检索结果-南通市图书馆

An Energy Trading Method Based on Alliance Blockchain and Multi-Signature

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computers, Materials & Continua 2024年第2期78卷 1611-1629页

作者： hongliang tian Jiaming Wang College of Electrical Engineering Northeast Electric Power UniversityJilin132012China

Blockchain,known for its secure encrypted ledger,has garnered attention in financial and data transfer realms,including the field of energy ***,the decentralized nature and identity anonymity of user nodes raise uncertainties in energy *** broadcast consensus authentication slows transaction speeds,and frequent single-point transactions in multi-node settings pose key exposure risks without protective measures during user *** address these,an alliance blockchain scheme is proposed,reducing the resource-intensive identity verification among *** integrates multi-signature functionality to fortify user resources and transac-tion security.A novel multi-signature process within this framework involves neutral nodes established through central *** neutral nodes participate in multi-signature’s signing and verification,ensuring user identity and transaction content *** interactions among user nodes enhances transaction efficiency by minimizing communication overhead during verification and consensus *** assessments on reliability and operational speed highlight superior security performance,resilient against conventional attack *** shows that compared to traditional solutions,this scheme has advantages in terms of running *** conclusion,the alliance blockchain framework introduces a novel approach to tackle blockchain’s limitations in energy *** integrated multi-signature process,involving neutral nodes,significantly enhances security and *** scheme’s efficiency,validated through analytical assessments and simulations,indicates robustness against security threats and improved transactional *** research underscores the potential for improved security and efficiency in blockchain-enabled energy trading systems.

关键词： Alliance blockchain multi-signature energy trading security performance transaction efficiency

Fecal microbiota transplantation: standardization or diversification?

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2019年第12期62卷 1714-1716页

作者： Xueying Zhang hongliang tian Qiyi Chen Huanlong Qin Ning Li Intestinal Microenvironment Treatment Center Shanghai Tenth People’s Hospital Tongji University School of Medicine

Call for standardization of fecal microbiota transplantation(FMT)The gut microbiota plays an important role in human health and *** is often recognized in patients with diseases of the digestive and other systems(Blaser,2019;Li et al.,2018b;Qin et al.,2018).FMT refers to the administration of fecal material containing distal gut microbiota from a healthy person(donor)to a patient(recipient)to restore the gut microecology of the recipient(Kelly et al.,2015).Clinical guidelines have strongly recommended FMT for the treatment of relapsed or refractory Clostridium difficile infection(CDI)(Mullish et al.,2018).FMT has also shown potential clinical benefits in many other diseases related to dysbiosis,including inflammatory bowel disease(IBD),irritable bowel syndrome(IBS),functional constipation(FC),liver diseases,metabolic syndrome,autism,and cancer(Huang et al.,2018;Li et al.,2018a;Zhang et al.,2018).Because of its broad curative potential,FMT has become a topic of great *** than 3,000 published articles have reported treatment of different diseases with FMT,and over 380 FMT trials have been registered on the *** website.

关键词： donor standardization registered

Long-term follow-up of the effects of fecal microbiota transplantation in combination with soluble dietary fiber as a therapeutic regimen in slow transit constipation

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2018年第7期61卷 779-786页

作者： Xueying Zhang hongliang tian Lili Gu Yongzhan Nie Chao Ding Xiaolong Ge Bo Yang Jianfeng Gong Ning Li Department of General Surgery Jinling Hospital Medical School of Nanjing University Shanghai Tenth People's Hospital Tenth People's Hospital of Tongji University Institute of Digestive Diseases Xi Jing Hospital Fourth Military Medical University Department of General Surgery Drum Tower Hospital Medical School of Nanjing University Department of General Surgery Sir Run Run Shaw Hospital Zhejiang University School of Medicine

As some studies have reported that strategies targeting the gut microbiota such as fecal microbiota transplantation(FMT) with or without other microecological therapy might have efficacy in treating slow transit constipation(STC), we conducted a singlecenter, open-label trial to study the long-term effect of FMT combined with soluble dietary fiber(pectin) on STC. Thirty-one adult patients with STC were enrolled into the trial. Patients received 6-day FMT procedures repeatedly for the first 3 months and soluble dietary fiber(pectin) daily during the follow-up. The rate of clinical remission and improvement, stool consistency, the Wexner constipation scale, and assessment of constipation-related symptoms were evaluated at week 4 and 1 year later. The clinical remission and improvement rates at week 4 were 69.0%(20/29) and 75.9%(22/29), respectively. At the end of the study,48.3%(14/29) of patients continued to have at least three complete spontaneous bowel movements per week and 58.6%(17/29)of patients showed clinical improvements. Stool consistency, the Wexner constipation scale, and constipation symptoms improved both at short-term and long-term follow-up. The results indicated that FMT in combination with soluble dietary fiber(pectin) had both short-term and long-term efficacy in treating STC.

