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P-wave Velocity Structure of Crustal and Upper Mantle beneath South China and its Tectonic Implications

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Acta Geologica Sinica(English Edition) 2022年第2期96卷 621-630页

作者： ZHENG hongwei LI Tingdong HE Rizheng YU Haiying YANG Hui WEN Yanlin WANG Peng LIU fang SUN Dongjun Institute of Geology Chinese Academy of Geological SciencesBeijing 100037China Shanghai Sheshan National Geophysical Observatory Shanghai 200062China Chinese Academy of Geological Sciences Beijing 100037China Institute of Geophysics China Earthquake AdministrationBeijing 100081China

The 3D P-wave velocity structure beneath the South China Block was determined by applying arrival times from 269 teleseismic events recorded by 240 seismic stations within the study region. Our tomographic results reveal the deep structural characteristics of major tectonic units and ore concentration areas. There are distinct high velocity anomalies beneath the ancient Yangtze and Cathaysia blocks, with the lithosphere of the Cathaysia Block being thinner than the Yangtze Block;the Jiangnan orogenic belt, located in the combined zone of two blocks, is a high and low velocity anomaly conversion zone;the famous metallogenic belts of Edongnan, the Youjiang Basin and the Cathaysia Block are obviously low velocity areas with different metallogenic mechanisms. The deep ore-forming material source in the Edongnan metallogenic belt is different from that of the Cathaysia Block. The low velocity anomaly under the Cathaysia Block related to mineralization results from the upwelling of mantle material, caused by the joint action of the Paleo-Tethys tectonic domain, the Paleo-Pacific tectonic domain and the Hainan mantle plume migration and erosion, which has been occurring from northeast to southwest since 80 Ma. The low-temperature mineralization mechanism of Youjiang Basin should be considered not only in terms of the influence of the Emeishan mantle plume in the west and the Paleo-Tethys tectonic domain in the south, but also in the context of the influence of the upwelling of asthenospheric material from the PaleoPacific tectonic domain in the east.

关键词： mineralization tomographic images lithosphere structure Youjiang Basin South China

Neuronal NR4A1 deficiency drives complement-coordinated synaptic stripping by microglia in a mouse model of lupus

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Signal Transduction and Targeted Therapy 2022年第3期7卷 840-855页

作者： Xiaojuan Han Tianshu Xu Congzhu Ding Dandan Wang Genhong Yao hongwei Chen Qijun fang Gang Hu Lingyun Sun Department of Rheumatology and Immunology Department of Traditional Chinese MedicineNanjing Drum Tower Hospital Clinical College of Traditional Chinese and Western MedicineNanjing University of Chinese MedicineNanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjingChina Department of Traditional Chinese Medicine Nanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjingChina Department of Rheumatology and Immunology Nanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjingChina Department of Pharmacology Nanjing University of Chinese MedicineNanjingJiangsuChina

Neuropsychiatric lupus(NPSLE)is a frequent manifestation of systemic lupus erythematosus(SLE)that occurs in 40-90%of SLE patients;however,the underlying mechanisms remain elusive,causing a severe lack of therapeutic targets for this ***,we show that complement-coordinated elimination of synapses participated in NPSLE in MRL/lpr mice,a lupus-prone murine *** demonstrated that lupus mice developed increased anxiety-like behaviors and persistent phagocytic microglial reactivation before overt peripheral lupus pathology.

关键词： lupus coordinated pathology

近20年来我国沉积物环境与污染控制研究进展与展望

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地球科学进展 2021年第4期36卷 346-374页

作者：范成新刘敏王圣瑞方红卫夏星辉曹文志丁士明侯立军王沛芳陈敬安游静王菊英盛彦清朱伟中国科学院南京地理与湖泊研究所湖泊与环境国家重点实验室江苏南京210008 地理信息科学教育部重点实验室华东师范大学地理科学学院上海200240 北京师范大学珠海校区水科学研究中心粤港水安全保障联合实验室广东珠海519087 清华大学水沙科学与水利水电工程国家重点实验室北京100084 北京师范大学水沙科学教育部重点实验室北京100875 厦门大学环境与生态学院福建厦门361102 华东师范大学地理科学学院上海200240 河海大学浅水湖泊综合治理与资源开发教育部重点实验室江苏南京210098 中国科学院地球化学研究所环境地球化学国家重点实验室贵州贵阳550081 暨南大学环境学院广东广州511443 国家海洋环境监测中心国家环境保护近岸海域生态环境重点实验室辽宁大连266003 中国科学院烟台海岸带研究所中国科学院海岸带环境过程与生态修复重点实验室山东烟台264003 河海大学环境学院江苏南京210098

