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Comparative proteomic analysis of plasma exosomes reveals the functional contribution of N-acetyl-alpha-glucosaminidase to Parkinson’s disease

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Neural Regeneration Research 2025年第10期20卷 2998-3012页

作者： Yuan Zhao Yidan Zhang Xin Liu Jian Zhang ya Gao Shuyue Li Cui Chang Xiang Liu Guofeng yang Department of Geriatrics Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Department of Neurosurgery The Second Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina

Parkinson’s disease is the second most common progressive neurodegenerative disorder,and few reliable biomarkers are available to track disease *** proteins,DNA,mRNA,and lipids carried by exosomes reflect intracellular changes,and thus can serve as biomarkers for a variety of *** this study,we investigated alterations in the protein content of plasma exosomes derived from patients with Parkinson’s disease and the potential therapeutic roles of these proteins in Parkinson’s *** a tandem mass tag-based quantitative proteomics approach,we characterized the proteomes of plasma exosomes derived from individual patients,identified exosomal protein signatures specific to patients with Parkinson’s disease,and identified N-acetyl-alpha-glucosaminidase as a differentially expressed protein.N-acetyl-alpha-glucosaminidase expression levels in exosomes from the plasma of patients and healthy controls were validated by enzyme-linked immunosorbent assay and western *** results demonstrated that the exosomal N-acetyl-alpha-glucosaminidase concentration was not only lower in Parkinson’s disease,but also decreased with increasing Hoehn-yahr stage,suggesting that N-acetyl-alpha-glucosaminidase could be used to rapidly evaluate Parkinson’s disease ***,western blot and immunohistochemistry analysis showed that N-acetyl-alpha-glucosaminidase levels were markedly reduced both in cells treated with 1-methyl-4-phenylpyridinium and cells overexpressingα-synuclein compared with control ***,N-acetyl-alpha-glucosaminidase overexpression significantly increased cell viability and inhibitedα-synuclein expression in 1-methyl-4-phenylpyridinium-treated *** together,our findings demonstrate for the first time that exosomal N-acetyl-alpha-glucosaminidase may serve as a biomarker for Parkinson’s disease diagnosis,and that N-acetyl-alpha-glucosaminidase may reduceα-synuclein expression and 1-methyl-4-phenylpyridinium-induced n

关键词： biomarker diagnosis exosomes N-acetyl-alpha-glucosaminidase Parkinson’s disease proteomic α-synuclein

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Dynamic evolution of Co species and morphological reconstruction on Co-N-C during the nitrate reduction reaction in neutral solution

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Nano Research 2025年第1期18卷 164-172页

作者： Yuanlin Fu Xiaoting yang ya Yu Kang Zhou Xiaoyang Ye Aoxiang Zhang Xiaojiao Hou Bingbing Chen Fuqiang Fan Yuhang Li Yu Fu Department of Chemistry College of SciencesNortheastern UniversityShenyang 110819China Department of Physical Education Shen Yang Institute of Science and TechnologyShenyang 110167China Sungrow Power Supply Co. Ltd.Hefei 230088China

The electrochemical nitrate reduction reaction(eNO_(3)^(-)RR)is considered an effective approach for converting nitrate-containing wastewater to *** adsorption and activation of NO_(3)^(-)is the critical step for many materials and the high energy barrier inhibits the continuation of the reduction *** Co nanoparticles encapsulated in the carbon layer we prepared spontaneously react with NO_(3)^(-)and the resulting Co^(2+)is then reduced by electroreduction to Co^(0),which circulates *** resulted in overcoming the energy input required for NO_(3)^(-)adsorption and conversion,thereby increasing the catalytic *** the same time,the morphology of the catalyst reconstructed from a dodecahedron to an interwoven nanosheet structure and the increased surface area also gives it better *** obtained Co(OH)_(2)@Co-N-C has an excellent eNO_(3)^(-)RR of 2774.7μg·h^(-1)·cm^(-2)with a Faraday efficiency of 81.4%in neutral *** the same time,the material-modified electrode can run stably for more than 100 *** work provides a new idea for the design of Co-based catalysts for eNO_(3)^(-)RR.

