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大跨曲线矮塔斜拉桥主梁锚固区蝶形应力区及优化配筋研究

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施工技术（中英文） 2024年第12期53卷 58-63,87页

作者：朱良黄博李佳文王江波朱厚达熊治华中国铁建投资集团有限公司陕西公司陕西西安710000 中交第一公路勘察设计研究院有限公司陕西西安710068 西北农林科技大学水利与建筑工程学院陕西杨凌712100

为了探究曲线矮塔斜拉桥主梁局部锚固区受弯扭耦合效应的影响,优化局部配筋方案,以王家河大桥为工程背景,从应力、变形及预应力施加效率3个层面,对成桥和最大悬臂工况下直桥和弯桥局部节段模型开展对比计算,提出弯扭耦合效应造成的锚固... 详细信息

为了探究曲线矮塔斜拉桥主梁局部锚固区受弯扭耦合效应的影响,优化局部配筋方案,以王家河大桥为工程背景,从应力、变形及预应力施加效率3个层面,对成桥和最大悬臂工况下直桥和弯桥局部节段模型开展对比计算,提出弯扭耦合效应造成的锚固区蝶形剪应力集中区域。结果表明:弯扭耦合效应增大了锚固区主梁各构件的主拉应力;同时,增大蝶形剪应力集中区域的面积约40%,在该区域可采用非对称配筋方案,适当增加锚固处弯曲侧抗剪钢筋比例;弯扭耦合效应会使主梁锚固区横向位移明显增大,增幅接近30%,但对挠度无显著影响;弯扭耦合效应下主梁锚固区预应力施加效率小幅度提升,在配束计算时应予以考虑。

关键词：桥梁工程矮塔斜拉桥曲线桥锚固区剪应力优化配筋

石化行业污水处理场除臭装置职业病防护措施问题探讨

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安全、健康和环境 2018年第3期18卷 22-25页

作者：李厚达牟洪祥李新鸾张磊陈华张云燕中国石化青岛安全工程研究院山东青岛266071

根据某石化行业污水处理场除臭装置的生产工艺,分析了恶臭气体处理过程中产生的主要职业病危害因素及其危害情况,提出关键控制环节及相应的控制措施,从而降低在类似装置运行过程中的职业病危害风险水平。

关键词：污水处理场恶臭气体职业病危害防护措施

AB035. Lactate receptor GPR81 modulates epigenetic modification in the subretina

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Annals of Eye Science 2018年第1期 441-441页

作者： Xiaojuan Yang Raphael Rouget Tang Zhu Christiane Quiniou Shasha Lv Suna Jung Francois Duhamel houda Tahiri Samy Omri Baraa Noueihed Xin Hou JoséCarlos Rivera Mathieu Nadeau-Vallée Pierre Lachapelle Sylvain Chemtob Department of Pharmacology McGill UniversityMontréalQCCanada Department of Pharmacology Universitéde MontréalMontréalQCCanada Research Center CHU Sainte-Justine Universitéde MontréalMontréalQCCanada Department of Ophthalmology and Neurology-Neurosurgery Montréal Children’s Hospital-Research InstituteMcGill UniversityMontréalQCCanada Research Center Hôpital Maisonneuve-Rosemont Universitéde MontréalMontréalQCCanada Department of Ophthalmology Universitéde MontréalMontréalQCCanada Department of Pediatrics Universitéde MontréalMontréalQCCanada

Background:Retinal pigment epithelium(RPE)is vital for the homeostasis of the subretina including photoreceptors and ***,our previous results suggested that the recently discovered lactate receptor GPR81 is abundantly expressed in *** date,only one previous study has shown that activating GPR81 could enhance DNA repair by activating ***,we investigated whether GPR81 exhibits epigenetic modification in the subretina by using GPR81−/−***:GPR81−/−mice and wide type littermates were generated on a background of C57BL/6J *** thicknesses of their choroid were evaluated by ***,Q-PCR,western blot and choroid sprout assay were *** vitro,primary retinal pigment epithelium(pRPE)cells were isolated from mice,and cultured for ***:The thickness of choroid was reduced in GPR81−/−mice compared to GPR81+/+mice,suggesting that GPR81 is important for the integrity of *** the choroid sprout assay,lactate treated RPE/choroid complex showed a significant increase in angiogenesis compared to controls while lactate treated KO RPE/choroid complex showed no difference compared to their *** Q-PCR,most of the genes screened elevated their expression in GPR81−/−mice compared to WT mice,suggesting epigenetic modification may exist,which were confirmed by histone acetylation and HDACs activity ***:Taking together,the lactate receptor GPR81 in RPE is very important for maintaining homeostasis of the *** novel discovery sheds new light on the relationship between metabolism and epigenetic modification.

