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Emerging roles and potential clinical applications of translatable circular RNAs in cancer and other human diseases

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Genes & Diseases 2023年第5期10卷 1994-2012页

作者： hongliang Liu Wenjing hao Jiao Yang Yuliang Zhang Xinfang Wang Chunming Zhang Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck Cancer First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Otolaryngology Head&Neck Surgery First Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Cell Biology and Genetics The Basic Medical School of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Anatomy The Basic Medical School of Shanxi Medical UniversityTaiyuanShanxi 030001China

Circular RNAs (circRNAs) are a special class of single-stranded RNA molecules with covalently closed loops widely expressed in eukaryotic organisms. CircRNAs have long been considered to play important roles in various physiological and pathological processes as non-coding RNAs. However, circRNAs have recently garnered considerable attention due to their ability to be translated into peptides/proteins via internal ribosome entry site- or N6-methyladenosine-mediated pathways or rolling translation mechanisms. Furthermore, dysregulation of translatable circRNAs and their encoded proteins has been associated with developing and progressing diseases such as cancer. This review aims to summarize the driving mechanisms of circRNA translation and the available strategies in circRNA translation research. The main focus is on the emerging biological functions of translatable circRNAs, their regulatory mechanisms, and potential clinical applications in human diseases to provide new perspectives on disease diagnosis, prognosis, and targeted therapy.

关键词： Circular RNA Clinical applications Function Peptide Translation

近岸海域溶解有机质与金属离子的配位机制及溶解氧的影响特性

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海洋科学 2024年第7期48卷 57-67页

作者：徐啸章天晏夏功伟李宏亮陈建芳郑豪浙江大学海洋学院海洋化学与环境研究所浙江舟山316021 自然资源部第二海洋研究所海洋生态系统与动力学重点实验室浙江杭州310012

溶解有机质(DOM)能与金属离子配位,从而影响金属离子的毒性、迁移转化以及生物可利用性,对近岸养殖区的生态环境产生深远的影响。本文利用三维荧光光谱结合平行因子法研究了舟山近岸海域DOM的组成,采用荧光猝灭滴定并运用修正Stern-Vol... 详细信息

溶解有机质(DOM)能与金属离子配位,从而影响金属离子的毒性、迁移转化以及生物可利用性,对近岸养殖区的生态环境产生深远的影响。本文利用三维荧光光谱结合平行因子法研究了舟山近岸海域DOM的组成,采用荧光猝灭滴定并运用修正Stern-Volmer模型系统研究了DOM各荧光组分与典型的过渡金属离子Cu^(2+)、Fe^(3+)和Pb^(2+)的配位机制,并进一步研究了海水溶解氧对DOM与Cu^(2+)、Fe^(3+)和Pb^(2+)配位作用的影响。结果表明:舟山近岸海域DOM的4种荧光组分,两种类腐殖质组分(C1、C2)明显比2种类蛋白质组分(C3、C4)更易与金属离子配位;DOM与金属离子配位化合物稳定性大小依次是:Cu-DOM>Fe-DOM>Pb-DOM;此外,缺氧环境明显抑制了溶解有机质与Fe^(3+)的配位能力,但Cu^(2+)、Pb^(2+)的配位能力则几乎不受溶解氧浓度的影响。这些结果将为海水养殖水体的调控、恢复提供科学依据。

关键词：海洋溶解有机质金属离子溶解氧配位

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潜油直线电机柱塞泵的研究与应用

设备管理与维修 2022年第24期 105-107页

作者：赵忠建郝洪亮吕哲张宏伟赵汉良张慧姝渤海装备辽河钻采装备公司辽宁盘锦124010 辽河石油勘探局有限公司石油化工分公司辽宁盘锦124010 华锦集团公司辽宁盘锦124010 宝石花物业公司辽宁盘锦124010

通过对比抽油机弊端引入新技术发展,研究无杆采油技术原理,设计了直线电机、柱塞式抽油泵、地面控制系统等。根据采油设备生产工艺流程,开发了人机界面应用软件,优化抽油泵体结构,提高无杆泵采油效率,节省设备功率耗能,解决油杆偏磨问... 详细信息

通过对比抽油机弊端引入新技术发展,研究无杆采油技术原理,设计了直线电机、柱塞式抽油泵、地面控制系统等。根据采油设备生产工艺流程,开发了人机界面应用软件,优化抽油泵体结构,提高无杆泵采油效率,节省设备功率耗能,解决油杆偏磨问题。现场试验结果表明,潜油直线电机泵设计合理、安全可靠、运行平稳,泵效与耗能指标有较大提高,具有明显的创新性和实用性,能够满足无杆采油新技术要求,可替代游梁式抽油机应用。

关键词：直线电机无杆采油技术变频器双向柱塞泵人机界面控制

Numerical study of effect of post injection coupled with EGR on combustion and emission performances of CRDI engine fueled with biodiesel-ethanol blends

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Journal of Traffic and Transportation Engineering(English Edition) 2023年第6期10卷 1174-1186页

