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用好的作风选人,选作风好的人

桂海论丛 2002年第1期18卷 21-23页

作者：陈鸿宁中共柳江县委广西柳江545500

坚持任人唯贤 ,是加强和改进党的作风建设的组织保证。用什么人 ,不用什么人 ,对党的作风建设具有重要的导向作用。因此 ,坚持用好的作风选人、选作风好的人 ,是新形势下对选拔任用工作提出的新要求 ,对建设一支符合“三个代表”重要思... 详细信息

坚持任人唯贤 ,是加强和改进党的作风建设的组织保证。用什么人 ,不用什么人 ,对党的作风建设具有重要的导向作用。因此 ,坚持用好的作风选人、选作风好的人 ,是新形势下对选拔任用工作提出的新要求 ,对建设一支符合“三个代表”重要思想要求的高素质干部队伍具有重要意义。

关键词：中国共产党党的作风建设干部人事制度改革

基于临床用药与社会学视角探讨中药用药风险的原因与防控对策

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西部中医药 2023年第9期36卷 55-59页

作者：祁梅顾志荣杨浩陈红宁葛斌甘肃省人民医院药剂科甘肃兰州730000 甘肃中医药大学药学院甘肃兰州730000

目的:从临床用药与社会学视角探讨中药用药风险的原因与防控对策。方法:收集临床及社会上有关中药用药风险的典型案例,探讨中药用药风险原因,并提出相应防控对策。结果:中药用药风险的主要原因包括中药用药相关指南与共识建设不足,忽视... 详细信息

目的:从临床用药与社会学视角探讨中药用药风险的原因与防控对策。方法:收集临床及社会上有关中药用药风险的典型案例,探讨中药用药风险原因,并提出相应防控对策。结果:中药用药风险的主要原因包括中药用药相关指南与共识建设不足,忽视中药用药警戒,临床中不严格甚至不辨证使用中药,无适应证及随意超适应证使用中药,根据偶见报道的现代药理作用随意选用中药,不合理联合使用中药,中药注射剂滴速及溶媒控制不严格,主要药味、功效主治相同或相近的中成药、汤剂、中药注射剂重复使用,以及社会舆论的非正确导向与传播等。建议进一步倡导遵守国家相关政策规定,强化中药合理使用相关政策规定与临床指南建设,构建基于临床大数据及循证医学证据的适合西医医师使用的常见疾病辨证用药数据库/手册、常见中药注射剂与中成药辨证使用数据库/手册等,建立特殊中药精准分级管理模式,加大中药安全合理使用相关科普力度与广度,积极干预医师根据偶见报道的现代药理作用随意选用中药,加强中药用药风险评价体系、预警机制及相关平台建设。结论:中药用药风险的原因涉及临床用药与社会学两个层面,应在两个层面同时加强警惕并积极合理干预。

关键词：中药临床用药用药风险风险防控社会舆论

Privacy Preserving Algorithm for Spectrum Sensing in Cognitive Vehicle Networks

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Chinese Journal of Electronics 2024年第1期33卷 30-42页

作者： hongning LI Tonghui HU Jiexiong chen Xiuqiang WU Qingqi PEI Guangzhou Institute of Technology Xidian University Guangzhou CEPREI Shaanxi Key Laboratory of Blockchain and Secure Computing

The scarcity of spectrum resources fails to meet the increasing throughput demands of vehicular networks. There is an urgent need to maximize the utilization of spectrum bands in mobile networks. To ascertain the availability of spectrum bands, users should engage in wireless channel sensing and collaboration. However, spectrum sensing data always involves users' privacy, such as their location. This paper first introduces sensing trajectory inference attack in cognitive vehicular networks and then proposes a data confusion-based privacy-preserving algorithm and a cryptonym array-based privacy-preserving aggregation scheme for spectrum sensing in cognitive vehicular networks. Unlike existing methods, the proposed schemes transmit confused data during the aggregation process. This deliberate obfuscation makes it almost impossible to infer users' location from the transmitted data. The analysis demonstrates the resilience of the proposed schemes against sensing trajectory inference attack.

