Decreases in Both the Seroprevalence of Serum Antibodies and Seroprotection against Japanese Encephalitis Virus among Vaccinated Children

作     者：Ran Wang Lyu Xie Na Gao Dongying Fan Hui Chen Peigang Wang Hongning Zhou Jing An 

作者机构：Department of MicrobiologySchool of Basic Medical Sciences. Chinese Capital Medical UniversityBeijing 100069China Yunnan Provincial Key Laboratory of Vector-borne Disease Control and ResearchYunnan Institute of Parasitic DiseasesPu'er 665000China Center of EpilepsyBeijing Institute for Brain DisordersBeijing 100069China 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2019年第34卷第3期

页      面：243-252页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 09[农学] 

基　　金：supported by grants from the National Natural Science Foundation of China (81471957, 81772172, 81671971, U1602223 and 81871641) a grant from the Open Research Projects of Key Laboratory of Beijing Ditan Hospital, Capital Medical University (DTKF201705) 

主　　题：Japanese encephalitis virus(JEV) SA14-14-2 Seroprevalence Neutralizing antibodies Waning of antibody 

摘      要：The incidence of Japanese encephalitis(JE)has significantly decreased in China due to JE *** this study,we investigated the post-JE vaccination seroprevalence and protection provided by vaccinated sera against Japanese encephalitis virus(JEV)to elucidate the persistence and waning of antibodies to JEV among JE-SA14-14-2-vaccinated children.A total of 300 serum samples were collected from vaccinated children aged 3-10 years in Zhaotong,Yunnan,*** seroprevalence of anti-JEV antibodies was determined by enzyme-linked immune sorbent assay and plaque reduction neutralization *** highest seropositivity of 82%was observed in vaccinated children during the first 0.5-1.5 years after booster ***,the seropositivity began to decline and remained lower than the original level observed in the 0.5-1.5-year *** association was found between the waning of seroprevalence and elapsed time of the post-booster ***,the neutralizing antibody(nAb)titres gradually decreased over time,and the levels showed a positive correlation with the protective efficacy in *** finding suggests that nAbs play an important role in the antiviral process and that the nAb titre is an adequately credible parameter for evaluating the protective efficacy induced by the JE *** results provide data that clarify the persistence and waning of antibodies to JEV,which may help elucidate the pathogenesis of JE.