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Cigarette smoking contributes to idiopathic pulmonary fibrosis associated with emphysema

Chinese Medical Journal 2014年第3期127卷 469-474页

作者： Ye Qiao Huang Kewu Ding Yi Lou Baohui Hou Ziliang Dai Huaping Wang Chen Department of Respiratory and Critical Care Medicine Beijing Chao Yang Hospital Capital Medical University Beijing 100020 China Department of Radiology Beijing Chao Yang Hospital Capital Medical University Beijing 100020 China Institute of Respiratory Medicine Beijing Hospital Ministry of Heath Beijing 100730 China

Background Combined emphysema and pulmonary fibrosis,including idiopathic pulmonary fibrosis （IPF）,is a distinct disorder described with upper-lobe emphysema and lower-lobe fibrosis on chest computed tomography.Smoking appears to be the predominant risk factor for this disorder.We aimed to compare clinical features,smoking history,physiological and radiological findings between IPF with and without emphysema.Methods A sample of 125 IPF patients over a period of 48 months were evaluated.High resolution CT scans were reviewed blinded to clinical data.The IPF patients with or without emphysema were classified accordingly.Results The prevalence of emphysema in this IPF sample was 70/125.IPF with emphysema was significantly associated with smoking status （OR 63; 95％ CI 4.4 to 915; P=0.002） and smoking pack year （OR 1.1; 95％ CI 1.05 to 1.13; P=-0.000）.The patients with IPF and emphysema had a higher decrease in carbon monoxide diffusing capacity adjusted for alveolar volume （（58±19）％ pred vs.（66：±：21）％ pred; P=-0.021） and a higher prevalence of pulmonary hypertension （24/70 vs.7/55; P=0.006）.The two groups of patients had similar forced and residual volumes.No significant differences were found in cell differentials of bronchoalveolar lavage or the scores of fibrosis on chest CT.Survival of the patients with emphysema was significantly less than that of patients with IPF alone.Conclusions Cigarette smoking induces IPF combined with emphysema.Emphysema further impairs physiological function and increases the prevalence of pulmonary hypertension that leads to poor prognosis.The inclusion of the patients with combined pulmonary fibrosis and emphysema in IPF clinical trials may lead to under evaluation of the effect of treatment in patients.

关键词： idiopathic pulmonary fibrosis emphysema smoking

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Influencing factors and optimization on mechanical performance of solid waste-derived rapid repair mortar

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Waste Disposal and Sustainable Energy 2023年第2期5卷 223-234页

作者： Jingwei Li Xiangshan hou Aiguang Jia Xin Xiao Xujiang Wang Yonggang Yao ziliang Zhang Wenlong Wang The National Engineering Laboratory of Coal-Fired Pollutants Emission Reduction Shandong University17923 Jingshi RoadJinanShandongChina

There is a great demand for high performance rapid repair mortar(RRM)because of the wide use of cement concrete.Solid-waste-based sulfoaluminate cement(WSAC)is very suitable as a green cementitious material for repair materials because of its characteristics of high early-age strength and short setting time.However,the influence and optimization of various factors of WSAC-based RRM,such as water-to-RRM ratio,binder-to-sand ratio and additives,as well as the further solid waste replacement of aggregate,remain to be studied.This paper comprehensively studied the influence of the above factors on the performance of WSAC-based RRM and obtained a green high-performance RRM by optimizing these factors.The experimental results showed that the early and late strength of the obtained RRM is excellent,and the setting time and fluidity are appropriate,which reflected good mechanical properties and construction performance.Ordinary Portland cement(OPC)doping could not improve RRM strength.It was feasible to prepare RRM with gold tailing sand replacing part of the quartz sand.This paper provides data and a theoretical basis for the preparation of high-performance RRM based on solid waste,expanding the high value utilization of solid waste,which is conducive to the development of a low carbon society.

