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China Ocean Engineering 2019年第3期33卷 268-278页

作者： hossein mousazadeh Ali KIAPEY Mechanical Engineering of Biosystems University of Tehran Tehran Iran Mechanical Engineering of Biosystems and Expert of Ports and Maritime Organization Tehran Iran

Performing repeatable duties automatically was the dreams of human being for centuries. Although full autonomy has long been dreamed of by visionaries, many researches have been performed for surface vehicles automation since the last century to get close to this dream stepwise. To increase daily working hours and accuracy and reduce cost, operations such as hydrography are susceptible for autonomy. Beside platform topology, installed sensors and energy resources, the core elements of any autonomous surface vehicle are navigation, guidance and control systems. To perform bathymetry operation in autonomy manner, a reliable and robust navigation algorithm is designed and embedded in an autonomous surface vehicle titled Morvarid. Morvarid is a plug-in hybrid solar powered catamaran boat. The developed algorithm is a combination of extended Kalman filter, search ball and potential field approaches. Many experimental field tests are carried out after simulation in Simulink environment. Test results illustrated the algorithm and improved the path followed by reducing SD and RMSE and there is a good correlation between simulation run and experimental tests.

关键词： autonomous surface vehicle extended Kalman filter search ball trajectory tracking bathymetry

Clinical applications of the CRISPR/Cas9 genome-editing system: Delivery options and challenges in precision medicine

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Genes & Diseases 2024年第1期11卷 268-282页

作者： Mohadeseh Khoshandam hossein Soltaninejad Marziyeh mousazadeh Amir Ali Hamidieh Saman hosseinkhani Department of Reproductive Biology Academic Center for EducationCultureand Research(ACECR)Qom BranchQom ***Iran National Institute of Genetic Engineering and Biotechnology(NIGEB) Tehran 14155-6463Iran Faculty of Interdisciplinary Science and Technology Tarbiat Modares UniversityTehran 14117-13116Iran Pediatric Cell and Gene Therapy Research Center GeneCell&Tissue Research InstituteTehran UniversityofMedical SciencesTehran14155-6559Iran Department of Nanobiotechnology Faculty of Biological SciencesTarbiat Modares UniversityTehran 14117-13116Iran Department of Biochemistry Faculty of Biological SciencesTarbiat Modares UniversityTehran 14117-13116Iran

CRISPR/Cas9 is an effective gene editing tool with broad applications for the pre-vention or treatment of numerous *** depends on CRiSPR(clustered regularly inter-spaced short palindromic repeats)as a bacterial immune system and plays as a gene editing *** to the higher specificity and efficiency of CRISPR/Cas9 compared to other editing ap-proaches,it has been broadly investigated to treat numerous hereditary and acquired ill-nesses,including cancers,hemolytic diseases,immunodeficiency disorders,cardiovascular diseases,visual maladies,neurodegenerative conditions,and a few X-linked ***/Cas9 system has been used to treat cancers through a variety of approaches,with sta-ble gene editing ***,the applications and clinical trials of CRisPR/Cas9 in various illnesses are *** to its high precision and efficiency,CRISPR/Cas9 strategies may treat gene-related illnesses by deleting,inserting,modifying,or blocking the expression of specific *** most challenging barrier to the in vivo use of CRISPR/Cas9 like off-target effects will be *** use of transfection vehicles for CRISPR/Cas9,including viral vectors(such as an Adeno-associated virus(AAV),and the development of non-viral vectors is also considered.

关键词： Clinical trials CRISPR/Cas9 Gene therapy Non-viral vectors Viral vectors

Development of an intelligent system based on ANFIS for predicting wheat grain yield on the basis of energy inputs

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Information Processing in Agriculture 2014年第1期1卷 14-22页

作者： Benyamin Khoshnevisan Shahin Rafiee Mahmoud Omid hossein mousazadeh Department of Agricultural Machinery Engineering Faculty of Agricultural Engineering and TechnologyUniversity of TehranKarajIran

Energy is regarded as one of the most important elements in agricultural *** the last decades energy consumption in agriculture has increased,so finding the relationship between energy consumption and crop yields in agricultural production can help to achieve sustainable *** this study several adaptive neuro-fuzzy inference system(ANFIS)models were evaluated to predict wheat grain yield on the basis of energy ***,artificial neural networks(ANNs)were developed and the obtained results were compared with ANFIS *** the best ANFIS structure gained in this study,R,RMSE and MAPE were calculated as 0.976,0.046 and 0.4,*** developed ANN was a multilayer perceptron(MLP)with eleven neurons in the input layer,two hidden layers with 32 and 10 neurons and one neuron(wheat grain yield)in the output *** the best ANN model,R,RMSE and MAPE were computed as 0.92,0.9 and 0.1,*** results illustrated that ANFIS model can predict the yield more precisely than ANN.

