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Cyclic arginine-glycine-aspartic acid-modified red blood cells for drug delivery:Synthesis and in vitro evaluation

Journal of Pharmaceutical Analysis 2022年第2期12卷 324-331页

作者： Chen Wang Min Wang Yan Zhang hongxin jia Binbin Chen Department of Pharmaceutics School of PharmacyXiamen Medical CollegeXiamenFujian361023China Institute of Respiratory Diseases Xiamen Medical CollegeXiamenFujian361023China Department of Pharmaceutics School of PharmacyHarbin University of CommerceHarbin150076China Department of Pharmacy Xiamen Xianyue HospitalXiamenFujian361012China

Red blood cells(RBCs)are an excellent choice for cell preparation research because of their biocompatibility,high drug loading,and long half-life.In this study,doxorubicin(DOX)was encapsulated with RBCs as the carrier.The biotin-avidin system binding principle was used to modify biotinylated cyclic arginine-glycine-aspartic acid(cRGD)onto RBC surfaces for accurate targeting,high drug loading,and sustained drug release.The RBC drug delivery system(DDS)was characterized,and the concentration of surface sulfur in the energy spectrum was 6.330%.The physical and chemical properties of RBC DDS were as follows:drug content,0.857 mg/mL;particle size,3339 nm;potential value,12.5 mV;and cumulative release rate,81.35%.There was no significant change in RBC morphology for up to seven days.The results of the targeting and cytotoxicity studies of RBC DDS showed that many RBCs covered the surfaces of U251 cells,and the fluorescence intensity was higher than that of MCF-7 cells.The IC50 value of unmodified drug-loaded RBCs was 2.5 times higher than that of targeted modified drug-loaded RBCs,indicating that the targeting of cancer cells produced satisfactory inhibition.This study confirms that the RBC DDS has the characteristics of accurate targeting,high drug loading,and slow drug release,which increases its likelihood of becoming a clinical cancer treatment in the future.

关键词： Cytotoxicity Red blood cells Drug delivery Targeting

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Synthesis and evaluation of peptide-fentanyl analogue conjugates as dualμ/δ-opioid receptor agonists for the treatment of pain

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Chinese Chemical Letters 2022年第8期33卷 4107-4110页

作者： Jing Li Tao Zhang jialin Sun Fengxia Ren hongxin jia Zixing Yu Jingchao Cheng Weiguo Shi State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and ToxicologyBeijing 100850China School of Chemical Engineering and Technology Tianjin UniversityTianjin 300350China

Novel peptide-fentanyl analogue conjugates were synthesized by the covalent coupling of carfentanyl derivatives to the C-terminus or N-terminus of the conformationally constrained dermorphin tetrapeptide BVD03 via a chemical linker.The carfentanyl-related analogues displayed distinct binding and functional activities atμ/δopioid receptors(MOR/DOR)and antinociceptive effects when conjugated to the peptide.The most potent compound,SW-LJ-11,displayed mixed MOR/DOR agonist properties in the low nanomolar range and significant analgesic efficacy in vivo in four classic mouse models of pain.Interestingly,SW-LJ-11 did not exhibit any physical dependence or respiratory depression,in contrast to an equipotent analgesic dose of morphine or BVD03,indicating that the use of opioid peptide-fentanyl analogue conjugates as dual MOR/DOR agonists may be a promising strategy for obtaining safer opioids.