关键词： Rapid repair mortar Solid-waste-based sulfoaluminate cement Ordinary Portland cement Pilot production Gold tailing sand Environmental friendliness

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J-shaped association between dietary zinc intake and new-onset hypertension:a nationwide cohort study in China

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Frontiers of Medicine 2023年第1期17卷 156-164页

作者： Panpan He Huan Li Mengyi Liu Zhuxian Zhang Yuanyuan Zhang Chun Zhou ziliang Ye Qimeng Wu Min Liang Jianping Jiang Guobao Wang Jing Nie Fan Fan hou Chengzhang Liu Xianhui Qin Division of Nephrology Nanfang HospitalSouthern Medical UniversityNational Clinical Research Center for Kidney DiseaseState Key Laboratory of Organ Failure ResearchGuangdong Provincial Institute of NephrologyGuangdong Provincial Key Laboratory of Renal Failure ResearchGuangdong Provincial Clinical Research Center for Kidney DiseaseGuangzhou Regenerative Medicine and Health Guangdong LaboratoryGuangzhou 510515China Department of Epidemiology and Biostatistics School of Public HealthAnhui Medical UniversityHefei 230032China Institute of Biomedicine Anhui Medical UniversityHefei 230032China

We aimed to investigate the relationship of dietary zinc intake with new-onset hypertension among Chinese adults.A total of 12,177 participants who were free of hypertension at baseline from the China Health and Nutrition Survey were included.Dietary intake was assessed by three consecutive 24-h dietary recalls combined with a household food inventory.Participants with systolic blood pressure≥140 mmHg or diastolic blood pressure≥90 mmHg or diagnosed by a physician or under antihypertensive treatment during the follow-up were defined as having new-onset hypertension.During a median follow-up duration of 6.1 years,4269 participants developed new-onset hypertension.Overall,the association between dietary zinc intake and new-onset hypertension followed a J-shape(P for non-linearity<0.001).The risk of new-onset hypertension significantly decreased with the increment of dietary zinc intake(per mg/day:hazard ratio(HR)0.93;95%confidence interval(CI)0.88–0.98)in participants with zinc intake<10.9 mg/day,and increased with the increment of zinc intake(per mg/day:HR 1.14;95%CI 1.11–1.16)in participants with zinc intake≥10.9 mg/day.In conclusion,there was a J-shaped association between dietary zinc intake and new-onset hypertension in general Chinese adults,with an inflection point at about 10.9 mg/day.

关键词： dietary zinc intake new-onset hypertension general population CHNS

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HEC-HMS水文模型不同降雨损失方法对比研究

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水文 2024年第2期44卷 83-88页

作者：赵直冯民权侯梓良西安理工大学西北旱区生态水利国家重点实验室陕西西安710048

为对比分析HEC-HMS模型三种降雨损失方法在沁河流域的适用性。借助Morris筛选法识别降雨损失方法的关键参数,选用流域内5场雨洪资料进行参数率定和模拟精度分析。结果表明:(1)SCS CN值曲线法、Green-Ampt法、Initial and Uniform法主要... 详细信息

为对比分析HEC-HMS模型三种降雨损失方法在沁河流域的适用性。借助Morris筛选法识别降雨损失方法的关键参数,选用流域内5场雨洪资料进行参数率定和模拟精度分析。结果表明:(1)SCS CN值曲线法、Green-Ampt法、Initial and Uniform法主要敏感性参数分别为CN值、土壤饱和导水率、恒定损失率。(2)选取洪峰流量、洪水总量、峰现时刻误差以及Nash系数对模型模拟精度进行评价,SCS CN值曲线法和Initial and Uniform法模拟结果达到乙等精度,Green-Ampt法模拟结果达到丙等精度。研究成果可为半湿润地区中小流域降雨损失方法的选择提供参考。

关键词： HEC-HMS 洪水模拟降雨损失方法参数敏感性分析沁河流域

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和川水库沉积物-水界面氮赋存特征及交换通量分析

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人民黄河 2023年第10期45卷 90-95,100页