关键词： fecal microbiota transplantation soluble dietary fiber slow transit constipation long-term efficacy

Outcomes and prognostic factors of fecal microbiota transplantation in patients with slow transit constipation:results from a prospective study with long-term follow-up

在线全文

学校读者我要写书评

暂无评论

Gastroenterology Report 2018年第2期6卷 101-107,I0002页

作者： Chao Ding Wenting Fan Lili Gu hongliang tian Xiaolong Ge Jianfeng Gong Yongzhan Nie Ning Li Department of General Surgery Drum Tower HospitalMedical School of Nanjing UniversityNanjingChina Department of General Surgery Jinling HospitalMedical School of Nanjing UniversityNanjingChina Medical Technology Institute of Xuzhou Medical University XuzhouChina Institute of Digestive Diseases Xi Jing HospitalFourth Military Medical UniversityXi’AnChina Shanghai Tenth People’s Hospital Tenth People’s Hospital of Tongji UniversityShanghaiChina

Background and aim:Gutmicrobiotamay contribute to regulate colonicmotility,which is involved in the etiology of *** transplantation(FMT)has been demonstrated to restore intestinal *** aimof this study was to evaluate the clinical outcomes and prognostic factors of FMT for the treatment of slow transit constipation(STC).Methods:Fifty-two patients with STC received standardized FMT and were followed up for 6 *** habit,colonic transit time,constipation-related symptoms(PAC-SYM score),quality of life(PAC-QOL score),treatment satisfaction scores and adverse events were *** primary efficacy endpoint was the proportion of patients having on average three or more complete spontaneous bowel movements(CSBMs)per ***:The primary efficacy endpoint was achieved in 50.0%,38.5%and 32.7%of patients over week intervals 3–4,9–12 and 21–24,respectively(P<0.01 for all comparisons).Significant improvements were also observed in other bowel movement assessments,colonic transit time,constipation-related symptoms and quality of life;but all improvements diminished at weeks 12 and *** of evacuation served as the only factor associated with *** serious treatmentrelated adverse events were ***:This study suggested FMT was effective and safe for STC,while a late loss of efficacy was also observed.A lower degree of sensation of incompleteness predicted a better outcome.

关键词： Fecal microbiota transplantation slow transit constipation gut microbiota colonic motility prognostic factors

非定长吊臂非定长系物绳固定旋转起重机的动力学模型

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

机械强度 2008年第1期30卷 20-23页

作者：田红亮三峡大学机械与材料学院宜昌443002

建立非定长吊臂非定长系物绳固定旋转起重机的三维动力学模型。利用第二类拉格朗日方程,推导出二自由度系统的通用运动非线性微分方程。利用软件MATLAB6.5,详细分析活动支座沿径向作加速运动时的响应相轨迹和吊臂作旋转运动时的响应相... 详细信息

建立非定长吊臂非定长系物绳固定旋转起重机的三维动力学模型。利用第二类拉格朗日方程,推导出二自由度系统的通用运动非线性微分方程。利用软件MATLAB6.5,详细分析活动支座沿径向作加速运动时的响应相轨迹和吊臂作旋转运动时的响应相轨迹。对于第一种情况,系统总机械能和哈密顿函数都不守恒,但角动量守恒,简化后的系统可积分。对于第二种情况,角动量不守恒,但哈密顿函数守恒。

关键词：非定长约束固定旋转起重机第二类拉格朗日方程哈密顿函数相轨迹混沌

Fecal microbiota transplantation in clinical practice:Present controversies and future prospects

在线全文

学校读者我要写书评

暂无评论

hLife 2024年第6期2卷 269-283页

作者： hongliang tian Xinjun Wang Zhixun Fang Long Li Chunyan Wu Dexi Bi Ning Li Qiyi Chen Huanlong Qin Department of Colorectal Disease Tenth People’s Hospital of Tongji UniversityShanghaiChina Shanghai Institution of Gut Microbiota Research and Engineering Development Tenth People’s Hospital of Tongji UniversityShanghaiChina Clinical Research Center for Digestive Diseases Tongji UniversityShanghaiChina Bengbu First People’s Hospital AnhuiChina Research Institute of Intestinal Diseases Tongji University School of MedicineShanghaiChina Department of Pathology Tenth People’s Hospital of Tongji UniversityShanghaiChina Realbio Genomics Institute ShanghaiChina

The gut microbiota,serving as the only“organ”that humans can share,has been extensively applied in the treatment of various intestinal and extraintestinal diseases through fecal microbiota transplantation(FMT)*** optimizing the donor selection strategy,FMT exhibited the highest effectiveness(more than 90%)in treating acute intestinal inflammations,such as recurrent Clostridium difficile ***,the efficacy diminishes when addressing intestinal functional diseases(more than 60%),chronic intestinal inflammations or organic diseases(less than 60%),and extraintestinal diseases,particularly those lacking any gastrointestinal symptoms(less than 50%).Ongoing efforts to enhance the therapeutic response of FMT across diverse diseases represent a central focus of current clinical *** review concentrates on donor selection,recipient management,precise donor-recipient matching,antagonistic mechanism of native bacteria to transplanted bacteria,and targeted treatment strategies for different diseases,with the aim of providing practical strategies to improve the clinical efficacy of FMT.

