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A plasma membrane nucleotide-binding leucinerich repeat receptor mediates the recognition of the Ralstonia pseudosolanacearum effector RipY in Nicotiana benthamiana

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Plant Communications 2023年第6期4卷 313-328页

作者： Boyoung Kim Wenjia Yu Haseong Kim Qian Dong Sera choi Maxim Prokchorchick Alberto PMacho Kee hoon Sohn Cécile Segonzac Department of Agriculture Forestry and BioresourcesSeoul National UniversitySeoul 08826Republic of Korea Plant Immunity Research Center Seoul National UniversitySeoul 08826Republic of Korea Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 201602China Department of Life Sciences Pohang University of Science and TechnologyPohang 37673Republic of Korea Plant Genomics and Breeding Institute Seoul National UniversitySeoul 08826Republic of Korea Research Institute of Agriculture and Life Sciences Seoul National UniversitySeoul 08826Republic of Korea Department of Agricultural Biotechnology Seoul National UniversitySeoul 08826Republic of Korea Present address:Institute of Plant and Microbial Biology and Zürich-Basel Plant Science Center University of Zürich8008 ZürichSwitzerland The Institute of Crop Science and Resource Conservation(INRES) University of BonnNussallee 953115 BonnGermany

Bacterial wilt disease caused by several Ralstonia species is one of the most destructive diseases in Solanaceae *** a few functional resistance genes against bacterial wilt have been cloned to ***,we showthat the broadly conserved typeⅢsecreted effector RipY is recognized by the Nicotiana benthamiana immune system,leading to cell death induction,induction of defense-related gene expression,and restriction of bacterial pathogen *** a multiplexed virus-induced gene-silencing-based *** nucleotide-binding and leucine-rich repeat receptor(NbNLR)library,we identified a coiled-coil(CC)nucleotide-binding and leucine-rich repeat receptor(CNL)required for recognition of RipY,which we named RESISTANCE TO RALSTONIA SOLANACEARUM RIPY(RRS-Y).Genetic complementation assays in RRS-Y-silenced plants and stable rrs-y knockout mutants demonstrated that RRS-Y is sufficient to activate RipY-induced cell death andRipY-induced immunity to Ralstonia ***-Y function is dependent on the phosphate-binding loop motif of the nucleotide-binding domain but independent of the characterized signaling components ENHANCED DISEASE SUSCEPTIBILITY 1,ACTIVATED DISEASE RESISTANCE 1,and N REQUIREMENT GENE 1 and the NLR helpers NB-LRR REQUIRED FOR HR-ASSOCIATED CELL DEATH-2,-3,and-4 in *** further show that RRS-Y localization at the plasma membrane is mediated by two cysteine residues in the CC domain and is required for RipY *** also broadly recognizes RipY homologs across Ralstonia ***,we show that the C-terminal region of RipY is indispensable for RRS-Y ***,our findings provide an additional effector/receptor pair system to deepen our understanding of CNL activation in plants.

关键词： typeⅢsecreted effector plant immune system nucleotide-binding leucine-rich repeat receptor virusinduced gene silencing

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A novel chitosan nanocapsule for enhanced skin penetration of cyclosporin A and effective hair growth in vivo

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Nano Research 2019年第12期12卷 3024-3030页

作者： Jin Sil Lee Youngmin Hwang Hyeryeon Oh Sunghyun Kim Jin-Hwa Kim Jeung-hoon Lee Yong Chui Shin Giyoong Tae Won II choi Center for Convergence Bioceramic Materials Convergence R&D DivisionKorea Institute of Ceramic Engineering and Technology202Osongsaengmyeong l-rof Osong-eupHeungdeok-guCheongjuChungbuk 28160Republic of Korea School of Materials Science and Engineering Gwangju Institute of Science and Technology123 Cheomdan-gwagiroBuk-guGwangju 61005Republic of Korea SKINMED Co. Ltd.Daejeon 34028Republic of Korea Amicogen Inc.64 Dongburo 1259JinsungJinju 52621Republic of Korea

