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Influence of survivin and caspase-3 on cell apoptosis and prognosis in gastric carcinoma

World Journal of Gastroenterology 2004年第13期10卷 1984-1988页

作者： Yun-hongli ChenWang long-BangChert KuiMeng Xiao-JunZhou DepartmentofGastroenterology GulouHospitalMedicalCollegeofNanjingUniversityNanjing210008JiangsuProvinceChina MedicalCollegeofNanjingUniversity Nanjing210093JiangsuProvinceChina DepartmentofOncology ClinicalSchoolofMedicalCollegeofNanjingUniversity/NanjingGeneralHospitalofNanjingCommandNanjing210002JiangsuProvinceChina DepartmentofPathology ClinicalSchoolofMedicalCollegeofNanjingUniversity/NanjingGeneralHospitalofNanjingCommand.Nanjing210002JiangsuProvinceChina

AIM: To evaluate the role of survivin and caspase-3 in apoptosis of gastric carcinoma, as well as in prognosis of patients with gastric ***: Expressions of survivin and caspase-3 were investigated immunohistochemically in 80 gastric carcinoma patients without a history of chemo-radiation therapy. Tumor cell apoptosis was examined by TUNEL ***: Immunohistochemical analysis showed that survivin expression was positive in 61 of 80 patients (76%) with gastric carcinoma. In contrast, no expression of survivin in adjacent normal tissues was detected. Expression level of caspase-3 was higher in normal tissues than in *** with higher expression of survivin had worse histological grades and pathological stages. Expression of caspase-3 was significantly associated with histological stages, but not with the pathological stages. Although survivin expression in carcinoma was not inversely related to caspase-3, patients with survivin (-) and caspase-3(+) had the maximum apoptosis ***: Expression level of survivin was associated with histological grades and pathological stages of the tumor,indicating that survivin may be a poor prognosis factor for gastric carcinoma. Unlike caspase-3, survivin (an apoptosis inhibitor) can markedly inhibit the apoptosis of tumor cells.

关键词： caspase-3 细胞凋亡预后作用胃癌肿瘤免疫组织化学

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十二醇对黑龙关难浮煤泥浮选的强化作用研究

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煤炭技术 2024年第2期43卷 280-283页

作者：韩雪莲李志红樊民强杨宏丽薛春丽毕海怡太原理工大学矿业工程学院太原030024

为提高难浮煤泥的精煤回收率,以黑龙关煤泥为研究对象,选用正癸醇、十二醇、十四醇三种长链脂肪醇,采用直接添加和与煤油复配的方式,进行了浮选试验。借助接触角、XPS、润湿热,分析了长链脂肪醇的作用机理。结果表明,无论是单独添加还... 详细信息

为提高难浮煤泥的精煤回收率,以黑龙关煤泥为研究对象,选用正癸醇、十二醇、十四醇三种长链脂肪醇,采用直接添加和与煤油复配的方式,进行了浮选试验。借助接触角、XPS、润湿热,分析了长链脂肪醇的作用机理。结果表明,无论是单独添加还是配制成复合捕收剂,十二醇的浮选效果最好,复配可以节省药剂用量。在捕收剂用量2 kg/t时,与煤油相比,15%比例复配药剂可将精煤产率提高23.89%,尾煤灰分提高9.53%,可燃体回收率提高28.23%。此外,十二醇处理过的煤泥接触角增加12.44°,润湿热降低5.37 J/g,亲水基团O—C=O含量降低3.25%。十二醇通过降低煤粒亲水性官能团含量,提高煤粒表面疏水性,十二醇复配药剂通过十二醇极性成分和煤油非极性成分的协同作用增大煤表面疏水面积提高浮选效果。

关键词：难浮煤浮选十二醇复配促进作用

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High Precision Ultrasonic Guided Wave Technique for Inspection of Power Transmission Line

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Chinese Journal of Mechanical Engineering 2017年第1期30卷 170-179页

作者： CHENG Jun QIU Jinhao JI hongli WANG Enrong TAKAGI Toshiyuki UCHIMOTO Tetsuya School of Physics and Technology Nanjing Normal UniversityNanjing 210042China School of Electrical and Automation Engineering Nanjing Normal UniversityNanjing 210042China State Key Laboratory of Mechanics and Control for Mechanical Structures Nanjing University of Aeronautics and AstronautiesNanjing 210016China Institute of Fluid Science Tohoku UniversitySendai 980-8577Japan