关键词： Privacy Data privacy Wireless sensor networks Authentication Data aggregation Throughput Inference algorithms

Recent developments of the high strength and high ductility nanostructured materials

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Baosteel Technical Research 2010年第S1期4卷 93-页

作者： Jian LU,Aiying chen,hongning KOU,Ying LI,Leyu WANG and Chunsheng WEN Department of Mechanical Engineering,The Hong Kong Polytechnic University,Hung Hom Kowloon,Hong Kong,China

This talk will summarize the recent work related to a kind of new nanomaterials produced by the SMAT (surface mechanical attrition treatment).The concept of surface nanocrystallization of materials will be *** terms of the grain refinement mechanism induced by plastic deformation,a novel surface mechanical attrition(SMA) technique was developed for synthesizing a nanostructured surface layer on metallic materials in order to upgrade the overall properties and *** grain refinement mechanism of the surface layer during the SMA treatment will be analyzed in terms of the nanostructure observations in several typical *** high yield stress(5 times of the base material) on the surface layer of the material obtained by the SMAT has been *** effect of surface nanostructures on the mechanical behavior and on the failure mechanism of metallic material shows the possibility to develop a new strength gradient composite using co-rolling and *** role of residual stress induced during the treatment will be investigated and *** developed materials are also porosity free materials which can be used as reference material for the local mechanical behavior investigation technique such as the nanoindentation.A general concept for obtaining high strength and high ductility nanostructured materials will be *** exceptional high strength and high ductility steels have *** simulation of the mechanisms for improving ductility of high strength nanostructured materials will be *** potential applications for the land transportation vehicles(car,bus,train) and wind energy have been *** examples of concept design for the integration of the advanced nanostructured steels will be presented.

关键词： nanostructured materials high strength high ductility surface mechanical attrition treatment(SMAT)

Liver metabolomic characteristics in three different rat models of Yin deficiency based on ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry

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Journal of Traditional Chinese Medicine 2023年第2期43卷 274-285页

作者： HU Xingyao LIU hongning YAN Xiaojun chen Zhong FU Liu LIU Ge chen Xuan SHANG Guangbin Jiangxi University of Chinese Medicine Research Center for Differention and Development of Traditional Chinese Medicine(TCM)Basic Theory Jiangxi Province Key Laboratory of TCM EtiopathogenisisNanchang 330004China

OBJECTIVE:To investigate the mechanism of Yin deficiency syndrome(YDS) by analyzing the liver metabolomic characteristics of three different Yin deficiency rat models METHODS:Following the TCM etiology,for clinical features and pathological manifestations of modern medicine,three kinds of animal models of Yin deficiency were induced and *** 48 Sprague-Dawley(SD) male rats were randomly divided into blank group,irritation induced model group,Fuzi-Ganjiang induced model group,and thyroxine-reserpine induced model *** successful development of model,the ultraperformance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry was carried out to detect metabolites in each *** metabolites of rat liver were analyzed for the characteristics of their *** pathway enrichment analysis and metabolic network construction were performed through various online databases including Metabolite Biology Role,Human Metabolome Database,MetaboAnalyst,and Kyoto Encyclopedia of Genes and ***:The SD rats in the experimental group showed symptoms like less weight gain,reduced diet and water intake,high body temperature,increased liver and kidney indexes,and abnormal liver and kidney tissue ***,the rats showed high increased levels of serum cyclic adenosine monophosphate,estradiol,alanine transaminase,and aspartate aminotransferase and decreased levels of cyclic guanosinc monophosphate and *** found four key interrelated metabolic pathways in the liver tissue metabolomics,including the biosynthesis of pantothenic acid and coenzyme A,and metabolism of alpha-linolenic acid metabolism,glycerophospholipid metabolism,and ***:The liver and kidney YDS is closely related to the biosynthesis of pantothenic acid and CoA and abnormal metabolism of α-linolenic acid,glycerophospholipid,and sphingolipid in SD rats.