关键词： electrochemical nitrate reduction reaction Co-based catalyst dynamic evolution of Co species morphological reconstruction

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g-C_(3)N_(4)负载双金属Rh@Ru催化氨硼烷析氢反应机理研究

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原子与分子物理学报 2025年第5期42卷 17-21页

作者：郭雅琼武警警官学院成都610213

本文采用密度泛函理论,研究了双金属Rh@Ru在g-C_(3)N_(4)上不同负载位点,确定了稳定的催化剂构型,并详细研究了该催化剂催化氨硼烷析氢的反应机理.通过比较氨硼烷析氢反应三条路径所需活化能,发现路径Ⅲ控制步骤活化能较低,而路径Ⅰ、... 详细信息

本文采用密度泛函理论,研究了双金属Rh@Ru在g-C_(3)N_(4)上不同负载位点,确定了稳定的催化剂构型,并详细研究了该催化剂催化氨硼烷析氢的反应机理.通过比较氨硼烷析氢反应三条路径所需活化能,发现路径Ⅲ控制步骤活化能较低,而路径Ⅰ、Ⅱ所需活化能较高,反应路径Ⅲ更容易进行,Ⅰ为最优析氢路径.从微观角度揭示双贵金属Rh@Ru负载g-C_(3)N_(4)催化氨硼烷析氢的三条机理,希望为氨硼烷析氢催化剂的优化和设计提供理论信息.

关键词：双金属催化剂 g-C_(3)N_(4) NH_(3)BH_(3) 密度泛函理论反应机理

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Mass Balance Modeling for Electric Arc Furnace and Ladle Furnace System in Steelmaking Facility in Turkey

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Journal of iron and Steel Research international 2007年第5期14卷 1-6,55页

作者： smail Ekmeki ya ar Yetisken nal ■amdali Engineering Faculty Marmara University Gztepe Campus Development Bank of Turkey

in the electric arc furnace （EAF） steel production processes, scrap steel is principally used as a raw material instead of iron ore. in the steelmaking process with EAF, scrap is first melted in the furnace and then the desired chemical composition of the steel can be obtained in a special furnace such as ladle furnace （LF）. This kind of furnace process is used for the secondary refining of alloy steel. LF furnace offers strong heating fluxes and enables precise temperature control, thereby allowing for the addition of desired amounts of various alloying elements. it also provides outstanding desulfurization at high-temperature treatment by reducing molten steel fluxes and removing deoxidation products. Elemental analysis with mass balance modeling is important to know the precise amount of required alloys for the LF input with respect to scrap composition. in present study, chemical reactions with mass conservation law in EAF and LF were modeled altogether as a whole system and chemical compositions of the final steel alloy output can be obtained precisely according to different scrap compositions, alloying elements ratios, and other input amounts. Besides, it was found that the mass efficiency for iron element in the system is 95.93%. These efficiencies are calculated for all input elements as 8. 45% for C, 30.31% for Si, 46.36% for Mn, 30.64% for P, 41.96% for S, and 69.79% for Cr, etc. These efficiencies provide valuable ideas about the amount of the input materials that are vanished or combusted for 100 kg of each of the input materials in the EAF and LF system.

关键词： electric arc furnace ladle furnace system modeling mass balance steelmaking liquid steel

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Cylinder Pressure Prediction of An HCCi Engine Using Deep Learning

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Chinese Journal of Mechanical Engineering 2021年第2期34卷 160-167页

作者： Halit yaşar GültekinÇağıl Orhan Torkul MerveŞişci Department of Mechanical Engineering Engineering FacultySakarya UniversityEsentepe Campus54187 SerdivanSakaryaTurkey Department of industrial Engineering Engineering FacultySakarya UniversityEsentepe Campus54187 SerdivanSakaryaTurkey

Engine tests are both costly and time consuming in developing a new internal combustion ***,it is of great importance to predict engine characteristics with high accuracy using artificial ***,it is possible to reduce engine testing costs and speed up the engine development *** Learning is an effective artificial intelligence method that shows high performance in many research areas through its ability to learn high-level hidden features in data *** present paper describes a method to predict the cylinder pressure of a Homogeneous Charge Compression ignition(HCCi)engine for various excess air coefficients by using Deep Neural Network,which is one of the Deep Learning methods and is based on the Artificial Neural Network(ANN).The Deep Learning results were compared with the ANN and experimental *** results show that the difference between experimental and the Deep Neural Network(DNN)results were less than 1%.The best results were obtained by Deep Learning *** cylinder pressure was predicted with a maximum accuracy of 97.83%of the experimental value by using *** the other hand,the accuracy value was increased up to 99.84%using *** results show that the DNN method can be used effectively to predict cylinder pressures of internal combustion engines.

