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年轻成年慢性乙型肝炎病毒感染患者无肝硬化的肝细胞性肝癌

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世界核心医学期刊文摘（胃肠病学分册） 2005年第1期1卷 53-54页

作者： Sezaki H. Kobayashi M. hosaka t. 姜建涛 Depart.ent.of Gast.oent.rology Toranomon Hospital 2-2-2 Toranomon Minato-ku Tokyo 105-8470 Japan

Background. t.e aims of t.is st.dy were t. define t.e clinical charact.rist.cs of hepat.t.s B virus (HBV)-relat.d hepat.cellular carcinoma (HCC) in young adult.pat.ent. wit.out.cirrhosis and t. evaluat. t.e efficacy of int.rferon (IFN) t.erapy on HCC recurrence. Met.ods. Of 187 pat.ent. wit. HBV-relat.d HCC t.eat.d at.our hospit.l, 4 had no liver cirrhosis and were less t.an 30 years of age (10, 22, 23, and 26 years). Result.. At.t.e t.me of diagnosis of HCC, all cases had ant.body t. hepat.t.s Be ant.gen (ant.-HBe) and hist.logical st.ging of nont.morous liver was F0 or F1, i.e., low-grade hepat.t.s. t.e mot.ers of all 4 young adult.pat.ent. wit. HCC had HBV-relat.d liver disease. t.ree cases developed recurrence of HCC. In t.ese pat.ent., long-t.rm int.rmit.ent.IFN t.erapy aft.r reresect.on of HCC result.d in long-t.rm survival wit.out.recurrence for more t.an 3 years of follow-up. Conclusions. (1) Young adult.pat.ent. wit. HCC are posit.ve for ant.-HBe, lack cirrhosis,and t.e rout. of infect.on seems t. be mot.er-t.-infant.*** t.ansmission of HBV and HBV DNA int.grat.on int. t.e cellular genomic DNA during fet.l life is a possible explanat.on of HBV-relat.d hepat.carcinogenesis in young adult.; and (2) long-t.rm IFN t.erapy seems t. be useful for prevent.on of t.mor recurrence aft.r radical operat.on for HBV-relat.d HCC.

关键词：肝细胞性肝癌轻度肝炎肝细胞癌变肝脏疾病临床特性 DNA 母-婴传播切除术胎儿期肿瘤复发

单用干扰素治疗血清转氨酶水平正常的慢性丙型肝炎患者

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世界核心医学期刊文摘（胃肠病学分册） 2005年第3期1卷 53-53页

作者： Mamori S. Suzuki F. hosaka t. 姜建涛 Depart.ent.of Gast.oent.rology Toranomon Hospital 2-2-2 Toranomon Minato-ku Tokyo 105-8470 Japan

Background. Approximat.ly 30%of pat.ent. wit. chronic hepat.t.s C have normal serumalanine amino t.ansferase (ALt. levels. While int.rferon (IFN) mono t.erapy is approved for pat.ent. wit. chronic hepat.t.s C infect.on, t.e effect.veness of such t.erapy for chronic hepat.t.s C pat.ent. wit. normal ALt.levels at.commencement.of t.eat.ent.remains poorly underst.od. Met.ods. Ninet. four individuals (M/F, 54∶40; median age, 46 years) wit. normal ALt.levels (t.t.e commencement.of t.eat.ent.who were posit.ve for bot. ant.hepat.t.s C virus (HCV) and serum HCV RNA were st.died. Among t.is group, 18 individuals (M/F, 9∶9; median age, 50 years) had had persist.nt.y normal ALt.levels for at.least.3 mont.s prior t. t.eat.ent. All pat.ent. received t.eir first.course of IFN t.erapy in t.is st.dy. Result.. Fort. t.ree (45.7 %) of 94 individuals had lost.serum HCV RNA at.6 mont.s aft.r cessat.on of t.erapy (complet. response; CR). t.e proport.on of pat.ent. wit. genot.pe 2a and HCV RNA level over 1 Meq/ml who showed CR was significant.y lower in t.ose wit. normal ALt.levels t.an in t.ose wit. elevat.d ALt.levels (23.8%vs 55.6%; P = 0.0189). t.o pat.ent. who had persist.nt.y normal ALt.levels and HCV RNA level over 1 Meq/ml were non responders (NR) and had ALt.flare ups aft.r IFN t.erapy. Pat.ent. wit. HCV RNA levels of less t.an 1 Meq/ml did not.show different.al responses based on ALt.levels. Conclusions. Our dat. suggest.t.at.IFN t.erapy is effect.ve for pat.ent. wit. normal ALt.levels and less t.an 1 Meq/ml HCV RNA. t.us, such pat.ent. should be considered for curat.ve IFN t.erapy.

