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黄麻链霉菌NF0919菌株发酵提取液HPLC检测分析及稳定性研究

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中国农学通报 2014年第33期30卷 145-149页

作者：张文文陈宏州杨敬辉吴琴燕庄义庆江苏丘陵地区镇江农业科学研究所江苏句容212400

采用HPLC法检测分析了黄麻链霉菌NF0919菌株发酵提取液的主要有效成分,以确定该发酵液的HPLC检测方法,采用菌丝生长速率法对不同处理条件下的发酵提取液进行抑菌活性测定,以确定该发酵提取液的稳定性。结果表明,在采用C18柱,波长305 nm... 详细信息

采用HPLC法检测分析了黄麻链霉菌NF0919菌株发酵提取液的主要有效成分,以确定该发酵液的HPLC检测方法,采用菌丝生长速率法对不同处理条件下的发酵提取液进行抑菌活性测定,以确定该发酵提取液的稳定性。结果表明,在采用C18柱,波长305 nm,甲醇与水梯度洗脱的条件下,所检测到的发酵提取液物质成分最多;该菌株发酵提取液对热、碱、紫外线的稳定性较差,对酸、光照均较稳定,在冰箱贮藏条件下,该菌株的发酵提取液稳定性较强,具有一定的研究开发价值。

关键词：黄麻链霉菌NF0919菌株 HPLC 稳定性生物活性

Long-term case-fatality rate of nontuberculous mycobacterial disease in people living with HIV

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Infectious Diseases of Poverty 2022年第1期11卷 47-55页

作者： Jingjing Hu Ling Gu Yueming Shao Renfang Zhang Tangkai Qi Jianjun Sun Zhenyan Wang Wei Song Yang Tang Jiangrong Wang Shuibao Xu Junyang Yang Yinzhong Shen Li Liu Jun chen hongzhou Lu School of Public Health Bengbu Medical CollegeBengbu233000AnhuiChina Department of Infectious Diseases and Immunology Shanghai Public Health Clinical CenterFudan University2901 Caolang RoadJinshan DistrictShanghai201508China Shenzhen Third People’s Hospital The Second Affiliated Hospital of Southern University of Science and TechnologyShenzhen518000China

Background:Few data are available regarding the long-term case-fatality rate(CFR)among people living with HIV(PLWH)with nontuberculous mycobacteria(NTM)*** aim of this study is to analyze the long-term CFR in patients with NTM disease and to identify risk factors for their ***:A retrospective cohort study of 379 cases of microbiologically confirmed NTM disease in PLWH was conducted from January 1,2012,to December 31,2020,in Shanghai,*** used Kaplan-Meier survival analysis and the log-rank test to compare the long-term CFR in patients with disseminated NTM(DNTM)and localized NTM *** Cox proportional hazards regression analysis and a stepwise Cox proportional hazards regression model were used to estimate the predictors of long-term ***:The cohort was followed up for a median of 26 *** total CFR was 15.7%by one year and increased to 22.6%at 5 years after the diagnosis of NTM *** 5-year CFR of PLWH with DNTM was significantly higher than that of PLWH with localized NTM(26.7%vs 19.6%for DNTM and localized NTM disease,respectively).Older age[hazard ratio(HR)=1.04,95%confidence interval(CI):1.02-1.06,P<0.001],comorbidity(HR=2.05,95%CI:1.21-3.49,P<0.01),DNTM(HR=2.08,95%CI:1.17-3.68,P<0.05),and HIV viral load(HR=1.32,95%CI:1.12-1.55,P<0.001)were all independent risk factors for long-term *** the subgroup analysis,time to culture positivity was negatively correlated with CFR in patients with DNTM(HR=0.90,95%CI:0.82-0.98,P<0.05).Conclusions:NTM was associated with a high long-term CFR in *** approaches to prevent NTM disease in PLWH are urgently needed.

关键词： HIV/AIDS Nontuberculous mycobacteria Case-fatality rate Risk factor

Immunological and metabolic characteristics of the Omicron variants infection

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Signal Transduction and Targeted Therapy 2023年第2期8卷 784-794页

作者： Jiejie Geng Xu Yang Kun Wang Ke Wang Ruo chen Zhi-Nan chen Chuan Qin Guizhen Wu Youchun Wang Ke Xu Peng Du Jiangning Liu Shirui chen Tao Zhang Xiuxuan Sun Ting Guo Ying Shi Zheng Zhang Ding Wei Peng Lin Qingyi Wang Jing Yuan Jiuxin Qu Jin Zou Yingxia Liu hongzhou Lu Ping Zhu Huijie Bian Liang chen Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital Fourth Military Medical UniversityXi’an 710032China Key Laboratory of Human Disease Comparative Medicine Chinese Ministry of HealthKey Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100871China MHC Key Laboratory of Biosafety National Institute for Viral Disease Control and Preven-tionChinese Center for Disease Control and PreventionBeijing 100871China Division of HIV/AIDS and Sex-transmitted Virus Vaccines Institute for Biological Product ControlNational Institutes for Food and Drug Control(NIFDC)and WHO Collaborating Center for Standardization and Evaluation of BiologicalsBeijing 102629China Beijing Institute of Biotechnology Beijing 100871China School of Basic Medicine Fourth Military Medical UniversityXi’an 710032China The Third People’s Hospital of Shenzhen Shenzhen 518112China School of Medicine Shanghai UniversityShanghai 200444China

