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Anti-Seizure and Neuronal Protective Effects of Irisin in Kainic Acid-Induced Chronic Epilepsy Model with Spontaneous Seizures

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Neuroscience Bulletin 2022年第11期38卷 1347-1364页

作者： Jie Yu Yao Cheng Yaru Cui Yujie Zhai Wenshen Zhang Mengdi Zhang Wenyu Xin Jia Liang Xiaohong Pan Qiaoyun Wang hongliu sun School of Pharmaceutical Sciences Binzhou Medical UniversityYantai 264003China The Sixth Scientifc Research Department Shandong Institute of Nonmetallic MaterialsJinan 250031China

An increased level of reactive oxygen species is a key factor in neuronal apoptosis and epileptic *** reportedly attenuates the apoptosis and injury induced by oxidative ***,we evaluated the effects of exogenous irisin in a kainic acid(KA)-induced chronic spontaneous epilepsy rat *** results indicated that exogenous irisin significantly attenuated the KA-induced neuronal injury,learning and memory defects,and *** treatment also increased the levels of brain-derived neurotrophic factor(BDNF)and uncoupling protein 2(UCP2),which were initially reduced following KA ***,the specific inhibitor of UCP2(genipin)was administered to evaluate the possible protective mechanism of *** reduced apoptosis,neurodegeneration,and spontaneous seizures in rats treated with irisin were significantly reversed by genipin *** findings indicated that neuronal injury in KA-induced chronic epilepsy might be related to reduced levels of BDNF and ***,our results confirmed the inhibition of neuronal injury and epileptic seizures by exogenous *** protective effects of irisin may be mediated through the BDNF-mediated UCP2 *** results thus highlight irisin as a valuable therapeutic strategy against neuronal injury and epileptic seizures.

关键词： Epilepsy Seizure Irisin Genipin Neuronal injury

Role of Elevated Thrombospondin-1 in Kainic Acid-Induced Status Epilepticus

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Neuroscience Bulletin 2020年第3期36卷 263-276页

作者： Yurong Zhang Mengdi Zhang Wei Zhu Xiaohong Pan Qiaoyun Wang Xue Gao Chaoyun Wang Xiuli Zhang Yuxia Liu Shucui Li hongliu sun School of Pharmaceutical Sciences Binzhou Medical UniversityYantai 264003China Shandong Academy of Medical Sciences Jinan 250062China

Previous studies have suggested that thrombospondin-1(TSP-1) regulates the transforming growth factor beta 1(TGF-b1)/phosphorylated Smad2/3(p Smad2/3) pathway. Moreover, TSP-1 is closely associated with epilepsy. However, the role of the TSP-1-regulated TGFb1/p Smad2/3 pathway in seizures remains unclear. In this study, changes in this pathway were assessed following kainic acid(KA)-induced status epilepticus(SE) in *** results showed that increases in the TSP-1/TGF-b1/p Smad2/3 levels spatially and temporally matched the increases in glial fibrillary acidic protein(GFAP)/chondroitin sulfate(CS56) levels following KA *** of TSP-1 expression by small interfering RNA or inhibition of TGF-b1 activation with a Leu-Ser-Lys-Leu peptide significantly reduced the severity of KA-induced acute seizures. These anti-seizure effects were accompanied by decreased GFAP/CS56 expression and Smad2/3 phosphorylation. Moreover, inhibiting Smad2/3 phosphorylation with ponatinib or SIS3 also significantly reduced seizure severity, alongside reducing GFAP/CS56 immunoreactivity. These results suggest that the TSP-1-regulated TGF-b1/p Smad2/3 pathway plays a key role in KA-induced SE and astrogliosis, and that inhibiting this pathway may be a potential anti-seizure strategy.