内陆水体(湖泊、水库、沼泽、河流)和河口海洋等底部,广泛且连续分布着沉积物质,在其形成过程中受自然和人类活动影响,具有与污染物有关的环境意义和特征。中国区域差异大,环境问题较为突出,经过近几十年来围绕沉积物环境和污染控制开... 详细信息

内陆水体(湖泊、水库、沼泽、河流)和河口海洋等底部,广泛且连续分布着沉积物质,在其形成过程中受自然和人类活动影响,具有与污染物有关的环境意义和特征。中国区域差异大,环境问题较为突出,经过近几十年来围绕沉积物环境和污染控制开展的研究,我国相关成果不断涌现。首先介绍了国际上有关沉积物环境的若干里程碑性研究,回顾了前70年我国沉积物研究的发展历程。然后侧重于与人为活动有关的环境污染,分别从沉积物环境和污染控制修复两个方面,总结和归纳了近20年来中国在沉积物水环境中的作用及效应、污染物在沉积物—水界面环境行为与影响因素、沉积物生态风险与质量基准、污染沉积物的原位修复、污染沉积物疏浚及异位处置利用等方面的主要研究进展,评述了其中一些研究成果的联系和差异。最后对我国沉积物环境研究中存在的问题进行了分析,提出关于多学科交叉、复合污染、新兴/非传统污染物、质量基准、治理技术创新等几个亟需和深入开展研究的科学和技术问题,给出了解决的思路和途径,并进行了展望。

关键词：沉积物环境效应生态风险质量基准污染控制与修复处理利用中国

Pathway-selective suppression of chemokine receptor signaling in B cells by LPS through downregulation of PLC-b2

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Cellular & Molecular Immunology 2010年第6期7卷 428-439页

作者： Aiko-Konno Shirakawa fang Liao hongwei H Zhang Michael N Hedrick Satya P Singh Dianqing Wu Joshua M Farber Inflammation Biology Section Laboratory of Molecular ImmunologyNational Institute of Allergy and Infectious DiseasesNational Institutes of HealthBethesdaMDUSA Department of Pharmacology Yale University School of MedicineNew HavenCTUSA

Lymphocyte activation leads to changes in chemokine receptor *** are limited data,however,on how lymphocyte activators can alter chemokine signaling by affecting downstream *** hypothesized that B cell-activating agents might alter chemokine responses by affecting downstream signal transducers,and that such effects might differ depending on the *** found that activating mouse B cells using either anti-IgM or lipopolysaccharide(LPS)increased the surface expression of CCR6 and CCR7 with large increases in chemotaxis to their cognate *** contrast,while anti-IgM also led to enhanced calcium responses,LPS-treated cells showed only small changes in calcium signaling as compared with cells that were freshly *** particular interest,we found that LPS caused a reduction in the level of B-cell phospholipase C(PLC)-b2 mRNA and *** obtained using PLC-b22/2 mice showed that the b2 isoform mediates close to one-half the chemokine-induced calcium signal in resting and anti-IgM-activated B cells,and we found that calcium signals in the LPS-treated cells were boosted by increasing the level of PLC-b2 using transfection,consistent with a functional effect of downregulating ***,our results show activator-specific effects on responses through B-cell chemokine receptors that are mediated by quantitative changes in a downstream signal-transducing protein,revealing an activity for LPS as a downregulator of PLC-b2,and a novel mechanism for controlling chemokine-induced signals in lymphocytes.

