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Transcription factor RBP-J-mediated signaling represses the differentiation of neural stem cells into intermediate neural progenitors

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Transcription factor RBP-J-mediated signaling represses the ...

基于教师描述的幼儿个性结构的验证性因素分析

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： Fang GAO~(1,2.,Qi ZHANG~(1,2.,Min-Hua ZHENG~1,Hui-ling liu~2.Yi-Yang HU~1,Ping ZHANG~1,Zheng-Ping ZHANG~1,Hong-Yan QIN~1,Lei FENG~1,Li WANG~1,Hua HAN~(1,2.*),Gong JU~(2.*) 1 {2. of Medical Genetics and developmental biology,Fourth Military Medical university,Xi''an 710032. China 2.Institute of Neurosciences,Fourth Military Medical university,Xi''an 710032.China

＜正＞Notch signaling is critical for multiple aspects of neurogenesis,but how it regulates the proliferation and differentiation of neural stem cells（NSCs） and intermediate neural progenitors（INPs） has not been well elucidated, especially in *** this study,we conditionally ablated the transcription factor RBP-J,which mediates signaling from all four mammalian Notch receptors,in the basal forebrain and ventral midbrain using the RBP-J-floxed mouse and a newly established Nestin-Cre *** found that at early stage of neurogenesis（E11.5）,the frequency of neurospheres increased significantly in the RBP-J-inactivated *** majority of the RBP-J deficient neurospheres were composed of INPs,suggesting precocious differentiation of NSCs into ***,neuronal differentiation was reduced in the same regions at E11.5,inconsistent with the precocious differentiation phenotype in most Notch-related *** late neurogenic stages（E17.5 and neonatal）,as expected from precociously exhausted NSC pool,neurosphere frequency and NSCs decreased in the RBP-J-ablated regions,accompanied by significant increases of both neurons and glial *** results indicate that the RBP-J-mediated signaling might inhibit the differentiation of NSCs into INPs and support the generation of certain early born neurons at early neurogenic stages.

关键词： neural stem cells intermediate neural progenitors notch RBP-J neuron glia

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心理科学 2004年第3期27卷 575-579页

作者：杨丽珠张野刘文辽宁师范大学心理系大连116029

该文以自然语言的方式,采用开放式问卷(n=1347)、理论分析等方法编制幼儿个性发展教师评定问卷,并通过探索性因素分析(n=715)、验证性因素分析(n=92.)得出,教师评价的幼儿个性结构由智能特征、认真自控、情绪性、亲社会性四个维度11个... 详细信息

该文以自然语言的方式,采用开放式问卷(n=1347)、理论分析等方法编制幼儿个性发展教师评定问卷,并通过探索性因素分析(n=715)、验证性因素分析(n=92.)得出,教师评价的幼儿个性结构由智能特征、认真自控、情绪性、亲社会性四个维度11个特质构成。问卷具有较好的信度和效度。

关键词：幼儿个性结构智能特征情绪结构验证性因素

A linear relationship between De Ritis ratio and mortality in hospitalized patients with COVID-19:A secondary analysis based on a large retrospective cohort study

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iLIVER 2022年第3期1卷 169-175页

作者： Yanling Fu Shouwen Du Xiaodi liu lin cao Guilin Yang hongtao Chen From the department of Infectious Diseases Shenzhen People's Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020GuangdongChina

Background and aims:Although some studies have identified a possible link between the De Ritis ratio and the mortality of patients with COVID-19),the predictive value and the optimal cut-value remain *** study aimed to explore the correlation between the De Ritis ratio and mortality in hospitalized ***:The data for this cohort study came from a retrospective cohort study that was carried out in a medical system in New York *** primary outcome was the in-hospital mortality of included *** researchers ran multivariate Cox regression analyses,curve fitting,and subgroup analysis to support our *** survival in different De Ritis ratio groups was plotted as Kaplan-Meier survival ***:The study enrolled 4371 participants with COVID-19 from March 1,2.2. to April 16,*** overall mortality was 2..8%(1082.4371).The curve fitting analyses indicated that the De Ritis ratio has a positive linear connection with mortality in patients with *** adjusting for all covariates,participants with a De Ritis ratio≥2.exhibited 1.2. times the risk of in-hospital mortality compared with those with a De Ritis ratio2.,95%confidence interval 1.02.1.62.p=0.031).The p for trend was2.experienced the shortest survival time in the Kaplan-Meier survival ***:A higher baseline De Ritis ratio is correlated with a corresponding higher mortality among hospitalized people with COVID-19.

