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Science China(Life Sciences) 2020年第11期63卷 1759-1761页

作者： hongtao liu Junping Zheng Hsin-Chih Lai Baifei Hu {2. Zhu Elaine Lai-Han Leung Hong Wei College of Basic Medicine Hubei University of Chinese MedicineWuhan 430065China department of Medical Biotechnology and Laboratory Science Chang Gung UniversityTao-Yuan 33302China State Key Laboratory of Quality Research in Chinese Medicine Macao Institute for Applied Research in Medicine and HealthMacao University of Science and TechnologyMacao SARChina Central Laboratory Clinical Medicine Scientific and Technical Innovation ParkShanghai Tenth People’s HospitalTongji UniversityShanghai 200435China State Key Laboratory of Agricultural Microbiology College of Animal Sciences and TechnologyHuazhong Agricultural UniversityWuhan 430070China

Application of microbiome technology to traditional Chinese medicine (TCM). Microbiome refers to the integration of composition, genetic information and bio-function of all microbial species under a specific environment.

关键词： environment. powers technology

Expression and characterization of anion exchangerl (AE1) 55 kD transmembrane region and glycophorin A

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Progress in Natural Science:Materials International 2002年第3期 69-72页

作者： FU Guohui , DU Hongqing, LI hongtao, liu Limei, WANG Tianying and YANG Baofeng({2. of Pathophysiology, Harbin Medical university, Harbin 150086, China)

A complete transmembrane coding region of human erythrocyte anion exchangerl (AE1, band 3) and the full length of glycophorin A (GPA) were amplified by PCR amplification. The genes were subcloned into the baculovirus transfer vectors and expressed in Sf9 cells. Western blot showed a cross reaction between band 3 transmembrane domain and GPA. The yeast two-hybrid experiment confirmed the interaction between the two proteins.

关键词： anion exchangerl glycophorin A baculovirus expression system.

Stopping Power of Compounds for ^(16)O and ^(19)F Ions

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Chinese Physics Letters 1994年第9期11卷 537-540页

作者： WU Zeqing LU Xiting JIN Changwen ZHENG Tao XIA Zonghuang liu hongtao JIANG Dongxing YE Yan{2. department of Technical Physics Peking UniversityBeijing 100871

The stopping powers of caF_(2. and MoO_(3) for ^(16)O and ^(19)F were measured with heavy-substrate Rutherford backscattering *** present results are compared with the prediction of Bragg's rule,and strong deviation w... 详细信息

关键词： technique deviation

Against all odds:The road to success in the development of human immune reconstitution mice

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Animal Models and Experimental Medicine 2024年第4期7卷 460-470页

作者： Yixiao Bin Jing Ren Haowei Zhang Tianjiao Zhang Peijuan liu Zhiqian Xin Haijiao Yang Zhuan Feng Zhinan Chen Hai Zhang School of Basic Medical Sciences Shaanxi University of Chinese MedicineXianyangChina department of cell {2. National Translational Science Center for Molecular MedicineFourth Military Medical UniversityXi'anChina State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Fourth Military Medical UniversityXi'anChina department of Occupational&Environmental Health and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment School of Public HealthFourth Military Medical UniversityXi'anChina

The mouse genome has a high degree of homology with the human genome,and its physiological,biochemical,and developmental regulation mechanisms are similar to those of humans;therefore,mice are widely used as experimental ***,it is undeniable that interspecies differences between humans and mice can lead to experimental *** differences in the immune system have become an impor-tant factor limiting current immunological *** application of immunodefi-cient mice provides a possible solution to these *** transplanting human immune cells or tissues,such as peripheral blood mononuclear cells or hematopoietic stem cells,into immunodeficient mice,a human immune system can be reconstituted in the mouse body,and the engrafted immune cells can elicit human-specific immune *** have been actively exploring the development and differen-tiation conditions of host recipient animals and grafts in order to achieve better im-mune *** genetic engineering methods,immunodeficient mice can be further modified to provide a favorable developmental and differentiation microenvironment for the *** initially only being able to reconstruct single T lymphocyte lineages,it is now possible to reconstruct lymphoid and myeloid cells,providing important research tools for immunology-related *** this review,we compare the differences in immune systems of humans and mice,describe the devel-opment history of human immune reconstitution from the perspectives of immuno-deficient mice and grafts,and discuss the latest advances in enhancing the efficiency of human immune cell reconstitution,aiming to provide important references for im-munological related researches.