Hair loss due to medical conditions,such as alopecia,male pattern baldness,and cancer chemotherapy treatment,has been a comm onproblem for many in *** n A(CsA),a fungal metabolite,has been reported to be a hair growth modulatory agent and is apotential drug for hair ***,the effect of topical application of CsA is limited by its poor water *** deliverysystems developed to enhance its solubility still showed poor skin *** overcome these limitations,in this study,we have developed a novel chitosan nanocapsule platform using Pluro nic F127 and chitosan without any chemical crosslinking or complicated preparati on steps for the enhanced water solubility and high tran sdermal penetration of *** chitosan nanocapsules(ChiNCs)optimized in terms of structural stability by using chitosan with various molecular weights ranging from 3 to 100 kDa enhanced the skin permeation of CsA through humancadaver skin in *** administration of the CsA loaded ChiNCs in creased the hair follicles by c.a.7 times higher than that of thecontrol group,and effectively induced hair growth in C57BL/6 mice in *** results suggest that ChiNCs could be used as a platform foreffective transdermal delivery of various hydrophobic drugs.

关键词： chitosan nanocapsule cyclosporin A transdermal delivery hair growth

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Acute liver injury induces expression of FGF23 in hepatocytes via orphan nuclear receptor ERRγ signaling

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Genes & Diseases 2023年第3期10卷 679-682页

作者： Yoon Seok Jung Yong-hoon Kim Kamalakannan Radhakrishnan Jung-Ran Noh Jung Hyeon choi Hyo-Jin Kim Jae-Ho Jeong Steven Dooley Chul-Ho Lee Hueng-Sik choi School of Biological Sciences and Technology Chonnam National UniversityGwangju 61186Republic of Korea Laboratory Animal Resource Center Korea Research Institute of Bioscience and Biotechnology125 Gwahak-roYuseong-guDaejeon 34141Republic of Korea Department of Functional Genomics KRIBB School of BioscienceKorea University of Science and Technology(UST)Daejeon 34113Republic of Korea Combinatorial Tumor Immunotherapy MRC Chonnam National University Medical SchoolHwasun-gunJeonnam 58128Republic of Korea Department of Microbiology Chonnam National University Medical SchoolGwangju 61186Republic of Korea Molecular Hepatology Section Medical Faculty MannheimHeidelberg University69117 HeidelbergGermany

Fibroblast growth factor 23(FGF23)is an osteocyte-and osteoblast-derived hormone that primarily regulates phosphate and vitamin D *** FGF23 levels are abnormally increased in pathological conditions like acute or chronic kidney injury,resulting in disease progression as well as increased rates of morbidity and mortality.^(1) However,FGF23 production in acute liver injury is not fully *** this study.

关键词： FGF23 acute vitamin

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Ternary layered double hydroxide oxygen evolution reaction electrocatalyst for anion exchange membrane alkaline seawater electrolysis

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Journal of Energy Chemistry 2022年第12期75卷 127-134,I0004页

作者： Yoo Sei Park Jae-Yeop Jeong Myeong Je Jang Chae-Yeon Kwon Geul Han Kim Jaehoon Jeong Ji-hoon Lee Jooyoung Lee Sung Mook choi Department of Hydrogen Energy Materials Surface&Nano Materials DivisionKorea Institute of Materials Science(KIMS)Changwon 51508Republic of Korea Department of Advanced Material Engineering Chungbuk National University1 Chungdae-roSeowon-guCheongjuChungbuk 28644Republic of Korea Department of Chemical Engineering University of WaterlooWaterlooOntario N2L 3G1 Canada School of Materials Science and Engineering Gyeongsang National UniversityJinju 52828Republic of Korea Department of Materials Science and Engineering Pusan National UniversityBusan 46241Republic of Korea Energy Industry Support Center Daegu Mechatronics&Materials InstituteDaegu 42704Republic of Korea Advanced Materials Engineering University of Science and Technology(UST)Yuseong-guDaejeon 34113Republic of Korea