关键词：慢性丙型肝炎干扰素治疗血清转氨酶证实有效 RNA

Origin of Dynamically Generat.d Baryon Rsonances

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原子核物理评论 2009年第S1期26卷 1-6页

作者： t.Hyodo D.Jido A.hosaka Physik-Depart.ent Technische Universitt Mnchen Yukawa Inst.t.t. for t.eoret.cal Physics Kyoto University Research Cent.r for Nuclear Physics(RCNP)

We st.dy t.e origin of baryon resonances which are dynamically generat.d in t.e chiral unit.ry approach. We propose a nat.ral renormalizat.on scheme for t.e dynamical generat.on of resonances using t.e low energy chiral int.ract.on and a general feat.re of t.e scat.ering t.eory. A deviat.on of a phenomenological scat.ering amplit.de from t.e nat.ral one is int.rpret.d by an effect.ve pole t.rm int.ract.on of genuine nat.re which can not.be described by t.e meson-baryon dynamics,reminiscent.of t.e CDD pole. Applying t.e present.met.od t. physical meson-baryon scat.erings,we find t.at.t.e Λ(1405) resonance is dominat.d by a meson-baryon component.forming a KN-πΣ molecular-like st.uct.re,while t.e N(1535) resonance requires some pole cont.ibut.on.

关键词： baryon resonances dynamical generat.on chiral unit.ry approach

React.on dynamics for phot.product.ons of baryon resonances

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Chinese Physics C 2009年第12期33卷 1167-1174页

作者： A. hosaka t. Hyodo D. Jido H.-Ch. Kim H. Nagahiro S.I. Nam M. Oka S. Ozaki Rresearch Cent.r for Nuclear Physics Osaka University Ibaraki 567-0047 Japan Depart.ent.of Physics Tokyo Institute of Technology Meguro 152-8551 Japan Yukawa Inst.t.t. for t.eoret.cal Physics Kyoto University Kyoto 606-8502 Japan Depart.ent.of Physics Inha University Incheon 402-751 Republic of Korea Depart.ent.of Physics Nara Women's University Nara 630-8506 Japan Depart.ent.of Physics Chung-Yuan Christian University Chung-Li 32023 China

t.e st.dy of exot.c st.uct.re of hadrons is fully achieved when react.on dynamics of t.e associat.d hadron product.ons is well underst.od. We employ as t.e st.ndard mechanism t.e effect.ve Lagrangian met.od and invest.gat. several physical observables wit.in t.e framework. t.e paramet.rs are const.ained by microscopic descript.on of hadrons. We discuss phot.product.ons of kaon associat.d wit. t.e ground st.t. A（1116） and it. resonances A（1405） and A（1520）. In t.e former example we emphasize t.e meson cloud effect.which significant.y renormalizes t.e phenomenological paramet.rs, while in t.e lat.er we discuss t.e feat.res of t.e st.ndard met.od. Finally we discuss briefly t.e N（1535） for t.e st.dy of chiral symmet.y of baryons. product.on of ηπ associat.d wit. t.e nucleon resonance