关键词： De Ritis ratio COVID-19 Mortality linear relationship Dryad database

Ladder-like metal oxide nanowires： Synthesis, electrical transport, and enhanced light absorption properties

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Nano Research 2014年第2期7卷 272-283页

作者： Bo Liang hongtao Huang Zhe liu Gui Chen Gang Yu Tao Luo Lei Liao Di Chen Guozhen Shen State Key Laboratory for Superlattices and Microstructures Institute of Semiconductors Chinese Academy of Sciences Beijing 100083 China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 China department of Physics and Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education Wuhan University Wuhan 430074 China

Transparent metal oxide nanowires （NWs） have attracted intense research interest in recent years. We report here the synthesis of interesting ladder-like metal oxide NWs, including In2.3, SnO2. ZnO, and Ga2.3, via a facile chemical vapor deposition （CVD） method. Their structural features and growth mechanism are demonstrated in detail by using the ladder-like In2.3 NWs as an example. Single ladder-like NW-based field-effect transistors （FETs） and photodetectors （PDs） of SnO2.were fabricated in order to investigate their electrical transport and light absorption properties. Compared with straight NW-based FETs which operate in an enhancement mode （E-mode）, FETs build on ladder-like NWs operate in a depletion mode （D-mode）. The ladder-like NWs also give higher carrier concentrations than conventional single nanowires. Finite-difference time-domain （FDTD） simulations have been performed on the ladder-like NWs and the results reveal a great enhancement of light absorption with both transverse-electric （TE） and transverse-magnetic （TM） polarization modes, which is in good agreement with the experimental results.

关键词： In2.3 SnO2 nanowires field-effect transistors photodetectors finite-differencetime-domain

Responses of Soybean GmSARK Gene to Environmental Stresses

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Responses of Soybean GmSARK Gene to Environmental Stresses

Biomolecular condensates and disease pathogenesis

2.07中国植物生理学会全国学术会议

作者： Peng-Li Li Fan Xu Dong liu Ning Ning Wang (department of Plant {2. and Ecology,Nankai university,Tianjin 300071,China)

＜正＞Leaf senescence is a form of programmed cell *** in gene expression and signalling pathways between {2. and stress-induced senescence in higher plants have been largely reported. We have previously described a soybean LRR-RLK gene,GmSARK,which plays an important role in regulation of soybean leaf *** also found that over-expression of GmSARK gene greatly

关键词： Soybean GrnSARK RLK Senescence Environmental Stress

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Science China(Life Sciences) 2024年第9期67卷 1792-1832页

作者： Ke Ruan Ge Bai Yanshan Fang Dan Li Tingting Li Xingguo liu Boxun Lu Qing Lu Zhou Songyang Shuguo Sun Zheng Wang Xin Zhang Wen Zhou Hong Zhang The First Affiliated Hospital&School of Life Sciences Ministry of Education Key Laboratory for Membrane-less Organelles&Cellular DynamicsHefei National Research Center for Interdisciplinary Sciences at the MicroscaleCenter for Advanced Interdisciplinary Science and Biomedicine of IHMDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230027China Nanhu Brain-computer Interface Institute Hangzhou 311100China department of Neurology of Second Affiliated Hospital and School of Brain Science and Brain Medicine Zhejiang University School of MedicineHangzhou 310058China Interdisciplinary Research Center on biology and Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 201210China university of Chinese Academy of Sciences Beijing 100049China Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders(Ministry of Education)Shanghai Jiao Tong UniversityShanghai 200030China department of Biomedical Informatics School of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China caS Key Laboratory of Regenerative biology Joint School of Life SciencesGuangzhou Institutes of Biomedicine and HealthChinese Academy of SciencesGuangzhou 510530China Joint School of Life Sciences Guangzhou Medical UniversityGuangzhou 510000China Neurology department at Huashan Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain ScienceInstitutes of Brain ScienceSchool of Life SciencesFudan UniversityShanghai 200433 China Key Laboratory for the Genetics of developmental and Neuropsychiatric Disorders Ministry of EducationBio-X InstitutesShanghai Jiao Tong UniversityShanghai 200030China State Key Laboratory of Biocontrol MOE Key Laboratory of Gene Function and Regulation and Guangzhou Key Laboratory of Healthy Aging ResearchSchool of Life SciencesSun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510275China department of Human Anatomy Hist

Biomolecular condensates or membraneless organelles(Mlos)formed by liquid-liquid phase separation(LLPS)divide intra{2.ular spaces into discrete compartments for specific *** of LLPS or aberrant phase transition that disturbs the formation or material states of Mlos is closely correlated with neurodegeneration,tumorigenesis,and many other pathological ***,we summarize the recent progress in development of methods to monitor phase separation and we discuss the biogenesis and function of Mlos formed through phase *** then present emerging proof-of-concept examples regarding the disruption of phase separation homeostasis in a diverse array of clinical conditions including neurodegenerative disorders,hearing loss,cancers,and immunological ***,we describe the emerging discovery of chemical modulators of phase separation.

