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动物模型与实验医学(英文) 2023年第4期6卷 346-354页

作者： Kaili Lin Meixuan Liu Lu Sun Hanjun Fu hongwei qiao Shunyi Wang Sidan Pan Hong Gao Institute of Laboratory Animal Sciences Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Background:Immunocompromised individuals have an increased risk of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection and severe outcomes,but we pay less attention to these people.Athymic nude mice are a murine strain with a spontaneous deficiency of the Foxn1 gene,which can result in thymic degeneration or its absence,leading to immunosuppression and a decrease in the number of T cells,and are widely used in preclinical evaluations of disease in immunocompromised populations.Methods:We investigated the protection of the coronavirus disease 2019(COVID-19)inactivated vaccine(CoronaVac)against the infection of wild-type SARS-CoV-2(WH-09)or Omicron variant utilizing a hybrid-type nude-hACE2 mouse model.Results:Compared with nude-hACE2/W mice,the viral load in the brain and lung tissue of nude-hACE2 mice(nude-hACE2/WV)infected with WH-09 after vaccination significantly decreased,and the histopathological changes were also reduced.The viral load in the brain and lung tissue of nude-hACE2 mice(nude-hACE2/OV)infected with the Omicron variant after vaccination was lower than that in nude-hACE2/O,but histopathological symptoms did not improve significantly.Conclusion:CoronaVac provides some protection against infection of both WH-09 and the Omicron variant in the nude-hACE2 mice.Our findings aimed to provide a reference for vaccination against SARS-CoV-2 in immunocompromised populations.

关键词： immunocompromised nude-hACE2 mice protection severe acute respiratory syndrome coronavirus 2

The effects of inactivated SARS-CoV-2 vaccination and subsequent infection of pregnant mice on the behaviors of offspring

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Animal Models and Experimental Medicine 2022年第5期5卷 430-435页

作者： Kaili Lin Meixuan Liu Lu Sun hongwei qiao Shunyi Wang Sidan Pan Hanjun Fu Jingzhu Wang Qiang Wei Hong Gao Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijingChina

The mass inoculation of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)vaccines to induce herd immunity is one of the most effective measures we can deploy in the fight against coronavirus disease 2019(COVID-19).Pregnant women are prone to a higher risk of COVID-19,and maternal infection is a risk fac-tor for a range of neurological disorders leading to abnormal behavior in adulthood.However,there are limited clinical data to support whether vaccination or infection post-immunization in pregnant women can affect the behavioral cognition of fetuses in adulthood.In this study,human angiotensin-converting enzyme 2 pregnant mice(F0 generation)were immunized with CoronaVac and then infected with SARS-CoV-2.Subsequently,we analyzed the behavioral cognition of their adult offspring(F1 gen-eration)using the open-field test and Morris water maze test.The adult F1 generation did not exhibit any impairments in spontaneous locomotor activity or spatial refer-ence memory.

关键词： offspring spatial reference memory spontaneous locomotor activity

A one-pot method for controlled synthesis and selective etching of organic-inorganic hybrid perovskite crystals

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Journal of Energy Chemistry 2019年第6期28卷 149-154页

作者： Yu Hou Mengjiong Chen hongwei qiao Huagui Yang Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East China University of Science and Technology

Organometal halide perovskites have recently emerged with a huge potential for photovoltaic applications. Moreover, preparation of high-quality perovskite crystals with controlled morphology is of great significance for the fundamental studies such as optical and electrical properties, as well as the applications. Here, we report a one-pot solvothermal process to synthesize sheet-shaped CH3NH3PbBr3 single crystals with the lateral size of 100 μm and the thickness of 3–8 μm. Furthermore, a controlled etching behavior on the crystalline surface was demonstrated, which could be the irregular collapse of the crystalline surface caused by the local accumulation of methylammonium cations. Using this technique,CH3NH3PbBr3 single crystal sheets could be used in the various optoelectronic devices, such as nanolaser,optical sensors, photodetectors and field effect transistors.

关键词： Crystal growth Perovskite Solvothermal Etching effect

Modulating MAPbI3 perovskite solar cells by amide molecules:Crystallographic regulation and surface passivation

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Journal of Energy Chemistry 2021年第5期30卷 179-185页

作者： Jin Xie Ziren Zhou hongwei qiao Mengjiong Chen Lijie Wang Shuang Yang Yu Hou Huagui Yang Key Laboratory for Ultrafine Materials of Ministry of Education Shanghai Engineering Research Center of Hierarchical NanomaterialsSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China

A controllable crystallization is of practical importance to produce high-quality perovskite thin films with reduced structural defects.Lewis bases as electron-pair donor chemicals can strongly coordinate to lead ions and have been extensively employed to manipulate the growth of perovskite crystals.In this work,we demonstrate a series of Lewis-base amides,for morphological regulation of methylammonium lead triiodide(MAPbI3)thin films.The screened acetamide was demonstrated to decently improve the grain size,along with a spatial distribution at grain boundaries(GBs).The mesostructured solar cells of acetamide-modified absorbers yielded an optimized power conversion efficiency(PCE)of 20.04%with a mitigated open-circuit voltage(V_(OC))deficit of 0.39 V.This work provides a facile and cost-effective strategy toward controllable fabrication of high-performance MAPbI3 solar cells.

