检索结果-南通市图书馆

Carboxymethyl chitosan-alginate enhances bone repair effects of magnesium phosphate bone cement by activating the FAK-Wnt pathway

在线全文

学校读者我要写书评

暂无评论

Bioactive Materials 2023年第2期20卷 598-609页

作者： Ling Yu Tian Gao Wei Li Jian Yang Yinchu Liu Yanan Zhao Ping He Xuefeng Li Weichun guo Zhengfu Fan honglian Dai Department of Orthopedic Surgery I(Spine Surgery) Renmin Hospital of Wuhan UniversityWuhan430060China Department of Bone and Soft Tissue Tumor Key Laboratory of Carcinogenesis and Translational ResearchMinistry of EducationPeking University Cancer Hospital&InstituteBeijing100000China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Biomedical Materials and Engineering Research Center of Hubei ProvinceWuhan University of TechnologyWuhan430070China Department of Orthopedic Surgery Renmin Hospital of ShayangJingmen448200China

There is a continuing need for artificial bone substitutes for bone repair and reconstruction,Magnesium phosphate bone cement(MPC)has exceptional degradable properties and exhibits promising ***,its mechanical strength needs improved and its low osteo-inductive potential limits its therapeutic application in bone *** functionally modified MPC by using a polymeric carboxymethyl chitosan-sodium alginate(CMCS/SA)gel *** had the advantages of:improved compressive strength,ease of handling,and an optimized interface for bioactive bone *** new composites with 2%CMCS/SA showed the most favorable physicochemical properties,including mechanical strength,wash-out resistance,setting time,injectable time and heat ***,the composite promoted the attachment and proliferation of osteoblast *** was also found to induce osteogenic differentiation in vitro,as verified by expression of osteogenic *** terms of molecular mechanisms,data showed that new bone cement activated the Wnt pathway through inhibition of the phosphorylation ofβ-catenin,which is dependent on focal adhesion *** micro-computed tomography and histological analysis,we found that the MPC-CMCS/SA scaffolds,compared with MPC alone,showed increased bone regeneration in a rat calvarial defect ***,our study suggested that the novel composite had potential to help repair critical bone defects in clinical practice.

关键词： Critical bone defect Magnesium phosphate cement Carboxymethyl chitosan Sodium alginate Osteogenic differentiation

Laboratory-based Surveillance and Clinical Profile of Sporadic HEV Infection in Shanghai,China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Virologica Sinica 2021年第4期36卷 644-654页

作者： Jie Lu Qing Li Jiayuan Jiang Ziqiang Li Peiyun Wang Zike Sheng Rongtao Lai Huijuan Zhou Wei Cai Hui Wang Qing guo honglian Gui Qing Xie Department of Infectious Diseases Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Clinical Research Institute Shanghai Jiao Tong University School of MedicineShanghai 200025China

The study aimed to describe the epidemiological,virological and clinical features of sporadic HEV infection in eastern China.A total of 6112 patient sera were tested for anti-HEV IgG or anti-HEV IgM during one consecutive year(between August 2018 and July 2019).HEV RNA presence was evaluated by RT-PCR and HEV sequences were phylogenetically *** features of confirmed HEV-infected patients were *** sero-positivity rate of anti-HEV IgG maintained stable around 40%,while an obvious winter spike of anti-HEV IgM prevalence was observed.A total of 111 patients were confirmed of HEV viremia by molecular *** 4d was *** analyses suggest that certain strains circulate across species and around the *** with confirmed current HEV infection had a high median age(58 years)and males were predominant(62.2%).Most patients presented with jaundice(75.7%)and anorexia(68.0%).Significantly elevated levels of liver enzymes and bilirubin were ***,the baseline bilirubin level was positively correlated with illness ***-existing HBV carriage may deteriorate *** clinical burden caused by locally acquired HEV infection is *** should be enforced especially during the transition period from winter to *** with higher level of bilirubin at disease onset had slower recovery from HEV infection.

关键词： Hepatitis E virus(HEV) Seroprevalence Genotyping Epidemiology Surveillance

Label-free breast cancer detection and classification by convolutional neural network-based on exosomes surface-enhanced raman scattering

在线全文

学校读者我要写书评

暂无评论

Journal of Innovative Optical Health Sciences 2023年第2期16卷 3-15页

作者： Xiao Ma honglian Xiong Jinhao guo Zhiming Liu Yaru Han Mingdi Liu Yanxian guo Mingyi Wang Huiqing Zhong Zhouyi guo MOE Key Laboratory of Laser Life Science&Institute of Laser Life Science SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology&Guangdong Provincial Key Laboratory of Laser Life Science Guangzhou Key Laboratory of Spectral Analysis and Functional Probes College of Biophotonics South China Normal University Guangzhou 510631 P.R.China Department of Physics and Optoelectronic Engineering Foshan University Guangdong 528011P.R.China