作者： Limin Geng hongliang Xiao Yuxuan Cui Nan Gao Qi Li hao Chen Yuantao Xie Key Laboratory of Shaanxi Province for Development and Application of New Transportation Energy Chang'an UniversityXian 710064China School of Energy and Electrical Engineering Chang'an UniversityXian 710064China Geely Automobile Research Institute(Ningbo)Co. Ltd.Ningbo 311228China

Energy shortage and environmental pollution are becoming more serious,biodiesel is regarded as the most promising alternative fuel for diesel engines due to its environmentally friendly and renewable *** this study,the biodiesel-ethanol blends were used in a diesel engine,and the purpose of the study was to simultaneously control the NOx and soot emissions of the diesel engine by adjusting the injection strategy and EGR rate.A turbocharged,six-cylinder,common rail direct injection(CRDI)engine model was established using *** effects of the main-post injection strategy and post injection coupled with exhaust gas recirculation(EGR)on combustion and emission characteristics were investigated at a maximum torque speed and a medium *** results show that when the main-post injection strategy is employed,the combustion duration of the main injection is shortened with an increase in the main-post injection interval(MPI).When the MPI increased to more than 18℃A,the heat release of post injection could be observed clearly from the curve of the heat release rate,NOx emissions decreased by 5.70%and 7.12%,respectively,and soot emissions decreased by 25.56%and 30.20%,***,with the increasing post injection quantity,the combustion duration of the main injection shortened,and the peak heat release rate(PHRR)of the post injection *** the fuel quantity for the post injection increased from 2 to 6 mg,NOx emissions decreased from 2.33%to 9.80%,and soot emissions decreased from 16.10%to 34.97%.The effect of post injection quantity on emissions was more significant than that of the *** addition,with increasing EGR rate,the ignition delay is prolonged,the peak cylinder pressure,PHRR,peak combustion temperature and NOx emissions decrease,whereas soot emissions increase ***-post injection can improve the NO-soot trade-off,the optimal EGR rate is 22.86%under a post injection quantity of 4 mg and a MPI of 22℃A.

关键词： Post injection Exhaust gas recirculation Combustion characteristics Exhaust emissions Biodiesel-ethanol blends

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无刷双馈感应电机耦合电路模型仿真研究

分布式能源 2022年第1期7卷 63-68页

作者：段琦玮孙涛郝洪亮朱鸿飞雷振锋夏天奇中国大唐集团新能源科学技术研究院有限公司北京市西城区100052

无刷双馈电机是一种特殊结构的电机,只需较小的变流器容量即可实现多种运行模式的变速运行,同时由于其没有电刷和滑环装置,相比普通双馈感应电机具有更高的稳定性和更低的维护成本,在风电领域被认为有潜力可以替代双馈电机作为风力发电... 详细信息

无刷双馈电机是一种特殊结构的电机,只需较小的变流器容量即可实现多种运行模式的变速运行,同时由于其没有电刷和滑环装置,相比普通双馈感应电机具有更高的稳定性和更低的维护成本,在风电领域被认为有潜力可以替代双馈电机作为风力发电机的主流机型,同时可以应用在变载恒速工况下。无刷双馈电机的控制策略是目前的主要研究方向,而要实现高性能控制则需要精准的电机模型。目前无刷双馈电机的仿真模型主要为d-q坐标轴建模,其参数均为定转子的平均参数值,模型较为简单,同时没有考虑转子的特殊结构。对特殊笼型转子无刷双馈感应电机的耦合电路模型进行了仿真建模,并进行了开环仿真实验,结果表明了该仿真模型可以很好地反映无刷双馈感应电机的动态特性。

关键词：无刷双馈电机无刷双馈感应电机耦合电路模型仿真实验开环实验

骨质疏松患者ETS1的SNP检测及其与miR-760的相关性研究

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中国骨质疏松杂志 2024年第9期30卷 1268-1274页

作者：刘飞飞寇南楠阮玉山岳浩周宏亮余顺毫任莉荣大理大学第一附属医院脊柱外科云南大理671000 昆明医科大学第二附属医院创伤外科云南昆明650106

目的通过检测骨质疏松患者和健康人群中E26转化特异性序列1(ETS1)基因的表达,及其单核苷酸多态性(SNP)位点rs4937333的基因型,探讨ETS1基因上rs4937333位点与其上游调控因子miR-760在骨质疏松发生机制中的关系。方法采集骨质疏松患者和... 详细信息