关键词： B cells calcium chemokine chemotaxis GPCR

右美托咪定滴鼻在经阴道无痛取卵术患者中的临床应用效果

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上海医学 2021年第11期44卷 832-835页

作者：秦佳文方洪伟张金源黄丽华杨雪王祥瑞廖丽君同济大学附属东方医院麻醉科上海200120

目的探讨右美托咪定在经阴道无痛取卵术静脉麻醉前应用的临床效果及其安全性。方法选取2020年2—6月在同济大学附属东方医院行超声引导下经阴道无痛取卵术的患者160例,随机分为观察组和对照组,每组80例。观察组术前30 min予1.5μg/kg右... 详细信息

目的探讨右美托咪定在经阴道无痛取卵术静脉麻醉前应用的临床效果及其安全性。方法选取2020年2—6月在同济大学附属东方医院行超声引导下经阴道无痛取卵术的患者160例,随机分为观察组和对照组,每组80例。观察组术前30 min予1.5μg/kg右美托咪定滴鼻,对照组术前予以等剂量0.9%氯化钠溶液滴鼻,两组均静脉注射盐酸氢吗啡酮,予丙泊酚行静脉麻醉。记录两组患者术中盐酸氢吗啡酮和丙泊酚用量、术后疼痛VAS评分、复苏期间镇静-躁动评分、术后复苏时间,以及术后恶心、呕吐、头晕发生率和患者麻醉满意率。结果两组患者均顺利完成超声引导下经阴道无痛取卵术。两组间患者年龄、身高、BMI、取卵数的差异均无统计学意义(P值均>0.05)。两组间术中盐酸氢吗啡酮用量的差异无统计学意义(P>0.05)。观察组术中丙泊酚用量为(125.8±30.9)mg,显著少于对照组的(156.8±40.8)mg(P0.05)。结论超声引导下行经阴道无痛取卵术前以右美托咪定滴鼻可提高麻醉效果,减少不良反应的发生。

关键词：右美托咪啶滴鼻无痛取卵术

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39例早期贲门癌外科治疗分析

肿瘤基础与临床 2017年第4期30卷 298-299页

作者：杨振华刘志才吕荣增管福顺申学昌马中州方卫红林州市肿瘤医院胸外科河南林州456550

目的探讨早期贲门癌外科治疗的远期疗效。方法回顾性分析39例早期贲门癌的术前内窥镜检查、病理类型、癌组织浸润深度、淋巴结转移、手术方式及预后。结果全组39例患者的1、3、5 a生存率分别为100.0%、94.8%、89.7%;5 a内死亡4例,均死... 详细信息

目的探讨早期贲门癌外科治疗的远期疗效。方法回顾性分析39例早期贲门癌的术前内窥镜检查、病理类型、癌组织浸润深度、淋巴结转移、手术方式及预后。结果全组39例患者的1、3、5 a生存率分别为100.0%、94.8%、89.7%;5 a内死亡4例,均死于远处脏器转移。结论影响贲门癌长期生存的因素除了疾病本身的因素外,可能还与患者的身体内环境、心理和社会因素有关。

关键词：早期贲门癌外科治疗生存率预后

Combined amendment reduces soil Cd availability and rice Cd accumulation in three consecutive rice planting seasons

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Journal of Environmental Sciences 2022年第1期34卷 141-152页

作者： Wenjun Yang Shilong Wang Hang Zhou Min Zeng Jingyi Zhang fang Huang Shiping Shan Zhaohui Guo hongwei Yi Zhiguang Sun Jiaofeng Gu Bohan Liao College of Environmental Science and Engineering Central South University of Forestry and TechnologyChangsha 410004China College of Resources and Environment Hunan Agricultural UniversityChangsha 410128China Hunan Engineering Laboratory for Control of Rice Quality and Safety Changsha 410004China Hunan Institute of Microbiology Changsha 410009China Hunan Shuanghong Agricultural Ecological Engineering Co. Ltd.Changsha 410205China