关键词： Peptide-small molecule conjugates Dual MOR/DOR agonists Lead compound Analgesics Physical dependence

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富含鱼油乳粉贮藏过程中糠醛类化合物及其挥发性成分变化研究

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中国乳品工业 2023年第12期51卷 20-23页

作者：贾宏信乳业生物技术国家重点实验室、上海乳业生物工程技术研究中心、光明乳业股份有限公司乳业研究院上海200436

将富含鱼油乳粉37℃加速贮藏3个月,以糠醛类化合物及挥发性成分为评价指标,评价乳粉贮藏过程中糠醛类化合物及其挥发性成分的变化。结果表明,4种乳粉(鱼油粉添加量分别为0、0.5、1.0和1.5 g/100 g)贮藏过程中,鱼油粉添加量1.0 g/100 g... 详细信息

将富含鱼油乳粉37℃加速贮藏3个月,以糠醛类化合物及挥发性成分为评价指标,评价乳粉贮藏过程中糠醛类化合物及其挥发性成分的变化。结果表明,4种乳粉(鱼油粉添加量分别为0、0.5、1.0和1.5 g/100 g)贮藏过程中,鱼油粉添加量1.0 g/100 g的乳粉其糠醛类化合物在贮藏过程中更稳定;且鱼油粉添加量越高其挥发性有机物丙酮、丁酮的含量越高,而对于贮藏过程中戊醛和己醛的含量变化,n-6多不饱和脂肪酸占多不饱和脂肪酸越高的乳粉(鱼油粉添加量越低的乳粉)其戊醛和己醛的变化增幅越高。添加鱼油粉会影响乳粉贮藏过程中糠醛类化合物及挥发性有机物的变化,且这种变化与鱼油的添加量有关,添加中剂量鱼油粉(鱼油粉添加量1.0 g/100 g)乳粉的稳定性越高。

关键词：乳粉稳定性鱼油羟甲基糠醛糠醛挥发性有机物

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Two-dimensional ballistic transistors for advanced-node integrated circuits

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National Science Review 2024年第3期11卷 9-10页

作者： jia Li Xidong Duan Hunan Provincial Key Laboratory of Two-Dimensional Materials State Key Laboratory for Chemo/Biosensing and Chemometrics College of Chemistry and Chemical Engineering Hunan University

As the feature size of metal-oxide-semiconductor-field-effect-transistors(MOSFETs) in integrated circuits(ICs)is reduced to sub-10-nm, the traditional channel materials are plagued by enhanced scattering and short-cha... 详细信息

关键词： CONTACT

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Facile synthesis of transition metal complexes with five coplanar metal-carbon σ-bonds

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National Science Review 2024年第4期11卷 11-12页

作者： Guocheng jia Department of Chemistry Hong Kong University of Science and Technology

Carbon is one of the most important elements in chemistry, forming a vast number of organic compounds. It can also form a variety of organometallic compounds with a metal–carbon bond. Metal alkyl, carbene and carbyne complexes are classical examples of organometallic compounds. A particularly interesting class of organometallic compounds are all-carbon metallacycles formed by combination of a metal and a hydrocarbon chain serving as a chelating agent with only carbon atoms as the donor atoms. Many interesting monocyclic metallacycles made of a chelating bidentate hydrocarbon chain are known, for example, metallacyclobutadienes, metallacyclopentadienes and metallabenzenes[1].

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Perenniality:From model plants to applications in agriculture

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Molecular Plant 2024年第1期17卷 141-157页

作者： Bo Zhao jia-Wei Wang National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant Sciences(CEMPS)Institute of Plant Physiology and Ecology(SIPPE)Chinese Academy of Sciences(CAS)Shanghai 200032China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China Key Laboratory of Plant Carbon Capture CASShanghai 200032China New Cornerstone Science Laboratory Shanghai 200032China

To compensate for their sessile nature,plants have evolved sophisticated mechanisms enabling them to adapt to ever-changing environments.One such prominent feature is the evolution of diverse life history strategies,particularly such that annuals reproduce once followed by seasonal death,while perennials live longer by cycling growth seasonally.This intrinsic phenology is primarily genetic and can be altered by environmental factors.Although evolutionary transitions between annual and perennial life history strategies are common,perennials account for most species in nature because they survive well under year-round stresses.This proportion,however,is reversed in agriculture.Hence,perennial crops promise to likewise protect and enhance the resilience of agricultural ecosystems in response to climate change.Despite significant endeavors that have been made to generate perennial crops,progress is slow because of barriers in studying perennials,and many developed species await further improvement.Recent findings in model species have illustrated that simply rewiring existing genetic networks can lead to lifestyle variation.This implies that engineering plant life history strategy can be achieved by manipulating only a few key genes.In this review,we summarize our current understanding of genetic basis of perenniality and discuss major questions and challenges that remain to be addressed.

