年轻成年慢性乙型肝炎病毒感染患者无肝硬化的肝细胞性肝癌

作     者：Sezaki H. Kobayashi M. Hosaka T. 姜建涛 

作者机构：Department of Gastroenterology Toranomon Hospital 2-2-2 Toranomon Minato-ku Tokyo 105-8470 Japan 

出 版 物：《世界核心医学期刊文摘（胃肠病学分册）》 (Core Journals in Gastroenterology)

年 卷 期：2005年第1卷第1期

页      面：53-54页

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100401[医学-流行病与卫生统计学] 100214[医学-肿瘤学] 10[医学] 

主　　题：肝细胞性肝癌 轻度肝炎 肝细胞癌变 肝脏疾病 临床特性 DNA 母-婴传播 切除术 胎儿期 肿瘤复发 

摘      要：Background. The aims of this study were to define the clinical characteristics of hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in young adult patients without cirrhosis and to evaluate the efficacy of interferon (IFN) therapy on HCC recurrence. Methods. Of 187 patients with HBV-related HCC treated at our hospital, 4 had no liver cirrhosis and were less than 30 years of age (10, 22, 23, and 26 years). Results. At the time of diagnosis of HCC, all cases had antibody to hepatitis Be antigen (anti-HBe) and histological staging of nontumorous liver was F0 or F1, i.e., low-grade hepatitis. The mothers of all 4 young adult patients with HCC had HBV-related liver disease. Three cases developed recurrence of HCC. In these patients, long-term intermittent IFN therapy after reresection of HCC resulted in long-term survival without recurrence for more than 3 years of follow-up. Conclusions. (1) Young adult patients with HCC are positive for anti-HBe, lack cirrhosis,and the route of infection seems to be mother-to-infant *** transmission of HBV and HBV DNA integration into the cellular genomic DNA during fetal life is a possible explanation of HBV-related hepatocarcinogenesis in young adults; and (2) long-term IFN therapy seems to be useful for prevention of tumor recurrence after radical operation for HBV-related HCC.