关键词： Wheat yield Energy consumption Prediction ANFIS ANN

Experimental evaluation of a hydrography surface vehicle in four navigation modes

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Journal of Ocean Engineering and Science 2017年第2期2卷 127-136页

作者： hossein mousazadeh Jafarbiglu Hamid Omrani Elham Monhaseri Farshid Kiapei Ali Salmani-Zakaria Yousef Makhsoos Ashkan Mechanical Engineering of Biosystems University of TehranIran Mechanical Engineering of Biosystems University of Shahrekord and Expert of Ports and Maritime OrganizationIran

Considering the effectiveness of maritime transportation,a large number of world’s trade is carried by sea and *** ports and harbors are essential for 24 hourly loading/unloading of *** this regard,bathymetry and monitoring of depth data especially in real time manner would be very valuable and *** plot hydrography map of ports and harbors in the bureau as online and with low cost,a Surface Vehicle(SV)is designed and *** vehicle could navigate in four *** could seat on the boat and run by joystick or stand in slipway and control by Remote Controller(RC)or seat in the office and navigate by a user friend graphical *** the boat could navigate fully autonomous without any *** accuracy and precision of four mentioned navigation modes was the main objective of this *** results illustrated that autonomous mode with Standard Deviation(SD)of below 0.5 m was the most precision and comfortable mode,while RC is the more reliable and trustworthy.

关键词： Autonomous,Navigation Hydrography Surface vehicle Monitoring

Complete ablation of tumors using synchronous chemoradiation with bimetallic theranostic nanoparticles

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Bioactive Materials 2022年第1期7卷 74-84页

作者： Hamed Nosrati Elahe Attari Fatemeh Abhari Murat Barsbay Mohammadreza Ghaffarlou Navid mousazadeh Rasoul Vaezi Taras Kavetskyy Hamed Rezaeejam Thomas J.Webster Behrooz Johari hossein Danafar Zanjan Pharmaceutical Biotechnology Research Center Zanjan University of Medical SciencesZanjanIran Joint Ukraine-Azerbaijan International Research and Education Center of Nanobiotechnology and Functional Nanosystems DrohobychUkraineBakuAzerbaijan Department of Radiology School of Paramedical SciencesZanjan University of Medical SciencesZanjan45139-56184Iran Hacettepe University Department of ChemistryBeytepeAnkara06800Turkey Department of Medical Biotechnology School of MedicineZanjan University of Medical SciencesZanjan45139-56184Iran Department of Pharmaceutical Nanotechnology School of PharmacyZanjan University of Medical SciencesZanjanIran Department of Surface Engineering The John Paul II Catholic University of Lublin20-950LublinPoland Drohobych Ivan Franko State Pedagogical University 82100DrohobychUkraine Department of Chemical Engineering Northeastern University360 Huntington AvenueBostonMA02115United States

Synchronous chemotherapy and radiotherapy,termed chemoradiation therapy,is now an important standard regime for synergistic cancer *** such treatment,nanoparticles can serve as improved carriers of chemotherapeutics into tumors and as better radiosensitizers for localized ***,we designed a Schottky-type theranostic heterostructure,Bi_(2)S_(3)-Au,with deep level defects(DLDs)in Bi_(2)S_(3) as a nano-radiosensitizer and CT imaging contrast agent which can generate reactive free radicals to initiate DNA damage within tumor cells under X-ray ***(MTX)was conjugated onto the Bi_(2)S_(3)-Au nanoparticles as a chemotherapeutic agent showing enzymatic stimuli-responsive release *** designed hybrid system also contained curcumin(CUR),which cannot only serve as a nutritional supplement for chemotherapy,but also can play an important role in the radioprotection of normal ***,this combined one-dose chemoradiation therapeutic injection of co-drug loaded bimetallic multifunctional theranostic nanoparticles with a one-time clinical X-ray irradiation,completely eradicated tumors in mice after approximately 20 days after irradiation showing extremely effective anticancer efficacy which should be further studied for numerous anti-cancer applications.

关键词： Combination therapy Radiosensitizer Semiconductor Heterojunction Radioprotector

A mild and efficient method for the methoxymethylation and acetylation of alcohols promoted by benzyltriphenylphosphonium tribromide

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Chinese Chemical Letters 2010年第10期21卷 1187-1190页

作者： Farhad Shirini Gholam hossein Imanzadeh Seyyed Ali Reza mousazadeh Iraj Mohammadpoor-Baltork Masoumeh Abedin Department of Chemistry College of ScienceUniversity of Guilan Department of Chemistry College of ScienceUniversity of Mohaghegh-Ardabili Department of Chemistry College of ScienceIsfahan University

A mild and efficient method for the conversion of alcohols to their corresponding methoxymethyl ethers and acetates using benzyltriphenylphosphonium tribromide （BTPTB） as catalyst is described. All reactions were pe... 详细信息

关键词： Benzyltriphenylphosphonium tribromide Alcohols Methoxymethylation Acetylation Heterogeneous reaction conditions