The Omicron variants of SARS-CoV-2,primarily authenticated in November 2021 in South Africa,has initiated the 5th wave of global ***,we systemically examined immunological and metabolic characteristics of Omicron variants *** found Omicron resisted to neutralizing antibody targeting receptor binding domain(RBD)of wildtype *** could hardly be neutralized by sera of Corona Virus Disease 2019(COVID-19)convalescents infected with the Delta *** mass spectrometry on MHC-bound peptidomes,we found that the spike protein of the Omicron variants could generate additional CD8+T cell epitopes,compared with *** epitopes could induce robust CD8+T cell ***,we found booster vaccination increased the cross-memory CD8+T cell responses against *** regulome analysis of Omicron-specific T cell showed a metabolic profile that promoted the response of memory T ***,a greater fraction of memory CD8+T cells existed in Omicron stimulated peripheral blood mononuclear cells(PBMCs).In addition,CD147 was also a receptor for the Omicron variants,and CD147 antibody inhibited infection of ***147-mediated Omicron infection in a human CD147 transgenic mouse model induced exudative alveolar *** together,our data suggested that vaccination booster and receptor blocking antibody are two effective strategies against Omicron.

关键词： infection inhibited neutral

VOICE ACTIVITY DETECTION UNDER RAYLEIGH DISTRIBUTION

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Journal of Electronics(China) 2009年第4期26卷 552-556页

作者： Li Yu chen Jianming Tan hongzhou School of Information Science and Technology Sun Yat-Sen University Guangzhou 510275 China

This paper presents an improved Voice Activity Detection (VAD) algorithm which uses the Signal-to-Noise Ratio (SNR) measure. We assume that noise Power Spectral Density (PSD) in each spectral bin follows a Rayleigh distribution. Rayleigh distributions with its asymmetric tail charac- teristics give a better description of the noise PSD distribution than Gaussian distribution. Under this assumption, a new threshold updating expression is derived. Since the analytical integral of the false alarm probability, the threshold updating expression can be represented without the inverse comple- mentary error function and low computational complexity is achieved in our system. Experimental results show that the proposed VAD outperforms or at least is comparable with the VAD scheme presented by Davis under several noise environments and has a lower computational complexity.

关键词：瑞利分布检测语音积分表达式噪声环境功率谱密度计算复杂度计算复杂性

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嘧霉胺有机酸盐结构鉴定及其生物活性研究

广东化工 2016年第15期43卷 89-90,96页

作者：徐韶康于康平罗志会陈宏州张海军江苏耕耘化学有限公司江苏连云港222523 镇江农业科学研究所江苏句容212400

为研发新的杀菌剂,对新合成的萘乙酸嘧霉胺盐、萘氧乙酸嘧霉胺盐、醋酸嘧霉胺盐进行了结构鉴定,确定为目的产物;同时对化合物进行了生物活性测试,结果表明:三个化合物均有明显的病菌抑制活性,其中萘乙酸嘧霉胺盐对草莓灰霉病菌的抑制活... 详细信息

为研发新的杀菌剂,对新合成的萘乙酸嘧霉胺盐、萘氧乙酸嘧霉胺盐、醋酸嘧霉胺盐进行了结构鉴定,确定为目的产物;同时对化合物进行了生物活性测试,结果表明:三个化合物均有明显的病菌抑制活性,其中萘乙酸嘧霉胺盐对草莓灰霉病菌的抑制活性最强,EC50为9.0952μg/m L。

关键词：新杀菌剂化合物结构鉴定生物活性

小麦赤霉病菌对多菌灵和不同杀菌剂敏感性的相关分析

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农学学报 2016年第9期6卷 31-36页

作者：陈宏州肖婷许媛狄华涛马圣洲范婷杨敬辉江苏丘陵地区镇江农业科学研究所江苏句容212400 江苏农林职业技术学院江苏句容212400

为探明江苏省小麦赤霉病菌[Gibberella zeae(Schwein.)Petch]对多菌灵的抗药性和该药剂与其他杀菌剂的交互抗性,采用区分剂量法检测了采自江苏省26个县(市)的520株小麦赤霉病菌对多菌灵的抗药性,并采用菌丝生长速率法分别检测了对多菌... 详细信息

为探明江苏省小麦赤霉病菌[Gibberella zeae(Schwein.)Petch]对多菌灵的抗药性和该药剂与其他杀菌剂的交互抗性,采用区分剂量法检测了采自江苏省26个县(市)的520株小麦赤霉病菌对多菌灵的抗药性,并采用菌丝生长速率法分别检测了对多菌灵不同敏感性的10个菌株对嘧菌酯、吡唑醚菌酯、肟菌酯、唑胺菌酯、氟环唑、己唑醇、灭菌唑和咯菌腈等杀菌剂的敏感性。结果表明:江苏省各县(市)菌株对多菌灵的抗性频率差异较大,总抗性频率为50.58%;通过EC_(50)值相关性分析,小麦赤霉病菌对多菌灵和上述杀菌剂之间不存在交互抗性。江苏省小麦赤霉病菌对多菌灵的抗性频率较高,迫切需要筛选新的杀菌剂防治小麦赤霉病。

关键词：小麦赤霉病菌多菌灵抗药性交互抗性

Comparison and Analysis of Tidal Level Monitoring Accuracy between GNSS-IR and Satellite Altimetry

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Comparison and Analysis of Tidal Level Monitoring Accuracy b...

