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Enriched photosensitizer for deep-seated-tumor photodynamic therapy

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Photonics Research 2024年第5期12卷 1024-1035页

作者： hongrui shan XUEQIAN WANG QIHENG WEI HAILANG DAI XIANFENG CHEN State Key Laboratory on Fiber Optic Local Area Communication Networks and Advanced Optical Communication Systems Department of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Metal Matrix Composites Shanghai Key Laboratory for Molecular Engineering of Chiral DrugsSchool of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Collaborative Innovation Center of Light Manipulations and Applications Shandong Normal UniversityJinan 250358China

Photodynamic therapy(PDT)is an innovative approach that utilizes photochemical reactions for non-invasive disease *** PDT is limited by the low penetration depth of visible light required for ***,we employed upconversion nanoparticles(UCNPs)to extend the activation wavelength of photosensitizers into the infrared range,enabling a treatment depth of over 10 ***,we also used the abundant amino groups of branched polyethyleneimine(PEI)with spatial structure to enhance the loading capacity of protoporphyrin(PPIX),and we ultimately improved skin tumor clearance ***,we achieved tumor-specific treatment by utilizing folic acid(FA)targeting and active enrichment of *** to cellular experimental results,we demonstrated the remarkable reactive oxygen species generation capability of the material and ultra-low dark ***,we investigated the apoptosis mechanism and demonstrated that the synthesized nanoparticle stimulates the up-regulation of apoptosis-associated proteins Bax/Bcl-2 and Cyto *** in vivo experiments involving intravenous injection in mouse tails,we investigated the anticancer efficacy of the nanoparticle,confirming its excellent PDT *** research provides a promising avenue for future non-invasive treatment of deep-seated tumors,offering a method for the treatment and management of specific cancers.

关键词： treatment utilize utilizing

Single-cell detection by enhancement of fluorescence in waveguides for cancer diagnosis and therapy

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Photonics Research 2021年第12期9卷 2381-2387页

作者： HAILANG DAI hongrui shan ZHANGCHI SUN DAOPENG DAI YUXI shanG ZHUANGQI CAO XIANFENG CHEN State Key Laboratory of Advanced Optical Communication Systems and Networks School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Zhejiang Rongjun Hospital Jiaxing 314000China School of Pharmacy Shanghai Jiao Tong UniversityShanghai 200240China Department of Cardiology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200240China Collaborative Innovation Centre of Light Manipulations and Applications Shandong Normal UniversityJinan 250358China

Cancer is one of the most common diseases to threaten human *** individuals are diagnosed with malignant tumors via a single cell,medical workers are greatly advantageous to early diagnose and intervene in malignant tumors *** this paper,we propose a fluorescence detection map to rapidly distinguish whether the chromosomes of a cell are normal or abnormal by detecting the fluorescent intensity of a single ***,we draw a map from a single cell with an abnormal number of chromosomes that is monitored in real ***,this way offers precise and prompt detection of the surviving of cancer cells at or near the site of the tumor after treatments for cancer,which can achieve personalized cancer diagnosis and ***,cancer recurrences and metastasis can be effectively identified,utilizing this ultrasensitive detection method of an abnormal chromosome number.

关键词： diagnosis utilizing prompt

风险感知、保险认知对农户参保苹果保险决策的影响

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北方园艺 2020年第6期 160-168页

作者：孙嘉馨罗添元单泓睿西北农林科技大学经济管理学院陕西杨凌712100 西北农林科技大学园艺学院陕西杨凌712100

利用2017年陕西省洛川县569个样本农户的微观调研数据,采用补充双对数模型和截断泊松回归模型对农户是否购买苹果保险及购买次数的影响因素进行了分析。结果表明:灾害风险感知和苹果保险认知均正向影响农户参保苹果保险决策;社会网络中... 详细信息

利用2017年陕西省洛川县569个样本农户的微观调研数据,采用补充双对数模型和截断泊松回归模型对农户是否购买苹果保险及购买次数的影响因素进行了分析。结果表明:灾害风险感知和苹果保险认知均正向影响农户参保苹果保险决策;社会网络中政府组织正向影响农户参保苹果保险决策;农户的种植规模越大越倾向于购买苹果保险。鉴于此,该研究提出我国农村地区深化政策性保险推广势必要同乡级、村级政府组织紧密结合,实现保险公司、政府组织与农户的有效对接;要深化农村土地制度改革,实现规模效应,推动农户层次的土地流转,促进苹果产业实现规模化经营的政策建议。