关键词： Astrogliosis Status epilepticus Ponatinib Thrombospondin-1

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药理学融课程思政案例教学设计与评价

卫生职业教育 2021年第8期39卷 42-43页

作者：王巧云孙红柳李志鹏滨州医学院山东烟台264003

从药物与疾病两个契合点入手挖掘药理学课程思政元素,设计教学案例,形成点、线、面的系统化药理学课程思政体系,并对教学路径与评价方法进行积极探索。

关键词：课程思政药理学案例教学

通痹胶囊对高脂血症大鼠血脂和血液流变学的影响

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中药药理与临床 2018年第6期34卷 159-162页

作者：王垣芳王巧云孙红柳赵峰牟琳琳刘同慎刘永俊滨州医学院药学院滨州医学院基础学院滨州256600 烟台渤海制药集团有限公司烟台264000

目的:观察通痹胶囊对实验性高脂血症大鼠血脂水平、血液流变学和肝功能的影响,为其临床研究及合理应用提供参考。方法:雄性SD大鼠60只,随机分为正常对照组、高脂模型组、阳性对照组(辛伐他汀片10mg/kg)和通痹胶囊186、93、46.5mg/kg组... 详细信息

目的:观察通痹胶囊对实验性高脂血症大鼠血脂水平、血液流变学和肝功能的影响,为其临床研究及合理应用提供参考。方法:雄性SD大鼠60只,随机分为正常对照组、高脂模型组、阳性对照组(辛伐他汀片10mg/kg)和通痹胶囊186、93、46.5mg/kg组。除正常对照组外,其余各组大鼠均每天上午灌胃高脂乳剂1 ml/100g,每天下午灌胃相应药物或生理盐水,30天后腹主动脉采血,检测各鼠血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、ALT和AST水平及血液流变学指标,并计算动脉粥样硬化指数(AI),显微镜下观察肝组织形态学变化。结果:模型组大鼠较正常组血清TG、TC、LDL-C、ALT、AST水平和AI显著升高,HDL-C水平显著降低;通痹胶囊186、93g/kg组大鼠与模型组比较血清TG、TC、LDL-C水平及AI显著降低;通痹胶囊186mg/kg组大鼠血清HDL-C水平显著升高;通痹胶囊高、中、低剂量组大鼠血清LDL-C和AI水平呈剂量依赖性降低。模型组大鼠较正常组全血粘度、血浆粘度和红细胞聚集指数显著升高;辛伐他汀片组和通痹胶囊186、93g/kg组全血粘度、血浆粘度和红细胞聚集指数较模型组显著降低;模型组大鼠肝细胞脂肪变性,通痹胶囊各剂量组大鼠肝细胞脂肪变性较轻。结论:通痹胶囊对实验性高脂血症大鼠具有一定的调血脂作用和改善血液流变学的作用,并可减轻高脂血症所致的肝细胞脂肪变性。

关键词：通痹胶囊高脂血症血脂血液流变学肝功能

研究生混合式教学开展的困境与突破——以生物医学研究生为例

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中国医学教育技术 2021年第4期35卷 431-433页

作者：高雪孙红柳秦加阳潘效红滨州医学院药学院细胞工程教研室山东烟台264003

混合式教学作为传统教学与网络教学结合的新兴教学模式,是目前我国高校教学改革的热点话题;但混合式教学在研究生教学开展过程中存在诸多问题,如内容更新不及时、学生不适应、家长不支持、教学评价系统复杂等,此外,对于混合式教学的改... 详细信息

混合式教学作为传统教学与网络教学结合的新兴教学模式,是目前我国高校教学改革的热点话题;但混合式教学在研究生教学开展过程中存在诸多问题,如内容更新不及时、学生不适应、家长不支持、教学评价系统复杂等,此外,对于混合式教学的改革效果也是褒贬不一。文章以生物医学研究生混合式教学实施为切入点,将结合混合式教学开展中的困境,剖析混合式教学实施的突破,力求完善研究生混合式教学的发展。