作者：侯梓良冯民权赵直西安理工大学省部共建西北旱区生态水利国家重点实验室陕西西安710048

为明确氮营养盐在沉积物-水界面的交换过程,以和川水库沉积物为研究对象,分析水库整体氮营养盐污染现状及内源释放特征。采集水库不同点位表层沉积物和上覆水,以此分析氮营养盐空间分布特征及差异性;以原位沉积物柱样沉积物静态释放试... 详细信息

为明确氮营养盐在沉积物-水界面的交换过程,以和川水库沉积物为研究对象,分析水库整体氮营养盐污染现状及内源释放特征。采集水库不同点位表层沉积物和上覆水,以此分析氮营养盐空间分布特征及差异性;以原位沉积物柱样沉积物静态释放试验获取沉积物-水界面氮营养盐交换通量,并分析和川水库内源释放对水体营养盐的潜在贡献率。结果表明:和川水库上覆水中总氮含量劣于V类水标准,且空间差异明显;上覆水中氮营养盐以硝酸盐氮为主,间隙水中氮营养盐以氨氮为主,沉积物中氮以有机氮为主;沉积物表现为总氮、氨氮的“源”和硝酸盐氮、亚硝酸盐氮的“汇”;和川水库库区界面交换对上覆水氮营养盐的贡献率较小,TN、NH^(+)_(4)-N、NO^(-)_(3)-N、NO^(-)_(2)-N的潜在贡献率小于10%。

关键词：沉积物-水界面氮营养盐交换通量和川水库

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Functional gastrointestinal disorders, mental health, genetic susceptibility, and incident chronic kidney disease

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中华医学杂志(英文版) 2024年第9期137卷 1088-1094页

作者： Liu Mengyi He Panpan Ye ziliang Yang Sisi Zhang Yanjun Wu Qimeng Zhou Chun Zhang Yuanyuan hou Fan Fan Qin Xianhui Guangzhou State Key Laboratory of Organ Failure Research Southern Medical University Division of Nephrology Nanfang Hospital China Guangdong Provincial Institute of Nephrology National Clinical Research Center for Kidney Disease Guangdong Provincial Key Laboratory of Renal Failure Research

Background: Whether functional gastrointestinal disorders (FGIDs) are associated with the long-term risk of chronic kidney disease (CKD) remains unclear. We aimed to investigate the prospective association of FGIDs with CKD and examine whether mental health mediated the association.Methods: About 416,258 participants without a prior CKD diagnosis enrolled in the UK Biobank between 2006 and 2010 were included. Participants with FGIDs (including irritable bowel syndrome [IBS], dyspepsia, and other functional intestinal disorders [FIDs; mainly composed of constipation]) were the exposure group, and non-FGID participants were the non-exposure group. The primary outcome was incident CKD, ascertained from hospital admission and death registry records. A Cox proportional hazard regression model was used to investigate the association between FGIDs and CKD, and the mediation analysis was performed to investigate the mediation proportions of mental health.Results: At baseline, 33,156 (8.0%) participants were diagnosed with FGIDs, including 21,060 (5.1%), 8262 (2.0%), and 6437 (1.6%) cases of IBS, dyspepsia, and other FIDs, respectively. During a mean follow-up period of 12.1 years, 11,001 (2.6%) participants developed CKD. FGIDs were significantly associated with a higher risk of incident CKD compared to the absence of FGIDs (hazard ratio [HR], 1.36; 95% confidence interval [CI], 1.28–1.44). Similar results were observed for IBS (HR, 1.27; 95% CI, 1.17–1.38), dyspepsia (HR, 1.30; 95% CI, 1.17–1.44), and other FIDs (HR, 1.60; 95% CI, 1.43–1.79). Mediation analyses suggested that the mental health score significantly mediated 9.05% of the association of FGIDs with incident CKD and 5.63–13.97% of the associations of FGID subtypes with CKD. Specifically, the positive associations of FGIDs and FGID subtypes with CKD were more pronounced in participants with a high genetic risk of CKD.Conclusion: Participants with FGIDs had a higher risk of incident CKD, which was partly explained by mental health scores and was more pronounced

