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Association Between Lipid Profiles and Left Ventricular Hypertrophy:New Evidence from a Retrospective Study

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Chinese Medical Sciences Journal 2022年第2期37卷 103-117页

作者： Xuewei Huang Keqiong Deng Juanjuan Qin Fang Lei Xingyuan Zhang Wenxin Wang Lijin Lin Yuming Zheng Dongai Yao Huiming Lu feng Liu Lidong Chen Guilan Zhang Yueping Liu Qiongyu Yang Jingjing Cai Zhigang She hongliang Li Department of Cardiology Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Cardiology Center Hospital of HuanggangHuanggangHubei 438000China Huanggang Institute of Translaten Medicine HuanggangHubei 438000China Department of Cardiology Zhongnan Hospital of Wuhan UniversityWuhan 430071China Institute of Model Animal Wuhan UniversityWuhan 430071China School of Basic Medical Science Wuhan UniversityWuhan 430071China Physical Examination Center The Central Hospital of WuhanWuhan 430014China Physical Exami nation Center Zhongnan Hospital of Wuhan UniversityWuhan 430071China General Medical Department CR&WISCO General HospitalWuhan 430000China In formation Center Hubei Provincial Hospital of Integrated Chinese and Western MedicineWuhan 430015China Department of Medical Examination Center Taihe HospitalHubei University of MedicineShiyanHubei 442000China Department of Health Management Xiaogan Hospital Affiliated to Wuhan University of Science and TechnologyXiaoganHubei 432000China Basic Medical Laboratory General Hospital of Central Theater CommandWuhan 430070China Hubei Key Laboratory of Central Nervous System Tumor and Intervention Wuhan 430070China Chinese Medicine Center Shiyan Renmin HospitalShiyanHubei 442000China Department of Cardiology The Third Xiangya HospitalCentral South UniversityChangsha 410000China

Objective To explore the association between lipid profiles and left ventricular hypertrophy in a Chinese general population.Methods We conducted a retrospective observational study to investigate the relationship between lipid markers[including triglycerides,total cholesterol,low-density lipoprotein cholesterol,high-density lipoprotein(HDL)cholesterol,non-HDL-cholesterol,apolipoprotein A-I,apolipoprotein B,lipoprotein[a],and composite lipid profiles]and left ventricular hypertrophy.A total of 309,400 participants of two populations(one from Beijing and another from nationwide)who underwent physical examinations at different health management centers between 2009 and 2018 in China were included in the cross-sectional study.7,475 participants who had multiple physical examinations and initially did not have left ventricular hypertrophy constituted a longitudinal cohort to analyze the association between lipid markers and the new-onset of left ventricular hypertrophy.Left ventricular hypertrophy was measured by echocardiography and defined as an end-diastolic thickness of the mterventricular septum or left ventricle posterior wall>11 mm.The Logistic regression model was used in the cross-sectional study.Cox model and Cox model with restricted cubic splines were used in the longitudinal cohort.Results In the cross-sectional study for participants in the highest tertile of each lipid marker compared to the respective lowest,triglycerides[odds ratio(OR):1.2S0,95%CI:1.060 to 1.474],HDL-cholesterol(OR:0.780,95%CI:0.662 to 0.918),and lipoprotein(a)(OR:1.311,95%C7:1.115 to 1.541)had an association with left ventricular hypertrophy.In the longitudinal cohort,for participants in the highest tertile of each lipid marker at the baseline compared to the respective lowest,triglycerides[hazard ratio(HR):3.277,95%C/:1.720 to 6.244],HDL-cholesterol(HR:0.516,95%C7:0.283 to 0.940),non-HDL-cholesterol(HR:2.309,95%C/:1.296 to 4.112),apolipoprotein B(HR:2.244,95%CI:1.251 to 4.032)showed an association with new-onset left ventricular hy