Anion exchange membrane(AEM)water electrolyzers are promising energy devices for the production of clean hydrogen from ***,the lack of active and robust electrocatalysts for the oxygen evolution reaction(OER)severely impedes the development of this *** this study,a ternary layered double hydroxide(LDH)OER electrocatalyst(NiFeCo-LDH)is developed for high-performance AEM alkaline seawater *** AEM alkaline seawater electrolyzer catalyzed by the NiFeCo LDH shows high seawater electrolysis performance(0.84 A/cm^(2)at 1.7 Vcell)and high hydrogen production efficiency(77.6%at 0.5 A/cm^(2)),thus outperforming an electrolyzer catalyzed by a benchmark IrO_(2)*** NiFeCo-LDH electrocatalyst greatly improves the kinetics of the AEM alkaline seawater electrolyzer,consequently reducing its activation loss and leading to high *** on the results,this NiFeCo-LDH-catalyzed AEM alkaline seawater electrolyzer can likely surpass the energy conversion targets of the US Department of Energy.

关键词： Anion exchange membranes water electrolysis Oxygen evolution reactions Alkaline seawater electrolysis Hydrogen production

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Parameterization of below-cloud scavenging for polydisperse fine mode aerosols as a function of rain intensity

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Journal of Environmental Sciences 2023年第10期132卷 43-55页

作者： Chang hoon Jung Hyung-Min Lee Dasom Park Young Jun Yoon Yongjoo choi Junshik Um Seoung Soo Lee Ji Yi Lee Yong Pyo Kim Department of Health Management Kyungin Women’s UniversityIncheon 21041Korea Department of Environmental Science and Engineering Ewha Woman’s UniversitySeoulKorea Department of Environmental Engineering Konkuk UniversitySeoulKorea Korea Polar Research Institute IncheonKorea Department of Environment Hankuk University of Foreign StudiesYonginKorea Department of Atmospheric Sciences Pusan National UniversityBusanKorea Earth System Science Interdisciplinary Center University of MarylandCollege ParkMDUSA Research Center for Climate Sciences Pusan National UniversityBusanKorea Department of Chemical Engineering and Materials Science Ewha Womans UniversitySeoulKorea

The below-cloud aerosol scavenging process by precipitation is one of the most important mechanisms to remove aerosols from the *** to its complexity and dependence on both aerosol and raindrop sizes,wet scavenging process has been poorly treated,especially during the removal of fine *** makes the numerical simulation of below-cloud scavenging in large-scale aerosolmodels *** consider the slip effects of submicron particles,a simplified expression for the diffusion scavenging was developed by approximating the Cunningham slip correction *** derived analytic solution was parameterized as a simple power function of rain intensity under the assumption of the lognormal size distribution of *** resultant approximated expression was compared to the observed data and the results of previous studies including a 3D atmospheric chemical transport model *** with the default GEOS-Chem coefficient of 0.00106R0.61 and the observation-based coefficient of 0.0144R0.9268,the coefficient of a and b in∧m=aRb spread in the range of 0.0002-0.1959 for a and 0.3261-0.525 for b over a size distribution of GSD of 1.3–2.5 and a geometric mean diameter of 0.01-2.5μ***,this study showed that the scavenging coefficient varies widely by orders of magnitude according to the size distribution of particles and rain *** study also demonstrated that the obtained simplified expression could consider the theoretical approach of aerosol *** proposed analytic approach showed that results can be effectively applied for reduced computational burden in atmospheric modeling.

关键词： Below-cloud scavenging Polydisperse aerosol Parameterization Cunningham correction factor Scavenging coefficient

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Antiinflammatory and analgesic effect of herbal cocktail Hongbaekjeong via inhibition of proinflammatory cytokines and prostaglandin E2 release

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Chinese Science Bulletin 2014年第25期59卷 3127-3133页

作者： Jinwon Lim Hyo-Jung Lee Bonglee Kim Jeong-Un choi Yoeok Shin Eun Jung Sohn Sung-hoon Kim Cancer Preventive Material Development Research Center College of Oriental Medicine Kyung Hee University

