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Single-cell transcriptomic profiling of the hypothalamic median eminence during aging

Journal of Genetics and Genomics 2022年第6期49卷 523-536页

作者： Zhen-Hua Chen Si Li Mingrui Xu Candace CLiu hongying ye Ben Wang Qing-Feng Wu State Key Laboratory of Molecular Development Biology Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100101China Department of Pathology Stanford University School of MedicineStanfordCA 94305USA Department of Endocrinology and Metabolism Huashan HospitalFudan UniversityShanghai 200040China Department of Obstetrics and Gynecology Baoding Second Central HospitalBaodingHebei 072750China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesBeijing 100101China Chinese Institute for Brain Research Beijing 102206China Beijing Children’s Hospital Capital Medical UniversityBeijing 100045China

Aging is a slow and progressive natural process that compromises the normal functions of cells,tissues,organs,and *** aging of the hypothalamic median eminence(ME),a structural gate linking neural and endocrine systems,may impair hormone release,energy homeostasis,and central sensing of circulating molecules,leading to systemic and reproductive ***,the molecular and cellular features of ME aging remain largely ***,we describe the transcriptional landscape of young and middleaged mouse ME at single-cell resolution,revealing the common and cell type-specific transcriptional changes with *** transcriptional changes in cell-intrinsic programs,cell-cell crosstalk,and cellextrinsic factors highlight five molecular features of ME aging and also implicate several potentially druggable targets at cellular,signaling,and molecular ***,our results suggest that vascular and leptomeningeal cells may lead the asynchronized aging process among diverse cell types and drive local inflammation and cellular senescence via a unique ***,our study uncovers how intrinsic and extrinsic features of each cell type in the hypothalamic ME are changed by the aging process,which will facilitate our understanding of brain aging and provide clues for efficient anti-aging intervention at the middle-aged stage.

关键词： Hypothalamic median eminence Single-cell transcriptomic analysis Vascular and leptomeningeal cells Aging

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Lactylation-driven METTL3-mediated RNA m6A modification promotes immunosuppression of tumor-infiltrating myeloid cells

Lactylation-driven METTL3-mediated RNA m6A modification prom...

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第十四届全国免疫学学术大会

作者： Jia Xiong Jia He Jiongli Pan Weijie Liao hongying ye Qingqing Wang Institute of Immunology Zhejiang University

Tumor-infiltrating myeloid cells( TIMs) are crucial cell populations involved in tumor immune escape, and their immunosuppressive functions are regulated by multiple epigenetic mechanisms. RNA N-methyladenosine(mA) modification has been shown to regulate tumor progression. Our study revealed that RNA methyltransferase methyltransferase-like 3(METTL3) promotes mA modification of phosphokinase Janus kinase 1(JAK1) mRNA in TIMs. The mA-YTH N-methyladenosine RNA-binding protein 1( YTHDF1) axis enhances its protein translation efficiency in polysomes. JAK1 significantly contributes to the phosphorylation of the signal transducer and activator of transcription 3(STAT3) and further nuclear translocation, which potently initiates the transcription of downstream genes that are responsible for the immunosuppressive functions of TIMs. Furthermore, we found that lactate accumulated in the tumor microenvironment promotes the expression of METTL3 in TIMs in the form of histone H3K18 lactylation. Interestingly, we also identified two lactylation modification sites in the Cys-Cys-Cys-His(CCCH) zinc finger domain of METTL3 and this type of lysine lactylation is essential for the target recognition domain of METTL3 to capture target RNA. Taken together, our study reveals that lactylation-driven METTL3-mediated RNA mA modification promotes the immunosuppressive function of TIMs.

关键词： METTL3 m~6A Tumor-infiltrating myeloid cells lactate lactylation JAK-STAT

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糖皮质激素对血糖的影响及其处理

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中华糖尿病杂志 2021年第1期13卷 1-4页

作者：叶红英李益明复旦大学附属华山医院内分泌科上海200040

外源性糖皮质激素(GC)摄入过多及内源性GC分泌过多均有可能通过多种机制引起血糖不同程度升高。使用外源性GC后的血糖监测方案和类固醇糖尿病的降糖方案均需考虑其午后血糖升高为主的特点。要充分了解GC所致糖代谢异常的特点和临床筛查... 详细信息