关键词： hematopoietic stem cell human immune reconstitution immune response immunodeficient mice peripheral blood mononuclear cell transplantation

Genome-Wide Association Study Identified HMGN3 Locus for Spine Bone Size Variation in Chinese

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Genome-Wide Association Study Identified HMGN3 Locus for Spi...

CBL教学法在麻醉后转运带教过程中的应用研究

中华医学会第六次全国骨质疏松和骨矿盐疾病学术会议暨中华医学会骨质疏松和骨矿盐疾病分会成立十周年

作者： Shu-Feng Lei~(1,2.,Hui Shen~2.Tie-lin Yang~3,Yan Guo~3,Shan-Shan Dong~3,Xiang-Hong Xu~3,Fei-Yan Deng~2.Qing Tia n~2.Yong-Jun liu~2.Yao-Zhong liu~2.Jian Li~2.Hong-Wen Deng~(1,2.4) 1 Laboratory of molecular and Statistical Genetics and the Key Laboratory of Protein Chemistry and developmental biology of Ministry of Education,College of Life Sciences,Hunan Normal university,Changsha,Hunan 410081,P.R. China 2.department of Biostatistics and Bioinformatics,School of Public Health and Tropical Medicine,Tulane university, New Orleans,Louisiana 70112.usa.3 School of Life Science and Technology,Xian Jiaotong university,Xian,Shanxi 710049,P.R.China 4 Center of Systematic Biomedical Research,university of Shanghai for Science and Technology,Shanghai 2.0093, P.R.China

Bone size(BS)is one of major risk factors for osteoporotic *** variation is determined genetically to a substantial degree with heritability over 50%,but specific genes underlying variation of BS are still largely *** identify specific genes for BS in Chinese,initial genome-wide association scan(GWAS)study and follow-up replication study were ***

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中国继续医学教育 2024年第20期16卷 61-64页

作者：郑思敏刘鸿涛刘英牛晓丽吕建瑞李伟西安交通大学第二附属医院麻醉科陕西西安710004

为探究临床麻醉带教过程中,可明显提升教学质量和学生处理危及事件应变能力的新型教学方法,文章以麻醉过程中较常出现的危急事件为核心,在麻醉教学中成立教学小组和考核小组,教师结合危急事件教学目标设计临床案例,由学生进行分析和讨论... 详细信息

为探究临床麻醉带教过程中,可明显提升教学质量和学生处理危及事件应变能力的新型教学方法,文章以麻醉过程中较常出现的危急事件为核心,在麻醉教学中成立教学小组和考核小组,教师结合危急事件教学目标设计临床案例,由学生进行分析和讨论,考核小组结合理论和实践过程进行评价和总结以及处理意见。案例教学法(case-based learning,CBL)可以激发学生结合实际案例主动学习相应理论知识的兴趣,更提升了学生处理危急事件的能力,改变以往的“教师讲学生听”的学习方法,同时也激发了教师主动思考和根据最新文献更新知识的能力,真正意义上实现了教学相长。麻醉医生是手术室的“内科医生”,需要掌握多方面的理论知识,应用CBL教学法可以快速地让学生在某类危急事件的学习中掌握周边理论知识及处理能力,在教学效果上有明显的提高,改善了以往麻醉教学“不理解、记不住,不会用”的现状,提升了学生的应变能力,为各类考试和临床工作打下坚实的基础。

关键词： CBL教学法麻醉学带教危急事件应变能力效果

Pestalotiopsis fici genome reveals the richness of secondary metabolites of endophytic fungus

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电生理监测^(12.)I粒子治疗癌性臂丛神经损伤临床疗效的价值

2.12.中国菌物学会学术年会

作者： Xiuna Wang~(1 2. ling liu~1 Xinyu Zhang~1 Gang liu~1 Liangdong Guo~1 Yongsheng Che~1 Chengshu Wang~3 Zhiqiang An~4 Liyun Guo~2.Xingzhong liu~(1*) (1 State Key Laboratory of Mycology Institute of Microbiology Chinese Academy of Sciences No 3 1~(st) West Beichen Rd Chaoyang District Beijing 100101 China 2.department of Plant Pathology China Agricultural university Beijing 100094 China 3 Key Laboratory of Insect developmental and Evolutionary biology Institute of Plant physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 2.0032.China 4 Institute of molecular Medicine university of Texas Health Science Center at Houston Houston TX 77030 usa. department of Plant Pathology China Agricultural University Beijing 100094 China State Key Laboratory of Mycology Institute of Microbiology Chinese Academy of SciencesNo 3 1st West Beichen Rd Chaoyang District Beijing 100101 China Key Laboratory of Insect Developmental and Evolutionary Biology Institute of Plant physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China Institute of Molecular Medicine University of Texas Health Science Center at Houston HoustonTX 77030 USA Department of Plant Pathology China Agricultural University Beijing 100094 China State Key Laboratory of Mycology Institute of Microbiology Chinese Academy of SciencesNo 3 1st West Beichen Rd Chaoyang District Beijing 100101 China