关键词： molecular biology integrative medicine Yin deficiency syndrome syndrome complex

Observations and analysis of environment and acoustic field changed by the passage of typhoon Damrey in the Yellow Sea in 2012

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Science China Earth Sciences 2015年第12期58卷 2260-2270页

作者： YANG GuangBing Lü LianGang YUAN YeLi JIANG Ying LIU ZongWei YANG ChunMei LIU hongning chen Zhao South China Sea Institute of Oceanology Chinese Academy of Sciences College of Earth Sciences University of Chinese Academy of Sciences Key Laboratory of Marine Science and Numerical Modeling The First Institute of OceanographyState Oceanic Administration

In order to investigate the environment and acoustic filed change induced by typhoon in shallow sea, we conducted two ex- periments just before and after the passage of typhoon Damrey, which is the strongest to affect the area north of the Yangtze River since 1949, in the Yellow sea in 2012. The data show that the temperature of the whole water column increases dramati- cally except the sea surface layer after the passage of Damrey while the salinity decreases obviously. The thermocline deepens and weakens, which leads to a change of internal wave activity. The transmission losses （TL） of the two experiments show that the environment change induced by typhoon can increase the TL as large as 8 dB at a distance of 9.2 km and depth of 15 m. The scintillation index （SI） of the sound intensity is simulated to estimate the change of the effect of internal wave activity on acoustic field showing that the SI decreases to a half after the typhoon＇s passage. The normal mode structures of the two experiments are also significanOy different due to the thermocline changes. In addition, the signal arrives earlier after the ty- phoon＇s passage due to the water temperature increase.

关键词： acoustic field typhoon Damrey thermocline internal wave Yellow Sea shallow sea

Decreases in Both the Seroprevalence of Serum Antibodies and Seroprotection against Japanese Encephalitis Virus among Vaccinated Children

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Virologica Sinica 2019年第3期34卷 243-252页

作者： Ran Wang Lyu Xie Na Gao Dongying Fan Hui chen Peigang Wang hongning Zhou Jing An Department of Microbiology School of Basic Medical Sciences. Chinese Capital Medical UniversityBeijing 100069China Yunnan Provincial Key Laboratory of Vector-borne Disease Control and Research Yunnan Institute of Parasitic DiseasesPu'er 665000China Center of Epilepsy Beijing Institute for Brain DisordersBeijing 100069China

The incidence of Japanese encephalitis(JE)has significantly decreased in China due to JE *** this study,we investigated the post-JE vaccination seroprevalence and protection provided by vaccinated sera against Japanese encephalitis virus(JEV)to elucidate the persistence and waning of antibodies to JEV among JE-SA14-14-2-vaccinated children.A total of 300 serum samples were collected from vaccinated children aged 3-10 years in Zhaotong,Yunnan,*** seroprevalence of anti-JEV antibodies was determined by enzyme-linked immune sorbent assay and plaque reduction neutralization *** highest seropositivity of 82%was observed in vaccinated children during the first 0.5-1.5 years after booster ***,the seropositivity began to decline and remained lower than the original level observed in the 0.5-1.5-year *** association was found between the waning of seroprevalence and elapsed time of the post-booster ***,the neutralizing antibody(nAb)titres gradually decreased over time,and the levels showed a positive correlation with the protective efficacy in *** finding suggests that nAbs play an important role in the antiviral process and that the nAb titre is an adequately credible parameter for evaluating the protective efficacy induced by the JE *** results provide data that clarify the persistence and waning of antibodies to JEV,which may help elucidate the pathogenesis of JE.