外源性糖皮质激素(GC)摄入过多及内源性GC分泌过多均有可能通过多种机制引起血糖不同程度升高。使用外源性GC后的血糖监测方案和类固醇糖尿病的降糖方案均需考虑其午后血糖升高为主的特点。要充分了解GC所致糖代谢异常的特点和临床筛查评估策略,采取恰当方式进行处理,才能达到较好的治疗效果。

关键词：糖皮质激素类血糖

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维普期刊数据库

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Clinical features of patients with pituitary stalk thickening: a review of 159 cases from one medical center

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Chinese Neurosurgical Journal 2017年第2期3卷 83-90页

作者： Yanjiao Cai Xuefei Shou Zhaoyun Zhang hongying ye Yao Zhao Yongfei Wang Rong Xie Shiqi Li Yiming Li Department of Endocrinology and Metabolism Huashan Hospital Shanghai Medical College Fudan University 12 Wulumuqi Zhong Road Shanghai 200040 China Department of Neurosurgery Huashan Hospital Shanghai Medical College Fudan University 12 Wulumuqi Zhong Road Shanghai 200040 China

Background:Pituitary stalk thickening (PST) used as an imaging diagnosis plays a major role in diagnosis and treatment of the hypothalamus and pituitary disease at an early *** until now,several lines of systematic investigations have been conducted among adolescents,and the results indicated that PST is possibly one of the principal early manifestations of sellar region *** characterize the major clinical features of PST and to identify the most effective treatments we conducted this ***:This was a retrospective review of patients with PST evaluated at Huashan Hospital over an eight-year period between 2007 and *** hundred fifty nine patients who were diagnosed PST were *** data including demographics,clinical presentations,imaging examinations,laboratory results and surgery were thoroughly reviewed and carefully *** to their clinical presentations and examinations,relevant treatments were adopted and different prognosis were ***:Of the 159 patients,57 were males and 102 were females (median age was 29 and 43.4％ were under the age of 21 years).And of the patients in the age group between 30 and 35 years,84％ were females.'Polydipsia and polyuria' was the most common clinical manifestation observed in 90 cases (＞50％).49.5％ of the patients were diagnosed to have at least one anterior pituitary *** sellar region MRI (SR-MRI) data showed that patients who had different clinical presentations or pituitary function showed different SR-MRI *** 60％ patients who performed followup MRI showed shrunken *** cases who received radiotherapy appeared to be improved as shown by ***:PST is most commonly seen in the teenagers and the women of reproductive *** etiology may be identified based on the clinical manifestations,age and SR-MRI,which would help to make the final decision for *** and immuno-suppressed therapy are effective in alleviating clin

关键词： Pituitary stalk thickening Central diabetes insipidus Hypopituitarism Radiotherapy Immuno-suppressed therapy

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Constraint-based Algorithm for Slab Sequencing Problem

Constraint-based Algorithm for Slab Sequencing Problem

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第二十六届中国控制会议

作者： Guo Dongfen,ye hongying Shijiazhuang Post and Telecommunication Technical College,Shijiazhuang 050021,P.R.China

Slab sequencing problem is an NP-hard problem with complex side *** this paper,slab sequencing problem is modeled as a constraint satisfaction problem.A constraint-based algorithm is proposed to solving this *** the solving procedure,domains of the variables are firstly preprocessed by using consistency technology to prune the search space;the solution is secondly constructed by the dynamic variable selection and value selection algorithm,when a variable is instantiated,the constraint propagation is triggered,domains of the unscheduled variables are filtered and the subtours are dynamically *** sequence is further adjusted by a modified 2-opt exchange to improve the solution *** validity of the proposed algorithm is demonstrated by the simulation experiment.

关键词： Slab sequencing Constraint satisfaction problem Constraint propagation

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溶出伏安法连续测定粮油制品中营养强化剂锌和铁

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理化检验（化学分册） 2000年第9期36卷 398-399页

作者：吴本复叶红鹰赵道辉福建省粮油科学技术研究所福州350002 福州市粮食局福建省卫生防疫站

研究了在 p H4.8介质中 ,锌和铁在 HOAc- Na OAc底液中各产生一个灵敏吸附波的最佳条件。应用于连续测定粮油制品中强化剂锌和铁含量 ,方法简便、快速 ,灵敏度。

关键词：锌铁溶出伏安法测定粮油制品营养强化剂

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The Effects of Thyroid Hormones on Brown Adipose Tissue in Humans

The Effects of Thyroid Hormones on Brown Adipose Tissue in H...

