédéric Noo Siemens AG Healthcare SectorForchheim 91301Germany UCAIR Department of RadiologyUniversity of UtahSalt Lake CityUT 84108USA

A direct filtered-backprojection （FBP） reconstruction algorithm is presented for circular cone-beam computed tomography （CB-CT） that allows the filter operation to be applied efficiently with shift-variant band-pass characteristics on the kernel function. Our algorithm is derived from the ramp-filter based FBP method of Feldkamp et al. and obtained by decomposing the ramp filtering into a convolution involving the Hilbert kernel （global operation） and a subsequent differentiation operation （local operation）. The differentiation is implemented as a finite difference of two （Hilbert filtered） data samples and carried out as part of the backprojection step. The spacing between the two samples, which defines the low-pass characteristics of the filter operation, can thus be selected individually for each point in the image volume. We here define the sample spacing to follow the magnification of the divergent-beam geometry and thus obtain a novel, depth-dependent filtering algorithm for circular CB-CT. We evaluate this resulting algorithm using computer-simulated CB data and demonstrate that our algorithm yields results where spatial resolution and image noise are distributed much more uniformly over the field-of-view, compared to Feldkamp＇s approach.

关键词： computed tomography (CT) reconstruction filtered backprojection circular cone-beam CT

Integrating fossils in a molecular-based phylogeny and testing them as calibration points for divergence time estimates in Menispermaceae

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Journal of Systematics and Evolution 2011年第1期49卷 25-49页

作者： frdric M.B. JACQUES Rosa del C. ORTIZ department of Biodiversity and Biogeography Kunming Institute of Botany Chinese Academy of Sciences State Key Laboratory of Systematic and Evolutionary Botany Institute of Botany Chinese Academy of Sciences Missouri Botanical Garden St. Louis MO 63166-0299 USA

The phylogeny of extant Menispermaceae (Ranunculales) is reconstructed based on dNA sequences of two chloroplast genes (rbcL and atpB) from 94 species belonging to 56 genera. Fossilized endocarps represent 34 genera. The positions of these are inferred using 30 morphological characters and the molecular phylogeny as a backbone constraint. Nine of the thirteen nodes that are each dated by a fossil are used as calibration points for the estimates of molecular divergence times. BEAST is used to estimate stem age (121.2 Myr) and crown age (105.4 Myr) for Menispermaceae. This method does not require an input tree topology and can also account for rate heterogeneity among lineages. The sensitivity of these estimates to fossil constraints is then evaluated by a cross-validation procedure. The estimated origin for Menispermaceae is dated to the mid-Jurassic if the customary maximum age of 125 Myr for eudicots is not implemented. All constraints when used alone failed to estimate node ages in some parts of the tree. Fossils from the Palaeocene and Eocene impose strict constraints. Likewise, the use of Prototinomiscium as a dating constraint for Menispermaceae appears to be a conservative approach.

关键词： age calibration cross-validation fossil Menispermaceae molecular scaffold phylogeny.

Antiseptic Efficacy of A Soap Made from Biosurfactants Isolated from Bacillus and Lactobacillus against Pathogenic Bacteria

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Advances in Microbiology 2024年第1期14卷 31-58页

作者： frédéric Yannick Okouakoua Christian Aimé Kayath Nicaise Saturnin Mokémiabeka Varelle Bervanie Ngala Elenga digne Nedjea N’goma-Mona Ndelani Nkalla Lambi Sandra Paola Elenga Wilson Christ dieuveil Bayakissa Malanda Rodinet Tsana Junior Patrick Sergy Bissoko1 Moïse doria Kaya-Ongoto duchel Jeanedvi Kinavouidi Etienne Nguimbi Laboratoire de Biologie Cellulaire et Molé culaire (BCM) Facult&eacute des Sciences et Techniques Universit&eacute Marien N’gouabi Brazzaville Congo Institut National de Recherche en Sciences Exactes et Naturelles (IRSEN) Avenue de l’Auberge Gascogne Brazzaville Congo

The aim of our study was to use a biosurfactant produced by Bacillus and Lactobacillus isolates as an antiseptic in the formulation of local soap. A total of 60 isolates were characterized by microbiological techniques (30 Bacillus and 30 Lactobacillus) and the ability to produce biosurfactants was demonstrated by a hydrocarbon emulsification index (E24). The emulsification indexes (E24) varied from 9% to 100% for Bacillus and from 33% to 100% for Lactobacillus as well. The antagonistic assay showed that biosurfactants were able to inhibit the formation of biofilms and growth of pathogens such as Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus cereus, Salmonella typhirium, Shigella boydii and Proteus mirabilis. The biosurfactant consortium (BioC) from Bacillus consortium and from Lactobacillus was able to inhibit biofilm formation and the pathogens growth. The BioC was stable to alkaline pH and the temperatures stability of Biosurfactant was ranging from 50°C to 90°C. The soap was made by the cold saponification process using one biosurfactant consortium formulated. This soap has a pH of 10 and showed good cleaning power and good foam stability. Similarly, the soap showed good antiseptic power and disinfection power against all pathogens tested. Handwashing is critical to preventing disease transmission. The persistence of pathogens in waste water was evaluated. The BioS produced showed good disinfection power against all pathogens tested. The valor of reduction on the hands and in the waste water was significantly more than compared to the control soaps used. This soap could be used in the prevention, fighting, and treatment of bacterial and viral infections.