Because the breast cancer is an important factor that threatens women's lives and health,early diagnosis is helpful for disease screening and a good *** are nanovesicles,secreted from cells and other body fluids,which can reflect the genetic and phenotypic status of parental *** with other methods for early diagnosis of cancer(such as circulating tumor cells(CTCs)and circulating tumor DNA),exosomes have a richer number and stronger biological stability,and have great potential in early ***,it has been proposed as promising biomarkers for diagnosis of early-stage ***,distinguishing different exosomes remain is a major biomedical *** this paper,we used predictive Convolutional Neural model to detect and analyze exosomes of normal and cancer cells with surface-enhanced Raman scattering(SERS).As a result,it can be seen from the SERS spectra that the exosomes of MCF-7,MDA-MB-231 and MCF-10A cells have similar peaks(939,1145 and 1380 cm^(-1)).Based on this dataset,the predictive model can achieve 95%*** with principal component analysis(PCA),the trained CNN can classify exosomes from different breast cancer cells with a superior *** results indicate that using the sensitivity of Raman detection and exosomes stable presence in the incubation period of cancer cells,SERS detection combined with CNN screening may be used for the early diagnosis of breast cancer in the future.

关键词： Exosomes surface-enhanced Raman scattering(SERS) breast cancer convolutional neural model label-free

Iron oxide nanoparticles with photothermal performance and enhanced nanozyme activity for bacteria-infected wound therapy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2022年第1期9卷 548-559页

作者： Jiaxin guo Wenying Wei Yanan Zhao honglian Dai State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Biomedical Materials and Engineering Research Center of Hubei ProvinceWuhan University of TechnologyWuhan 430070China Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Xianhu Hydrogen ValleyFoshan 528200China Shenzhen Research Institute of Wuhan University of Technology Shenzhen 518000China

Metal-based nanomaterials usually have broad-spectrum antibacterial properties,low biological toxicity and no drug resistance due to their intrinsic enzyme-like catalytic properties and external field(magnetic,thermal,acoustic,optical and electrical)***,iron oxide(Fe_(3)O_(4))nanoparticles(IONPs)synthesized by us have good biosafety,excellent photothermal conversion ability and peroxidase-like catalytic activity,which can be used to construct a photothermal-enzymes combined antibacterial treatment *** with peroxide-like catalytic activity can induce H_(2)O_(2)to catalyze the production of·OH in a slightly acidic environment,thus achieving certain bactericidal effects and increasing the sensitivity of bacteria to *** stimulated by near-infrared light,the photothermal effect could destroy bacterial cell membranes,resulting in cleavage and inactivation of bacterial protein,DNA or ***,it can also improve the catalytic activity of peroxidase-like and promote IONPs to catalyze the production of more·OH for killing *** IONPs synergistic treatment,the antibacterial rate of Escherichia coli and Staphylococcus aureus reached nearly 100%.It also has an obvious killing effect on bacteria in infected wounds of mice and can effectively promote the healing of *** wounds,which has great application potential in clinical anti-infection treatment.

关键词： antibacterial photothermal therapy peroxidase-like catalytic therapy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

1例乙状结肠人工阴道成形术病人的护理

护理研究 2009年第5期23卷 463-463页

作者：李晋娥郭红莲程云霞山西省晋城市城区计划生育妇幼保健服务中心

先天性无阴道系胚胎期副中肾管汇合后未能向末端伸展所致,多数病人无子宫,有正常的卵巢功能,第二性征发育良好,除原发性闭经外,无其他临床症状[1].如子宫发育正常,在青春期后可出现周期性腹痛及经血潴留,妇科检查外阴正常.

关键词：病人乙状结肠阴道模具人工阴道成形术

Insights into the deep-tissue photothermal therapy in near-infrared II region based on tumor-targeted MoO2 nanoaggregates

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Materials 2020年第6期63卷 1085-1098页

作者： Yanxian guo Yang Li Wolun Zhang Hongru Zu Haihong Yu Dongling Li honglian Xiong Tristan THormel Chaofan Hu Zhouyi guo Zhiming Liu Guang Provincial Key Laboratory of Laser Life Science&SATCM Third Grade Laboratory of Chinese Medicine and Photonics Technology College of BiophotonicsSouth China Normal UniversityGuangzhou510631China Guangdong Provincial Engineering Technology Research Center for Optical Agriculture College of Materials and EnergySouth China Agricultural UniversityGuangzhou 510642China Department of Physics and Optoelectronic Engineering Foshan UniversityFoshan 528000China Casey Eye Institute Oregon Health and Science UniversityPortland97239 OregonUSA