关键词：苹果保险参保决策影响因素泊松门栏模型

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猪源抗菌肽分子改造与应用进展

动物营养学报 2024年第6期36卷 3413-3424页

作者：邵长轩庞佳楠关红蕊单安山东北农业大学动物科学技术学院哈尔滨150030

抗菌肽(AMPs)是动植物、微生物中普遍存在的一种小肽类物质,多数具有广谱抗菌活性,已逐渐发展为替代抗生素的有力候选者之一。猪源AMPs是第一批从哺乳动物中分离得到的AMPs,已发现有30多种,主要包括Cathelicidins家族和防御素(defensins... 详细信息

抗菌肽(AMPs)是动植物、微生物中普遍存在的一种小肽类物质,多数具有广谱抗菌活性,已逐渐发展为替代抗生素的有力候选者之一。猪源AMPs是第一批从哺乳动物中分离得到的AMPs,已发现有30多种,主要包括Cathelicidins家族和防御素(defensins)家族。这些猪源AMPs抗菌机制与抗生素不尽相同,其可以与细菌细胞膜相互作用破坏膜的完整性,最终导致细菌细胞内容物泄漏并杀死细菌,因此不易产生耐药性。但天然猪源AMPs还存在稳定性差、细胞毒性高及规模生产成本高等问题,目前的研究在于先后开发了氨基酸替换、序列截断、杂合、结构优化和/或脂肪酸修饰等方法,以期获得兼具高效和低毒的短序列AMPs。本文根据猪源AMPs的来源家族进行分类,并对其二级结构、抑菌机制及现阶段的改造和应用状况进行了综述。

关键词：猪源抗菌肽抑菌机制分子改造应用

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技术时代的非虚构新闻写作

媒介批评 2024年第1期 227-241页

作者：柳珊张宏睿同济大学艺术与传媒学院

非虚构新闻写作近年来引起了新闻传播学界和业界的广泛关注,大家讨论的重心主要集中在“what”和“why”两个层面,并试图从中获得借助新媒体技术重振新闻业的可能。本文从非虚构新闻写作的实践逻辑出发,在强调其“新闻性”的同时,通过... 详细信息

非虚构新闻写作近年来引起了新闻传播学界和业界的广泛关注,大家讨论的重心主要集中在“what”和“why”两个层面,并试图从中获得借助新媒体技术重振新闻业的可能。本文从非虚构新闻写作的实践逻辑出发,在强调其“新闻性”的同时,通过其以“讲故事”的形态表现在形式、内容、读者社区三方面的特征去考察它是如何(how)与当今这个技术时代的普通人的心灵建立内在联系的,并指出非虚构写作的恒久魅力在于心理真实,进而力图为理解当下我们的时代、我们的新闻业以及与新闻生产密切相关的受众提供一条可能的路径。

关键词：非虚构新闻写作技术时代讲故事

A vector hybrid triboelectric sensor(HTS)for motion identification via machine learning

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Nano Research 2023年第7期16卷 10120-10130页

作者： Nannan Zhou hongrui Ao Xiaoming Chen shan Gao Hongyuan Jiang School of Mechatronics Engineering Harbin Institute of TechnologyHarbin 150001China School of Control Engineering Northeastern University at QinhuangdaoQinhuangdao 066004China

Rapidly responding and cost-effective sensors played a crucial role in industrial ***,the lack of versatile strategies for identifying and classifying operating states on various practical behaviors has limited the rapid development of monitoring *** study developed a vector hybrid triboelectric sensor(HTS)with surface nanocrystalline containing triboelectric vibration and rotation units(triboelectric vibration unit(TVU),triboelectric rotation unit(TRU))capable of detecting the vibrational and rotary states of the *** synchronous detection of two sensing signals can be achieved due to the hierarchical structure as the basic unit of the HTS,which contributed to reducing the volume and spatial distribution of the *** on the voltage/current/charge(U-I-Q)signal amplitudes and phase features generated by the TVU,the vibration frequency and orientation of the device can be identified by using a double-layer neural network(D-LNN),in which the accuracy reaches 96.5%and 95.5%***,by combining logistic regression,D-LNN,and linear regression,the accuracy of the TRU for rotary classification exceeds 93.5%in practical *** this study,the great potential application of the HTS combined with the machine learning methods was successfully explored and exhibited and it might speed up the development of industrial detection in the near future.

