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Ray-optics model for optical force and torque on a spherical metal-coated Janus microparticle

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Photonics Research 2015年第5期3卷 265-274页

作者： Jing Liu Chao Zhang Yiwu Zong honglian guo Zhi-Yuan Li Key Laboratory of Optical Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Key Laboratory of Soft Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China

In this paper, we develop a theoretical method based on ray optics to calculate the optical force and torque on a metallo-dielectric Janus particle in an optical trap made from a tightly focused Gaussian beam. The Janus particle is a 2.8 μm diameter polystyrene sphere half-coated with gold thin film several nanometers in thickness. The calculation result shows that the focused beam will push the Janus particle away from the center of the trap,and the equilibrium position of the Janus particle, where the optical force and torque are both zero, is located in a circular orbit surrounding the laser beam axis. The theoretical results are in good agreement qualitatively and quantitatively with our experimental observation. As the ray-optics model is simple in principle, user friendly in formalism, and cost effective in terms of computation resources and time compared with other usual rigorous electromagnetics approaches, the developed theoretical method can become an invaluable tool for understanding and designing ways to control the mechanical motion of complicated microscopic particles in various optical tweezers.

关键词： Ray-optics model for optical force and torque on a spherical metal-coated Janus microparticle

Reconfigurable nano-kirigami metasurfaces by pneumatic pressure

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Photonics Research 2020年第7期8卷 1177-1182页

作者： Shanshan Chen Wei Wei Zhiguang Liu Xing Liu Shuai Feng honglian guo Jiafang Li Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement(Ministry of Education) Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic Systemsand School of PhysicsBeijing Institute of TechnologyBeijing 100081China School of Science Minzu University of ChinaBeijing 100081China Institute of Physics Chinese Academy of SciencesBeijing 100190China

Tunable/reconfigurable metasurfaces that can actively control electromagnetic waves upon external stimuli are of great importance for practical applications of ***,we demonstrate a reconfigurable nano-kirigami metasurface driven by pneumatic pressure operating in the near-infrared wavelength *** metasurfaces consist of combined Archimedean spirals and are fabricated in a free-standing gold/silicon nitride nanofilm by employing focused ion beam(FIB)*** deformable spirals are instantly transformed from two dimensional(2 D)to three-dimensional(3 D)by the FIB-based nano-kirigami *** 2 D–to–3 D transformation induces a dramatic irreversible change of the plasmonic quadruple modes and results in significant modulation in reflection by 137%.The suspended porous nano-kirigami metasurface is further integrated with an optofluidics device,with which the optical resonance is reversibly modulated by the pneumatic *** work provides a strategy for tunable/reconfigurable metasurfaces,which are useful to build a promising lab-ona-chip platform for microfluidics,biological diagnostics,chemical sensing,and pressure monitoring.

关键词： process. irreversible porous

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薄膜干涉的衬比度研究

物理通报 2024年第9期 128-132页

作者：代展峰舒俊男刘佳芮崔彬蔡园园邹斌郭红莲陈笑王义全中央民族大学理学院北京100081

在薄膜干涉的相关教学中,教师和学生的关注点一般在于产生干涉的位置以及干涉条纹的分布状况,对干涉条纹的衬比度往往讨论的较少,而干涉场的衬比度对基于干涉的测量与制造是非常重要的.以菲涅尔反射公式为基础,从薄膜与背景材料的折射... 详细信息

在薄膜干涉的相关教学中,教师和学生的关注点一般在于产生干涉的位置以及干涉条纹的分布状况,对干涉条纹的衬比度往往讨论的较少,而干涉场的衬比度对基于干涉的测量与制造是非常重要的.以菲涅尔反射公式为基础,从薄膜与背景材料的折射率差和光在薄膜上的入射角两方面,研究了薄膜干涉的衬比度,得到了一些具有价值的结论,这些结论对于学生进一步理解薄膜干涉,以及基于干涉的精密测量和微结构制造,具有一定的参考价值.