关键词： perenniality developmental plasticity flowering time poplar Arabis alpina perennial crops life history strategy

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新型复式钢管混凝土墩柱轴压受力机理分析及承载力计算

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工业建筑 2022年第12期52卷 128-135,155页

作者：张玉芬张燕贾宏鑫河北工业大学土木与交通学院天津300401

综合圆钢管和矩形单钢管对混凝土的约束效果,提出矩形内配异心双圆的复式钢管混凝土新型墩柱,首先基于极限平衡理论,将组合柱分成考虑长短边变形屈服差异的矩形外钢管、外钢管约束的夹层混凝土和内部圆钢管混凝土三部分,推导出新型墩柱... 详细信息

综合圆钢管和矩形单钢管对混凝土的约束效果,提出矩形内配异心双圆的复式钢管混凝土新型墩柱,首先基于极限平衡理论,将组合柱分成考虑长短边变形屈服差异的矩形外钢管、外钢管约束的夹层混凝土和内部圆钢管混凝土三部分,推导出新型墩柱的轴压承载力计算式。其次利用ABAQUS对墩柱进行三维精细有限元分析,得到新型复式钢管混凝土墩柱和矩形单钢管混凝土轴压短柱的破坏形态和轴压极限承载力,均与试验结果吻合较好;然后分析了新型墩柱构件各部分全过程受力机理,并研究混凝土抗压强度、钢管屈服强度、内钢管同含钢率时直径变化、内钢管径厚比、外钢管宽厚比等参数对该类新型墩柱的极限承载力影响。结果表明:轴压极限承载力随混凝土抗压强度、钢管屈服强度增加而提高,随外钢管宽厚比增加而降低;当内钢管含钢率相同时,内钢管直径增大对内层混凝土约束增强,故墩柱的极限承载力提高,但当内钢管直径增大到一定程度时(约2/3外钢管宽度)对轴压极限承载力影响则不大。复式钢管混凝土墩柱轴压承载力计算结果与有限元模拟值相近,两者比值平均为0.923,比值的均方差为0.046。

关键词：矩形钢管混凝土极限平衡理论轴压受力机理分析承载力

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A prognostic four-gene signature and a therapeutic strategy for hepatocellular carcinoma:Construction and analysis of a circRNA-mediated competing endogenous RNA network

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Hepatobiliary & Pancreatic Diseases International 2024年第3期23卷 272-287页

作者： Hai-Yan Zhang jia-Jie Zhu Zong-Ming Liu Yu-Xuan Zhang jia-jia Chen Ke-Da Chen Zhejiang Chinese Medical University Hangzhou 310053China Shulan International Medical College Zhejiang Shuren UniversityHangzhou 310015China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious DiseasesNational Medical Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China