关键词： Japanese encephalitis virus(JEV) SA14-14-2 Seroprevalence Neutralizing antibodies Waning of antibody

Bioactive substances and therapeutic potential of camellia oil:An overview

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Food Bioscience 2022年第5期49卷 28-39页

作者： Zhe Li Ao Liu Qing Du Weifeng Zhu hongning Liu Abid Naeem Yongmei Guan Lihua chen Liangshan Ming Institute for Advanced Study Key Laboratory of Modern Preparation of TCMMinistry of EducationJiangxi University of Chinese MedicineNanchang330004JiangxiChina

Camellia oil(CO)extracted from mature camellia seeds has gained considerable attention for nutritional and medicinal applications because of its excellent biological *** main bioactive components present in CO are fatty acids,vitamin E,squalene,phytosterol,flavonoids,and *** studies have demonstrated the potential health benefits of CO,including regulation of lipid and blood pressure levels,inhibiting tumor growth,protecting against Alzheimer’s disease,and having anti-asthmatic,anti-diabetic,anti-inflammatory,antioxidant,and antibacterial ***,the molecular mechanisms of the bioactive substances present in CO are still unclear,limited,and no adequate data has been gathered regarding their health *** to the rapid growth of biological applications of CO,it is necessary to provide an updated review of the current research progress in this *** this review,the advancements in the compositions and structures of CO are discussed in ***,recent research related to CO’s therapeutic potential is *** conclusion,a perspective on the prospects and challenges of CO in biomedicine is also provided.A mechanistic understanding of the chemical compositions and multifunctional properties of CO can provide the basis for the further exploitation of CO in medicine and functional foods.

关键词： Camellia oil Chemical composition Edible oil Functional food Pharmacological activities

Pretreatment with low-frequency repetitive transcranial magnetic stimulation may influence neuronal Bcl-2 and Fas protein expression in the CA1 region of the hippocampus: A possible anti-epilepsy mechanism in a lithium-pilocarpine-induced epileptic rat mod

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Neural Regeneration Research 2010年第12期5卷 895-900页

作者： Sha Ke hongning Zhao Xiaoming Wang Junqiang Zhang Fang chen Yuanxu Wang Xiaoqiong Zhao Hui Huang Jianxiu Hu Department of Electroneurophysiology Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000 Sichuan Province China Department of Electroneurophysiology Research Institute of Neurological Disease North Sichuan Medical College Nanchong 637000 Sichuan Province China

BAOKGROUND： Bcl-2 and Fas proteins are well known as anti-apoptotic and pro-apoptotic factors respectively. However, whether the anti-epileptic mechanism of low-frequency repetitive transcranial magnetic stimulation （rTMS） involves an anti-apoptotic effect via regulating Bcl-2 and Fas protein expression remains to be determined. OBJECTIVE： To verify the correlation between the anti-epileptic mechanism following pretreatment of low-frequency rTMS and anti-hippocampal apoptosis. DESIGN, TIME AND SETTING： A randomized controlled animal experiment was performed at Institute of Neurological Disorders, Affiliated Hospital of North Sichuan Medical College between September 2007 and March 2008. MATERIALS： Pilocarpine （053K13011） was provided by Sigma, USA; lithium was provided by Shanghai Biotechnology Co., Ltd., China; Dantec Maglite-r25 rTMS instrument was provided by Dundee, Denmark. METHODS： A total of 21 adult male Wistar rats were randomly divided into control （n = 6）, rTMS pretreatment （n = 9）, and sham-stimulation （n = 6） groups. The rTMS pretreatment group was pretreated with low-frequency rTMS （0.5 Hz, 75% threshold intensity, 20 times/bundle, and 5 bundles/day）, while the sham-stimulation group was sham-stimulated with a similar sound for 7 successive days to establish lithium-pilocarpine-induced epileptic state models. MAIN OUTCOME MEASURES： Epileptic stroke latency; neuronal morphology was observed using hematoxylin and eosin staining; mean positive-reactive cell number and mean absorbance of Bcl-2 and Fas protein in the hippocampal CA1 region was observed using immunohistochemistry. RESULTS： Epileptic latency in the rTMS pretreatment group was significantly enhanced （P 〈 0.01）, and a number of degenerated neurons were observed to be apoptotic. Bcl-2 protein expression increased at each time point, but Fas protein expression decreased （P 〈 0.01）. CONCLUSION： Low-frequency rTMS has an anti-epileptic effect, which may be via regulation of Bcl-2 and Fas protein ex

关键词： transcranial magnetic stimulation epileptic state Bcl-2 protein Fas protein brain injury neural regeneration