Progress in clinical research on the integration of Chinese and Western medicines for treating primary liver cancer

作     者：Kaiqi Liu Hongliang Li Jufeng Duan Xiaojing Chen Xiongjie Yu Xianhe Wang Ming Liu Bei Li Minglun Li Yibin Feng Xiaojun Cai Xuanbin Wang Kaiqi Liu;Hongliang Li;Jufeng Duan;Xiaojing Chen;Xiongjie Yu;Xianhe Wang;Ming Liu;Bei Li;Minglun Li;Yibin Feng;Xiaojun Cai;Xuanbin Wang

作者机构：Laboratory of Chinese Herbal PharmacologyOncology CenterRenmin HospitalSchool of PharmacyHubei University of MedicineShiyan442000China Biomedical Research InstituteHubei Key Laboratory of Wudang Local Chinese Medicine ResearchHubei University of MedicineShiyan442000China Department of Radiation OncologyUniversity HospitalLMU MunichMunich81377Germany School of Chinese MedicineThe University of Hong KongHong KongChina 

出 版 物：《Journal of Traditional Chinese Medical Sciences》 (中医科学杂志（英文）)

年 卷 期：2021年第8卷第3期

页      面：173-185页

学科分类：1007[医学-药学(可授医学、理学学位)] 1005[医学-中医学] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：financially supported by the National Natural Science Foundation of China(81874356) the Open Project of Hubei Key Laboratory of Wudang Local Chinese Medicine Research from Hubei University of Medicine(WDCM2018002,WDCM201917,WDCM201918) the Chinese Medicine Project of Health Commission of Hubei Province(ZY2021010) the Foundation for Innovative Research Team of Hubei University of Medicine(2018YHKT01)。 

主　　题：Traditional Chinese medicines Primary liver cancer Integrative medicine Clinical research 

摘      要：Primary liver cancer(PLC) is one of the most common malignant tumors in China. PLC is characterized by insidious onset, rapid progress, poor quality of life, and short survival time. Notably, current treatment strategies remain unsatisfactory. Traditional Chinese medicines(TCM) have been used to treat a variety of diseases, including liver diseases, for more than 2000 years. In this study, we performed a review of the use frequency and clinical efficacy of TCM in treating PLC. Relevant literature from January 1, 2009, to January 1, 2021 was retrieved from network databases of China National Knowledge Infrastructure(CNKI), Chongqing VIP, Wanfang, PubMed, and SinoMed. The most frequently used TCM and their efficacy in PLC treatment were summarized. Based on the inclusion and exclusion criteria, 33 articles were selected. Overall, the efficacy of the combination of TCM and Western medicines in the treatment of PLC was higher than that in the control groups(i.e. treatment with Western medicines alone)(65.11% vs.44.31%, P .05). Among the 33 selected articles, 11 were investigated for TCM preparation(marketed drugs) and 22 for TCM formulas. In total, 102 types of TCM(single herbs) were used to treat PLC. The top five most frequently used TCM were Poria(14.71%), Astragali radix(13.73%), Atractylodis Macrocephalae Rhizoma(12.75%), Bupleuri radix(12.75%), and Glycyrrhizae radix et Rhizoma(11.76%). Of the 102 types of TCM, tonics were the most frequently used categories, followed by heat-clearing medicines, blood-invigorating medicines, and stasis-resolving medicines. Of 207 papers, 174(84.06%) could not be subjected to statistical analysis due to research quality. Further high-quality research on herb sources, formula components and dosage, toxicology, and ethics of TCM is necessary. In conclusion, TCM play a promising role in the treatment and management of PLC, although further investigations are warranted.