The scientific application of stabilized materials has been considered an effective method for the in situ remediation of Cd-contaminated *** study aimed to investigate the persistence of the effect of a combined amendment of limestone and sepiolite(LS)on soil Cd availability and accumulation in rice grown in a mildly Cd-contaminated paddy field(0.45 mg/kg of Cd)over three consecutive rice seasons.1125–4500 kg/ha of LS was applied to the soil before the first rice planting season and 562.5–2250 kg/ha of LS was supplemented before the third rice planting *** application of LS(1125–4500 kg/ha)increased the soil p H by 0.44–1.09,0.18–0.53,and 0.42–0.68 in the first,second,and third season,respectively,and decreased the soil acid-extractable Cd content by 18.2–36.4%,17.7–33.5%,and9.6–17.6%.LS application significantly decreased the Cd contents in the rice *** application of 4500 kg/ha of LS decreased the Cd content in brown rice to below the National Food Limit Standard of 0.2 mg/kg(GB 2762-2017)in the three consecutive rice ***,the effect of LS on the soil-rice system was significantly weakened in the third *** supplementary application of 562.5–2250 kg/ha of LS further decreased the Cd content in brown rice by 26.1–56.5%and decreased the health risk index by 23.7–43.8%.Therefore,it was recommended to apply 4500 kg/ha of LS in the first season and to supplement2250 kg/ha of LS in the third season to effectively guarantee the clean production of rice in three consecutive rice seasons.

关键词： Rice(Oryza sativa L.) Stabilization Cadmium Health risk Remediation persistence

肠道菌群紊乱与神经病理性疼痛中的病理生理作用的研究进展

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中华疼痛学杂志 2022年第6期18卷 837-840页

作者：侯千暠钱淑雯师浩兵方洪伟张金源王祥瑞廖丽君同济大学附属东方医院麻醉科上海市200121 同济大学附属东方医院疼痛科上海市200121

神经病理性疼痛(NP)的发病机制仍不清楚。近年来,肠-脑轴紊乱是NP病理机制的研究热点,尤其是肠道菌群紊乱与宿主的免疫调控、神经递质的生成与释放、神经胶质细胞的稳定以及情绪的调节等均密切相关。本文就肠道菌群紊乱在NP中的病理生... 详细信息

神经病理性疼痛(NP)的发病机制仍不清楚。近年来,肠-脑轴紊乱是NP病理机制的研究热点,尤其是肠道菌群紊乱与宿主的免疫调控、神经递质的生成与释放、神经胶质细胞的稳定以及情绪的调节等均密切相关。本文就肠道菌群紊乱在NP中的病理生理作用的最新进展做一综述。

关键词：神经痛肠道菌群肠-脑轴免疫系统神经递质

MXR7 facilitates liver cancer metastasis via epithelial-mesenchymal transition

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Science China(Life Sciences) 2017年第11期60卷 1203-1213页

作者： guishuai lv yexiong tan hongwei lv tian fang changzheng wang ting li yanting yu congli hu wen wen hongyang wang wen yang international cooperation laboratory on signal transduction eastern hepatobiliary surgery institutesecond military medical universityShanghai 200438China national center for liver cancer Shanghai 201805China state key laboratory of oncogenes and related genes shanghai cancer institute renji hospitalshanghai jiaotong university school of medicineShanghai 200127China

MXR7 is a cell-surface protein and highly expressed in hepatocellular carcinoma(HCC). The aim of this study is to determine the expression profile of MXR7 in HCC and investigate the influence of MXR7 on invasion and metastasis of HCC cells. For this purpose, immunohistochemical assay was used to identify the differential expression of MXR7 in 94 HCC specimens. Expression of MXR7 in 4 pairs of HCC and portal vein tumor thrombus(PVTT) was also tested. The motility of HCC cells were characterized by transwell migration and matrigel invasion assays. In vivo metastasis potential was determined via tail vein injection ***, compared with noninvasive HCC tumors or human HCC cell lines with low metastatic potential, invasive HCC samples and HCC cell lines with high metastatic potential exhibited higher MXR7 expression. Furthermore, forced expression of MXR7 in SMMC-7721 promoted cell proliferation, migration and invasion in vitro and accelerated tumor growth and metastasis in vivo. Conversely, knockdown of MXR7 expression in HuH7 cells inhibited proliferation and motility of cells. Mechanically,overexpression of MXR7 promoted epithelial-mesenchymal transition(EMT) progress, and MXR7 depletion repressed the EMT phenotype. In conclusion, MXR7 is a mediator of EMT and metastasis in HCC and may serve as a novel therapeutic target.

关键词： hepatocellular carcinoma(HCC) MXR7 metastasis epithelial-mesenchymal transition(EMT)