关键词：薄膜干涉衬比度干涉条纹

Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene

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Oncology Research 2024年第7期32卷 1185-1195页

作者： XIAOBI HUANG CHUNYUAN CHEN YONGYANG CHEN honglian ZHOU YONGHUA CHEN ZHONG HUANG YULIU XIE BAIYANG LIU YUDONG guo ZHIXIONG YANG GUANGHUA CHEN WENMEI SU Department of Pulmonary Oncology Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Thoracic Surgery Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Department of Orthopedics Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases Affiliated Hospital of Guangdong Medical UniversityZhanjiang524001China

Background:Long non-coding RNAs are important regulators in cancer biology and function either as tumor suppressors or as *** dysregulation has been closely associated with ***00265 is upregulated in lung adenocarcinoma and is a prognostic biomarker of this ***,the mechanism underlying its function in cancer progression remains poorly ***:Here,the regulatory role of LINC00265 in lung adenocarcinoma was examined using lung cancer cell lines,clinical samples,and ***:We found that high levels of LINC00265 expression were associated with shorter overall survival rate of patients,whereas knockdown of LINC00265 inhibited proliferation of cancer cell lines and tumor growth in *** blot andﬂow cytometry analyses indicated that silencing of LINC00265 induced autophagy and ***,we showed that LINC00265 interacted with and stabilized the transcriptional co-repressor Switch-independent 3a(SIN3A),which is a scaffold protein functioning either as a tumor repressor or as an oncogene in a context-dependent *** of SIN3A also reduced proliferation of lung cancer cells,which was correlated with the induction of *** observations raise the possibility that LINC00265 functions to promote the oncogenic activity of SIN3A in lung ***:Ourﬁndings thus identify SIN3A as a LINC00265-associated protein and should help to understand the mechanism underlying LINC00265-mediated oncogenesis.

关键词： LINC00265 Autophagy Lung adenocarcinoma(LUAD) Cancer progression Switch-independent 3a(SIN3A)

Light-induced tumor theranostics based on chemical-exfoliated borophene

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Light(Science & Applications) 2022年第12期11卷 2886-2899页

作者： Zhongjian Xie Yanhong Duo Taojian Fan Yao Zhu Shuai Feng Chuanbo Li honglian guo Yanqi Ge Shakeel Ahmed Weichun Huang Huiling Liu Ling Qi Rui guo Defa Li Paras N.Prasad Han Zhang Institute of Pediatrics Shenzhen Children’s HospitalShenzhenGuangdongChina Shenzhen Engineering Laboratory of phosphorene and Optoelectronics International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationShenzhen Institute of Translational MedicineDepartment of OtolaryngologyShenzhen Second People’s Hospitalthe First Affiliated HospitalInstitute of Microscale OptoelectronicsShenzhen University518060 ShenzhenChina Department of Microbiology Tumor and Cell Biology(MTC)Karolinska InstituteStockholmSweden Shenzhen Medical Ultrasound Engineering Center Department of UltrasonographyShenzhen People’s HospitalSecond Clinical Medical College of Jinan UniversityFirst Clinical Medical College of Southern University of Science and Technology518020 ShenzhenChina Optoelectronics Research Center School of ScienceMinzu University of China100081 BeijingPR China Nantong Key Lab of Intelligent and New Energy Materials College of Chemistry and Chemical EngineeringNantong University226019 NantongJiangsuChina Key Laboratory of Biomaterials of Guangdong Higher Education Institutes Guangdong Provincial Engineering and Technological Research Centre for Drug Carrier DevelopmentDepartment of Biomedical EngineeringJinan University510632 GuangzhouChina Department of Core Medical Laboratory the Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuanGuang Dong ProvinceChina Department of Laboratory Medicine Shenzhen Children’s HospitalShenzhenGuangdongChina Institute for Lasers Photonicsand Biophotonics and Department of ChemistryUniversity at BuffaloState University of New YorkBuffaloNYUSA

Among 2D materials(Xenes)which are at the forefront of research activities,borophene,is an exciting new entry due to its uniquely varied optical,electronic,and chemical properties in many polymorphic forms with widely varying band gaps including the lightest 2D metallic *** this paper,we used a simple selective chemical etching to prepare borophene with a strong near IR light-induced photothermal *** photothermal efficiency is similar to plasmonic Au nanoparticles,with the added benefit of borophene being degradable due to electron deficiency of *** introduce this selective chemical etching process to obtain ultrathin and large borophene nanosheets(thickness of ~4 nm and lateral size up to ~600 nm)from the precursor of AlB_(2).We also report first-time observation of a selective Acid etching behavior showing HCl etching of Al to form a residual B lattice,while HF selectively etches B to yield an Al *** demonstrate that through surface modification with polydopamine(PDA),a biocompatible smart delivery nanoplatform of B@PDA can respond to a tumor environment,exhibiting an enhanced cellular uptake *** demonstrate that borophene can be more suitable for safe photothermal theranostic of thick tumor using deep penetrating near IR light compared to gold nanoparticles which are not degradable,thus posing longterm toxicity *** about 40 kinds of borides,we hope that our work will open door to more discoveries of this top-down selective etching approach for generating borophene structures with rich unexplored thermal,electronic,and optical properties for many other technological applications.

