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Chuanxiong Rhizoma extracts prevent liver fibrosis via targeting CTCF-c-MYC-H19 pathway

Chinese Herbal Medicines 2024年第1期16卷 82-93页

作者： Yajing li Fanghong li Mingning Ding Zhi Ma shuo li Jiaorong Qu Xiaojiaoyang li School of life Sciences Beijing University of Chinese MedicineBeijing 100029China School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 100029China

Objective:Hepatic fibrosis has been widely considered as a conjoint consequence of almost all chronic liver *** Rhizoma(Chuanxiong in Chinese,CX)is a traditional Chinese herbal product to prevent cerebrovascular,gynecologic and hepatic *** previous study found that CX extracts significantly reduced collagen contraction force of hepatic stellate cells(HSCs).Here,this study aimed to compare the protection of different CX extracts on bile duct ligation(BDL)-induced liver fibrosis and investigate plausible underlying ***:The active compounds of CX extracts were identified by high performance liquid chromatography(HPLC).Network pharmacology was used to determine potential targets of CX against hepatic *** duct hyperplasia and liver fibrosis were evaluated by serologic testing and histopathological *** expression of targets of interest was determined by quantitative real-time PCR(qPCR)and Western ***:Different CX extracts were identified by tetramethylpyrazine,ferulic acid and senkyunolide *** on the network pharmacological analysis,42 overlap targets were obtained via merging the candidates targets of CX and liver *** aqueous,alkaloid and phthalide extracts of CX(CX_(AE),CX_(AL) and CXP_(HL))significantly inhibited diffuse severe bile duct hyperplasia and thus suppressed hepatic fibrosis by decreasing CCCTC binding factor(CTCF)-c-MYC-long non-coding RNA H19(H19)pathway in the BDL-induced mouse ***,CX extracts,especially CX_(AL) and CX_(PHL) also suppressed CTCF-c-MYC-H19 pathway and inhibited ductular reaction in cholangiocytes stimulated with taurocholate acid(TCA),lithocholic acid(LCA)and transforming growth factor beta(TGF-β),as illustrated by decreased bile duct proliferation ***:Our data supported that different CX extracts,especially CX_(AL) and CX_(PHL) significantly alleviated hepatic fibrosis and bile duct hyperplasia via inhibiting CTCF-c-MYC-H19

关键词： Chuanxiong Rhizoma cholangiocytes ductular reaction ligusticum chuanxiong Hort. liver fibrosis lncRNA H19

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Clinical manifestations and the prenatal diagnosis of trisomy 7 mosaicism:Two case reports

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World Journal of Clinical Cases 2024年第8期12卷 1544-1548页

作者： Fei hou Yan li Hua Jin Department of Prenatal Diagnosis Jinan Maternal and Child Health HospitalJinan 250001Shandong ProvinceChina

BACKGROUND The clinical manifestations of trisomy 7 mosaicism are diverse and nonspecific,so prenatal diagnosis is very *** SUMMARY Two pregnant women with abnormal prenatal screening results were *** was a 22-year-old woman(G1P0).At 31st week of gestation,ultrasound revealed that the posterior horn of the left lateral ventricle was 10 mm and the right renal pelvis had a separation of 7 *** other pregnant woman was 33 years old(G2P1L1A0),and her fetus was found to have a cardiac malformation at the 24th week of *** number variation sequencing,whole-exome sequencing and karyotype analysis were carried out after amniocentesis,and both fetuses were diagnosed with trisomy 7 *** parental counseling,one woman continued the pregnancy,and the other woman terminated the *** In trisomy 7 mosaicism,the low proportion of trisomy does not lead to abortion,but can result in abnormal fetal development,which can be detected via ***,clinicians need to pay more attention to various aspects of fetal growth and development,combining with imaging,cellular,molecular genetics and other methods to perform comprehensive evaluations of fetuses to provide more reliable genetic counseling for pregnant women.

