Pestalotiopsis fici genome reveals the richness of secondary metabolites of endophytic fungus

作     者：Xiuna Wang~(1 2) Ling Liu~1 Xinyu Zhang~1 Gang Liu~1 Liangdong Guo~1 Yongsheng Che~1 Chengshu Wang~3 Zhiqiang An~4 Liyun Guo~2 Xingzhong Liu~(1*) (1 State Key Laboratory of Mycology Institute of Microbiology Chinese Academy of Sciences No 3 1~(st) West Beichen Rd Chaoyang District Beijing 100101 China 2 Department of Plant Pathology China Agricultural University Beijing 100094 China 3 Key Laboratory of Insect Developmental and Evolutionary Biology Institute of Plant physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China 4 Institute of Molecular Medicine University of Texas Health Science Center at Houston Houston TX 77030 USA) 

作者单位：Department of Plant Pathology China Agricultural University Beijing 100094 China State Key Laboratory of Mycology Institute of Microbiology Chinese Academy of SciencesNo 3 1st West Beichen Rd Chaoyang District Beijing 100101 China Key Laboratory of Insect Developmental and Evolutionary Biology Institute of Plant physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200032 China Institute of Molecular Medicine University of Texas Health Science Center at Houston HoustonTX 77030 USA Department of Plant Pathology China Agricultural University Beijing 100094 China State Key Laboratory of Mycology Institute of Microbiology Chinese Academy of SciencesNo 3 1st West Beichen Rd Chaoyang District Beijing 100101 China 

会议名称：《2012年中国菌物学会学术年会》

会议日期：2012年

学科分类：0710[理学-生物学] 07[理学] 071007[理学-遗传学] 

关 键 词：Endophytic fungi secondary metabolite genome 

摘      要：正Endophytic fungi grow within their plant hosts without causing apparent disease symptoms and are an important source of novel bioactive secondary metabolites（Schulz,*** C. Boyle 2006,Strobel,G.,***,et al.2004）.Pestalotiopsis fici,an important woody plant endophyte,produces numerous bioactive secondary metabolites（Liu,L 2011）.To reveal the mystery of so many secondary metabolites,the genome of *** was shotgun sequenced using a Roche 454 GS FLX *** is a 51.91 Mb genome size containing～16,063 predicted protein-encoding *** indicated that the gene clusters for secondary metabolites were significantly expanded in number and diversity comparing with other fungal *** protein families related to secondary metabolism,such as MFS general substrate transporter, aromatic compound dioxygenase,cytochrome P450,FAD-binding domain oxidase,ankyrin repeat, Zn2/Cys6 DNA-binding domain *** more abundant in the genome of *** based on the Pfam and CAFE *** preliminary analysis also found evidence for horizontal transfer of a secondary metabolite gene cluster from host plants to *** research explained that the richness of secondary metabolites in endophytic fungi from gene expansion and horizontal transfer of gene clusters.