关键词： chemical uniquely electronic

六种禽蛋中脂肪酸、氨基酸及胆固醇的营养成分分析

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食品工业科技 2022年第10期43卷 323-330页

作者：赵悦菡侯召华郭红莲天津科技大学食品科学与工程学院天津300457 齐鲁工业大学(山东省科学院)食品科学与工程学院山东济南250353

对六种禽蛋营养成分进行分析,以期为禽蛋开发利用提供技术基础。本文对六种禽蛋(白羽鸡、金定鸭、贵妃鸡、珍珠鸡、中国环颈雉、鹌鹑)物理指标及冻干禽蛋蛋黄脂肪酸、蛋白氨基酸和胆固醇等成分进行研究。结果表明,六种禽蛋蛋黄中共鉴定... 详细信息

对六种禽蛋营养成分进行分析,以期为禽蛋开发利用提供技术基础。本文对六种禽蛋(白羽鸡、金定鸭、贵妃鸡、珍珠鸡、中国环颈雉、鹌鹑)物理指标及冻干禽蛋蛋黄脂肪酸、蛋白氨基酸和胆固醇等成分进行研究。结果表明,六种禽蛋蛋黄中共鉴定出24种脂肪酸,金定鸭蛋黄中总脂肪酸含量最高(20.67 g/100 g),饱和脂肪酸(22.49%)和胆固醇含量(1.94 g/100 g)均低于其它禽蛋,且动脉粥样硬化指数和血栓指数较低,这是由于单不饱和脂肪酸和多不饱和脂肪酸含量高的原因;禽蛋蛋白中氨基酸成分和含量无明显差异,32.22~37.85 g/100 g;六种禽蛋的营养成分主成分分析(PCA)与层次聚类分析(HCA)表明,珍珠鸡蛋与白羽鸡蛋聚为一类,贵妃鸡蛋、雉鸡蛋和鹌鹑蛋聚为一类,而金定鸭蛋单独一类。金定鸭蛋白蛋白质含量低,但金定鸭蛋黄中脂肪酸含量显著高于其他禽蛋(P<0.05)。本文研究结果可为以禽蛋为原料的加工选择提供一定的参考。

关键词：禽蛋物理指标脂肪酸氨基酸胆固醇

膜醭毕赤酵母挥发性物质对灰葡萄孢菌的抑菌活性及组分分析

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食品与发酵工业 2023年第13期49卷 64-69页

作者：陈莹莹张亚敏郭红莲天津科技大学食品科学与工程学院天津300457

为探究膜醭毕赤酵母(Pichia membranaefaciens)对采后灰葡萄孢菌的抑菌机制,该研究对其挥发性物质进行了抑菌活性与抑菌机制分析。结果表明,灰葡萄孢菌被挥发性物质熏蒸48 h时,菌丝长势明显受阻,抑制率高达72.41%,其产孢量始终低于空白... 详细信息

为探究膜醭毕赤酵母(Pichia membranaefaciens)对采后灰葡萄孢菌的抑菌机制,该研究对其挥发性物质进行了抑菌活性与抑菌机制分析。结果表明,灰葡萄孢菌被挥发性物质熏蒸48 h时,菌丝长势明显受阻,抑制率高达72.41%,其产孢量始终低于空白组(P<0.05)。经熏蒸后72 h,菌丝体细胞膜内核酸、蛋白质的大量外泄(P<0.05)改变了细胞膜的通透性,同时,通过扫描电镜观察到处理过的菌丝表面出现干瘪、皱缩甚至部分菌丝胞内的内容物渗漏。有伤接种实验证明熏蒸处理的番茄果实病斑直径仅为(1.47±0.16)cm,显著低于空白对照组。利用顶空固相微萃取-气质联用法(headspace solid-phase microextraction gas chromatography-mass spectrometry,HS-SPME-GC-MS)分离鉴定到20种挥发性物质,主要组分为醇类(39.26%)、酮类(24.72%)和有机酸类物质(8.51%)。上述结果为研究酵母菌防控采后果蔬腐烂提供了理论依据,为生防菌的安全防腐策略提供新思路。