关键词： Artificial neural network Deep neural network HCCi engine Cylinder pressure Excess air coefficient

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Accretivity of the General Second Order Linear Differential Operator

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Acta Mathematica Sinica,English Series 2019年第6期35卷 832-852页

作者： V.G.MAZ'ya.i.E.VERBiTSKY Department of Mathematics Linkoping University SE-581 83 Linkoping Sweden RUDN University 6 Miklukho-Maklay St. Moscow 117198 Russia Department of Mathematics University of Missouri Columbia Missouri 65211 USA

For the general second order linear differential operator ■ with complex-valued distributional coefficients a_(jk), b_j, and c in an open set Ω ? R^n(n ≥ 1), we present conditions which ensure that-L^0 is accretive... 详细信息

关键词： Accretive differential operators complex-valued coefficients Schr?dinger operator form boundedness

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四波混频Autler-Townes分裂中的探测光影响

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原子与分子物理学报 2025年第3期42卷 110-115页

作者：裴丽娅侯海龙北京化工大学数理学院北京100029

在双Λ-型四波混频系统中,研究了探测光强度对Autler-Townes(AT)分裂效应的影响.随着弱探测光强度增大,由缀饰态共振产生的AT分裂双峰间隔不变,但却逐渐增宽线宽且减弱直至消失;而在强耦合光失谐条件下,不对称地位于单光子共振峰两侧的A... 详细信息

在双Λ-型四波混频系统中,研究了探测光强度对Autler-Townes(AT)分裂效应的影响.随着弱探测光强度增大,由缀饰态共振产生的AT分裂双峰间隔不变,但却逐渐增宽线宽且减弱直至消失;而在强耦合光失谐条件下,不对称地位于单光子共振峰两侧的AT分裂双峰却会逐渐趋于对称分布.详细讨论了探测光场对原子的缀饰影响,提出通过探测光强度可以调控原子两基态之间的有效Raman相干,从而影响AT分裂双峰的特征.

关键词：四波混频原子相干 Autler-Townes分裂缀饰态横向弛豫率

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Alpine ecotone in the Siberian Mountains:vegetation response to warming

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Journal of Mountain Science 2021年第12期18卷 3099-3108页

作者： KHARUK Viacheslav i. iM Sergei T. PETROV il’ya A. Sukachev institute of Forest Federal Scientific CenterRussian Academy of ScienceSiberian BranchAcademgorodok 50/28Krasnoyarsk 660036Russia Siberian Federal University Svobodny str.79Krasnoyarsk 660041Russia Reshetnev Siberian State University of Science and Technology Krasnoyarsky rabochy str.31Krasnoyarsk 660014Russia

Birch(Betula tortuosa)is one of the treeline forming species within the Siberian *** analysed the area dynamics of birch stands and the upslope climb of birch treeline based on the Landsat time series scenes and on-ground *** found that since the warming onset(1970th)birch area increased by 10%,birch stands and treeline boundary were moving upslope with a rate of 1.4 m/yr and 4.0 m/*** upslope shift correlated with air temperatures at the beginning(May-June)and the end(August-October)of the growth ***,no correlation was found between birch upslope migration and *** negatively influenced both birch area growth and birch upslope climb during spring,fall,and *** the windy habitats,birch,together with larch and Siberian pine,formed clusters(hedges)which mitigated the influence of adverse *** clusters are the adaptive pattern for trees’upslope climb within windward *** other adaptation to the harsh alpine ecotone habitat is non-leaf(bark)photosynthesis which supports tree ***,Betula tortuosa upslope climb depends on the wind impact and warming in spring and fall that extended growth *** ongoing warming and observed wind speed decrease on the background of sufficient precipitation,it is expected to further birch advance into alpine tundra in the Siberian Mountains.