关键词： Trisomy 7 mosaicism Copy number variation sequencing Whole-exome sequencing Karyotype analysis Prenatal diagnosis Case report

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Insights into effects of thermotolerant nitrifying and sulfur-oxidizing inoculants on nitrogen-sulfur co-metabolism in sewage sludge composting

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Journal of Environmental Sciences 2024年第10期144卷 76-86页

作者： Tingting hou Yujie Zhou Rongchun Du Jiali liu Weiguang li Shumei Zhang Muzi li Junhong Chu liqiang Meng Institute of Microbiology Heilongjiang Academy of SciencesHarbin 150010China Hebei University of Environmental Engineering Hebei Key Laboratory of Agroecological SafetyQinhuangdao 066102China School of Environment Harbin Institute of TechnologyHarbin 150090China

In this study,high temperature thermotolerant nitrifying bacteria(TNB)and high temperature thermotolerant sulfide oxidizing bacteria(TSOB)were obtained from compost samples and inoculated into sewage sludge(SS)*** effects of inoculation on physical and chemical parameters,ammonia and hydrogen sulfide release,nitrogen form and sulfur compound content change and physical-chemical properties during nitrogen and sulfur conversion were *** results showed that inoculation of TNB and TSOB increased the temperature,pH,OM degradation,C/N ratio and germination index(GI)of *** with the control treatment(CK),the addition of inoculants reduced the release of NH3 and H2S,and transformed them into nitrogen and sulfur compounds,the hydrolysis of polymeric ferrous sulfate was promoted,resulting in relatively high content of sulfite and *** the same time,the physical and chemical properties of SS have a strong correlation with nitrogen and sulfur compounds.

关键词： Sewage sludge Composting Inoculation Thermotolerant nitrifying bacteria Thermotolerant sulfurized oxidizing bacteria

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Recent progresses in the development of tubular segmented-in-series solid oxide fuel cells:Experimental and numerical study

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 427-442页

作者： shuo Han Tao Wei Sijia Wang Yanlong Zhu Xingtong Guo liang He Xiongzhuang li Qing Huang Daifen Chen School of Energy and Power Jiangsu University of Science and TechnologyZhenjiang 212003China College of Materials Science and Engineering Nanjing Forestry UniversityNanjing 210037China

Solid oxide fuel cells(SOFCs)have attracted a great deal of interest because they have the highest efficiency without using any noble metal as catalysts among all the fuel cell ***,traditional SOFCs suffer from having a higher volume,current leakage,complex connections,and difficulty in gas *** solve these problems,Rolls-Royce has fabricated a simple design by stacking cells in series on an insulating porous support,resulting in the tubular segmented-in-series solid oxide fuel cells(SIS-SOFCs),which achieved higher output *** work systematically reviews recent advances in the structures,preparation methods,perform-ances,and stability of tubular SIS-SOFCs in experimental and numerical ***,the challenges and future development of tubular SIS-SOFCs are also *** findings of this work can help guide the direction and inspire innovation of future development in this field.

关键词： solid oxide fuel cell segmented-in-series tubular experimental study numerical study

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Phase equilibria relations in the V_(2)O_(5)-rich part of the Fe_(2)O_(3-)TiO_(2)-V_(2)O_(5) system at 1200℃ related to converter vanadium-bearing slag

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International Journal of Minerals,Metallurgy and Materials 2024年第9期31卷 2017-2024页

作者： Junjie Shi Yumo Zhai Yuchao Qiu Changle hou Jingjing Dong Maoxi Yao Haolun li Yongrong Zhou Jianzhong li Key Laboratory for Ecological Metallurgy of Multimetallic Mineral(Ministry of Education) Northeastern UniversityShenyang 110819China School of Metallurgy Northeastern UniversityShenyang 110819China

