检索结果-南通市图书馆

Combating acoustic heterogeneity in photoacoustic computed tomography:A review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2020年第3期3卷 32-47页

作者： Tong Wang wen Liu Chao tian Department of Optics and Optical Engineering University of Science and Technology of China Hefei Anhui 230026 P.R.China Department of Precision Machinery and Precision Instrumentation University of Science and Technology of China Hefei Anhui 230026P.R.China Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes University of Science and Technology of China Hefei Anhui 230026P.R.China

Based on the energy conversion of light into sound,photoacoustic computed tomography(PACT)is an emerging biomedical imaging modality and has unique applications in a range of biomedical *** PACT,image formation relies on a process called acoustic inversion from received photoacoustic *** most PACT systems perform this inversion with a basic assumption that biological tissues are acoustically homogeneous,the community gradually rea-lizes that the intrinsic acoustic heterogeneity of tissues could pose distortions and artifacts to finally formed *** paper surveys the most recent research progress on acoustic het-erogeneity correction in *** major strategies are reviewed in detail,including half-time or partial-time reconstruction,autofocus reconstruction by optimizing sound speed maps,joint reconstruction of optical absorption and sound speed maps,and ultrasound computed tomog-raphy(USCT)enhanced *** correction of acoustic heterogeneity helps improve the imaging performance of PACT.

关键词： Photoacoustic computed tomography image reconstruction acoustic heterogeneity ultrasound computed tomography speed of sound

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

石家庄地区急性中毒5000例流行病学分析

解放军医药杂志 2014年第6期26卷 78-80页

作者：郑运周范川鹏王缚鲲陈晶侯天文李军涛龙建国解放军白求恩国际和平医院检验实验科石家庄050082

目的了解石家庄地区急性中毒流行病学特点。方法采用气相色谱法对5209例血液、尿液、呕吐物标本进行检测。结果检出毒物阳性标本5000例,阳性率为96.0%;毒物种类以农药为主（48.3%）,其次为药物（27.1%）、乙醇（8.5%）、鼠药（5.5%）、... 详细信息

目的了解石家庄地区急性中毒流行病学特点。方法采用气相色谱法对5209例血液、尿液、呕吐物标本进行检测。结果检出毒物阳性标本5000例,阳性率为96.0%;毒物种类以农药为主（48.3%）,其次为药物（27.1%）、乙醇（8.5%）、鼠药（5.5%）、一氧化碳（4.0%）。男女比例为1∶2.1。急性中毒患者中20～岁占42.6%,40～岁占31.8%。有意中毒占91.2%,中毒途径以消化道为主（86.4%）。结论毒物检测可及时明确中毒病因,为临床诊断和及时救治急性中毒提供依据。

关键词：中毒流行病学毒物

Bipartite consensus of edge dynamics on coopetition multi-agent systems

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2019年第12期62卷 257-268页

作者： Lei tian Zhijian JI Ting hou Haisheng YU Institute of Complexity Science College of Automation and Electrical Engineering Qingdao University School of Mathematics and Statistics Qingdao University College of Mathematics and Systems Science Shandong University of Science and Technology

Dear editor,The cooperative control of multi-agent systems has attracted wide attention from scholars in various fields because of its wide applications. The controllability and consensus problem of multi-agent system... 详细信息

关键词： Bipartite consensus of edge dynamics on coopetition multi-agent systems agent

Effects of winds,tides and storm surges on ocean surface waves in the Sea of Japan

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2007年第3期26卷 9-21页

作者： ZHAO Wei tian Jiwei LI Peiliang hou Yijun College of Physical and Environmental Oceanography Ocean University of ChinaQingdao 266100 China Institute of Oceanology Chinese Academy of SciencesQingdao 266071 China

Ocean surface waves are strongly forced by high wind conditions associated with winter storms in the Sea of Japan. They are also modulated by tides and storm surges. The effects of the variability in surface wind forcing, tides and storm surges on the waves are investigated using a wave model, a high-resolution atmospheric mesoscale model and a hydrodynamic ocean circulation model. Five month-long wave model simulations are inducted to examine the sensitivity of ocean waves to various wind forcing fields, tides and storm surges during January 1997. Compared with observed mean wave parameters, results indicate that the high frequency variability in the surface wind filed has very great effect on wave simulation. Tides and storm surges have a significant impact on the waves in nearshores of the Tsushima-kaihyS, but not for other regions in the Sea of Japan. High spatial and temporal resolution and good quality surface wind products will be crucial for the prediction of surface waves in the JES and other marginal seas, especially near the coastal regions.