关键词： Antiseptic Soap Biosurfactants Bacillus Lactobacillus disinfection Pathogens bacteria

Global progress against cancer—challenges and opportunities

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Cancer Biology & Medicine 2013年第4期10卷 183-186页

作者： frédéric Biemar Margaret Foti American Association for Cancer Research

The last ten years have seen remarkable progress in cancer research. However, despite significant breakthroughs in the understanding, prevention, and treatment of cancer, the disease continues to affect millions of people worldwide. Cancer＇s complexity compounded with financial, policy and regulatory roadblocks has slowed the rate of progress being made against cancer. In this paper, we review a few of the most recent breakthroughs that are fueling medical advances and bringing new hope for patients affected by this devastating disease. We also address the challenges facing us and the opportunities to accelerate future progress against cancer. The efforts of the American Association for Cancer Research （AACK） to address the cancer burden already extend beyond the borders of the United States of America. The AACR is committed to increasing its efforts to stem the tide of cancer worldwide by promoting innovative programs, strategies, and initiatives for cancer researchers and all those engaged in cancer-related biomedical sciences around the world.

关键词： Collaboration prevention translational research genetics genomics epigenetics immunotherapy

Exact Efficient Handling of Interrupted Illumination in Helical Cone-Beam Computed Tomography with Arbitrary Pitch

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Tsinghua Science and Technology 2010年第1期15卷 36-43页

作者： Harald Schndube Karl Stierstorfer frédéric Noo department of Radiology University of UtahSalt Lake CityUT 84132-2140USA Siemens Healthcare 91301 ForchheimGermany

We present a theoretically-exact and stable computed tomography （CT） reconstruction algorithm that is capable of handling interrupted illumination and therefore of using all measured data at arbitrary pitch This algorithm is based on a differentiated backprojection （dBP） on M-lines. First, we discuss the problem of interrupted illumination and how it affects the dBP. Then we show that it is possible to take advantage of some properties of the dBP to compensate for the effects of interrupted illumination in a mathematically exact way. from there, we have developed an efficient algorithm which we have successfully implemented. We show encouraging preliminary results using both computer-simulated data and real data. Our results show that our method is capable of achieving a substantial reduction of image noise when decreasing the helix pitch compared with the maximum pitch case. We conclude that the proposed algorithm defines for the first time a theoretically-exact and stable reconstruction method that is capable of beneficially using all measured data at arbitrary pitch.

关键词： computed tomography (CT) theoretically-exact and stable image reconstruction differentiated backprojection M-lines redundant data

Pathological and Clinical Correlation European Union-Thyroid Imaging Reporting and data System (EU-TIRAdS) Classification of Thyroid Nodules in Two University Hospitals in Cotonou

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Open Journal of Endocrine and Metabolic diseases 2024年第2期14卷 15-25页

作者： Annelie Kerekou Hode Hubert dedjan fréjus Alamou department of Endocrinology Metabolism Nutrition of National University Hospital Center-Hubert Koutoukou Maga Cotonou Bénin department of Medicine and Medical Specialties of the departemental University Hospital Center of Ouémé/Plateau Porto-Novo Bénin

Introduction: Since its creation in 2017 by the European community, the EU-TIRAdS classification has enjoyed an excellent reputation in several countries around the world. Indeed, several studies conducted in these countries testify to the effectiveness of this tool for the management of nodular thyroid pathology. However, in Benin, the contribution of this classification has not yet been evaluated. It is therefore to overcome this inadequacy that we undertook this study. Objective: Participate in improving the diagnostic and therapeutic management of thyroid nodules at the CNHU HKM in Cotonou and at the CHUZ in Suru-Léré. Methods: This is a cross-sectional study with retrospective data collection spread over a period of 3 years 5 months, from January 2019 to May 2022 and carried out jointly in the Endocrinology Metabolism Nutrition and ORL-CCF departments of the CNHU HKM of Cotonou and in the ORL-CCF department of the CHUZ of Suru-Léré. The study population consisted of patients who consulted the University Clinic of Endocrinology Metabolism Nutrition, the University Clinic of ORL-CCF of the CNHU-HKM and the University Clinic of ORL-CCF of the CHUZ of Suru-Léré for thyroid nodule and who have had surgery. The study data was collected from patients hospitalization records using a survey form. Results: On ultrasound, according to the EU-TIRAdS classification, 56.8% of nodules presented a low risk of malignancy (EU-TIRAdS 3) compared to respectively 19.8%;23% and 2.5% of nodules with zero (EU-TIRAdS 2), intermediate (EU-TIRAdS 4) and high (EU-TIRAdS 5) risk of malignancy. Regarding the performance of this classification, it is sensitive in 37.5% of cases and has a specificity of 78.5% with a PPV (Positive Predictive Value) and a NPV (Negative Predictive Value) respectively of 6.6 % and 91.6%. Furthermore, the bivariate correlations revealed that the size of the nodule was significantly associated with the malignancy of the nodule (p = 0.014) and the calculated value o

关键词： Thyroid Nodules EU-TIRAdS Classification Malignancy