The efficient recycling of vanadium from converter vanadium-bearing slag is highly significant for sustainable development and circular *** key to developing novel processes and improving traditional routes lies in the thermodynamic *** this study,the equilibrium phase relations for the Fe_(2)O_(3)-TiO_(2)-V_(2)O_(5)system at 1200℃in air were investigated using a high-temperature equilibrium-quenching technique,followed by analysis using scanning electron microscopy-energy dispersive X-ray spectrometer and X-ray photoelectron *** liquid-phase region,two two-phase regions(liquid-rutile and liquid-ferropseudobrookite),and one three-phase region(liquid-rutile-ferropseudobrookite)were *** variation in the TiO_(2)and V_(2)O_(5)contents with the Fe_(2)O_(3)content was examined for rutile and ferropseudobrookite solid ***,on further comparison with the predictions of FactSage 8.1,significant discrepancies were identified,highlighting that greater attention must be paid to updating the current thermodynamic database related to vanadium-bearing slag systems.

关键词： vanadium-bearing slag thermodynamics FactSage phase equilibria recovery

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Corrosion Behavior of Graphene Nanosheets Reinforced Magnesium Matrix Composites in Simulated Body Fluids

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 525-536页

作者： liwen Chen Jianhui Jing Lulu Zhang Jing li Weipeng Chen limin li Yuan Zhao Hua hou Yuhong Zhao School of Materials Science and Engineering Collaborative Innovation Center of Ministry of Education and Shanxi Province for High-Performance Al/Mg Alloy MaterialsNorth University of ChinaTaiyuan 030051China Shanxi Key Laboratory of Advanced Manufacturing Technology School of Mechanical EngineeringNorth University of ChinaTaiyuan 030051China School of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan 030024China Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Institute of Materials Intelligent Technology Liaoning Academy of MaterialsShenyang 110004China

Magnesium(Mg)alloy is considered as a promising biodegradable implant material but restricted to rapid ***,the new strategies based on thixomolding process had been explored to utilize the outstanding anti-permeability of graphene nanosheets(GNPs)while inhibit its galvanic corrosion with the matrix,so as to improve the corrosion resistance of *** agglomerate of GNPs with 0.9 wt%content is the main reason for the deterioration of corrosion performance due to the formation of micro-galvanic *** grain refinement of composites with 0.6 wt%content had positive effects on the better corrosion *** process adjusting,the unique distributions of GNPs along grain boundaries play a vital role in improving the corrosion *** can be ascribed to the following mechanisms:(I)The barriers can be established between the Mg matrix and corrosive medium,hence blocking the charge transfer at the interface;(II)The GNPs can effectively promote apatite deposition on the Mg matrix,leading to form dense apatite layers and prevent the further invasion of SBF;(III)The GNPs acting as reinforcements exists in the corrosion layer and apatite layer,impede the apatite layer falling off from the Mg *** findings broaden the horizon for biomedical applications in Mg matrix composites to realize desired performances.

关键词： Magnesium matrix composite Graphene nanosheets Corrosion resistance

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Development and formation of wing cuticle based on transcriptomic analysis in Locusta migratoria during metamorphosis

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Journal of Integrative Agriculture 2024年第4期23卷 1285-1299页

作者： Jing Zhang Zhaochen Wu shuo li He Huang Suning liu Weimin liu Xiaoming Zhao Jianzhen Zhang Shanxi Key Laboratory of Nucleic Acid Biopesticides Institute of Applied BiologyShanxi UniversityTaiyuan 030006China College of life Science Shanxi UniversityTaiyuan 030006China Guangmeiyuan R&D Center/Guangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology South China Normal UniversityMeizhou 514779China