关键词： Functional gastrointestinal disorders Chronic kidney diseases Genetic susceptibility Mental health

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Liquid metal E-tattoo

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Science China(Technological Sciences) 2023年第6期66卷 1551-1575页

作者： GAO Shang CUI ziliang WANG XueLin SUN XuYang School of Engineering Medicine Beihang UniversityBeijing 100191China

The past twenty years have witnessed a rapid advancement in medical devices and healthcare techniques.Motivated by the growing demand for personalized,preventive,predictive and participatory medicine,the on-skin portable healthcare system with fascinating merits has attracted great interest.Especially,the electronic tattoo(E-tattoo)that can form intimate contact and deform with the skin movement is regarded to play an important role in further healthcare monitoring and disease treatment.Endowed with the combination of fluidity and metallic properties,liquid metals(LMs)have become an emerging class of functional materials and are regarded as the ideal candidate for soft electronics.Here,we highlighted the key advantages of LM in E-tattoo,classified the LM based conductive inks,and summarized the important pattern technologies in fabrication of LM E-tattoo.The typical applications of healthcare detection and therapy were also discussed.Finally,outlooks were provided for future E-tattoo development.

关键词： liquid metal E-tattoo flexible electronic skin printing technologies healthcare applications

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中国火电厂自动化发展趋势及对策

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中国电力 1999年第10期32卷 41-45页

作者：侯子良国家电力公司电力规划设计总院北京100011

在研究国外自动化技术发展及其在火电厂工程中应用经验的基础上，从工程观点出发，对未来２１世纪最初１０年火电厂自动化化技术应用的发展趋势、管理体制的改革。

关键词：火电厂自动化信息网络化现场总线控制系统

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民初山西村禁约制度的执行

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山西高等学校社会科学学报 2018年第2期30卷 93-97,102页

作者：周子良侯怡宁山西大学法学院山西太原030006

村禁约制度是民国初年山西村治运动中训练村民自治能力的重要制度。山西省政府村政处从村禁约的制定、执行、救济等方面对村禁约制度的执行加以规制和引导。村禁约的执行,依照县署指导,共同议定,惩罚与教化并重,遵循法理、不违情理等原... 详细信息

村禁约制度是民国初年山西村治运动中训练村民自治能力的重要制度。山西省政府村政处从村禁约的制定、执行、救济等方面对村禁约制度的执行加以规制和引导。村禁约的执行,依照县署指导,共同议定,惩罚与教化并重,遵循法理、不违情理等原则。通过观察村禁约制度的执行概况,可以看到,山西村禁约制度在一定程度上起到了推进民治、倡行仁化、整饬风俗、补阙国法的作用。

关键词：民国初年山西村治村禁约制度民治

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A Braille Reading System Based on Electrotactile Display With Flexible Electrode Array

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IEEE/CAA Journal of Automatica Sinica 2022年第4期9卷 735-737页

作者： ziliang Zhou Yicheng Yang Honghai Liu IEEE the State Key Laboratory of Mechanical System and Vibration Shanghai Jiao Tong University the State Key Laboratory of Robotics and Systems Harbin Institute of Technology Shenzhen

Dear editor,Due to visual impairment and lack of social attention,the reading problem of the blind has not been well resolved.Many existing Braille reading devices still have many problems and are not accepted by the public.This paper developed a portable Braille reading system based on electrotactile display technology.The proposed system is composed of a six-channel electrotactile stimulator,a flexible electrode array for Braille display and a graphical user interface(GUI)for monitoring and control.Based on the flexibility of the system,two Braille reading strategies have been designed:spatial mode and sequential mode.The system was preliminary tested by six sighted subjects.The results showed that subjects were able to recognize Braille characters with more than 80%accuracy within less than 10 seconds for the initial use.Compared to existing Braille reading systems,this system is portable,wearable and flexible in control.

关键词： portable editor Bra

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