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消防员心血管危险因素及运动干预的研究进展

辽宁体育科技 2021年第3期43卷 47-52页

作者：季冬陈钢锐周洪刚戴剑松南京体育学院研究生部江苏南京210014 南京体育学院竞技体育研究院江苏南京210014 南京体育学院运动健康学院江苏南京210014

消防员的职业特点决定了他们经常会处于高温、高压的环境当中,加大了他们产生心血管疾病(CVD)的风险。运用文献资料法,阐述了大量国外运动干预对降低消防员CVD风险因素的研究,对消防员CVD的风险因素、不同运动形式干预消防员CVD危险因... 详细信息

消防员的职业特点决定了他们经常会处于高温、高压的环境当中,加大了他们产生心血管疾病(CVD)的风险。运用文献资料法,阐述了大量国外运动干预对降低消防员CVD风险因素的研究,对消防员CVD的风险因素、不同运动形式干预消防员CVD危险因素等进行综述。结果显示:CVD是导致消防员死亡的主要原因之一;年龄、肥胖、心肺适应能力(CRF)低下和心理压力等是影响消防员CVD的风险因素;不同的运动干预可以改善消防员的CVD风险因素。

关键词：消防员运动干预心血管疾病心肺适应能力

The emerging role of nitric oxide in the synaptic dysfunction of vascular dementia

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Neural Regeneration Research 2025年第2期20卷 402-415页

作者： Xiaorong Zhang Zhiying Chen Yinyi Xiong Qin zhou Ling-Qiang Zhu Dan Liu Department of Pathology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Jiujiang Clinical Precision Medicine Research Center JiujiangJiangxi ProvinceChina Center for Cognitive Science and Transdisciplinary Studies Jiujiang UniversityJiangxi ProvinceChina Department of Neurology Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Rehabilitation Affiliated Hospital of Jiujiang UniversityJiujiangJiangxi ProvinceChina Department of Pathophysiology School of Basic MedicineTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

With an increase in global aging,the number of people affected by cerebrovascular diseases is also increasing,and the incidence of vascular dementia-closely related to cerebrovascular risk-is increasing at an epidemic ***,few therapeutic options exist that can markedly improve the cognitive impairment and prognosis of vascular dementia *** in Alzheimer’s disease and other neurological disorders,synaptic dysfunction is recognized as the main reason for cognitive *** oxide is one of the ubiquitous gaseous cellular messengers involved in multiple physiological and pathological processes of the central nervous ***,nitric oxide has been implicated in regulating synaptic plasticity and plays an important role in the pathogenesis of vascular *** review introduces in detail the emerging role of nitric oxide in physiological and pathological states of vascular dementia and summarizes the diverse effects of nitric oxide on different aspects of synaptic dysfunction,neuroinflammation,oxidative stress,and blood-brain barrier dysfunction that underlie the progress of vascular ***,we propose that targeting the nitric oxide-sGC-cGMP pathway using certain specific approaches may provide a novel therapeutic strategy for vascular dementia.

关键词： endoplasmic reticulum stress endothelial nitric oxide synthase gene therapy nitric oxide NO-sGC-cGMP pathway synaptic dysfunction vascular dementia

Drug discovery by targeting the protein–protein interactions involved in autophagy

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Acta Pharmaceutica Sinica B 2023年第11期13卷 4373-4390页

作者： honggang Xiang Mi zhou Yan Li Lu zhou Renxiao Wang Department of Medicinal Chemistry School of PharmacyFudan UniversityShanghai 201203China

Autophagy is a cellular process in which proteins and organelles are engulfed in autophagosomal vesicles and transported to the lysosome/vacuole for ***–protein interactions(PPIs)play a crucial role at many stages of autophagy,which present formidable but attainable targets for autophagy ***,selective regulation of PPIs tends to have a lower risk in causing undesired off-target effects in the context of a complicated biological ***,small-molecule regulators,including peptides and peptidomimetics,targeting the critical PPIs involved in autophagy provide a new opportunity for innovative drug *** article provides general background knowledge of the critical PPIs involved in autophagy and reviews a range of successful attempts on discovering regulators targeting those *** strategies and existing limitations in this field are also discussed.