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中华医学会第十二次全国内分泌学学术会议

作者： Qing Miao hongying ye Qiongyue Zhang Zhaoyun Zhang Chuantao Zuo Shuo Zhang Wanzhu Jin Yihui Guan Yiming Li Division of Endocrinology and Metabolism Huashan HospitalDepartment of Internal MedicineShanghai Medical CollegeFudan University Division of Endocrinology and Metabolism Huashan HospitalDepartment of Internal MedicineShanghai Medical CollegeFudan University PET Center Division of Nuclear MedicineHuashan HospitalDepartment of RadiologyShanghai Medical CollegeFudan University The Key Laboratory of Animal Ecology and Conservation Biology Institute of ZoologyChinese Academy of Sciences

Aims/hypothesis Brown adipose tissue(BAT)is important for energy expenditure through thermogenesis,although its regulatory factors are not well known in *** is evidence suggesting that thyroid hormones affect BAT func...

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病情反复的特发性肉芽肿性垂体炎疗效分析

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中华内分泌代谢杂志 2022年第5期38卷 430-432页

作者：张烁苗青程海霞叶红英复旦大学附属华山医院内分泌科上海200040 复旦大学附属华山医院病理科上海200040

通过回顾分析3例病理确诊的病情反复的肉芽肿性垂体炎患者起病时临床表现、实验室和影像学特点及术后治疗方案和疗效,总结、分析、讨论病情反复的肉芽肿性垂体炎临床特点和治疗方案及疗效,以提高对其认识,提供可借鉴的治疗经验。3例患... 详细信息

通过回顾分析3例病理确诊的病情反复的肉芽肿性垂体炎患者起病时临床表现、实验室和影像学特点及术后治疗方案和疗效,总结、分析、讨论病情反复的肉芽肿性垂体炎临床特点和治疗方案及疗效,以提高对其认识,提供可借鉴的治疗经验。3例患者分别因头痛、视物模糊、中枢性尿崩症就诊,MRI发现鞍区或垂体柄占位,行大部切除或活检术后症状未完全缓解而使用糖皮质激素治疗可控制症状和病灶,但激素减量后复发。2例联合硫唑嘌呤治疗后有效控制,其中1例停药后随访14个月未见复发,1例仍在治疗中。因此对于术后症状未缓解,糖皮质激素减量后病情反复的患者,联合免疫抑制剂硫唑嘌呤的方案或可达到满意疗效和预后。

关键词：肉芽肿性垂体炎硫唑嘌呤糖皮质激素

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Recovery of HPA axis function after successful gonadotropin-induced pregnancy and delivery in a woman with panhypopituitarism

Recovery of HPA axis function after successful gonadotropin-...

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中华医学会第十二次全国内分泌学学术会议

作者： Yi Wang Qiongyue Zhang Jianzhi Yang Xiaolong Zhao Min He Xuefei Shou Shiqi Li Yiming Li Yongfei Wang hongying ye Department of Endocrinology and Metabolism Huashan HospitalFudan University Assistant Reproductive Technology Center First Maternity and Infant Health Hospital Tongji University Department of Nerosurgery Huashan HospitalFudan University

Context Hypopituitarism is defined as the partial or complete defect of anterior pituitary hormone secretion,may result from pituitary macroadenoma or other sella region tumors,also not rare after pituitary *** with h...

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重庆市中职教师队伍建设现状、问题与对策

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职业技术教育 2008年第34期29卷 42-46页

作者：叶红英重庆教育学院继续教育学院重庆400067

调查表明,2003～2007年,随着中等职业教育规模的发展,重庆市中职教师数量也有了一定程度的增长,但重庆市中职师资队伍建设仍面临经费支持不足、管理体制不顺、教师数量不足、"双师型"教师缺乏、教师素质不高、培训体系不完善等问题。为... 详细信息

调查表明,2003～2007年,随着中等职业教育规模的发展,重庆市中职教师数量也有了一定程度的增长,但重庆市中职师资队伍建设仍面临经费支持不足、管理体制不顺、教师数量不足、"双师型"教师缺乏、教师素质不高、培训体系不完善等问题。为此,重庆市可采取以下对策:更新观念,加强组织领导和条件保障;改革管理体制;多渠道补充教师队伍;实施中职教师素质提升工程;完善教师培训体系。

关键词：中等职业学校师资队伍建设重庆

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