Background:Hepatocellular carcinoma(HCC)has a poor long-term prognosis.The competition of circular RNAs(circRNAs)with endogenous RNA is a novel tool for predicting HCC prognosis.Based on the alterations of circRNA regulatory networks,the analysis of gene modules related to HCC is feasible.Methods:Multiple expression datasets and RNA element targeting prediction tools were used to construct a circRNA-microRNA-mRNA network in HCC.Gene function,pathway,and protein interaction analyses were performed for the differentially expressed genes(DEGs)in this regulatory network.In the proteinprotein interaction network,hub genes were identified and subjected to regression analysis,producing an optimized four-gene signature for prognostic risk stratification in HCC patients.Anti-HCC drugs were excavated by assessing the DEGs between the low-and high-risk groups.A circRNA-microRNA-hub gene subnetwork was constructed,in which three hallmark genes,KIF4A,CCNA2,and PBK,were subjected to functional enrichment analysis.Results:A four-gene signature(KIF4A,CCNA2,PBK,and ZWINT)that effectively estimated the overall survival and aided in prognostic risk assessment in the The Cancer Genome Atlas(TCGA)cohort and International Cancer Genome Consortium(ICGC)cohort was developed.CDK inhibitors,PI3K inhibitors,HDAC inhibitors,and EGFR inhibitors were predicted as four potential mechanisms of drug action(MOA)in high-risk HCC patients.Subsequent analysis has revealed that PBK,CCNA2,and KIF4A play a crucial role in regulating the tumor microenvironment by promoting immune cell invasion,regulating microsatellite instability(MSI),and exerting an impact on HCC progression.Conclusions:The present study highlights the role of the circRNA-related regulatory network,identifies a four-gene prognostic signature and biomarkers,and further identifies novel therapy for HCC.

关键词： Hepatocellular carcinoma circRNA-related ceRNA network Biomarker Least absolute shrinkage and selection operator Bioinformatics

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Extending Structures for Gel'fand-Dorfman Bialgebras

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Acta Mathematica Sinica,English Series 2024年第2期40卷 619-638页

作者： jia jia WEN Yan Yong HONG School of Mathematics Hangzhou Normal UniversityHangzhou 311121P.R.China

Gel'fand-Dorfman bialgebra,which is both a Lie algebra and a Novikov algebra with some compatibility condition,appeared in the study of Hamiltonian pairs in completely integrable systems.They also emerged in the description of a class special Lie conformal algebras called quadratic Lie conformal algebras.In this paper,we investigate the extending structures problem for Gel'fand-Dorfman bialgebras,which is equivalent to some extending structures problem of quadratic Lie conformal algebras.Explicitly,given a Gel'fand-Dorfman bialgebra(A,o,[.,.]),this problem is how to describe and classify all Gel'fand-Dorfman bialgebra structures on a vector space E(A⊂E)such that(A,o,[.,.])is a subalgebra of E up to an isomorphism whose restriction on A is the identity map.Motivated by the theories of extending structures for Lie algebras and Novikov algebras,we construct an object gH2(V,A)to answer the extending structures problem by introducing the notion of a unified product for Gel'fand-Dorfman bialgebras,where V is a complement of A in E.In particular,we investigate the special case when dim(V)=1 in detail.

关键词： Gel'fand-Dorfman bialgebra Lie conformal algebra Extending structures problem Novikovalgebra

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Large isolated fibrous tumors in the upper esophagus: A case report

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 543-549页

作者： jia-jia Yu Huan-Shuang Pei Yu Meng Department of Anesthesiology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Solitary fibrous tumors(SFT)are rare spindle cell tumors that are usually benign.A total of 10 cases of SFTs in the upper esophagus have ever been reported.Here,we report the anesthetic management of a patient with a large isolated fibrous tumor of the upper esophagus compressing the tracheal membrane.We also provide a literature review of the current research.CASE SUMMARY We report the case of a 49 year old male with“cough aggravation and wheezing after exercise”,who underwent esophagectomy for a large isolated fibrous tumor compressing the tracheal membrane in the upper esophagus.We advise the use of a single-lumen tube with a blocker in patients with difficult airways to reduce the incidence of airway injury and fibrinoscopy at all stages of the perioperative period to guide airway management.This case study is the first report of the anesthetic management of a large,isolated fibrous tumor compressing the tracheal membrane in the upper esophagus.CONCLUSION This rare case emphasizes the importance of perioperative management of anesthesia in patients with large isolated fibrous tumors of the upper esophagus that compress the tracheal membrane.The use of blocker reduce the incidence of airway injury and fibrinoscopy at the perioperative period to guide airway mana-gement.

关键词： Upper esophagus Isolated fibrous tumor Tracheal membrane Peak airway pressure Case report

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