关键词： Amide Methylammonium lead triiodide Crystallization Solar cell

基于VLW状态方程的氢氟爆轰参数理论分析及数值模拟研究

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兵器装备工程学报 2024年第5期45卷 65-71页

作者：陈庆慈陈放周壮壮乔红伟北京理工大学爆炸科学与技术国家重点实验室北京100081

氟气是具有强氧化性的气体,与氢气会发生剧烈的化学反应,为了得到氢氟爆轰的爆轰参数,基于VLW状态方程与爆轰理论对氟气与氢气在标准状况预混条件下爆轰性能进行了理论计算,当氢气与氟气的摩尔比为1∶1时,计算得到爆压为15.31 MPa,爆温... 详细信息

氟气是具有强氧化性的气体,与氢气会发生剧烈的化学反应,为了得到氢氟爆轰的爆轰参数,基于VLW状态方程与爆轰理论对氟气与氢气在标准状况预混条件下爆轰性能进行了理论计算,当氢气与氟气的摩尔比为1∶1时,计算得到爆压为15.31 MPa,爆温为6 479 K。利用materials studio与CP/2K分子动力学模拟计算了氢与氟的反应,对现有氢氟反应机理进行了完善。最后通过FLUENT流体动力学仿真软件对摩尔比为1∶1时的氢氟爆轰进行了仿真计算,因爆轰波在管道内多次叠加,所以计算出超压可达46 MPa,高于理论爆压值的15.31 MPa;管道内计算出的温度可达6 800 K,与理论爆温值相差4.6%,对研究氢氟爆轰条件与能量释放规律具有一定借鉴意义。

关键词： VLW状态方程氢与氟气相爆轰分子动力学理论分析数值模拟

后缘开槽型超燃冲压发动机凹腔燃烧室及其促燃特性实验研究

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Acta Mechanica Sinica 2024年第1期40卷 74-84页

作者：张林乔玮梁剑寒王翼丁猛杨雷超孙明波 Science and Technology on Scramjet Laboratory National University of Defense TechnologyChangsha 410073China

为了改善传统的二维梯形凹腔在促进混合和燃烧方面的效果,本文提出了一种在凹腔后缘设置开槽的三维凹腔,并在超声速模型燃烧室中进行了研究.在直连式实验台上开展实验,对传统的二维梯形凹腔(基线)和后缘开槽凹腔进行了对比.结果表明,后... 详细信息

为了改善传统的二维梯形凹腔在促进混合和燃烧方面的效果,本文提出了一种在凹腔后缘设置开槽的三维凹腔,并在超声速模型燃烧室中进行了研究.在直连式实验台上开展实验,对传统的二维梯形凹腔(基线)和后缘开槽凹腔进行了对比.结果表明,后缘开槽凹腔增强了沿燃烧室的燃烧。具体而言,凹腔附近的压力在燃料喷注压力较低时增加6.1%,在燃料喷注压力较高时增加12.7%.基于准一维分析,后缘开槽凹腔的燃烧效率提高了20%以上。对于后缘开槽凹腔,燃烧面积和火焰基底位置受喷注压力的影响小于基线情况.与此同时,后缘开槽凹腔的火焰稳定能力较基线构型更优。凹腔交换面积增加、长深比增大以及开槽诱导的横向流动和流向涡可能是增强混合和燃烧的主要原因.

关键词：燃烧面积横向流动超燃冲压发动机火焰稳定准一维凹腔燃烧效率

Laboratory biosafety emergency management for SARS-CoV-2

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Journal of Biosafety and Biosecurity 2020年第2期2卷 99-101页

作者： Kaili Lin Meixuan Liu Haoran Ma Sidan Pan hongwei qiao Hong Gao Institute of Laboratory Animal Sciences Chinese Academy of Medical Sciences&Comparative Medicine CenterPeking Union Medical CollegeBeijing 100021China

A biosafety laboratory is a prerequisite for studying emerging infectious diseases.Safe and effective operation in laboratories and the handling of pathogens determine the safety of the personnel,pathogens,and the environment in the laboratory,which are among the key factors for successful experimentation.In this article,we aimed to provide ideas for the emergency management of biosafety laboratories,including a discussion on the urgency of the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)related experimental activities,tracking clinical information,taking emergency measures,revision of the risk assessment process,and standardization of personal protective equipment and personnel behavior standards.