关键词： liquid-liquid phase separation biomolecular condensate membraneless organelle

Fundamental cycles and graph embeddings

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Science China Mathematics 2009年第9期52卷 1920-1926页

作者： REN Han ZHAO hongtao LI Haoling department of Mathematics East China Normal UniversityShanghai 200062China

In this paper, we investigate fundamental cycles in a graph G and their relations with graph embeddings. We show that a graph G may be embedded in an orientable surface with genus at least g if and only if for any spanning tree T, there exists a sequence of fundamental cycles C 1,C 2,…,C 2g with C 2i?1 ∩ C 2i ≠ /0 for 1 ? i ? g. In particular, among β(G) fundamental cycles of any spanning tree T of a graph G, there are exactly 2γM (G) cycles C 1, C 2,…,C 2γM(G) such that C 2i?1 ∩ C 2i ≠ /0 for 1 ? i ? γM (G), where β(G) and γM (G) are the Betti number and the maximum genus of G, respectively. This implies that it is possible to construct an orientable embedding with large genus of a graph G from an arbitrary spanning tree T (which may have very large number of odd components in G E(T)). This is different from the earlier work of Xuong and liu, where spanning trees with small odd components are needed. In fact, this makes a common generalization of Xuong, liu and Fu et al. Furthermore, we show that (1) this result is useful for locating the maximum genus of a graph having a specific edge-cut. Some known results for embedded graphs are also concluded; (2) the maximum genus problem may be reduced to the maximum matching problem. Based on this result and the algorithm of Micali-Vazirani, we present a new efficient algorithm to determine the maximum genus of a graph in $ O((\beta (G))^{\frac{5} ca} ) $ steps. Our method is straight and quite different from the algorithm of Furst, Gross and McGeoch which depends on a result of Giles where matroid parity method is needed.

关键词： fundamental cycle maximum genus upper-embedded 05C10 05C70

Engagement of N^(6)-methyladenisine methylation of Gng4 mRNA in astrocyte dysfunction regulated by CircHECW2

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Acta Pharmaceutica Sinica B 2024年第4期14卷 1644-1660页

作者： Ying Bai Di Chang Hui Ren Minzi Ju Yu Wang Biling Chen Han Li Xue liu Daxing Li Xinchen Huo Xiaofei Guo Mengze Tong Ying Tan Honghong Yao Bing Han department of Pharmacology Jiangsu Provincial Key Laboratory of Critical Care MedicineSchool of MedicineSoutheast UniversityNanjing 210009China department of Radiology Zhongda HospitalJiangsu Key Laboratory of Molecular and Functional ImagingMedical School of Southeast UniversityNanjing 210009China Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001China Institute of Life Sciences Key Laboratory of Developmental Genes and Human DiseaseSoutheast UniversityNanjing 210096China Center for Global Health School of Public HealthNanjing Medical UniversityNanjing 211166China

The N^(6)-methyladenosine(m^(6)A)modification is the most prevalent modification of eukaryotic mRNAs and plays a crucial role in various physiological processes by regulating the stability or function of target *** evidence has suggested that m6A methylation may be involved in the pathological process of major depressive disorder(MDD),a common neuropsychiatric disorder with an unclear ***,we found that the levels of the circular RNA HECW2.circHECW2.were significantly increased in the plasma of both MDD patients and the chronic unpredictable stress(CUS)mouse ***,the downregulation of circHECW2.attenuated astrocyte dysfunction and depression-like behaviors induced by ***,we demonstrated that the downregulation of circHECW2.increased the expression of the methylase WTAP,leading to an increase in Gng4 expression via m^(6)A *** findings provide functional insight into the correlation between circHECW2.and m^(6)A methylation,suggesting that circHECW2.may represent a potential target for MDD treatment.

关键词： N^(6)-Methyladenosine Depression circHECW2 Astrocyte WTAP Ubiquitination GNG4 Dysfunction

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转菊芋凝集素基因烟草对桃蚜的抗虫性研究

武汉大学学报（理学版） 2003年第6期49卷 793-798页

作者：常团结刘茵马原松梁峰闫永峰朱祯商丘师范学院生物系河南商丘476000 中国科学院遗传与发育生物学研究所北京100101

研究了菊芋凝集素基因(hta)对同翅目害虫的抗性.4个同源的hta基因置于caMV35S启动子和nos终止子的控制下,通过根癌农杆菌(Agrobacteriumtumefaciens)介导法被转入烟草.Southern杂交显示,外源hta被整合到转化烟草的基因组中.Northern杂... 详细信息

研究了菊芋凝集素基因(hta)对同翅目害虫的抗性.4个同源的hta基因置于caMV35S启动子和nos终止子的控制下,通过根癌农杆菌(Agrobacteriumtumefaciens)介导法被转入烟草.Southern杂交显示,外源hta被整合到转化烟草的基因组中.Northern杂交表明htamRNA在转基因烟草中进行了表达.利用桃蚜进行的抗虫试验表明,转基因烟草对桃蚜具有抗性.同对照植株相比,T0代转基因烟草使桃蚜的平均虫头数下降70%.在T1代转基因烟草中,转hta b和hta c基因烟草对桃蚜繁殖的抑制率分别为53.0%、64.6%,同时,对桃蚜若虫的发育具有明显的抑制作用.

关键词：菊芋凝集素抗虫性桃蚜转基因烟草