关键词：混合式教学研究生教育教学质量课程改革

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硅灰石表面的有机化改性及其应用

江苏化工 1994年第4期22卷 15-19页

作者：孙洪流邵长生褚翠英沈钟江苏石油化工学院

本文研究了硅灰石从正丙醇－水溶液中吸附阴离子表面活性剂的吸附等温线，以及溶液中正丙醇含量和温度对吸附量的影响。测定了改性样品的物理结构和表面性质，并讨论了改性硅灰石在橡胶和涂料中的应用。

关键词：硅灰石表面改性表面活性剂吸附改性偏硅酸钙

Intelligent Knee Prostheses: A Systematic Review of Control Strategies

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Journal of Bionic Engineering 2022年第5期19卷 1242-1260页

作者： Linrong Li Xiaoming Wang Qiaoling Meng Changlong Chen Jie sun hongliu Yu Institute of Rehabilitation Engineering and Technology University of Shanghai for Science and TechnologyNo.516Jungong RoadYangpu DistrictShanghai 200093China Shanghai Engineering Research Center of Assistive Devices Shanghai 200093China Key Laboratory of Neural-Functional Information and Rehabilitation Engineering of the Ministry of Civil Affairs Shanghai 200093China

The intelligent knee prosthesis is capable of human-like bionic lower limb control through advanced control systems and artificial intelligence algorithms that will potentially minimize gait limitations for above-knee amputees and facilitate their reintegration into *** this paper,we sum up the control strategies corresponding to the prevailing control objectives(position and impedance)of the current intelligent knee *** these control strategies have been successfully implemented and validated in relevant experiments,the existing deficiencies still fail to achieve optimal performance of the controllers,which complicates the definition of a standard control *** a mature control system can be developed,it is more important to realize the full potential for the control strategy,which requires upgrading and refining the relevant key technologies based on the existing control *** this reason,we discuss potential areas for improvement of the prosthetic control system based on the summarized control strategies,including intent recognition,sensor system,prosthetic evaluation,and parameter optimization algorithms,providing future directions toward optimizing control strategies for the next generation of intelligent knee prostheses.

关键词： Intelligent knee prosthesis Finite-state machine Volitional control Sensor system Intent recognition Parameter tuning

Translational status of biomedical Mg devices in China

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Bioactive Materials 2019年第1期4卷 358-365页

作者： Yu sun hongliu Wu Wenhui Wang Rui Zan Hongzhou Peng Shaoxiang Zhang Xiaonong Zhang State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai200240China Suzhou Origin Medical Technology Co.Ltd. Suzhou215513China

Magnesium(Mg)and its alloys as temporary medical implants with biodegradable and properly mechanical properties have been investigated for a long *** are already three kinds of biodegradable Mg implants which are approved by Conformite Europeene(CE)or Korea Food and Drug Administration(KFDA),but not China Food and Drug Administration(CFDA,now it is National Medical Products Administration,NMPA).As we know,Chinese researchers,surgeons,and entrepreneurs have tried a lot to research and develop biodegradable Mg implants which might become other new approved implants for clinical *** in this review,we present the representative Mg implants of three categories,orthopedic implants,surgical implants,and intervention implants and provide an overview of current achievement in China from academic publications and Chinese *** would like to provide a systematic way to translate Mg and its alloy implants from experiment designs to clinical products.

关键词： Magnesium Implant Device Biomedical translation China

Tail Dependence Study of SSE Composite Index and SZSE Component Index Based on the Copula

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Applied Mathematics 2013年第7期4卷 1065-1069页

作者： Guohua sun hongliu Su Guoqiang Tang College of Science Guilin University of Technology Guilin China

With the rapid development of financial industry, copula methods are more and more widely used for the study of financial fields. By selecting the appropriate copulas, the tail dependence of financial variables can be measured easily. Using the nonparametric estimation method to select A12 copula from Archimedean copulas, and do tail dependence study of SSE composite index and SESE component index. The results show that the SSE composite index and SESE component index simultaneously have the upper tail dependence and lower tail dependence, and the upper tail dependence coefficient is less than the lower tail dependence coefficient, which is consistent with the real financial market rule.

关键词： Rank Copula Nonparametric Estimation Tail Dependence