关键词：膜醭毕赤酵母灰葡萄孢菌抑菌机理生物防治

京津沪知识密集型服务业技术进步贡献率的测算

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开发性金融研究 2018年第5期 72-79页

作者：郭红莲北京物资学院

知识密集型服务业具有高知识性、高技术性、高互动性、高创新性、高附加值性、强渗透与强辐射性等特点,它将是我国未来经济新的增长点和经济新动能的重要来源。本文以北京、天津、上海的知识密集型服务业为研究对象,比较了2004～2016年... 详细信息

知识密集型服务业具有高知识性、高技术性、高互动性、高创新性、高附加值性、强渗透与强辐射性等特点,它将是我国未来经济新的增长点和经济新动能的重要来源。本文以北京、天津、上海的知识密集型服务业为研究对象,比较了2004～2016年这三个直辖市知识密集型服务业的增加值及其占GDP的比重、从业人员数量以及其内部各行业增加值的发展趋势;运用C-D生产函数测算了这三座城市12年间知识密集型服务业的技术进步贡献率,并针对京津沪发展知识密集型服务业提出了对策建议。

关键词：知识密集型服务业技术进步贡献率比较

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基于数据挖掘的抗胃癌植物类中药组方设计

中国药房 2018年第24期29卷 3407-3411页

作者：蒋先仲郭红莲重庆市三峡库区自然疫源性疾病临床防治研究所重庆405499

目的:为临床抗胃癌中药组方设计及新药研发提供参考。方法:通过检索《中国药典(一部)》(2015年版)、《中药学》(第4版)以及PubMed、中国知网、维普等国内外数据库,对抗胃癌植物类中药的品种、抗肿瘤机制、性味归经特点以及肠道微生态环... 详细信息

目的:为临床抗胃癌中药组方设计及新药研发提供参考。方法:通过检索《中国药典(一部)》(2015年版)、《中药学》(第4版)以及PubMed、中国知网、维普等国内外数据库,对抗胃癌植物类中药的品种、抗肿瘤机制、性味归经特点以及肠道微生态环境的影响因素等信息进行挖掘、整理,并结合肿瘤分期进行抗胃癌植物类中药的组方设计。结果与结论:明确有抗胃癌活性的植物类中药共85种,其抗肿瘤机制以抑制增殖/生长、调节免疫、诱导凋亡、抑制侵袭/转移为主,丰度分别为0.741、0.718、0.447、0.271;药性以寒、温、平为主,丰度分别为0.424、0.282、0.200;药味以苦、甘、辛为主,丰度分别为0.612、0.518、0.271;归经以肝、肺、肾、脾经为主,丰度分别为0.553、0.424、0.376、0.365;主要涉及品种包括太子参、胡颓子叶、人参、黄芩、黄连、白花蛇舌草、缬草等。微生态制剂的使用、饮食习惯的改善、毒性应激的减少以及补虚、清热、消食类中药(如党参、山药、熟地黄、蒲公英、山楂等)的应用均会对肠道微生态环境的平衡产生有利影响。临床应按照"目标调节+整体调节+肠道微生态环境调节"的规则进行组方设计,其中胃癌早期宜以抑制增殖/生长为主,应选择性寒、凉,味辛、甘,归肝、心经的植物类中药;胃癌中期宜以抑制侵袭/转移为主,应选择性平、凉、温,味甘、苦、辛,归胃、脾、肝、肺经的植物类中药;胃癌晚期宜以调节免疫和诱导凋亡为主,应选择性温、平,味苦、甘、酸,归肾、肺、脾、胃经的植物类中药;同时辅以具肠道微环境调节作用的植物类中药,结合中医辨证和患者病情特征进行个体化组方,以充分发挥中药对胃癌的治疗作用。

关键词：抗胃癌植物类中药中药组方设计抗肿瘤机制性味归经肠道微生态环境丰度数据挖掘