关键词： phot.product.on st.angeness baryon resonances

QCD Sum Rule St.dy of π_1s St.t.s

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原子核物理评论 2009年第S1期26卷 129-132页

作者： A. hosaka Research Cent.r for Nuclear Physics Osaka University

We st.dy t.e st.t.s π1(1600) and π1(2015) in t.e QCD sum rule. We classify t.e t.t.aquark current. of t.e quant.m numbers IGJPC=1-1-+,and find t.at.t.e flavor st.uct.re (3 6 )(6  3 ) is preferred when using a diquark-ant.diquark const.uct.on. By using bot. t.e SVZ and finit. energy sum rules,we obt.in a mass around 1.6 and 2.0 GeV,for t.e st.t.s wit. t.e quark cont.nt. qq and qs,respect.vely. We also st.dy t.eir decay pat.erns.

关键词： exot.c mesons t.t.aquark QCD sum rule

Nat.re experience promot.s preference for and willingness t. coexist.wit. wild animals among urban and suburban resident. in Malaysia

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Ecological Processes 2018年第1期7卷 177-188页

作者： Huda Farhana Mohamad Muslim hosaka t.t.uro Numat. Shinya Noor Azlin Yahya Forest.Research Inst.t.t. Malaysia(FRIM) 52109 KepongSelangorMalaysia Depart.ent.of t.urism Science Graduate School of Urban Environmental ScienceTokyo Metropolitan University1-1 Minami OsawaHachiojiTokyo 192-0397Japan Graduat. School for Int.rnat.onal Development.and Cooperat.on Hiroshima University1-5-1KagamiyamaHigashihiroshima 739-8529Japan.

Int.oduct.on:A decline in direct.experience wit. nat.re can lead t. disaffect.on of nat.ral environment.,wildlife,and public indifference t.wards biodiversit. *** st.dy measured on affect.ve at.it.de t.wards wildlife(i.e.,preferences for and willingness t. coexist.wit. 22 animal species)and examined t.e relat.onships bet.een t.ese at.it.des and childhood experiences wit. ***:A face t. face int.rview was carried out.in rapidly urbanizing Malaysia for bot. urban and suburban 357 adult.(age>20 years old).Result.:It.found t.at.Malaysian people liked several insect. and squirrels,but.disliked mammals *** analysis,wit. cont.olling sociodemographic fact.rs(gender,age and et.nicit.),showed t.at.childhood nat.re experience was posit.vely associat.d wit. preference for wild animals(st.ndardized pat. coefficient.0.18;pt.e preference had a st.ong correlat.on wit. willingness t. coexist.nce(st.ndardized pat. coefficient.0.61;pt. t.e *** nat.re experience,however,had limit.d effect. on willingness t. coexist.wit. t.e animals via t.e preference,part.cularly for unfavourable *** result. suggest.t.at.preference and willingness scores,even t.ough t.ey were significant.y correlat.d,were different.sides of affect.ve at.it.des t.ward ***:t.erefore,t. promot. biodiversit. conservat.on programs,we need st.at.gies t. increase accept.nce of wild animals via relevant.environment.l educat.on and public communicat.on,as well as opport.nit.es for nat.re act.vit.es for children.

关键词： Childhood t.opical biodiversit. Nat.re experience Percept.on Sout.east.Asia

Pion Effect.of Nuclear Mat.er in a Chiral Sigma Model

维普期刊数据库评论

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原子核物理评论 2009年第S1期26卷 75-78页

作者： Y.Ogawa H.t.ki A.hosaka Research Cent.r for Nuclear Physics (RCNP) Osaka University

We develop a new framework for t.e st.dy of t.e nuclear mat.er based on t.e linear sigma model. We int.oduce a complet.ly new viewpoint.on t.e t.eat.ent.of t.e nuclear mat.er wit. t.e inclusion of t.e pion. We ext.nd t.e relat.vist.c chiral mean field model by using t.e similar met.od in t.e t.nsor opt.mized shell model. We also regulat. t.e pion-nucleon int.ract.on by considering t.e form-fact.r and short.range repulsion effect.. We obt.in t.e equat.on of st.t. of nuclear mat.er and st.dy t.e import.nce of t.e pion effect.

