Emerging roles and potential clinical applications of translatable circular RNAs in cancer and other human diseases

作     者：Hongliang Liu Wenjing Hao Jiao Yang Yuliang Zhang Xinfang Wang Chunming Zhang Hongliang Liu;Wenjing Hao;Jiao Yang;Yuliang Zhang;Xinfang Wang;Chunming Zhang

作者机构：Shanxi Key Laboratory of Otorhinolaryngology Head and Neck CancerFirst Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Shanxi Province Clinical Medical Research Center for Precision Medicine of Head and Neck CancerFirst Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Otolaryngology Head&Neck SurgeryFirst Hospital of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of Cell Biology and GeneticsThe Basic Medical School of Shanxi Medical UniversityTaiyuanShanxi 030001China Department of AnatomyThe Basic Medical School of Shanxi Medical UniversityTaiyuanShanxi 030001China 

出 版 物：《Genes & Diseases》 (基因与疾病（英文）)

年 卷 期：2023年第10卷第5期

页      面：1994-2012页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(No.81802793 and 82103465) Natural Science Foundation of Shanxi Province(China)(No.201801D221419) Youth Foundation of First Hospital Affiliated with Shanxi Medical University(China)(No.YQ161701) Science Research Start-up Fund for Doctor of Shanxi Medical University(China)(No.XD1801) Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi(China)(STIP No.2021-185) Fund of Shanxi"1331 Project"Key Subjects Construction(China) 

主　　题：Circular RNA Clinical applications Function Peptide Translation 

摘      要：Circular RNAs (circRNAs) are a special class of single-stranded RNA molecules with covalently closed loops widely expressed in eukaryotic organisms. CircRNAs have long been considered to play important roles in various physiological and pathological processes as non-coding RNAs. However, circRNAs have recently garnered considerable attention due to their ability to be translated into peptides/proteins via internal ribosome entry site- or N6-methyladenosine-mediated pathways or rolling translation mechanisms. Furthermore, dysregulation of translatable circRNAs and their encoded proteins has been associated with developing and progressing diseases such as cancer. This review aims to summarize the driving mechanisms of circRNA translation and the available strategies in circRNA translation research. The main focus is on the emerging biological functions of translatable circRNAs, their regulatory mechanisms, and potential clinical applications in human diseases to provide new perspectives on disease diagnosis, prognosis, and targeted therapy.