关键词： ocean surface wave Sea of Japan winter storm tide storm surge

Traffic Sign Recognition Using an Attentive Context Region-Based Detection Framework

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2021年第6期30卷 1080-1086页

作者： LIU Zhigang DU Juan tian Feng wen Jiazheng School of Computer and Information Technology Northeast Petroleum University Postdoctoral Workstation on Applied Technology Research Institute Northeast Petroleum University Department of Computer Science for Artificial Intelligence University of Nottingham Ningbo

Accurate small traffic sign recognition is more important for the safety of intelligent transportation systems. A recognition framework named attentive context region-based detection framework(AC-RDF) is proposed in this paper. We construct the attentive context feature for the recognition of small traffic signs,which combines the target information and the contextual information by the concatenation operation following a pointwise convolutional layer. The proposed attentive context feature exploits the surrounding information for a given object proposal. Next, we propose a novel attentive loss function to replace the original crossentropy function. It distinguishes hard negative samples from easy positive ones in the total loss, allows the proposed framework to obtain enough training, and further improve the recognition accuracy. The proposed method is evaluated on the challenging Tsinghua-Tencent 100 K dataset. The experimental results indicate that the attentive context region-based detection framework is superior at detecting small traffic signs and achieves stateof-the-art performance compared with other methods.

关键词： attentive context region-based detection framework intelligent transportation systems convolutional neural nets attentive context feature AC-RDF framework attentive loss function traffic signs learning (artificial intelligence) Tsinghua-Tencent 100K dataset object recognition feature extraction traffic sign recognition object detection entropy recognition framework

Study on the Preparation and Antileukemic Activity of New Lipophilic 1-β-D-arabinofuranosylcytosine Derivatives

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Ocean University of China 2018年第2期17卷 385-391页

作者： CHU Yanyan tian Zhenhua hou Yingwei LI wenbao School of Medicine and Pharmacy Ocean University of ChinaQingdao 266003China Innovation Center for Marine Drug Screening and Evaluation Qingdao National Laboratory for Marine Science and TechnologyQingdao 266071China Marine Biomedical Research Institute of Qingdao Qingdao 266003China

Cytarabine(1-β-D-arabinofuranosylcytosine, Ara-C), isolated from a Caribbean sponge species Tethyacrypta, is the first antitumor drug from a marine resource. In 1980, the US Food and Drug Administration approved this drug for the treatment of different types of leukemia. This drug has a short plasma half-life, low stability, limited bioavailability, and severe side effects. To improve stability and bioavailability, we synthesized nine novel derivatives by blocking the cytarabine metabolic sites and improving lipophilicity. The c Log P values of the newly synthesized compounds were calculated. All the synthesized compounds were more lipophilic than cytarabine, resulting in membrane permeability and bioavailability improvement. The antitumor activities against leukemia cell line HL-60 were evaluated by using the MTT assay. The bioassay results revealed that the IC_(50) values of compounds 5, 8 and 9 were 0.080, 0.090 and 0.057 μmol L^(-1), respectively, which was similar with that of cytarabine(0.056 μmol L^(-1),). In comparison, compound 4 with a phosphate group at O5' was inactive. Because phosphoester bonds are easily hydrolyzed by alkaline phosphatase and are commonly used in producing prodrug strategies, compound 4 might also be metabolized in vivo and generate compound 3 or even cytarabine through a multi-step reaction. Thus, compound 4 might be a promising compound to be developed as a prodrug.

关键词： cytarabine leukemia marine drug prodrug antitumor drug

Correlation linking illness perception,negative emotions,and the post-operative recovery effect in patients with perianal disease

在线全文

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2024年第11期14卷 1718-1727页

作者： Shu-Xiang hou Feng-Jun Dai Xian-Xue Wang Shao-wen Wang Ting tian Department of General Surgery The First People’s Hospital of Changde City(Changde HospitalXiangya School of MedicineCentral South University)Changde 415000Hunan ProvinceChina Department of Anesthesiology The First People’s Hospital of Changde City(Changde HospitalXiangya School of MedicineCentral South University)Changde 415000Hunan ProvinceChina

BACKGROUND Improvements in the standard of living have led to increased attention to perianal *** surgical treatments are effective,the outcomes of postoperative recovery(POR)are influenced by various factors,including individual differences among patients,the characteristics of the disease itself,and the psychological state of the *** these factors can help healthcare providers develop more personalized and effective post-operative care plans for patients with perianal *** To investigate the effect of illness perception(IP)and negative emotions on POR outcomes in patients with perianal *** A total of 146 patients with perianal disease admitted to the First People's Hospital of Changde City from March to December 2023 were *** employed a general information questionnaire,the Brief Illness Perception Questionnaire(B-IPQ),and the Hospital Anxiety and Depression Scale(HADS).We used the 15-item Quality of Recovery Score(QoR-15)to measure patients’recovery ***,we conducted Pearson’s correlation analysis to examine the relationship between pre-operative IP and anxiety and depression levels with POR *** Fifty-three(36.3%)had poor knowledge of their ***(20.5%)were suspected of having anxiety and 99(67.8%)exhibited ***(27.4%)were suspected of having depression and 102(69.9%)displayed *** B-IPQ,HADS-A,HADS-D,and QoR-15 scores were 46.82±9.97,12.99±3.60,12.58±3.36,and 96.77±9.85,*** was a negative correlation between pre-operative IP,anxiety,and depression with POR *** influence of age and disease course on post-operative rehabilitation effect are both *** impact of B-IPQ,HADS-A,and HADS-D on POR was ***,these variables accounted for 72.6%of the variance in *** The quality of POR in patients with perianal disease is medium and is related to age,disease course,IP,anxiety,and depression.