Wings are an important flight organ of *** development is a complex process controlled by a series of *** flightless wing pad transforms into a mature wing with the function of migratory flight during the nymphto-adult ***,the mechanism of wing morphogenesis in locusts is still *** study analyzed the microstructures of the locust wing pads at pre-eclosion and the wings after eclosion and performed the comparative transcriptome ***-seq identified 25,334 unigenesand 3,430 differentially expressed genes(DEGs)(1,907 up-regulated and 1,523 down-regulated).The DEGs mainly included cuticle development(LmACPs),chitin metabolism(Lm Idgf4),lipid metabolism-related genes,cell adhesion(Integrin),zinc finger transcription factors(LmSalm,LmZF593 andLmZF521),and *** analysis based on RNA interference and hematoxylin and eosin(H&E)staining showed that the three genes encoded zinc finger transcription factors are essential for forming wing cuticle and maintaining morphology in Locusta ***,the study found that the LmSalm regulates the expression of LmACPs in the wing pads at pre-eclosion,and LmZF593 and LmZF521 regulate the expression of LmIntegrin/LmIdgf4/LmHMT420 in the wings after *** study revealed that the molecular regulatory axis controls wing morphology in nymphal and adult stages of locusts,offering a theoretical basis for the study of wing development mechanisms in hemimetabolous insects.

关键词： Locusta migratoria wing development metamorphosis RNA-seq

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Enhancement of beneficial microbiomes in plant-soil continuums through organic fertilization:Insights into the composition and multifunctionality

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Soil Ecology Letters 2024年第3期6卷 109-120页

作者： Wen-Jing li Xin-Yuan Zhou Xin-li An li-Juan li Chen-shuo lin Hua li Hong-Zhe li Key Lab of Urban Environment and Health Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products Institute of EnvironmentResourceSoil and FertilizersZhejiang Academy of Agricultural SciencesHangzhou 310021China

Soil microbiomes play a crucial role in maintaining ecological functions and are of great importance for soil *** of them could bring benefits to plants for growth *** numerous studies have focused on specific beneficial bacteria and their interactions with soils and plants,we still lack a comprehensive understanding of beneficial communities in plant–soil continuums and their responses to agricultural *** address this gap,we carried out a microcosm experiment using 16S rRNA amplicon sequencing to explore the effects of organic fertilization on beneficial communities in plant–soil continuums and assess their potential *** findings reveal that organic fertilization had a positive impact on the beneficial functionality of bacterial communities in plant–soil *** improvement was primarily attributed to the optimized soil physicochemical conditions resulting from organic ***,organic fertilization increased the complexity of bacterial co-occurrence networks in both soils and the *** taxa in the endosphere undergone a shift of functions toward pathogen suppression as the result of organic ***,this study revealed that plants exhibited a preference for internalizing beneficial bacteria over other type of *** also provided new insights for evaluating the multifunctionality of microbiomes,and found that the functionality of beneficial communities in plant–soil continuums is enhanced by organic *** these findings suggested that organic fertilization can be an effective strategy for maintaining plant and soil health.

关键词： plant–soil continuums beneficial bacteria agricultural activities multifunctionality endosphere

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Effects of long-term partial substitution of inorganic fertilizer with pig manure and/or straw on nitrogen fractions and microbiological properties in greenhouse vegetable soils

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Journal of Integrative Agriculture 2024年第6期23卷 2083-2098页

作者： shuo Yuan Ruonan li Yinjie Zhang Hao'an Luan Jiwei Tang liying Wang Hongjie Ji Shaowen Huang State Key Laboratory of Efficient Utilization of Arid and Semi-arid Arable Land in Northern China/Institute of Agricultural Resources and Regional Planning Chinese Academy of Agricultural SciencesBeijing 100081China Institute of Agricultural Resources and Environment Hebei Academy of Agriculture and Forestry SciencesShijiazhuang 050051China College of Resources and Environment Henan Agricultural UniversityZhengzhou 450002China College of Forestry Hebei Agricultural UniversityBaoding 071000China