Due to the merits of high inspection speed and long detecting distance, Ultrasonic Guided Wave（UGW） method has been commonly applied to the on-line maintenance of power transmission line. However, the guided wave propagation in this structure is very complicated, leading to the unfavorable defect localization accuracy. Aiming at this situation, a high precision UGW technique for inspection of local surface defect in power transmission line is proposed. The technique is realized by adopting a novel segmental piezoelectric ring transducer and transducer mounting scheme, combining with the comprehensive characterization of wave propagation and circumferential defect positioning with multiple piezoelectric elements. Firstly, the propagation path of guided waves in the multi-wires of transmission line under the proposed technique condition is investigated experimentally. Next, the wave velocities are calculated by dispersion curves and experiment test respectively, and from comparing of the two results, the guided wave mode propagated in transmission line is confirmed to be F（1,1） mode. Finally, the axial and circumferential positioning of local defective wires in transmission line are both achieved, by using multiple piezoelectric elements to surround the stands and send elastic waves into every single wire. The proposed research can play a role of guiding the development of highly effective UGW method and detecting system for multi-wire transmission line.

关键词： ultrasonic guided wave inspection power transmission line piezoelectric transducer defect positioning wavelet transform

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Post-Rifting Magmatism and the Drowned Reefs in the Xisha Archipelago Domain

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Journal of Ocean University of China 2018年第1期17卷 195-208页

作者： WANG hongli ZHAO Qiang WU Shiguo WANG Dawei WANG Bin Key Laboratory of Marine Geology and Environment Institute of Oceanology Chinese Academy of Sciences College of Earth Sciences University of Chinese Academy of Sciences Key Laboratory of Marine Sedimentology and Environmental Geology First Institute of OceanographySOA Laboratory for Marine Geology Qingdao National Laboratory for Marine Science and Technology Laboratory of Marine Geophysics and Deep-Sea Georesources Institute of Deep-Sea Science and Engineering Chinese Academy of Sciences Hangzhou Institute of Petroleum Geology PetroChina

Fourteen isolated drowned reefs have been identified around the Xisha Uplift by multibeam and seismic data. The drowning processes of these reefs can be divided into three different stages, which correspond to three different accelerated tectonic subsidence periods. The drowning of the Xisha reefs is the result of the combined action of tectonic subsidence and sea level fluctuations, and the tectonic subsidence rate had to remain above 0.2 mm yr^(-1 )for a long time. Three abrupt accelerated tectonic subsidence events that occurred in the late Miocene, Pliocene and early Quaternary in the Xisha Uplift were closely related to the thermal subsidence processes after three stages of post-rifting magmatism. The magmatism of the middle Miocene and the following thermal subsidence resulted in the drowning of reefs in the northwestern Xisha uplift(Zone A). During the early Pliocene, massive magmatic intrusions and volcanic eruptions occurred in the Xisha Uplift. Then, the subsequent thermal subsidence started the drowning process of reefs in the northeastern and western regions of the Xisha Uplift(Zone B and C). During the early Quaternary, large-scale magmatism also occurred in the Xisha Uplift. The subsequent thermal subsidence resulted in a new rapid tectonic subsidence, which caused the reefs in the southern and southeastern regions of the Xisha Uplift to drown(Zone D and E).

关键词： magmatism tectonic subsidence drowned reef Xisha Archipelago

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基于模糊免疫PID的非线性汽车悬架控制策略与仿真研究

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机械强度 2008年第6期30卷 911-915页

作者：王洪礼郭龙天津大学机械工程学院天津300072

汽车悬架控制系统是一个由较多非线性因素共同作用的复杂系统,针对传统PID控制效果不理想的问题,通过数值拟合的方式引入弹簧与阻尼等非线性影响因素,建立1/4汽车悬架非线性动力学模型,借鉴免疫反馈原理,结合积分控制的规律,提出一种模... 详细信息

汽车悬架控制系统是一个由较多非线性因素共同作用的复杂系统,针对传统PID控制效果不理想的问题,通过数值拟合的方式引入弹簧与阻尼等非线性影响因素,建立1/4汽车悬架非线性动力学模型,借鉴免疫反馈原理,结合积分控制的规律,提出一种模糊免疫PID(proportion integral derivative)控制方法,并利用免疫进化算法进行参数优化设计。仿真结果表明,该方法在汽车非线性悬架控制系统中可行且有效,其控制器性能也优于常规的PID控制器,具有更好的响应特性,同时也提高了汽车的操作稳定性和乘坐舒适性。

关键词：免疫反馈模糊免疫PID(proportion integral derivative) 非线性汽车悬架控制策略

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鳞状CoMn_2O_4/石墨烯复合材料的制备及在超级电容器中的应用

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高等学校化学学报 2018年第9期39卷 2010-2016页

作者：李龙胡红利丁书江西安交通大学电力设备电气绝缘国家重点实验室西安交通大学理学院西安710049

通过简单的共沉淀反应和热处理过程在还原氧化石墨烯(rGO)表面生长鳞状锰酸钴(CoMn_2O_4)纳米片,得到了CoMn_2O_4/rGO复合材料.通过场发射扫描电子显微镜(FESEM)、透射电子显微镜(TEM)、X射线衍射(XRD)以及X射线光电子能谱(XPS)对样品... 详细信息

通过简单的共沉淀反应和热处理过程在还原氧化石墨烯(rGO)表面生长鳞状锰酸钴(CoMn_2O_4)纳米片,得到了CoMn_2O_4/rGO复合材料.通过场发射扫描电子显微镜(FESEM)、透射电子显微镜(TEM)、X射线衍射(XRD)以及X射线光电子能谱(XPS)对样品的结构和组成进行了表征.电化学性能测试结果表明,CoMn_2O_4/rGO具有较好的储能性能和优良的循环稳定性.当电流密度为2 A/g时,CoMn_2O_4/rGO的比电容可达1000.8 F/g.经过1000周充放电循环后比电容保持率为93.6%.

关键词：鳞状结构锰酸钴纳米片还原氧化石墨烯超级电容器电极材料

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光疗对睡眠剥夺小鼠学习记忆以及BDNF-TrkB信号通路的影响

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中国激光 2022年第5期49卷 224-234页

作者：陈洪丽高静静姜忠迪王仲朋陈龙明东天津大学医学工程与转化医学研究院天津300072 天津工业大学生命科学学院天津300387

睡眠障碍是临床中的常见多发病,睡眠障碍易诱发和加重认知障碍疾病,损害海马依赖的学习记忆功能。光疗是一种改善睡眠的有效方法,鉴于此,本课题组研究了光疗对睡眠剥夺小鼠炎症反应、氧化应激反应及BDNF-TrkB信号通路的影响,探索光疗对... 详细信息

睡眠障碍是临床中的常见多发病,睡眠障碍易诱发和加重认知障碍疾病,损害海马依赖的学习记忆功能。光疗是一种改善睡眠的有效方法,鉴于此,本课题组研究了光疗对睡眠剥夺小鼠炎症反应、氧化应激反应及BDNF-TrkB信号通路的影响,探索光疗对睡眠剥夺小鼠学习记忆的影响。通过旋转圆筒法建立睡眠剥夺模型,小鼠随机被分为对照组、睡眠剥夺组、光疗组(468nm,光照强度分别为100,300,900lx)。光疗组边剥夺边治疗,每天早晚进行光照30 min,于剥夺3d后对各组小鼠进行水迷宫实验和旷场实验,采用ELISA法检测小鼠血浆和海马组织中TNF-α、SOD、5-HT因子的表达量,采用RT-PCR法检测小鼠BDNF、TrkB和Akt中的mRNA表达量。结果显示:与对照组相比,睡眠剥夺导致小鼠体重下降,游泳潜伏期增长,促进了炎性因子TNF-α的表达,降低了SOD活性和5-HT的表达,并降低了BDNF、TrkB和Akt中的mRNA表达;与睡眠剥夺组相比,光疗组小鼠的游泳潜伏期缩短,平台交叉次数增多,TNF-α表达下降,SOD和5-HT表达呈上升趋势,焦虑样行为减轻,BDNF、TrkB与Akt中的mRNA表达升高;300lx光照剂量的效果较为显著。光疗可以修复睡眠剥夺引起的氧化应激损伤,调节炎症反应,促进BDNF表达,代偿相对较短时间的睡眠剥夺,保护自身的认知能力,缓解睡眠剥夺引起的学习记忆缺陷。

关键词：医用光学光疗睡眠剥夺氧化应激学习记忆突触可塑性

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SnO2-based electron transporting layer materials for perovskite solar cells: A review of recent progress

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Journal of Energy Chemistry 2019年第8期28卷 144-167,I0006页

作者： Yichuan Chen Qi Meng Linrui Zhang Changbao Han hongli Gao Yongzhe Zhang Hui Yan College of Material Sciences and Engineering Beijing University of TechnologyBeijing 100124 China School of Mechanical and Electrical Engineering Jingdezhen Ceramic InstituteJingdezhen 333403 Jiangxi China

In recent years, due to their high photo-to-electric power conversion efficiency(PCE)(up to 23%(certified)) and low cost, perovskite solar cells(PSCs) have attracted a great deal of attention in photovoltaics field. The high PCE can be attributed to the excellent physical properties of organic–inorganic hybrid perovskite materials, such as a long charge diffusion length and a high absorption coefficient in the visible range. There are different diffusion lengths of holes in electrons in a PSC device, and thus the electron transporting layer(ETL) plays a critical role in the performance of PSCs. An alternative for TiO2, to the most common ETL material is SnO2, which has similar physical properties to TiO2 but with much higher electron mobility, which is beneficial for electron extraction. In addition, there are many facile methods to fabricate SnO2 nanomaterials with low cost and low energy consumption. In this review paper, we focus on recent developments in SnO2 as the ETL of PSCs. The fabrication methods of SnO2 materials are briefly introduced. The influence of multiple Sn O2 types in the ETL on the performance of PSCs is then reviewed. Different methods for improving the PCE and long-term stability of PSCs based on SnO2 ETL are also summarized. The review provides a systematic and comprehensive understanding of the influence of different Sn O2 ETL types on PSC performance and potentially motivates further development of PSCs with an extension to SnO2-based PSCs.

关键词： Perovskite solar cells Electron transport materials Tin oxide Nanostructures

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Information Classification and Extraction on Official Web Pages of Organizations

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Computers, Materials & Continua 2020年第9期64卷 2057-2073页

作者： Jinlin Wang Xing Wang hongli Zhang Binxing Fang Yuchen Yang Jianan Liu School of Computer Science and Technology Harbin Institute of TechnologyHarbin150006China China Electronic Equipment System Engineering Company Beijing100039China

As a real-time and authoritative source,the official Web pages of organizations contain a large amount of *** diversity of Web content and format makes it essential for pre-processing to get the unified attributed data,which has the value of organizational analysis and *** existing research on dealing with multiple Web scenarios and accuracy performance is *** paper aims to propose a method to transform organizational official Web pages into the data with *** locating the active blocks in the Web pages,the structural and content features are proposed to classify information with the specific *** extraction methods based on trigger lexicon and LSTM(long Short-Term Memory)are proposed,which efficiently process the classified information and extract data that matches the ***,an accurate and efficient method to classify and extract information from organizational official Web pages is *** results show that our approach improves the performing indicators and exceeds the level of state of the art on real data set from organizational official Web pages.

关键词： Web pre-process feature classification data extraction trigger lexicon LSTM

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SARS-CoV-2感染对男性精液质量影响的研究及meta分析

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临床检验杂志 2024年第2期42卷 141-148页

作者：张耀东朱亚庆张悦李友婷胡元波鄢桃飞郑菊芬颜宏利徐健海军第九七一医院检验科山东青岛266071 海军军医大学第一附属医院生殖医学中心上海200433

目的通过meta分析和回顾性研究探讨SARS-CoV-2感染对男性精液质量的影响。方法检索PubMed、中国知网、万方数据库及CBM中国生物医学文献数据库,运用Stata15.0进行meta分析。选取本院就诊并符合meta分析纳入标准的男性为研究对象,统计其... 详细信息

目的通过meta分析和回顾性研究探讨SARS-CoV-2感染对男性精液质量的影响。方法检索PubMed、中国知网、万方数据库及CBM中国生物医学文献数据库,运用Stata15.0进行meta分析。选取本院就诊并符合meta分析纳入标准的男性为研究对象,统计其一般人口学资料和精液参数,采用GraphPad Prism9.5.1对精液参数进行单因素方差分析和制图。检验水准为0.05。结果Meta分析共纳入9项研究,267例患者。精子浓度和存活率在感染前后差异均无统计学意义(P>0.05)。感染后1~3个月,精液量和正常形态精子百分率均增加(P=0.005,P=0.010),精液量于感染后>3个月恢复至感染前水平(P>0.05)。精子活动率和前向运动精子百分率于感染后>3个月增加(P=0.046,P=0.045),并恢复至感染前水平(P=0.099,P=0.098)。精子DNA碎片化指数于感染后3个月内可短时增高,>3个月后逐渐降低。回顾性研究8例,各阶段精液参数与感染前比较差异无统计学意义(P>0.05),但感染后3个月恢复至感染前水平。结论本实验室研究结果与meta分析基本一致。男性感染SARS-CoV-2后仅对精子形态、活力及DNA完整性产生短暂负面影响,但一般于感染后>3个月恢复至感染前水平。由于本研究对象人群和数量有限,SARS-CoV-2感染对男性精液质量影响仍需长期前瞻性大规模研究观察证实。

关键词：新型冠状病毒男性睾丸精子 meta分析

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