Research on deep-tissue photothermal therapy(PTT)in the near-infrared II(NIR-II,1000–1350 nm)region has bloomed in recent years,owing to higher maximum permissible exposure and deeper tissue penetration over that in the near-infrared I(NIR-I,650–950 nm)***,more details need to be uncovered to facilitate a fundamental understanding of NIR-Ⅱ***,a tumor-targeted therapeutic nanosystem based on NIR-responsive molybdenum oxide(MoO2)nanoaggregates was *** photothermal conversion capabilities of MoO2 in the NIR-I andⅡregions were investigated step by step,from a simple tissue phantom to a three-dimensional cellular system,and further to a tumor-bearing animal ***-Ⅱlaser exhibited a lower photothermal attenuation coefficient(0.541 at1064 nm)in a tissue phantom compared with its counterpart(0.959 at 808 nm),which allows it to be more capable of deeptissue PTT in vitro and in *** profile analysis elucidated a negative correlation between the microstructural collapse of tumor tissue and the penetration ***,the depth-related tumor ablation was also studied by Raman fingerprint analysis,which demonstrated the major biochemical compositional disturbances in photothermal ablated tumor tissues,providing fundamental knowledge to NIR-Ⅱdeeptissue photothermal therapy.

关键词： second near-infrared window photothermal therapy molybdenum oxide depth profile analysis Raman biochemical assay

复合光合菌剂PS21对四环素胁迫下黄瓜幼苗生长及抗氧化酶活性的影响

在线全文

学校读者我要写书评

暂无评论

河南农业科学 2017年第10期46卷 71-75页

作者：葛红莲郭宁周口师范学院生命科学与农学学院河南周口466001

采用室内模拟试验法研究复合光合菌剂PS21与不同剂量四环素(10、20、40、60、80、100 mg/kg)协同处理对黄瓜幼苗生长及抗氧化酶活性的影响,初步探讨复合光合菌剂PS21缓解四环素对黄瓜幼苗生长和抗氧化酶活性的抑制效应。结果表明,单独... 详细信息

采用室内模拟试验法研究复合光合菌剂PS21与不同剂量四环素(10、20、40、60、80、100 mg/kg)协同处理对黄瓜幼苗生长及抗氧化酶活性的影响,初步探讨复合光合菌剂PS21缓解四环素对黄瓜幼苗生长和抗氧化酶活性的抑制效应。结果表明,单独四环素处理显著降低黄瓜幼苗的株高、根长、鲜质量、干质量和叶绿素含量,同时显著提高丙二醛(MDA)的含量。低剂量四环素激活超氧化物歧化酶(SOD)、过氧化氢酶(CAT)和过氧化物酶(POD)活性,高剂量四环素降低SOD、CAT和POD活性。108cfu/m L的PS21能缓解不同剂量四环素对黄瓜幼苗的伤害,与四环素单独处理相比,黄瓜株高、根长、鲜质量、干质量、叶绿素含量和抗氧化酶活性提高,MDA含量下降。因此,复合光合菌剂PS21对黄瓜的四环素毒害具有较强的缓解作用。

关键词：复合光合菌剂四环素黄瓜幼苗生长叶绿素含量抗氧化酶系

Combination of Clinical features and Semi-quantitative pathological scoring system provides insights for the diagnosis of drug-induced liver injury

在线全文

学校读者我要写书评

暂无评论

Combination of Clinical features and Semi-quantitative patho...

中华医学会第十六次全国病毒性肝炎及肝病学术会议

作者： Rongtao Lai Xiqi Hu Hui Wang honglian Gui Shiming guo Peng Wang Ruidong Mo Qing Xie Department of Infectious Diseases Ruijin Hospital shanghai jiaotong University Shool of Medicine Department of Pathology Fudan University Shanghai Medical College

Background&Aims Diagnosis of Drug-induced liver injury(DILI)remains a *** role of liver biopsy in diagnosis of DILI is one of the most difficult aspects of liver *** 2010,Hu proposed the DILI semi-quantitative pathological scoring system(DILI-PSS)for histological diagnosis of *** validated the DILI-PSS in Chinese patients with DILI and other liver diseases to find out the potential diagnostic parameters

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

基于变频技术的离心浇铸机监控系统

微计算机信息 2006年第6S期22卷 164-166页

作者：唐红莲郭艳萍河南省漯河职业技术学院机电系漯河职业技术学院

介绍了基于变频技术的离心浇铸机控制系统的硬件系统构成和主要功能,给出了系统的控制思想和监控画面设计。针对离心浇铸机两驱动辊在运行过程中既要保持同步,又要保证两台电机的负荷平衡的问题,提出了一种基于变频器主从控制方式的双... 详细信息

介绍了基于变频技术的离心浇铸机控制系统的硬件系统构成和主要功能,给出了系统的控制思想和监控画面设计。针对离心浇铸机两驱动辊在运行过程中既要保持同步,又要保证两台电机的负荷平衡的问题,提出了一种基于变频器主从控制方式的双闭环控制系统。实践证明,该方法简单易行,解决了以往控制系统中负荷分配不均匀的问题。

关键词：离心浇铸机变频调速监控负荷分配