关键词： left ventricular hypertrophy lipid triglycerides apolipoprotein

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高层装配式住宅立面设计技术探讨

住宅科技 2015年第8期35卷 17-20页

作者：颜宏亮郭峰同济大学建筑与城市规划学院

随着城市高层装配式住宅建筑的增多,对于其建筑立面细部处理已引起建筑师和使用者的关注。结合工业化建造技术特点,探索预制混凝土构件在高层装配式住宅立面设计中的应用、设计方法和构造技术等问题。

关键词：预制混凝土构件装配式高层住宅立面设计

Progress in clinical research on the integration of Chinese and Western medicines for treating primary liver cancer

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Journal of Traditional Chinese Medical Sciences 2021年第3期8卷 173-185页

作者： Kaiqi Liu hongliang Li Jufeng Duan Xiaojing Chen Xiongjie Yu Xianhe Wang Ming Liu Bei Li Minglun Li Yibin feng Xiaojun Cai Xuanbin Wang Laboratory of Chinese Herbal Pharmacology Oncology CenterRenmin HospitalSchool of PharmacyHubei University of MedicineShiyan442000China Biomedical Research Institute Hubei Key Laboratory of Wudang Local Chinese Medicine ResearchHubei University of MedicineShiyan442000China Department of Radiation Oncology University HospitalLMU MunichMunich81377Germany School of Chinese Medicine The University of Hong KongHong KongChina

Primary liver cancer(PLC) is one of the most common malignant tumors in China. PLC is characterized by insidious onset, rapid progress, poor quality of life, and short survival time. Notably, current treatment strategies remain unsatisfactory. Traditional Chinese medicines(TCM) have been used to treat a variety of diseases, including liver diseases, for more than 2000 years. In this study, we performed a review of the use frequency and clinical efficacy of TCM in treating PLC. Relevant literature from January 1, 2009, to January 1, 2021 was retrieved from network databases of China National Knowledge Infrastructure(CNKI), Chongqing VIP, Wanfang, PubMed, and SinoMed. The most frequently used TCM and their efficacy in PLC treatment were summarized. Based on the inclusion and exclusion criteria, 33 articles were selected. Overall, the efficacy of the combination of TCM and Western medicines in the treatment of PLC was higher than that in the control groups(i.e. treatment with Western medicines alone)(65.11% vs.44.31%, P <.05). Among the 33 selected articles, 11 were investigated for TCM preparation(marketed drugs) and 22 for TCM formulas. In total, 102 types of TCM(single herbs) were used to treat PLC. The top five most frequently used TCM were Poria(14.71%), Astragali radix(13.73%), Atractylodis Macrocephalae Rhizoma(12.75%), Bupleuri radix(12.75%), and Glycyrrhizae radix et Rhizoma(11.76%). Of the 102 types of TCM, tonics were the most frequently used categories, followed by heat-clearing medicines, blood-invigorating medicines, and stasis-resolving medicines. Of 207 papers, 174(84.06%) could not be subjected to statistical analysis due to research quality. Further high-quality research on herb sources, formula components and dosage, toxicology, and ethics of TCM is necessary. In conclusion, TCM play a promising role in the treatment and management of PLC, although further investigations are warranted.

关键词： Traditional Chinese medicines Primary liver cancer Integrative medicine Clinical research

三维多波束系统在库区冲刷淤积计算分析中的应用

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物探化探计算技术 2020年第1期42卷 104-110页

作者：冯艺孙红亮雅砻江流域水电开发有限公司成都610072 四川中水成勘院工程物探检测有限公司成都610072

库区冲刷淤积是水工建筑的安全运行的直接威胁,目前检测方法相对落后。三维多波束系统是一套成熟的海洋测绘技术,由于内陆水电水利工程水下检查需求的特殊性、复杂性,暂未在该方面得到广泛应用。这里基于三维多波束系统检测的高精度水... 详细信息