关键词： fecal microbiota transplantation clinical research colonization antagonism

The crystal structure of Zika virus helicase:basis for antiviral drug design

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2016年第6期7卷 450-454页

作者： hongliang tian Xiaoyun Ji Xiaoyun Yang Wei Xie Kailin Yang Cheng Chen Chen Wu Heng Chi Zhongyu Mu Zefang Wang Haitao Yang School of Life Sciences Tianjin University tianjin International Joint Academy of Biotechnology and Medicine The State Key Laboratory of Pharmaceutical Biotechnology School of Life SciencesNanjing University Cleveland Clinic Lerner College of Medicine of Case Western Reserve University

Dear Editor The genus of Flavivirus contains important human pathogens,including dengue(DENV),yellow fever(YFV),West Nile(WNV),Japanese encephalitis(JEV),and tick-borne encephalitis(TBEV)viruses,which cause a number of serious human diseases throughout the world(Pierson TC,2013).Zika virus(ZIKV)is also an arthropod-borne flavivirus,which was initially isolated in 1947 from a febrile sentinel rhesus monkey in the Zika forest in Entebbe,*** is

关键词： genus Flavivirusv important

Discovery of the first macrolide antibiotic binding protein in Mycobacterium tuberculosis： a new antibiotic resistance drug target

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2018年第11期9卷 971-975页

作者： Qingqing Zhang Huijuan Liu Xiang Liu Dunquan Jiang Bingjie Zhang hongliang tian Cheng Yang Luke W. Guddat Haitao Yang Kaixia Mi Zihe Rao College of Life Sciences Nankai University Tianjin 300071 China College of Pharmacy Nankai University Tianjin 300071 China CAS Key Laboratory of Pathogenic Microbiology and Immunology Institute of Microbiology Chinese Academy of Sciences Beijing100101 China School of Life Sciences Tianjin University Tianjin 300072 China School of Chemistry and Molecular Biosciences The University ofQueensland Brisbane QLD 4072 Australia Laboratory of Structural Biology School of Medicine TsinghuaUniversity Beijing 100084 China tianjin International Joint Academy of Biotechnology & Medicine Tianjin 300457 China

Dear Editor The prevalence of multidrug-resistant Mycobacterium tuberculosis （M. tuberculosis） is an increasing problem worldwide （Zumla et al., 2013; Dong et al., 2015）. According to a 2014 World Health Organization （WHO） report, 480,000 individuals world-wide .developed multidrug-resistant tuber- culosis （MDR-TB） and more than 100 countries have cases of extensively drug-resistant tuberculosis （XDR-TB）. Com- pared with drug-susceptible TB, MDR-TB and XDR-TB require prolonged therapeutic treatment with a combination of a number of second-line drugs （Chen et al., 2013）. For patients where TB remains persistent despite prolonged therapy with second-line TB drugs, the add-on agents including bedaquiline and delamanid are recommended for salvage therapy （GUnther, 2014; WHO, 2014; Shim and Jo, 2013）.

关键词：

Effects of Cooling Rate on High-temperature Mechanical Properties of A356 Alloys

在线全文

学校读者我要写书评

暂无评论

稀有金属材料与工程 2011年第S3期40卷 63-68页

作者： Zhang Kai, Sun Yucheng, Wang Suolin, Zheng hongliang, Xu Rongfu, tian Xuelei Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials (Ministry of Education), Shandong University, Jinan 250061, China Shandong Univ Key Lab Liquid Solid Struct Evolut & Proc Mat Minist Educ Jinan 250061 Peoples R China

High temperature mechanical properties of A356 alloy castings under different solidification cooling rates have been studied and the influence of cooling rates on secondary dendrite arm spacing (SDAS) and mechanical properties has been discussed. To get different cooling rates, three different types of mold—green sand, green sand with chill and permanent mold, were used to pour castings which would subsequently be machined into tensile test and metallographic specimens. The temperature curves of castings’ solidification in three different mold were recorded using thermal couples, which would be used to calculate their corresponding cooling rates. Tensile tests were carried out at 20, 200, 300, 400 and 500 ℃ and then mechanical properties, such as tensile strength, yield strength, elongation, of specimens from different mold types at different test temperatures were obtained. And SDAS of different specimens were measured using optical metallographic photos. From integrated analysis of all those results, following conclusions could be reached. The relationship between SDAS and cooling rates is negative, and the quantitative relationship has been obtained through data fitting analyzing. Generally speaking, tensile strength and yield strength decease as the temperature elevates while elongation behaves in the contrary trend. Through the regression analysis of SDAS, mechanical properties and temperature, the relationship among them is obtained, which makes quantitative prediction of A356 alloy’s mechanical properties at different temperatures with different solidification cooling rates be possible.

关键词： A356 alloy high temperature mechanical properties cooling rate SDAS