Though Hongbaekjeong(HBJ),a hebal mixture of three medicinal plants,has been traditionally used for arthritis and muscular pain,its scientific evidence still remains ***,in the present study,analgesic and anti-inflammatory mechanism of HBJ was evaluated in vitro and in *** significantly reduced NO production and prostaglandin E2(PGE2)release and also attenuated the expression of cyclooxygenase 2(COX-2)in lipopolysaccharides(LPS)and interferon(IFN)-c treated RAW 264.7 ***,HBJ abrogated the production of proinflammatory cytokines such as interleukin(IL)1b,IL-6,IL-8 and monocyte chemoattractant protein-1(MCP-1)in LPS and IFN-c treated RAW 264.7 *** addition,HBJ significantly decreased the number of writhing syndrome induced by acetic acid,and also increased latency in hot-plate method and tail flick test in ***,HBJ significantly reduced the edema volume in the hind paw of the rats with arthritis induced by Freund’s complete adjuvant(FCA)compared to untreated ***,our findings demonstrate the antiinflammatory and analgesic potential of HBJ via inhibition of proinflammatory cytokines and PGE2 release for treatment of arthritis and muscular pain.

关键词：前列腺素E2 炎性细胞因子和镇痛抗炎单核细胞趋化蛋白-1 鸡尾酒 IFN-γ

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Appropriate empirical antibiotic use and 30-d mortality in cirrhotic patients with bacteremia

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World Journal of Gastroenterology 2015年第12期21卷 3587-3592页

作者： Hyun Park Ki Jun Jang Won Jang Sang hoon Park Ji Young Park Tae Joo Jeon Tae hoon Oh Won Chang Shin Won-Choong choi Dong Hyun Sinn Department of Internal Medicine Sanggye Paik Hospital Inje University Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine

AIM: To analyze whether prompt and appropriate empirical antibiotic(AEA) use is associated with mortality in cirrhotic patients with bacteremia. METHODS: A total of 102 episodes of bacteremia in 72 patients with cirrhosis were analyzed. AEA was defined as a using or starting an antibiotic appropriate to the isolated pathogen at the time of bacteremia. The primary endpoint was 30-d mortality. RESULTS: The mortality rate at 30 d was 30.4%(31/102 episodes). Use of AEA was associated with better survival at 30 d(76.5% vs 46.9%, P = 0.05), and inappropriate empirical antibiotic(IEA) use was an independent factor associated with increased mortality(OR = 3.24; 95%CI: 1.50-7.00; P = 0.003, adjusted for age, sex, ChildPugh Class, gastrointestinal bleeding, presence of septic shock). IEA use was more frequent when the isolated pathogen was a multiresistant pathogen, and when infection was healthcare-related or hospital-acquired. CONCLUSION: AEA use was associated with increased survival of cirrhotic patients who developed bacteremia. Strategies for AEA use, tailored according to the local epidemiological patterns, are needed to improve survival of cirrhotic patients with bacteremia.

关键词： Liver cirrhosis Bacteremia Appropriate antibiotics

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Early experience of the compression anastomosis ring (CAR^(TM) 27) in left-sided colon resection

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World Journal of Gastroenterology 2011年第43期17卷 4787-4792页

作者： Jung-Yeon Lee Jin-Hee Woo Hong-Jo choi Ki-Jae Park Young-hoon Roh Ki-Han Kim Hak-Yoon Lee Department of Surgery Dong-A University Medical Center