关键词： ext.nded relat.vist.c mean field model chiral symmet.y pion exchange

Phot.-product.ons of baryon resonances and pent.quarks

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Photo-productions of baryon resonances and pentaquarks

Hepat.t.s C virus enhances incidence of idiopat.ic pulmonary fibrosis

t.e 6t. China-Nuclear Physics Symposium

作者： A. hosaka RCNP

We discuss some general aspect. of t.e phot.product.on of hyperon resonance Lambda(1520) and t.e pent.quark t.et.+, gamma + N -> K + Y, where K denot.s eit.er a kaon or ant.kaon, and Y eit.er t.et.+ or Lambda(1520). t.e product.on amplit.des are comput.d by using an effect.ve Lagrangian sat.sfying t.e gauge and chiral invariance. t.e gauge invariance requires t.e presence of t.e cont.ct.t.rm which

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World Journal of Gast.oent.rology 2008年第38期14卷 5880-5886页

作者： Yasuji Arase Fumit.ka Suzuki Yoshiyuki Suzuki Norio Akut. Masahiro Kobayashi Yusuke Kawamura Hiromi Yat.uji Hit.mi Sezaki t.t.uya hosaka Miharu Hirakawa Sat.shi Sait. Kenji Ikeda Hiromit.u Kumada Depart.ent.of Hepat.logy Toranomon HospitalTokyo 105-8470 Japan

AIM： t. invest.gat. t.e cumulat.ve development.incidence and predict.ve fact.rs for idiopat.ic pulmonary fibrosis in hepat.t.s C virus （HCV） posit.ve pat.ent.. MEt.ODS： We st.died 6150 HCV infect.d pat.ent. who were bet.een 40-70 years old （HCV-group）. Anot.er 2050 pat.ent. wit. hepat.t.s B virus （HBV） were select.d as cont.ol （HBV-group）. t.e mean observat.on period was 8.0 ± 5.9 years in HCV-group and 6.3 ± 5.5 years in HBV-group. t.e primary goal is t.e development.of idiopat.ic pulmonary fibrosis （IPF） in bot. groups. t.e cumulat.ve appearance rat. of IPF and independent.fact.rs associat.d wit. t.e incidence rat. of IPF were calculat.d using t.e Kaplan- Meier met.od and t.e Cox proport.onal hazard model. All of t.e st.dies were performed ret.ospect.vely by collect.ng and analyzing dat. from t.e pat.ent.records in our hospit.l. RESULt.： Fift.en pat.ent. in HCV-group developed IPF. On t.e ot.er hand, none of t.e pat.ent. developed IPF in HBV-group. In HCV-group, t.e cumulat.ve rat.s of IPF development.were 0.3% at.10t. year and 0.9% at.20t. year. t.e IPF development.rat. in HCV-group was higher t.an t.at.in HBV-group （P = 0.021）. t.e IPF development.rat. in pat.ent. wit. HCV or HBV was high wit. st.t.st.cal significance in t.e following cases：（1） pat.ent. ≥ 55 years （P 〈 0.001）; （2） pat.ent. who had smoking index （package per day x year） of ≥20 （P = 0.002）; （3） pat.ent. wit. liver cirrhosis （P = 0.042）. CONCLUSION： Our result. indicat. t.at.age, smoking and liver cirrhosis enhance t.e development.of IPF in HCV posit.ve pat.ent..

关键词： Hepat.t.s B virus Hepat.t.s C virus Idiopat.ic pulmonary fibrosis A ret.ospect.ve cohort.st.dy