关键词： SARS-CoV-2 Biosafety Laboratory Emergency Management

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超声速燃烧中的概率密度函数方法研究进展

航空学报 2024年第8期45卷 24-45页

作者：乔竑玮梁剑寒张林孙明波陈玉俏国防科技大学高超声速技术实验室长沙410073

概率密度函数方法能够精确封闭湍流/化学反应相互作用,在湍流燃烧数值模拟中得到了广泛应用。随着高超声速推进技术的不断发展,超燃冲压发动机内的超声速湍流燃烧为概率密度函数方法的应用带来了新的挑战。首先,综述了概率密度函数方法... 详细信息

概率密度函数方法能够精确封闭湍流/化学反应相互作用,在湍流燃烧数值模拟中得到了广泛应用。随着高超声速推进技术的不断发展,超燃冲压发动机内的超声速湍流燃烧为概率密度函数方法的应用带来了新的挑战。首先,综述了概率密度函数方法应用于超声速湍流燃烧的最新进展,概述了概率密度函数方法的基本理论、关键模型和求解框架;其次,介绍了超声速湍流燃烧对概率密度函数方法的理论、模型和数值求解方面的具体挑战和相关研究工作,包括考虑可压缩效应、高速源项模型修正、小尺度混合模型改进等;然后,综述了概率密度函数方法在超声速湍流燃烧中的应用情况;最后,对超声速燃烧中概率密度函数方法的应用前景和发展方向做出了展望。

关键词：概率密度函数方法湍流燃烧超声速燃烧超燃冲压发动机大涡模拟

巴林特小组活动对护理人员职业倦怠感负性情绪及自我效能的影响

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临床心身疾病杂志 2024年第3期30卷 157-160页

作者：杨福娟方晓霞乔红伟蔡楠楠张洁新乡市中心医院河南新乡453000

目的探讨巴林特小组活动对呼吸与危重症医学科护理人员职业倦怠感、负性情绪及自我效能的影响。方法将64名护理人员随机均分为对照组和试验组。对照组护理人员给予心理健康讲座,试验组护理人员在对照组基础上给予巴林特小组活动。采用... 详细信息

目的探讨巴林特小组活动对呼吸与危重症医学科护理人员职业倦怠感、负性情绪及自我效能的影响。方法将64名护理人员随机均分为对照组和试验组。对照组护理人员给予心理健康讲座,试验组护理人员在对照组基础上给予巴林特小组活动。采用相应的量表评估两组护理人员干预前后的职业倦怠感、负性情绪及自我效能状况。结果干预后试验组护理人员中文版职业倦怠量表(MBI)总分及情绪衰竭、去个性化维度评分均低于干预前和对照组,个人成就感维度评分高于干预前和对照组(P<0.01);干预后试验组护理人员焦虑自评量表(SAS)和抑郁自评量表(SDS)评分均低于干预前和对照组,一般自我效能感量表(GSES)评分高于干预前和对照组(P<0.01)。结论巴林特小组活动能够提高呼吸与危重症医学科护理人员的自我效能感,改善其职业倦怠感及负性情绪状况。

关键词：巴林特小组护理人员职业倦怠感负性情绪自我效能

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基于液体循环的动力电池低温加热方法研究

当代化工研究 2024年第10期 161-163页

作者：崔巍崔瑞军李渊王文震武斌乔宏伟内蒙古工业大学能源与动力工程学院内蒙古010051 内蒙古地质矿产集团有限公司内蒙古010010

加热板中液体循环结构与参数对动力电池包的温升效果和均匀性具有显著影响。针对不同结构加热板存在温升速率差,温度一致性差等不足,改进加热板设计。通过COMSOL流-热耦合仿真对加热板结构进行设计,建立电池模组液体循环加热有限元模型... 详细信息

加热板中液体循环结构与参数对动力电池包的温升效果和均匀性具有显著影响。针对不同结构加热板存在温升速率差,温度一致性差等不足,改进加热板设计。通过COMSOL流-热耦合仿真对加热板结构进行设计,建立电池模组液体循环加热有限元模型。研究不同液体温度、不同液体流速对电池包温升效果和温度一致性能。仿真与实验结果表明,采用蛇形加热板输入液体温度为40℃,流速为1?m/s时,液体循环加热满足最佳的加热均匀性及系统设计要求。

关键词：锂离子电池低温加热液体循环 COMSOL仿真