AIM:To evaluate clinical validity of the compression anastomosis ring(CARTM27) anastomosis in left-sided colonic resection. METHODS:A non-randomized prospective data collection was performed for patients undergoing an elective left-sided colon resection,followed by an anastomosis using the CARTM27 between November 2009 and January *** criteria of the use of the CARTM27 were anastomoses between the colon and at or above the intraperitoneal *** primary short-term clinical endpoint,rate of anastomotic leakage,and other clinical outcomes,including intraand postoperative complications,length of operation time and hospital stay,and the ring elimination time were evaluated. RESULTS:A total of 79 patients(male,43;median age,64 years) underwent an elective left-sided colon resection,followed by an anastomosis using *** was performed laparoscopically in 70 patients,in whom two patients converted to open procedure(2.9%) .There was no surgical *** an intraoperative complication,total disruption of the anastomosis occurred by premature enforced tension on the proximal segment of the anastomosis in one *** ring was removed and another new CARTM27 anastomosis was *** patient with sigmoid colon cancer showed postoperative anastomotic leakage after 6 d postoperatively and temporary diverting ileostomy was *** date of expulsion of the ring could not be recorded because most patients were not aware that the ring had been *** patients manifested clinical symptoms of anastomotic stricture. CONCLUSION:Short-term evaluation of the CARTM27 anastomosis in elective left colectomy suggested it to be a safe and efficacious alternative to the standard hand-sewn or stapling technique.

关键词： Compression anastomosis Colon Anastomotic leakage CARTM27

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Identifying and Verifying Vulnerabilities through PLC Network Protocol and Memory Structure Analysis

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Computers, Materials & Continua 2020年第10期65卷 53-67页

作者： Joo-Chan Lee Hyun-Pyo choi Jang-hoon Kim Jun-Won Kim Da-Un Jung Ji-Ho Shin Jung-Taek Seo Department of Information Security Engineering Soonchunhyang UniversityAsan31538Korea

Cyberattacks on the Industrial Control System(ICS)have recently been increasing,made more intelligent by advancing *** such,cybersecurity for such systems is attracting *** a core element of control devices,the Programmable Logic Controller(PLC)in an ICS carries out on-site control over the ICS.A cyberattack on the PLC will cause damages on the overall ICS,with Stuxnet and Duqu as the most representative ***,cybersecurity for PLCs is considered essential,and many researchers carry out a variety of analyses on the vulnerabilities of PLCs as part of preemptive efforts against *** this study,a vulnerability analysis was conducted on the XGB *** vulnerabilities were identified by analyzing the network protocols and memory structure of PLCs and were utilized to launch replay attack,memory modulation attack,and FTP/Web service account theft for the verification of the *** on the results,the attacks were proven to be able to cause the PLC to malfunction and disable it,and the identified vulnerabilities were defined.

关键词： Industrial control system programmable logic controller cybersecurity network protocol vulnerability

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Comparison of sequential and 7-,10-,14-d triple therapy for Helicobacter pylori infection

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World Journal of Gastroenterology 2012年第19期18卷 2377-2382页

作者： Hyuk Soon choi hoon Jai Chun Sang hoon Park Bora Keum Yeon Seok Seo Yong Sik Kim Yoon-Tae Jeen Soon Ho Um Hong Sik Lee Chang Duck Kim Ho Sang Ryu Division of Gastroenterology and Hepatology Department of Internal MedicineInstitute of Digestive Disease and NutritionKorea University College of MedicineSeoul 136-705South Korea

AIM:To compare the effectiveness of sequential therapy for Helicobacter pylori(***) infection with that of triple therapy of varying ***:The 460 patients enrolled in this study had ***-associated gastritis or a gastric or duodenal *** screening,***-infected patients were randomly assigned to receive either conventional triple therapy for 7,10 or 14 d,or a new 10-d sequential *** of the 4 treatment groups included 115 *** outcomes of eradication therapy were assessed 4 wk after treatment by the urea breath test and ***:The overall eradication rate was 81.0%,and eradication rates were 75.7% for 7-d conventional triple therapy,81.9% for 10-d conventional triple therapy,84.4% for 14-d conventional triple therapy,and 82.0% for 10-d sequential *** intention-to-treat analysis nor per protocol analysis showed significant differences in eradication rates using sequential therapy or the standard triple therapy(P = 0.416 and P = 0.405,respectively).CONCLUSION:There are no significant differences between 10-d sequential eradication therapy for *** and any duration of standard triple treatment in Korean patients.

关键词： He/icobacter pylori Sequential therapy Triple therapy Gastric ulcer Duodenal ulcer Gastritis

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