关键词： Subretina GPR81 epigenetic modification

Labat法坐骨神经阻滞下局部麻醉药低容量高浓度较高容量低浓度更有效：一项前瞻性随机对照研究

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麻醉与镇痛 2010年第2期6卷 83-86页

作者： Manuel Taboada Muniz, MD, PhD Jaime Rodriguez, MD, PhD Maria Bermudez, MD Cristina Valino, MD Noemi Blanco, MD Marcos amor, MD Pilar, Aguirre, MD Ana Masid, MD Joaquin Cortes, MD, Ph Julian Alvarez, MD, PhD Peter G. Atanassoff, MD 杨光(译) 崔苏扬(校) Department of Anesthesiology University of Santiago de Compostela Hospital Clfnico Universitario de Santiago Spain Department of Anesthesiology Hospital Meixoeiro CHUVI Vigo Spain Department of Anesthesiology Yale University School of Medicine New Haven Connecticut 不详

背景有很多因素可以明显影响外周神经阻滞的起效时间和成功率，本项前瞻、随机、双盲研究比较了Labat后路法行坐骨神经阻滞时，单剂量的甲哌卡因300mg分别稀释至20和30ml注射后的阻滞效果差异。方法90例行足部手术的患者，随机分为2组... 详细信息

背景有很多因素可以明显影响外周神经阻滞的起效时间和成功率，本项前瞻、随机、双盲研究比较了Labat后路法行坐骨神经阻滞时，单剂量的甲哌卡因300mg分别稀释至20和30ml注射后的阻滞效果差异。方法90例行足部手术的患者，随机分为2组接受坐骨神经阻滞，一组给予1．5％甲哌卡因20m1（45例），另一组给予1％甲哌卡因30m1（45例），所有阻滞均在神经刺激仪定位下进行（参数为刺激频率2Hz；刺激电流为1．5～0．5mA）。两组中，神经刺激反应在〈0．5mA时引出，亦可以定向诱发足部肌肉向跖侧屈曲，分别记录胫神经和腓总神经的运动感觉功能被阻滞的起效时间。而坐骨神经支配区域的针刺感觉消失，同时足部跖曲及背曲运动消失为阻滞成功的标准。结果用20ml的1．5％甲哌卡因组阻滞成功率（96．6％）显著高于30ml的1％甲哌卡因组（68．9％，P〈0．05）。而前者达到感觉与运动完全阻滞所需要的时间（11±6分钟，13±7分钟）也短于后者（17±8分钟，19±8分钟，P〈0．05）。结论Labat法行坐骨神经阻滞时，与高容量低浓度的局部麻醉药（1％甲哌卡因）比较，使用低容量高浓度的局部麻醉药（1．5％甲哌卡因）能够获得更高的阻滞成功率及更短的起效时间。

关键词：前瞻性随机对照研究坐骨神经阻滞局部麻醉药低浓度高容量低容量运动感觉功能甲哌卡因

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我国市政公用关键信息基础设施安全现状研究

信息技术与信息化 2018年第6期 123-124,128页

作者：冯峰王锋候大鹍宋云波胡谦李程程张成爽韩飞舟王萌山东省电子信息产品检验院山东济南250014 山东赛宝电子信息产品监督检测研究院山东济南250014 青岛积成电子股份有限公司山东青岛266071

市政公用设施是经济基础设施中的一部分,近年来针对公用事业的信息化系统的攻击事件频繁出现,市政公用事业领域基础设施的安全问题日益凸显。本文通过对我国市政公用行业的发展情况、行业信息化发展情况进行调查研究,并重点对水务、燃... 详细信息

市政公用设施是经济基础设施中的一部分,近年来针对公用事业的信息化系统的攻击事件频繁出现,市政公用事业领域基础设施的安全问题日益凸显。本文通过对我国市政公用行业的发展情况、行业信息化发展情况进行调查研究,并重点对水务、燃气行业基础设施进行了分析研究,总结市级公共密钥信息基础设施中存在的安全问题。

关键词：市政公用关键信息基础设施 DCS系统 SCADA系统 GIS系统营业收费系统信息安全问题

Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE

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世界最新医学信息文摘 2017年第30期 281-281页

作者： Marloes van Zwam Ruth Huizinga Marie-José Melief Annet F.Wierenga-Wolf Marjan van Meurs Jane S.Voerman Knut P.H.Biber Hendrikus W G.M.Boddeke Uta E.H?pken Christian Meisel Andreas Meisel Ingo Bechmann Rogier Q.Hintzen Bert A.'t Hart Sandra amor Jon D.Laman Leonie A.Boven