库区冲刷淤积是水工建筑的安全运行的直接威胁,目前检测方法相对落后。三维多波束系统是一套成熟的海洋测绘技术,由于内陆水电水利工程水下检查需求的特殊性、复杂性,暂未在该方面得到广泛应用。这里基于三维多波束系统检测的高精度水下地形数据,采用自编软件系统,建立DEM模型,对库区水下地形、冲刷淤积及三维成图进行计算分析与应用。结合现场实际情况,表明三维多波束系统在该方面的应用效果较好,可以精确计算库区冲刷淤积现状,建立三维数据基准库并实现三维可视化。

关键词：三维多波束水下地形冲刷淤积计算三维可视化

从国家自然科学基金资助看中国药物成瘾研究的现状和挑战

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中国药物依赖性杂志 2019年第5期28卷 323-328,365页

作者：张洪亮时杰冯雪莲国家自然科学基金委生命科学部北京100085 北京大学中国药物依赖性研究所北京100191

药物成瘾是一种慢性复发性脑疾病,主要表现为成瘾者对药物的过度摄取和无法获取时产生的严重戒断症状及强迫性觅药行为。药物成瘾不仅对个体造成严重的躯体和精神损害,也给家庭和社会造成巨大的危害和经济负担。药物成瘾涉及神经可塑性... 详细信息

药物成瘾是一种慢性复发性脑疾病,主要表现为成瘾者对药物的过度摄取和无法获取时产生的严重戒断症状及强迫性觅药行为。药物成瘾不仅对个体造成严重的躯体和精神损害,也给家庭和社会造成巨大的危害和经济负担。药物成瘾涉及神经可塑性、奖赏、学习记忆等神经科学多个前沿领域。开展成瘾和成瘾相关行为的研究,是国家重大战略需求和服务人口健康事业的重要保障。本文通过回顾国家自然科学基金关于成瘾研究的资助情况,总结现阶段药物成瘾研究的发展现状和趋势,并展望未来药物成瘾研究的机遇与挑战。

关键词：药物成瘾国家自然科学基金国家重大战略需求人口健康事业

能量色散X射线荧光光谱法快速测定固体生物质中砷的含量

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理化检验（化学分册） 2023年第9期59卷 1053-1056页

作者：张宏亮曹嘉洌冯永新梁汉贤南方电网电力科技股份有限公司广州510600 德国斯派克分析仪器公司北京100015

为实现“碳达峰、碳中和”目标,我国加快调整能源结构,大力发展绿色低碳新能源替代化石能源,生物质能作为可再生能源的重要组成部分,是一种取之不尽的可再生能源,也是唯一可以直接存储和运输的可再生能源。由于生物质生长过程中吸收的CO... 详细信息

为实现“碳达峰、碳中和”目标,我国加快调整能源结构,大力发展绿色低碳新能源替代化石能源,生物质能作为可再生能源的重要组成部分,是一种取之不尽的可再生能源,也是唯一可以直接存储和运输的可再生能源。由于生物质生长过程中吸收的CO_(2)与其燃烧利用中排放的CO_(2)是相等的,在总量上实现了零排放,消除了产生温室效应的根源,是我国实现“双碳”目标的重要能源,因此生物质能得到我国政府的高度重视。在国家政策支持下,截止2020年底,我国生物质发电装机容量达2952万千瓦[1]。

关键词：能量色散X射线荧光光谱法可再生能源生物质发电温室效应碳中和直接存储调整能源结构零排放

无创呼吸机联合氧气雾化吸入治疗危重症支气管哮喘的效果研究

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系统医学 2021年第11期6卷 96-98,107页

作者：冯裕广许宏亮北京市大兴区人民医院急诊内科北京102600 中国中医科学院广安门中医院南区内分泌科北京102600

目的探讨无创呼吸机联合氧气雾化吸入治疗危重症支气管哮喘的效果。方法从2018年5月—2020年5月选取84例危重症支气管哮喘患者,随机抽签分为对照组与观察组,各42例,对照组给予常规雾化吸入治疗,观察组给予无创呼吸机联合氧气雾化吸入治... 详细信息