Partial substitution of inorganic fertilizers with organic amendments is an important agricultural management *** 11-year field experiment(22 cropping periods)was carried out to analyze the impacts of different partial substitution treatments on crop yields and the transformation of nitrogen fractions in greenhouse vegetable *** treatments with equal N,P_(2)O_(5),and K_(2)O inputs were selected,including complete inorganic fertilizer N(CN),50%inorganic fertilizer N plus 50%pig manure N(CPN),50%inorganic fertilizer N plus 25%pig manure N and 25%corn straw N(CPSN),and 50%inorganic fertilizer N plus 50%corn straw N(CSN).Organic substitution treatments tended to increase crop yields since the 6th cropping period compared to the CN *** the 8th to the 22nd cropping periods,the highest yields were observed in the CPSN treatment where yields were 7.5-11.1%greater than in CN *** 11-year fertilization,compared to CN,organic substitution treatments significantly increased the concentrations of NO_(3)^(-)-N,NH_(4)^(+)-N,acid hydrolysis ammonium-N(AHAN),amino acid-N(AAN),amino sugar-N(ASN),and acid hydrolysis unknown-N(AHUN)in soil by 45.0-69.4,32.8-58.1,49.3-66.6,62.0-69.5,34.5-100.3,and 109.2-172.9%,*** analysis indicated that soil C/N and OC concentration significantly affected the distribution of N *** highest concentrations of NO_(3)^(-)-N,AHAN,AAN,AHUN were found in the CPSN *** substitution treatments increased the activities ofβ-glucosidase,β-cellobiosidase,N-acetyl-glucosamidase,L-aminopeptidase,and phosphatase in the *** substitution treatments reduced vector length and increased vector angle,indicating alleviation of constraints of C and N on soil *** substitution treatments increased the total concentrations of phospholipid fatty acids(PLFAs)in the soil by 109.9-205.3%,and increased the relative abundance of G^(+)bacteria and fungi taxa,but decreased the relat

关键词： organic substitution management greenhouse vegetable production N fractions microbial community composition extracellular enzyme activity enzyme stoichiometry coefficients

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Challenges and countermeasures for developing countries in addressing loss and damage caused by climate change

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Advances in Climate Change Research 2024年第2期15卷 353-363页

作者： shuo liU Yu-E li Bin WANG An-Dong CAI Chao FENG Hua LAN Ruo-Chen ZHAO Institute of Environment and Sustainable Development in Agriculture Chinese Academy of Agricultural SciencesBeijing 100081China Key Laboratory of Agricultural Environment Ministry of Agriculture and Rural AffairsBeijing 100081China China Clean Development Mechanism Fund Management Center Beijing 100045China School of International Law China University of Political Science and LawBeijing 100088China

Loss and damage caused by extreme climate events have attracted increasing *** 28th Conference of the Parties to the United Nations Framework Convention on Climate Change(hereinafter referred to as the Convention)has agreed to adopt Loss and Damage Fund agreement,which identified the source of funding and the funds to be entrusted to the World ***,there is still ambiguous that how to allocate the funds could accelerate the effectiveness of meeting the needs for developing ***-disaster prevention and preparedness is one of the most effective measures to deal with loss and damage,which closely related to *** studies rarely analyzed quantitatively the financial needs of pre-disaster prevention and preparedness relating to adaptation to reduce loss and *** on the official reports submitted by countries under the Convention,this study analyzes the annual change in the total financial support provided by developed countries to developing countries,the proportion of pre-disaster prevention and preparedness in the adaptation needs of developing countries,and the progress in raising the current annual funding target of 100 billion USD for developed countries,to reveal the financial and technical challenges facing by developing countries on addressing loss and *** results show that by 2030,the total adaptation financial needs of developing countries are estimated to be about 3.8 trillion USD,of which pre-disaster prevention matters account for about 9%.Therefore,by 2030,developing countries will need about 342 billion USD in pre-disaster prevention and preparedness finance to withstand loss and *** addition,developing countries face a lack of technical methods to quantify information about their *** on the above analysis,this study puts forward countermeasures and suggestions,including strengthening the allocation amount of loss and damage fund on pre-disaster warning,prevention and control actions,and

关键词： Loss and damage Funding mechanism Pre-disaster warning and preparedness Convention negotiations Countermeasures

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