LOGIC STRUCTURE OF PROGRAMMABLE INSTRUCTIONS FOR JAVA PROCESSORS

第十四届中国卫星导航年会

作者： Naiquan Zheng hongzhou Chai Zhiyuan An Peng chen Lingqiu chen Lixia Liu Institute of Geospatial Information PLA Information Engineering University College of Geomatics Xi'an University of Science and Technology The First Geographic Information Mapping Institute Ministry of Natural Resources

The coexistence of multiple methods has become a general trend in tidal level monitoring, especially the Global Navigation Satellite System Interferometric Reflectometry(GNSS-IR) technology and satellite altimetry technology provide a richer database for sea level monitoring. Few studies have carried out the comparison of tidal level accuracy obtained by the two *** on this, this study takes BUR2 station as an example to carry out the research on tidal level monitoring of GNSS-IR and satellite altimetry(HY-2B and Jason-3), and compares them with the measured tidal level data provided by the tidal gauge station(BURTG). First, unify the respective time bases to Coordinated Universal Time(UTC) and the elevation base to Tide Gauge Zero(TGZ). Then, the characteristics of the two methods to monitor the tidal level are compared and analyzed. GNSS-IR technology has higher temporal resolution(R: 0.957, RMSE: 0.257 m, ME:-0.008 m, Number: 73936), while HY-2B(R: 0.994, RMSE: 0.105 m, ME: 0.025 m, Number: 178) and Jason-3(R: 0.995, RMSE: 0.113 m, ME:-0.040 m, Number: 461) have higher inversion accuracy. This study explored the respective characteristics of GNSS-IR technology and satellite altimetry technology for tidal level monitoring, laying a foundation for the subsequent integration of tidal level monitoring.

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Journal of Electronics(China) 2009年第5期26卷 711-714页

作者： chen Zhirui Tan hongzhou School of Information Science and Technology Sun Yat-Sen University Guangzhou 510005 China

There are varieties of embedded systems in the world. It is a big challenge to optimize the instruction sets of System on Chips (SoCs) according to different systems' working environments. The idea of programmable instruction set is an effective method to gain embedded system's re-configurability. This letter presents a logic module for Java processor to be capable of using programmable instruction set. Cost (area, power, and timing) of the module is trivial. Such module is also reusable for other embedded system solutions besides Java systems.

关键词： Java处理器可编程逻辑结构嵌入式系统嵌入式Java 系统工作环境可重复使用指令集

西藏色林错国家级自然保护区鸟类区系和多样性

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绵阳师范学院学报 2021年第8期40卷 57-63页

作者：唐敏廖家红覃海芬赵振坤钱前杨凯霖陈红州毛世平谢坤军陈哲宇陈伟绵阳师范学院生态安全与保护四川省重点实验室四川绵阳621006 西藏那曲市林业和草原局西藏那曲852000 四川农业大学理学院四川雅安625014

为了解高海拔地区西藏色林错国家级自然保护区的鸟类区系及其多样性,2019年8月至2020年7月,采用样点法、样线法和文献查阅法,对该保护区的鸟类进行了调查.结果表明:该区域共有鸟类14目30科101种.在分类组成上,雀形目Passerines鸟类最多... 详细信息

为了解高海拔地区西藏色林错国家级自然保护区的鸟类区系及其多样性,2019年8月至2020年7月,采用样点法、样线法和文献查阅法,对该保护区的鸟类进行了调查.结果表明:该区域共有鸟类14目30科101种.在分类组成上,雀形目Passerines鸟类最多(10科41种),其次为鸻形目Charadriiformes鸟类(5科14种);鹈形目Pelletiformes、沙鸡目Sassafeans、鹃形目Rhododendrons和佛法僧目Coraciiformes鸟类数量最少;在物种区系组成方面,古北界种物种最多(70种),广布种其次(26种),东洋界种最少(5种);在居留型组成中,以留鸟种类为主(44种),夏候鸟较多(40种),旅鸟其次(10种),冬候鸟较少(7种);物种保护与濒危等级构成中,国家Ⅰ级保护物种有6种;国家Ⅱ级保护物种有13种;列入CITES(2019)附录Ⅰ和Ⅱ分别有4种和16种;列入IUCN(2020)濒危(EN)的有3种.

关键词：西藏色林错国家自然保护区鸟类区系鸟类多样性保护等级