关键词： Illness perception anxiety Depression Crissum disease/perianal disease Post-operative recovery Relativity

老年肺部感染患者病原菌耐药性及凝血、纤维溶解指标变化

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

临床误诊误治 2021年第9期34卷 61-66页

作者：郑运周侯天文张会峰高鹏米明强李亚娟宋静静解放军联勤保障部队第九八〇(白求恩国际和平)医院检验实验科石家庄050082 河北省中医院检验科石家庄050011

目的探讨老年肺部感染患者病原菌耐药性及凝血、纤维溶解指标变化。方法选取2019年1月—2020年10月住院的老年肺部感染410例,根据痰培养结果将其中细菌感染35例作为细菌组,真菌感染14例作为真菌组;另选取同期老年健康体检者40例作为对... 详细信息

目的探讨老年肺部感染患者病原菌耐药性及凝血、纤维溶解指标变化。方法选取2019年1月—2020年10月住院的老年肺部感染410例,根据痰培养结果将其中细菌感染35例作为细菌组,真菌感染14例作为真菌组;另选取同期老年健康体检者40例作为对照组。分析老年肺部感染患者病原菌分布、构成比及耐药性,比较细菌组、真菌组和对照组凝血和纤维溶解指标。结果老年肺部感染410例中病原菌检出率为65.12%,共检出病原菌428株,其中革兰阴性菌321株,革兰阳性菌24株,真菌83株。老年肺部感染患者肺炎克雷伯菌耐药率从高到低依次是阿莫西林-克拉维酸钾、氨苄西林钠-舒巴坦钠和头孢唑啉钠等,铜绿假单胞菌耐药率从高到低依次是替卡西林钠-克拉维酸钾、哌拉西林钠和庆大霉素等,嗜麦芽寡养单胞菌耐药率从高到低依次是头孢他啶、氯霉素和左氧氟沙星等,黏质沙雷菌耐药率从高到低依次是头孢噻肟、莫西沙星和庆大霉素等;金黄色葡萄球菌耐药率从高到低依次是青霉素、红霉素、克拉霉素和阿奇霉素等;白色念珠菌耐药率从高到低依次是卡泊芬净、伊曲康唑和氟康唑。细菌组和真菌组凝血酶原时间、活化部分凝血活酶时间、纤维蛋白原、D-二聚体和纤维蛋白原降解产物长于或高于对照组,抗凝血酶Ⅲ低于对照组;细菌组血小板(PLT)和血小板压积(PCT)高于真菌组和对照组,真菌组PLT和PCT低于对照组,差异有统计学意义(P<0.05或P<0.01)。结论老年肺部感染患者病原菌以革兰阴性菌为主,临床应结合药敏试验结果合理选用抗生素;若患者凝血和纤维溶解指标异常,应早期采取干预措施。

关键词：感染肺老年人病原菌肺炎克雷伯菌铜绿假单胞菌白色念珠菌耐药性凝血酶原时间纤维蛋白原

Construction of a CaHP04-PGUSl hybrid nanoflower through protein-inorganic self-assembly, and its application in glycyrrhetinic acid 3-0-mono-β-D-glucuronide preparation

在线全文

学校读者我要写书评

暂无评论

Frontiers of Chemical Science and Engineering 2019年第3期13卷 554-562页

作者： tian Jiang Yuhui hou Tengjiang Zhang Xudong Feng Chun Li Institute for Synthetic Biosystem/Department of Biochemical Engineering School of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China

Glycyrrhetinic acid 3-0-mono-β-D-glucuronide (GAMG), an important pharmaceutical intermediate and functional sweetener, has broad applications in the food and medical industries. A green and cost-effective method for its preparation is highly desired. Using sitedirected mutagenesis, we previously obtained a variant of β-glucuronidase from Aspergillus oryzae Li-3 (PGUS1), which can specifically transform glycyrrhizin (GL) into GAMG. In this study, a facile method was established to prepare a CaHP04-PGUSl hybrid nanoflower for enzyme immobilization, based on protein-inorganic hybrid selfassembly. Under optimal conditions, 1.2 mg of a CaHP04- PGUS1 hybrid nanoflower precipitate with 71.2% immobilization efficiency, 35.60 mg·g^-1 loading capacity, and 118% relative activity was obtained. Confocal laser scanning microscope and scanning electron microscope results showed that the enzyme was encapsulated in the CaHP04-PGUSl hybrid nanoflower. Moreover, the thermostability of the CaHP04-PGUSl hybrid nanoflower at 55°C was improved, and its half-life increased by 1.3 folds. Additionally, the CaHP04-PGUSl hybrid nanoflower was used for the preparation of GAMG through GL hydrolysis, with the conversion rate of 92% in 8 h, and after eight consecutive runs, it had 60% of its original activity.

关键词： β-glucuronidase enzyme-inorganic hybrid nanoflower biotransformation glycyrrhizin glycyrrtinic acid 3-O-mono-β-D-glucuronide