目的通过检测骨质疏松患者和健康人群中E26转化特异性序列1(ETS1)基因的表达,及其单核苷酸多态性(SNP)位点rs4937333的基因型,探讨ETS1基因上rs4937333位点与其上游调控因子miR-760在骨质疏松发生机制中的关系。方法采集骨质疏松患者和健康人外周血,分离出PBMC、CD4+T细胞和CD19+B细胞,利用qPCR法检测ETS1基因mRNA在不同种细胞中的表达。同时,运用SNaPShot技术对200例骨质疏松患者和45例健康人进行ETS1基因多态位点rs4937333基因型及等位基因频率的检测。另外,构建重组的psi-CHECK-2-ETS1-3′UTR WT和psi-CHECK-2-ETS1-3′UTR MT质粒,用于通过双荧光素酶活性实验检测细胞中荧光素酶的活性。此外,使用qPCR和Western blot技术对突变株和野生株细胞中ETS1基因的表达水平进行了检测。结果与健康人组相比,骨质疏松患者外周血中PBMC、CD4+T和CD19+B细胞中ETS1的表达水平显著降低(P均<0.01)。此外,在骨质疏松患者ETS1基因-3'UTR区域上的SNP位点rs4937333上,C/T基因型占比高于健康人组;qPCR结果显示,C/T基因型患者的ETS1表达水平显著低于C/C基因型患者(P均<0.01)。Luciferase检测发现,miR-760 mimic和ETS1野生型3′UTR共同作用时荧光素酶活性明显下降(P<0.01)。qPCR和Western blot实验检测到,在B淋巴细胞质粒感染过程中,突变株的ETS1表达量低于野生株(P<0.01)。结论miR-760通过靶向调控ETS1基因3′UTR序列上的rs4937333位点,降低ETS1的表达,参与骨质疏松的病理发生。

关键词： ETS1 单核苷酸多态性骨质疏松 miR-760

相容剂对PBAT/硅灰石复合材料性能的影响

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北京化工大学学报（自然科学版） 2024年第1期51卷 59-66页

作者：卢波陆永昌季君晖王萍丽吴毓炜赵宏亮刘芳吴贤王浩海南正翔科技发展有限公司海口570208 中国科学院理化技术研究所北京100190 湖北大学材料科学与工程学院武汉430062 海南省产品质量监督检验所海口570203

以生物降解塑料聚对苯二甲酸己二酸丁二醇酯(PBAT)为聚合物基体,硅灰石(WT)作为填料,以2,3-甲基丙烯酸环氧丙酯(ADR)作为相容剂,通过熔融挤出制备得到PBAT/硅灰石复合材料,考察了相容剂ADR对PBAT/硅灰石复合材料结构及性能的影响。研究... 详细信息

以生物降解塑料聚对苯二甲酸己二酸丁二醇酯(PBAT)为聚合物基体,硅灰石(WT)作为填料,以2,3-甲基丙烯酸环氧丙酯(ADR)作为相容剂,通过熔融挤出制备得到PBAT/硅灰石复合材料,考察了相容剂ADR对PBAT/硅灰石复合材料结构及性能的影响。研究结果表明,相容剂可改善硅灰石在PBAT基体中的分散性,增强界面相互作用,提高复合材料的力学性能和热稳定性。

关键词：生物降解聚对苯二甲酸己二酸丁二醇酯(PBAT) 硅灰石复合材料

Abnormal behaviors of Goos–Hänchenshift in hyperbolic metamaterials madeof aluminum zinc oxide materials

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Photonics Research 2013年第4期1卷 160-163页

作者： Jing Zhao hao Zhang Xiangchao Zhang Dahai Li hongliang Lu Min Xu Shanghai Ultra-precision Optical Manufacturing Engineering Center Department of Optical Science and EngineeringFudan UniversityShanghai 200433China State Key Laboratory of ASIC and System Department of MicroelectronicsFudan UniversityShanghai 200433China

In this paper,the Goos–Hänchen shift(GHS)at the interface between air and the aluminum zinc oxide(AZO)/ZnO hyperbolic metamaterial(AZO-HMM)is theoretically *** results herein show that AZO-HMM can enhance the GHS at the interface to a value at 3 orders of the incident wavelength under special conditions,which is much larger than conventional GHS ***,the GHS can be tuned to be negative or positive by changing the incident wavelength or the volume fraction of AZO.

关键词： GHS oxide interface

Terrestrial water storage variation in Hebei plain area of China,based on ground surface gravimetry

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Geodesy and Geodynamics 2021年第3期12卷 190-196页

作者： Hongtao hao hongliang Liu Xinlin Zhang Jin Wei Bin Zhao Minzhang Hu Key Laboratory of Earthquake Geodesy Institute of SeismologyCEAWuhan430071China Gavitation and Earth Tide National Observation and Research StationWuhan430071China Hubei Earthquake Administration Wuhan430071China Mobile Survey Team of Hebei Earthquake Agency Baoding071000China

Variation of terrestrial water storage in the Hebei plain area from March 2010 to June 2014 was studied using ground gravimetry combined with vertical displacement data from the Global Navigation Satellite *** show that observed gravity variation in this area increased continuously,basically reflecting a trend toward land *** the effect of this subsidence removed,a dominantnegative change in gravity variation was evident,reflecting an average rate of decrease in terrestrial water in this area of 0.10±0.053 m/y,and this is equivalent to a volume of 81.5±43.2×108 m^(3)and is consistent with the spatial distribution of groundwater change from measured hydrologic *** results can be an essential reference and supplement for the study of terrestrial water variation in the Hebei plain area,and indicate that ground surface gravimetry can be used as an important mean for studying changes in terrestrial water.

关键词： Hebei plain area Gravity variation Terrestrial water storage variation Ground surface gravimetry Land subsidence