关键词： Autophagy regulation Protein–protein interactions Small-molecule regulators Drug discovery

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基于DSP的无线伺服清除鸟巢装置

电工技术 2019年第9期 68-69,72页

作者：戴钦来王宇周洪刚沈庆赟国网江西省电力有限公司检修分公司

针对变电站电气设备鸟巢清除需停电登高作业的问题,设计出一种基于DSP的无线伺服装置,可在电气设备带电情况下实施鸟巢清除作业。该装置可带电作业,避免了停电造成的负荷损失和非计划停运。

关键词：伺服驱动鸟巢清除无线

氯胺酮复合右美托咪定对七氟烷麻醉下小儿扁桃体腺样体切除术后谵妄的影响

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海军医学杂志 2022年第12期43卷 1335-1339页

作者：徐红梅周红刚胡秀改刘晶淮安市第一人民医院分院麻醉科江苏淮安223002

目的探索七氟烷麻醉下低剂量的氯胺酮复合右美托咪定在小儿扁桃体腺样体切除术中的术后谵妄发生率和其他麻醉不良反应。方法共90名接受扁桃体腺样体切除术的患儿被分成试验组(45例)及对照组(45例)。手术期间使用七氟烷诱导和维持麻醉... 详细信息

目的探索七氟烷麻醉下低剂量的氯胺酮复合右美托咪定在小儿扁桃体腺样体切除术中的术后谵妄发生率和其他麻醉不良反应。方法共90名接受扁桃体腺样体切除术的患儿被分成试验组(45例)及对照组(45例)。手术期间使用七氟烷诱导和维持麻醉。手术结束前10 min,试验组患儿接受0.15 mg/kg低剂量的氯胺酮静脉注射,随后给予0.3μg/kg的右美托咪定静脉注射。对照组患儿接受与体重匹配的生理盐水静脉注射。术后谵妄和疼痛情况分别使用儿童麻醉苏醒期谵妄(PAED)量表和客观疼痛评分(OPS)进行评估。记录患儿临床信息、术中及术后麻醉情况。结果试验组患儿的术后谵妄发生率和严重程度显著低于对照组(11.11%vs. 28.89%, 2.22%vs. 13.33%,均P4分的比例为15.56%,显著低于对照组的62.22%(P<0.05)。与对照组16例(35.56%)比较,试验组中需要补充芬太尼镇静镇痛的患儿为6例(13.33%)。试验组患儿麻醉结束到睁眼的时间及麻醉结束到拔除气管插管的时间显著长于对照组(均P<0.05)。结论手术结束前10 min加入低剂量的氯胺酮和右美托咪定可使得小儿扁桃体腺样体切除术后谵妄和严重术后谵妄的发生率和持续时间降低,且氯胺酮复合右美托咪定的使用方式和剂量安全可靠,不会导致不良反应发生率增加。

关键词：氯胺酮右美托咪定七氟烷小儿麻醉术后谵妄

Early-diverging Titanosauriform(Dinosauria,Sauropoda)Teeth from the Lower Cretaceous Yixian Formation of Southeastern Inner Mongolia,Northeast China

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Acta Geologica Sinica(English Edition) 2024年第2期98卷 303-310页

作者： ZHANG honggang YIN Yalei PEI Rui zhou Changfu College of Earth Science and Engineering Shandong University of Science and TechnologyQingdaoShandong 266570China College of Paleontology Shenyang Normal UniversityShenyang 110034China Key Laboratory of Evolution of Past Life in NE Asia Ministry of Natural ResourcesShenyang 110034China Key Laboratory of Evolutionary Systematics of Vertebrates Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China CAS Center for Excellence in Life and Paleoenvironment Beijing 100044China

Three eusauropod teeth(SDUST-V1064,PMOL-AD00176,PMOL-ADt0005)are reported from the Lower Cretaceous Yixian Formation of Ningcheng,southeastern Inner Mongolia,*** of them(SDUST-V1064,PMOL-AD00176)are assigned to early-diverging titanosauriforms in having slightly mesiodistal expansion at the base of the tooth crown,a slenderness index value>2.0 and<4.0,and D-shaped cross ***,SDUST-V1064 and PMOL-AD00176 are referred as an Euhelopus-like titanosauriform on the basis of having a sub-circular boss on the lingual surface and an asymmetrical crown-root margin which slants apically,*** scan data of SDUST-V1064 reveals new dental information of early-diverging titanosauriforms,for example,the enamel on the labial side thicker than that on the lingual side,an enamel/dentine ratio of 0.26 and a boss present on the lingual side of the dentine of the crown.