关键词： Alpine biomes Treeline shift rate Treeline ecotone Siberian mountain forests Betula tortuosa Forest densification Tree clustering

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Chiral universality class of normal-superconducting and exciton condensation transitions on surface of topological insulator

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Frontiers of physics 2015年第3期10卷 65-82页

作者： Dingping Li Baruch Rosenstein B. ya. Shapiro i. Shapiro School of Physics Peking University Beijing 100871 China Collaborative innovation Center of Quantum Matter Beijing 100084 China Electrophysics Department National Chiao Tung University Hsinchu 30050 Taiwan China physics Department Ariel University Ariel 40700 Israel Physics Department Bar-Ilan University 52900 Ramat-Gan Israel

New two-dimensional systems such as the surfaces of topological insulators （Tis） and graphene offer the possibility of experimentally investigating situations considered exotic just a decade ago. These situations include the quantum phase transition of the chiral type in electronic systems with a relativistic spectrum. Phonon-mediated （conventional） pairing in the Dirac semimetal appearing on the surface of a Ti causes a transition into a chiral superconducting state, and exciton condensation in these gapless systems has long been envisioned in the physics of narrow-band semiconductors. Starting from the microscopic Dirac Hamiltonian with local attraction or repulsion, the Bardeen- Cooper-Schrieffer type of Gaussian approximation is developed in the framework of functional integrals. it is shown that owing to an ultrarelativistic dispersion relation, there is a quantum critical point governing the zero-temperature transition to a superconducting state or the exciton condensed state. Quantum transitions having critical exponents differ greatly from conventional ones and belong to the chiral universality class. We discuss the application of these results to recent experiments in which surface superconductivity was found in Tis and estimate the feasibility of phonon pairing.

关键词： topological insulator Weyl semimetal superconductivity quantum criticality

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Warming hiatus-and evergreen conifers in Altay-Sayan Region,Siberia

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Journal of Mountain Science 2018年第12期15卷 2579-2589页

作者： Viacheslav i.KHARUK Sergei T.iM il'ya A.PETROV Sukachev institute of Forest Federal Scientific CenterRussian Academy of ScienceSiberian BranchAcademgorodok 50/28Krasnoyarsk660036Russia Siberian Federal University Suobodny str.79Krasnoyarsk 660041Russia Reshetnev Siberian State University of Science and Technology Krasnoyarsky rabochy str.31Krasnoyarsk 660014Russia

"Warming hiatus" occurred in the AltaySayan Mountain Region, Siberia in c. 1997–2014. We analyzed evergreen conifer(EGC) stands area(satellite data) and trees(Siberian pine, Pinus sibirica Du Tour, Siberian fir, Abies sibirica Ledeb.) growth increment(dendrochronology data) response to climate variables before and during the hiatus. During the hiatus, EGC area increased in the highlands(>1000 m)(+30%), whereas at low and middle elevations(increase was observed on the rain-ward northwest slopes mainly. in highlands, EGC area increase mainly correlated with summer air temperature, whereas at low and middle elevations EGC area decrease correlated with drought index SPEi and vapor pressure deficit(VPD). EGC mortality(fir and Siberian pine) in lowland was caused by the synergy of water stress(inciting factor) and barkbeetle attacks(contributing factor). Tree growth increment(Gi) dynamics differs with respect to elevation. At high elevation(1700 m) Gi permanently increased since warming onset, whereas at the middle(900 m) and low elevations(450 m) Gi increased until c. 1983 yr. with followed depression. That Gi "breakpoint" occurred about a decade before hiatus onset. in spite of growth depression, during hiatus Gi was higher than that in pre-warming period. At high elevation, Gi positively responded to elevated June temperatures and negatively to moisture increase(precipitation, root zone moisture content, VPD, and SPEi). At low elevation Gi negatively responded to June temperatures and positively to moisture increase. For both, low and high elevation, these patterns persisted throughout the study period(1967–2014). On the contrary, at middle elevations Gi dependence on climate variables switch after breakpoint year(1983). Before breakpoint, June air temperature(positive correlation) and moisture(negative correlations) controlled Gi. Further temperature increase leads Gi depression and switched correlation signs

关键词： Growth increment Warming hiatus Warming impact Conifer decline Tree growth Tree mortality Conifer mortality Water stress

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