关键词： vector triboelectric sensor surface nanocrystalline hierarchical structure sensing properties state detection machine learning

机器学习在婴幼儿孤独症谱系障碍早期筛查中的应用进展

维普期刊数据库评论

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教育生物学杂志 2024年第2期12卷 149-153,159页

作者：朱宏锐张华任珊梅媛肖归海南医学院海口571199

孤独症谱系障碍(autism spectrum disorder,ASD)起病于发育早期,对婴幼儿进行早期筛查是实现尽早干预和改善预后的关键。随着信息技术和医疗信息化的不断发展,机器学习在婴幼儿ASD早期筛查中的应用备受关注,并显示出其特有的优势。该文... 详细信息

孤独症谱系障碍(autism spectrum disorder,ASD)起病于发育早期,对婴幼儿进行早期筛查是实现尽早干预和改善预后的关键。随着信息技术和医疗信息化的不断发展,机器学习在婴幼儿ASD早期筛查中的应用备受关注,并显示出其特有的优势。该文梳理机器学习在婴幼儿ASD早期筛查中的研究进展,旨在全面了解其发展态势,并剖析现有不足,为推动婴幼儿ASD早期筛查提供有益的借鉴。

关键词：孤独症谱系障碍机器学习早期筛查婴幼儿

Fluid inclusions in whiteschist in the ultrahigh-pressure metamorphic belt of Dabie shan,China

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Chinese Science Bulletin 2002年第12期47卷 1028-1032页

作者： hongrui Fan Jingbo Liu Jinghui Guo Kai Ye Bolin Cong Chinese Acad Sci Inst Geol & Geophys Beijing 100029 Peoples R China

Hualiangting whiteschist in the Dabie shan ultrahigh-pressure eclogite complex is a specific Mg-Al-rich metamorphic rock. Its protolith was a felsic dyke, which suffered replacement by high-pressure fluids during ec-logite-facies metamorphism. Based on fluid inclusion results in whiteschist, primary high-pressure fluids are CO2-bearing aqueous solutions. Those prove that there exists CO2-H2O fluid during the ultrahigh-pressure metamorphism. Pseu-dosecondary H2O inclusions were trapped during ultra-high-pressure exhumation, whereas secondary H2O inclusions were related to the latest evolutionary stage of the ultrahigh-pressure exhumation.

关键词： fluid inclusion whiteschist ultrahigh-pressure Dabie shan.

太原市血液筛查后输血传播HIV残余风险度的评估

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中国艾滋病性病 2020年第5期26卷 540-542页

作者：陕柏峰史宏睿焦东丽太原市红十字血液中心太原030024 长治医学院山西长治046000

目的评估太原市无偿献血者艾滋病病毒(HIV)感染情况,血液筛查后经输血传染HIV的残余风险度。方法回顾性分析2013-2017年无偿献血者HIV检测结果,比较初次献血者组和重复献血者组中男性和女性的HIV阳性率,用流行率/窗口期数学模型法对残... 详细信息

目的评估太原市无偿献血者艾滋病病毒(HIV)感染情况,血液筛查后经输血传染HIV的残余风险度。方法回顾性分析2013-2017年无偿献血者HIV检测结果,比较初次献血者组和重复献血者组中男性和女性的HIV阳性率,用流行率/窗口期数学模型法对残余危险度进行评估。结果共检测无偿献血者血液标本444501份。初次献血者组男性和女性的抗-HIV阳性率分别为0.73‰和0.13‰,重复献血者组男性和女性的抗-HIV阳性率分别为0.33‰和0.02‰。经评估抗-HIV筛查后总残余风险为14.81×10-6,其中男性无偿献血者HIV残余风险为14.03×10-6,女性为0.78×10-6,初次献血者HIV残余风险为9.70×10-6,重复献血者为5.11×10-6。结论太原市无偿献血者HIV流行率初次献血者高于重复献血者,男性高于女性。现有条件下,传播HIV的残余风险男性献血者较女性大,初次献血者较重复献血者大。

关键词：艾滋病病毒无偿献血者残余风险