Fecal microbiota transplantation in clinical practice:Present controversies and future prospects
作者机构：Department of Colorectal DiseaseTenth People’s Hospital of Tongji UniversityShanghaiChina Shanghai Institution of Gut Microbiota Research and Engineering DevelopmentTenth People’s Hospital of Tongji UniversityShanghaiChina Clinical Research Center for Digestive DiseasesTongji UniversityShanghaiChina Bengbu First People’s HospitalAnhuiChina Research Institute of Intestinal DiseasesTongji University School of MedicineShanghaiChina Department of PathologyTenth People’s Hospital of Tongji UniversityShanghaiChina Realbio Genomics InstituteShanghaiChina
出 版 物：《hLife》 (健康科学（英文）)
年 卷 期：2024年第2卷第6期
页 面：269-283页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：This study was supported by the National NaturalScience Foundation of China(81972221,81730102,and 82300753) China postdoctoral science foundation(2022M722412) Top priority project of Shanghai(076478684Q/2023-00154) Major project of Zhangjiang(ZJ2022-ZD-005) Clinical Research Plan of SHDC(SHDC2020CR4026,SHDC2020CR1030B,and SHDC2022CRS041) Project of Shanghai Science and Technology Commission(YDZX20213100003690) Project of Shanghai Municipal Health Commission(19YF1431000 and ZHYY-ZXYJHZX-202105) Anhui Provincial Key R&D Programmes(202304295107020025) Climb Plan of Tenth People’s Hospital of Tongji University(2021SYPDRC045)
主 题：fecal microbiota transplantation clinical research colonization antagonism
摘 要：The gut microbiota,serving as the only“organthat humans can share,has been extensively applied in the treatment of various intestinal and extraintestinal diseases through fecal microbiota transplantation(FMT)*** optimizing the donor selection strategy,FMT exhibited the highest effectiveness(more than 90%)in treating acute intestinal inflammations,such as recurrent Clostridium difficile ***,the efficacy diminishes when addressing intestinal functional diseases(more than 60%),chronic intestinal inflammations or organic diseases(less than 60%),and extraintestinal diseases,particularly those lacking any gastrointestinal symptoms(less than 50%).Ongoing efforts to enhance the therapeutic response of FMT across diverse diseases represent a central focus of current clinical *** review concentrates on donor selection,recipient management,precise donor-recipient matching,antagonistic mechanism of native bacteria to transplanted bacteria,and targeted treatment strategies for different diseases,with the aim of providing practical strategies to improve the clinical efficacy of FMT.
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