Drainage of central nervous system(CNS) antigens to the brain-draining cervical lymph nodes(CLN) is likely crucial in the initiation and control of autoimmune responses during multiple sclerosis(MS).We demonstrate neuronal antigens within CLN of MS *** monkeys and mice with experimental autoimmune encephalomyelitis(EAE) and in mouse models with non-inflammatory CNS damage,the type and extent of CNS damage was associated with the frequencies of CNS antigens within the cervical lymph *** addition,CNS antigens drained to the spinal-cord-draining lumbar lymph *** human MS CLN,neuronal antigens were present in pro-inflammatory antigen-presenting cells(APC),whereas the majority of myelincontaining cells were *** may reflect a different origin of the cells or different drainage ***,neuronal antigen-containing cells in human CLN did not express the lymph node homing receptor CCR7,whereas myelin antigen-containing cells in situ and in vitro ***,CLN from EAE-affected CCR7-deficient mice contained equal amounts of myelin and neuronal antigens as wild-type *** conclude that the type and frequencies of CNS antigens within the CLN are determined by the type and extent of CNS ***,the presence of myelin and neuronal antigens in functionally distinct APC populations within MS CLN suggests that differential immune responses can be evoked.

关键词： Neuroinflammation Immune regulation Autoreactive Tcells Tolerance Chemokines Cytokines

Brain antigens in functionally distinct antigen-presenting cell populations in cervical lymph nodes in MS and EAE

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世界最新医学信息文摘 2016年第11期 8-8页

作者： Marloes van Zwam Ruth Huizinga Marie-José Melief Annet F.Wierenga-Wolf Marjan van Meurs Jane S.Voerman Knut P.H.Biber Hendrikus W.G.M.Boddeke Uta E.H?pken Christian Meisel Andreas Meisel Ingo Bechmann Rogier Q.Hintzen Bert A.‘t Hart Sandra amor Jon D.Laman Leonie A.Boven

Drainage of central nervous system(CNS) antigens to the brain-draining cervical lymph nodes(CLN) is likely crucial in the initiation and control of autoimmune responses during multiple sclerosis(MS). We demonstrate neuronal antigens within CLN of MS patients. In monkeys and mice with experimental autoimmune encephalomyelitis(EAE) and in mouse models with non-inflammatory CNS damage, the type and extent of CNS damage was associated with the frequencies of CNS antigens within the cervical lymph nodes. In addition, CNS antigens drained to the spinal-cord-draining lumbar lymph nodes. In human MS CLN, neuronal antigens were present in pro-inflammatory antigen-presenting cells(APC), whereas the majority of myelincontaining cells were anti-inflammatory. This may reflect a different origin of the cells or different drainage mechanisms. Indeed, neuronal antigen-containing cells in human CLN did not express the lymph node homing receptor CCR7, whereas myelin antigen-containing cells in situ and in vitro did. Nevertheless, CLN from EAE-affected CCR7-deficient mice contained equal amounts of myelin and neuronal antigens as wild-type mice. We conclude that the type and frequencies of CNS antigens within the CLN are determined by the type and extent of CNS damage. Furthermore, the presence of myelin and neuronal antigens in functionally distinct APC populations within MS CLN suggests that differential immune responses can be evoked.

关键词： Neuroinflammation Immune regulation Autoreactive Tcells Tolerance Chemokines Cytokines

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli M.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik M.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot M. Ait Tamlihat B. Aitbenchikh I. Aizenberg M. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt M. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi M. Algren M. Alhroob B. Ali H.M.J. Ali S. Ali S.W. Alibocus M. Aliev G. Alimonti W. Alkakhi C. Allaire B.M.M. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani M. Alvarez Estevez A. Alvarez Fernandez M. Alves Cardoso M.G. Alviggi M. Aly Y. Amaral Coutinho A. Ambler C. Amelung M. Amerl C.G. Ames D. Amidei S.P. amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel M.T. Anthony E. Antipov M. Antonelli F. Anulli M. Aoki T. Aoki J.A. Aparisi Pozo M.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin M. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia M. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.M. Baldin P. Balek E. Ballabene F. Balli L.M. Baltes W.K. Balunas J. Balz E. Banas M. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak M. Barakat E.L. Barberio D. Barberis M. Barbero M.Z. Barel K.N. Barends T. Barillari M-S. Barisits T. Barklow P. Baron D.A. Baron Mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard Model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING