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Polyketides with potential bioactivities from the mangrove‑derived fungus Talaromyces ***0362

Marine Life Science & Technology 2023年第2期5卷 232-241页

作者： Huawei Lv Haibo Su Yaxin Xue Jia Jia hongkai bi Shoubao Wang Jinkun Zhang Mengdi Zhu Mahmoud Emam Hong Wang Kui Hong Xing-Nuo Li College of Pharmaceutical Science&Key Laboratory of Marine Fishery Resources Exploitment&Utilization of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China School of Pharmaceutical Sciences Wuhan UniversityWuhan 430072China Department of Pathogen biology&Jiangsu Key Laboratory of Pathogen biology Nanjing Medical UniversityNanjing 211166China Beijing Key Laboratory of Drug Target Research and New Drug Screening Institute of Materia MedicaChinese Academy of Medical SciencesBeijing 100700China Research Center of Analysis and Measurement Zhejiang University of TechnologyHangzhou 310014China Department of Phytochemistry and Plant Systematics National Research CentreGizaEgypt

Metabolites of microorganisms have long been considered as potential sources for drug *** this study,fve new depsidone derivatives,talaronins A-E(1-5)and three new xanthone derivatives,talaronins F-H(6-8),together with 16 known compounds(9-24),were isolated from the ethyl acetate extract of the mangrove-derived fungus Talaromyces species *** structures were elucidated by analysis of spectroscopic data and chemical methods including alkaline hydrolysis and Mosher’s *** 1 and 2 each attached a dimethyl acetal group at the aromatic ring.A putative biogenetic relationship of the isolated metabolites was presented and suggested that the depsidones and the xanthones probably had the same biosynthetic precursors such as chrysophanol or *** antimicrobial activity assay indicated that compounds 5,9,10,and 14 showed potent activity against Helicobacter pylori with minimum inhibitory concentration(MIC)values in the range of 2.42-36.04μmol/*** secalonic acid D(19)demonstrated signifcant antimicrobial activity against four strains of *** with MIC values in the range of 0.20 to 1.57μmol/***,secalonic acid D(19)exhibited cytotoxicity against cancer cell lines Bel-7402 and HCT-116 with IC_(50) values of 0.15 and 0.19μmol/L,*** structure–activity relationship of depsidone derivatives revealed that the presence of the lactone ring and the hydroxyl at C-10 was crucial to the antimicrobial activity against *** depsidone derivatives are promising leads to inhibit *** and provide an avenue for further development of novel antibiotics.

关键词： Mangrove-derived fungus Talaromyces sp. Depsidone Xanthone Antimicrobial

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Highly oxygenated dihydrostilbenoids and flavones from the aerial part of Glycyrrhiza uralensis and their antimicrobial activities

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Science of Traditional Chinese Medicine 2024年第4期2卷 291-302页

作者： Xinyi Wei Junfei Zhou Liping Zeng Mingming Xu Chuntao Che Jin’ao Duan Hui Yan hongkai bi Ming Zhao Jiangsu Collaborative Innovation Centre of Chinese Medicinal Resources Industrialization National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative MedicineSchool of PharmacyNanjing University of Chinese MedicineNanjingChina Department of Pharmaceutical Sciences College of Pharmacythe University of Illinois ChicagoChicagoILUSA Department of Pathogen biology Jiangsu Key Laboratory of Pathogen BiologyNanjing Medical UniversityNanjingChina

Background:Multidrug-resistant bacteria(MDRB)represent a significant global challenge due to their high mortality rates,substantial economic burden,and rapid *** triple or quadruple therapies have demonstrated limited efficacy as a result of increasing drug ***,it is urgent to develop novel anti-MDRB drugs with high efficiency and low ***:To isolate and identify the dihydrostilbenoids and flavones from the aerial part of Glycyrrhiza uralensis(Fabaceae)and to screen their antimicrobial *** and methods:The aerial part of *** was extracted with 75%aqueous *** crude extract was repeatedly isolated by macroporous resin,silica gel,Sephadex LH-20,C_(18)-MPLC,and MCI-MPLC,which were then purified by semipreparative RPHPLC to obtain monomer *** structures of the isolates were assigned by a combination of optical rotations,UV spectra,nuclear magnetic resonance,and high-resolution electrospray ionization mass spectrometry,and the absolute configurations of compounds 2,3,and 7 were further confirmed by electronic circular dichroism ***,we investigated their antimicrobial activities by the broth microdilution ***:Seventeen previously undescribed phenolic compounds(1–17)and 26 known analogs(18–43),including dihydrostilbenoids,flavones,and dihydroflavones,were identified from the aerial part of *** vitro,antimicrobial bioassays demonstrated that compound 31 displayed the strongest inhibitory effect against 4 drug-resistant Helicobacter pylori strains(MIC=2–4μg/mL),comparable to metronidazole(MIC=1–32μg/mL).Additionally,compounds 10,13,and 15 demonstrated bactericidal activity against Staphylococcus aureus(MIC=4μg/mL),while compounds 15 and 22 exhibited inactivation effects against Mycobacterium smegmatis,Enterococcus faecium,and ***(MIC=4–8μg/mL).Conclusions:These monomeric compounds with antimicrobial activities were isolated from the aerial parts

关键词： Phenolic compounds Electronic circular dichroism(ECD) Bactericidal activity Helicobacter pylori

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Schiff-base silver nanocomplexes formation on natural biopolymer coated mesoporous silica contributed to the improved curative effect on infectious microbes

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Nano Research 2021年第8期14卷 2735-2748页

作者： Ling Cai Yanqiang Huang Yuanyuan Duan Qiao Liu Qilan Xu Jia Jia Jianming Wang Qian Tong Peipei Luo Yujie Wen Luming Peng Qian Wu Xudong Hang Huijun Jiang Ping Zhu Yanmei Yang Boshen Zhou Liping Zeng hongkai bi Jin Chen Center for Global Health The Key Laboratory of Modern ToxicologyMinistry of EducationSchool of Public HealthNanjing Medical UniversityNanjing 211166China Department of Pathogen biology Jiangsu Key Laboratory of Pathogen BiologyNanjing Medical UniversityNanjing 211166China Research Center for the Prevention and Treatment of Drug Resistant Microbial Infecting Youjiang Medical University for Nationalities Baise 533000China The Laboratory Center for Basic Medical Sciences Nanjing Medical UniversityNanjing 211166China Key Laboratory of Mesoscopic Chemistry of MOE and Collaborative Innovation Center of Chemistry for Life Sciences School of Chemistry and Chemical Engineering Nanjing UniversityNanjing 210023China School of Pharmacy Nanjing Medical UniversityNanjing 211166China Department of Gastroenterology Sir Run Run HospitalNanjing Medical UniversityNanjing 211166China Key Laboratory of Antibody Technique of National Health Commission Nanjing Medical UniversityNanjing 211166China

Infectious microbes that spread easily in healthcare facilities remain as the severe threat for the public health,especially among immunocompromised *** the intricate problem of dramatic increase in resistance to common biocides,the development of safe and efficient biocide formulated agents to alleviate drug resistance is highly *** this study,Schiff-base ligands were successfully formed on natural biopolymer of epsilon-poly-L-lysine(ε-PL)decorated aldehyde functionalized mesoporous silica SBA-15(CHO-SBA-15)for the selective coordination of silver ions,which was affirmed by various physicochemical *** the identified broad-spectrum antibacterial activities,the as-prepared Schiff-base silver nanocomplex(CHO-SBA-15/ε-PL/Ag,CLA-1)exhibited an improved inhibitory effect on infectious pathogen growth typified by Escherichia coli and Staphylococcus aureus in comparison with two control silver complexes without Schiff-base conjugates,SBA-15/ε-PL/Ag and CHO-SBA-15/Ag,*** addition,CLA-1 remarkably inhibited the growth of Mycobacterium tuberculosis due to the excellent antimicrobial activity of silver ***,CLA-1 kills Candida albicans cells,inhibits biofilm formation,and eliminates preformed biofilms,with no development of resistance during continuous serial *** antifungal activity is connected to disruption of bacterial cell membranes and increased levels of intracellular reactive oxygen *** mouse models of multidrug-resistant *** infection,CLA-1 exhibited efficient in vivo fungicidal efficacy superior to two antifungal drugs,amphotericin B and ***,CLA-1 treatment induces negligible toxicity against normal tissues with ***,this study reveals the pivotal role of the molecular design of Schiff-base silver nanocomplex formation on biopolymer surface-functionalized silica mesopores as a green and efficient nanoplatform to tackle infectious microbes.

关键词： biopolymer drug delivery mesoporous silica silver nanoparticles antimicrobial drug resistance

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一株海洋真菌Aspergillus jensenii LW128的次级代谢产物及其抗菌活性研究

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微生物学报 2023年第1期63卷 419-429页

作者：张金新段园园毕洪凯蔡磊刘玲中国科学院微生物研究所真菌学国家重点实验室北京100101 中国科学院大学北京100049 南京医科大学基础医学院江苏南京211166

【目的】研究一株西北太平洋深海沉积物来源真菌Aspergillus jensenii LW128的次级代谢产物及其抗菌活性。【方法】利用硅胶柱色谱(silica gel column chromatography)、凝胶柱色谱(Sephadex LH-20 column chromatography)和反相高效液... 详细信息

【目的】研究一株西北太平洋深海沉积物来源真菌Aspergillus jensenii LW128的次级代谢产物及其抗菌活性。【方法】利用硅胶柱色谱(silica gel column chromatography)、凝胶柱色谱(Sephadex LH-20 column chromatography)和反相高效液相色谱(reversed-phase high-performance liquid chromatography,RP-HPLC)等方法对菌株的发酵粗提物进行分离纯化得到单体化合物;将核磁共振波谱(nuclear magnetic resonance,NMR)、质谱(mass spectrometry,MS)数据与相关文献报道数据进行比对后确定化合物结构;采用肉汤微量稀释法测定化合物的抗菌活性。【结果】从海洋真菌Aspergillus jensenii LW128中分离并鉴定了10个已知化合物,分别为diorcinol D(1)、diorcinol K(2)、diorcinol I(3)、(+)-(7S)-7-O-methylsydonic acid(4)、(+)-sydonic acid(5)、pseudaboydin B(6)、anthraquinone aversin(7)、6,8-di-O-methylnidurufin(8)、5-methoxysterigmatocystin(9)和sterigmatocystin(10);抗菌活性测试结果表明,化合物1、2和3具有一定的抑菌作用。【结论】Aspergillus jensenii LW128具有被开发成抗菌药物的潜力。

关键词：海洋真菌次级代谢产物抗菌活性

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无“幽”才无虑

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科学 2020年第5期72卷 48-51页

作者：贾佳毕洪凯南京医科大学基础医学院病原生物学系南京211166

幽门螺杆菌感染全球一半以上的人口,与胃部多种疾病的发生发展密切相关,被世界卫生组织列为胃癌的头号致癌因子。本文对幽门螺杆菌的发现、流行病学、致病机制和药物治疗研发进展等几个方面进行阐述,旨为提高公众对幽门螺杆菌的认识,正... 详细信息

幽门螺杆菌感染全球一半以上的人口,与胃部多种疾病的发生发展密切相关,被世界卫生组织列为胃癌的头号致癌因子。本文对幽门螺杆菌的发现、流行病学、致病机制和药物治疗研发进展等几个方面进行阐述,旨为提高公众对幽门螺杆菌的认识,正确理解何为无"幽"才无虑。

关键词：幽门螺杆菌致病性胃癌治疗方案

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一株红树林曲霉菌Aspergillus ***0343的次级代谢产物研究

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微生物学报 2022年第7期62卷 2658-2670页

作者：于洪佳薛雅馨洪葵贾佳毕洪凯徐利剑刘玲黑龙江大学现代农业与生态环境学院黑龙江哈尔滨150080 武汉大学药学院湖北武汉430070 中国科学院微生物研究所真菌学国家重点实验室北京100101 南京医科大学基础医学院江苏南京211166

【目的】研究分离自三亚亚龙湾红树林根系土壤的真菌Aspergillus ***0343的次级代谢产物及其生物活性。【方法】利用硅胶柱层析、Sephadex LH-20凝胶柱层析和半制备高效液相色谱等技术对该菌的发酵产物进行分离纯化;综合利用核磁共振波... 详细信息

【目的】研究分离自三亚亚龙湾红树林根系土壤的真菌Aspergillus ***0343的次级代谢产物及其生物活性。【方法】利用硅胶柱层析、Sephadex LH-20凝胶柱层析和半制备高效液相色谱等技术对该菌的发酵产物进行分离纯化;综合利用核磁共振波谱(NMR)和质谱(MS)等现代波谱技术以及与文献数据对照确定化合物的结构;分别采用肉汤微量稀释检测法和MTS法对化合物进行抗菌和肿瘤细胞毒活性测试。【结果】从真菌Aspergillus ***0343的发酵产物共分离并鉴定了10个化合物,分别为isoechinulin A(1)、neoechinulin A(2)、neoechinulin E(3)、preechinulin(4)、neoechinulin D(5)、variecolorin J(6)、dehydroechinulin(7)、questinol(8)、emodin(9)和catenarin(10)。活性评价显示化合物2、9和10对幽门螺杆菌(Helicobacter pylori)和金黄色葡萄球菌(Staphylococcus aureus)及其耐药菌株具有较强的抑制活性;化合物1对3株肿瘤细胞B16、Hep G2和MCF-7均具有细胞毒活性。【结论】Aspergillus ***0343具有开发为微生物药物的潜在研究价值。

关键词：红树林真菌次级代谢产物抗菌活性细胞毒活性

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深度学习视角下的病原生物学PRIDE教学创新策略

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基础医学教育 2022年第3期24卷 157-160页

作者：邱竞帆季旻珺严沁周莎毕洪凯于鑫焱贾佳南京医科大学基础医学院病原生物学系南京211166 南京医科大学教务处南京211166

病原生物学是临床医学和预防医学专业的基础课程,主要教授与医学相关的病原微生物学知识。为适应全球感染性疾病谱和医学教育模式的改变,培养具有核心胜任力的卓越医生,课程围绕以学生为中心的教学理念,在教学过程中对标深度学习理论,创... 详细信息

病原生物学是临床医学和预防医学专业的基础课程,主要教授与医学相关的病原微生物学知识。为适应全球感染性疾病谱和医学教育模式的改变,培养具有核心胜任力的卓越医生,课程围绕以学生为中心的教学理念,在教学过程中对标深度学习理论,创建PRIDE教学策略,形成培养深度学习能力的课程教学环境,全面提高医学生的高阶思维。

关键词：病原生物学教学改革深度学习

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PARALLEL IMPLEMENTATIONS OF THE FAST SWEEPING METHOD

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Journal of Computational Mathematics 2007年第4期25卷 421-429页

作者： hongkai Zhao Department of Mathematics University of California Irvine CA 92697-3875 USA

The fast sweeping method is an efficient iterative method for hyperbolic problems. It combines Gauss-Seidel iterations with alternating sweeping orderings. In this paper several parallel implementations of the fast sweeping method are presented. These parallel algorithms are simple and efficient due to the causality of the underlying partial different equations. Numerical examples are used to verify our algorithms.

关键词： Hamilton-Jacobi equation Eikonal equation Characteristics viscosity solution Upwind difference Courant-Friedrichs-Levy (CFL) condition Gauss-Seidel iteration,Domain decomposition.

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Negative Sentiment Shift on a Chinese Movie-Rating Website

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Journal of Social Computing 2023年第2期4卷 168-180页

作者： hongkai Mao the Social Sciences Division University of ChicagoChicagoIL 60637USA

Shifting to negativity is more and more prevalent in online communities and may play a key role in group *** current research indicates a close relationship between group polarization and negative sentiment,they often link negative sentiment shifts with echo chambers and misinformation within echo *** this work,we explore the sentiment drift using over 4 million comments from a Chinese online movie-rating community that is less affected by misinformation than other mainstream online communities and has no echo chamber *** measure the sentiment shift of the community and users of different engagement *** analysis reveals that while the community does not show a tendency toward negativity,users of higher engagement levels are generally more negative,considering factors like the different movies they *** results indicate a fitting-in process,suggesting the possible mechanism of group identity on sentiment shift on social media *** findings also provide guidance on web design to tackle the negativity issue and expand sentiment shift analysis to non-English contexts.

关键词： computational social science online community group polarization sentiment analysis user engagement negative sentiment

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Genetic algorithm for λ-optimal translation sequence of rough communication

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Journal of Systems Engineering and Electronics 2011年第4期22卷 609-614页

作者： hongkai Wang Yanyong Guan Chunhua Yuan School of Mathematics University of Jinan Jinan 250022 R R. China

In rough communication, because each agent has a different language and can not provide precise communication to each other, the concept translated among multi-agents will loss some information, and this results in a less or rougher concept. With different translation sequences the amount of the missed knowledge is varied. The λ-optimal translation sequence of rough communication, which concerns both every agent and the last agent taking part in rough communication to get information as much as he （or she） can, is given. In order to get the λ-optimal translation sequence, a genetic algorithm is used. Analysis and simulation of the algorithm demonstrate the effectiveness of the approach.

关键词： rough sets rough communication λ-optimal trans-lation sequence genetic algorithm.

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