目的探讨无创呼吸机联合氧气雾化吸入治疗危重症支气管哮喘的效果。方法从2018年5月—2020年5月选取84例危重症支气管哮喘患者,随机抽签分为对照组与观察组,各42例,对照组给予常规雾化吸入治疗,观察组给予无创呼吸机联合氧气雾化吸入治疗,对比治疗效果、血清炎性因子、血气指标情况。结果观察组与对照组治疗总有效率分别为(95.24%)及(73.81%),差异有统计学意义(χ^(2)=7.372,P<0.05);治疗后,两组白细胞介素-6(IL-6)及白细胞介素-8(IL-8)均降低,观察组IL-6(132.12±21.45)、IL-8(105.23±24.61)ng/L低于对照组(145.34±21.52)、(155.12±26.78)ng/L,差异有统计学意义(t=2.820、8.890,P<0.05);治疗后,两组动脉血氧分压(PaO_(2))升高,动脉血二氧化碳分压(PaCO_(2))下降,观察组PaO_(2)(85.23±3.56)mmHg、PaCO_(2)(43.81±5.23)mmHg优于对照组(70.27±3.61)、(57.23±4.28)mmHg,差异有统计学意义(t=19.122、12.869,P<0.05)。结论无创呼吸机联合氧气雾化吸入治疗危重症支气管哮喘效果良好,血气指标改善,血清炎性因子水平降低,具有推广价值。

关键词：无创呼吸机氧气雾化吸入危重症支气管哮喘效果

Construction and application of time-effect assessment database for experiments on war-traumatized animals

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Emergency and Critical Care Medicine 2022年第4期2卷 219-224页

作者： Junkang Wang Jing Wang hongliang Zhang Chengyu Guo Yanbiao Wang Bing Lu Cong feng Fei Pan Tanshi Li Medical School of Chinese PLA BeijingChina Department of Emergency First Medical CentreChinese PLA General HospitalBeijingChina Nankai University School of Medicine Tian JinChina NCO School of Army Medical University ShijiazhuangHebeiChina.

Background:High-quality real war trauma data are important,but they are still lacking.Using the database to realize the networked,systematic,standardized,and dynamic management of war injury animal experimental data can provide a real and reliable supplement for the research of war injury treatment.Methods:Through demand analysis,module design,architecture design,compilation and debugging,and other processes,JAVA language development tools were used to develop a time-effect assessment database for experiments on war-traumatized animals,where the browser/server architecture(B/S architecture)is used as the technical architecture and SQL Server as the database management system.Results:A time-effect assessment database for experiments on war-traumatized animals that features reasonable structural design,rich data resources,and convenient use has been established,in which case efficient collection,storage,display,retrieval,and management of animal experimental data have been achieved.At present,the database is running well and has good data quality.

关键词： Animal experiment Database design War trauma

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中厚板轧制过程夹杂物的有限元分析

热加工工艺 2011年第12期40卷 41-44页

作者：张宏亮冯光宏钢铁研究总院冶金工艺研究所北京100081

基于ANSYS有限元软件,对中厚板轧制过程中的夹杂物变形进行数值模拟分析,通过厚度方向的压下传递,解决了微小夹杂物的建模问题,获得了更为准确的数据结果。还分别对MnS和Al2O3软硬两种夹杂物进行数值分析,得到了不同夹杂物产生裂纹缺陷... 详细信息

基于ANSYS有限元软件,对中厚板轧制过程中的夹杂物变形进行数值模拟分析,通过厚度方向的压下传递,解决了微小夹杂物的建模问题,获得了更为准确的数据结果。还分别对MnS和Al2O3软硬两种夹杂物进行数值分析,得到了不同夹杂物产生裂纹缺陷的过程,为更好地控制轧制过程中的夹杂物形态及钢板内部裂纹萌生提供了理论计算基础。

关键词：热轧夹杂物有限元