＜正＞Endophytic fungi grow within their plant hosts without causing apparent disease symptoms and are an important source of novel bioactive secondary metabolites（Schulz,*** C. Boyle 2.06,Strobel,G.,***,et al.2.04）.Pestalotiopsis fici,an important woody plant endophyte,produces numerous bioactive secondary metabolites（liu,L 2.11）.To reveal the mystery of so many secondary metabolites,the genome of *** was shotgun sequenced using a Roche 454 GS FLX *** is a 51.91 Mb genome size containing～16,063 predicted protein-encoding *** indicated that the gene clusters for secondary metabolites were significantly expanded in number and diversity comparing with other fungal *** protein families related to secondary metabolism,such as MFS general substrate transporter, aromatic compound dioxygenase,cytochrome P450,FAD-binding domain oxidase,ankyrin repeat, Zn2.Cys6 DNA-binding domain *** more abundant in the genome of *** based on the Pfam and caFE *** preliminary analysis also found evidence for horizontal transfer of a secondary metabolite gene cluster from host plants to *** research explained that the richness of secondary metabolites in endophytic fungi from gene expansion and horizontal transfer of gene clusters.

关键词： Endophytic fungi secondary metabolite genome

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中华核医学与分子影像杂志 2024年第9期44卷 545-548页

作者：裴晓路高贞宋林敬底彦张利娟刘泽洲张宏涛河北省人民医院肿瘤科石家庄050051 河北省人民医院神经内科石家庄050051

目的通过神经电生理监测来探讨^(12.)I粒子植入术对癌性臂丛神经压迫所致疼痛及运动障碍的临床疗效。方法回顾性选择2.2.年1月至2.2.年8月河北省人民医院肿瘤科行^(12.)I粒子治疗癌性臂丛神经损伤的8例患者(男女各4例, 年龄58~63岁), ... 详细信息

目的通过神经电生理监测来探讨^(12.)I粒子植入术对癌性臂丛神经压迫所致疼痛及运动障碍的临床疗效。方法回顾性选择2.2.年1月至2.2.年8月河北省人民医院肿瘤科行^(12.)I粒子治疗癌性臂丛神经损伤的8例患者(男女各4例, 年龄58~63岁), 采用疼痛数字评价(NRS)量表及运动功能评定(F-M)量表评估患者的患肢疼痛及运动障碍情况, 应用电生理监测肌皮神经、腋神经、正中神经、尺神经、桡神经感觉及运动支于治疗前及治疗后3个月的传导速度。采用配对样本t检验分析数据。结果 8例患者均为中重度疼痛(6例伴运动功能障碍), 术前及术后3个月NRS评分分别为(5.9±1.0)和(3.3±1.7)分(t=4.93, P=0.002., F-M评分分别为(44.8±7.6)和(54.8±5.7)分(t=-3.52. P=0.017)。电生理结果显示, 7例患者病灶累及臂丛下干, 1例患者累及臂丛上干。术前及术后3个月尺神经运动支传导速度分别为(47.2.2.6)和(59.7±8.2. m/s(t=-3.17, P=0.034), 感觉支传导速度为(41.8±1.2.和(56.0±5.7) m/s(t=-5.82. P=0.001), 神经传导速度较术前升高。结论 ^(12.)I粒子植入术对因臂丛神经受压导致的癌性疼痛及运动障碍具有良好临床疗效, 电生理前后变化可定量监测臂丛神经的感觉及运动功能恢复。

关键词：臂丛神经病肿瘤近距离放射疗法碘放射性同位素神经电生理监测

Measurements of the 2._(3/2. Vacancy State Alignment of Au Induced by Proton, Lithium and Boron Ion Impact

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Chinese Physics Letters 1993年第3期10卷 135-138页

作者： XIA Zonghuang MA Hongji ZHUANG Yongzhong XIE Xiaohong liu hongtao LU Xiting department of Technical Physics Peking UniversityBeijing 100871

In this paper,the degree of alignment of 2._(3/2. vacancy state in Au induced by proton,lithium and boron ion impact was measured using a Si(Li)*** the projectile-energy dependence of the degree of alignment was investigated over the projectile energy range from 0.2.MeV/amu to 2.0MeV/*** de-alignment phenomenon was observed for small relative impact velocities.

关键词： alignment boron lithium