关键词： teeth Titanosauriformes Lower Cretaceous Yixian Formation Ningcheng

Effect of Post-weld Heat Treatment on Properties of Friction Welded Joint Between TC4 Titanium Alloy and 40Cr Steel Rods

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Journal of Materials Science & Technology 2015年第9期31卷 962-968页

作者： honggang Dong Lianzhen Yu Dewei Deng Wenlong zhou Chuang Dong School of Materials Science and Engineering Dalian University of Technology State Key Laboratory of Advanced Welding and Joining Harbin Institute of Technology Key Lab of Materials Modification (Dalian University of Technology) Ministry of Education

Dissimilar metal joining of Ti-6AI-4V （TC4） titanium alloy to as-rolled 40Cr steel rods was conducted with friction welding, and the effect of post-weld heat treatment （PWHT） on the microstructure and mechanical properties of the resultant joints was investigated. The average tensile strength of the as-welded joints reached 766 MPa and failure occurred in 40Cr steel base metal. However, after PWHT at 600℃ for 0.5, 1, 2 and 3 h, the tensile strength of the joints decreased and fracture happened through the interface with quasi-cleavage features. The bending angle of specimens was improved from 9.6° in as-welded state to 32.5° after PWHT for 2 h. The tensile strength of the joint was enhanced by martensitic transformation near the interface in as-welded state. Sorbite formed near the interface in PWHT state and improved the bending ductility of the joint. TiC brittle phase formed at the interface after PWHT for 0.5 h and deteriorated the tensile strength and bending ductility of the joint. After PWHT for 2 h, no TiC phase was detected at the interface. The microhardness on the interface in as-welded state was higher than that after PWHT, indicating that the decrease of microhardness around the interface could be accompanied by degradation of tensile strength but improvement of bending ductility of the joints.

关键词： Dissimilar metal joiningFriction weldingTitaniumSteelPost-weld heat treatmentlntermetallic

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在役钢管混凝土系杆拱桥结构检测与安全评估

市政技术 2008年第5期26卷 456-457页

作者：卢炳灿周洪刚何顶顶毛东建淮安市市政公用事业管理局江苏淮安223001 东南大学土木工程学院南京210096

以某在役钢管混凝土系杆拱桥为对象,对其进行常规检测,并在此基础上,建立了该桥的有限元模型,并对其实施了静载试验,通过有限元分析与试验结果的对比,对该桥进行了安全评估。

关键词：混凝土钢管混凝土系杆拱桥静载试验安全评估

Statistical characteristics and classification of ionospheric mid-latitude trough as revealed by the observations of DMSP-F18

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Earth and Planetary Physics 2025年第1期9卷 137-147页

作者： Yi Liu JiuHou Lei FuQing Huang Su zhou School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China School of Science Guiyang UniversityGuiyang 550005China

Statistical characteristics and the classification of the topside ionospheric mid-latitude trough are systemically analyzed,using observations from the Defense Meteorological Satellite Program F18(DMSP-F18)*** data was obtained at an altitude of around 860 km in near polar orbit,throughout *** study identified the auroral boundary based on the in-situ electron density and electron spectrum,allowing us to precisely determine the location of the mid-latitude *** differs from most previous works,which only use Total Electron Content(TEC)or in-situ electron *** our study,the troughs exhibited a higher occurrence rate in local winter than in summer,and extended to lower latitudes with increasing geomagnetic *** was found that the ionospheric mid-latitude trough,which is associated with temperature changes or enhanced ion drift,exhibited distinct ***,the ionospheric mid-latitude troughs related to electron temperature(Te)peak were located more equatorward of auroral oval boundary in winter than in *** ionospheric mid-latitude troughs related to Te-maximum were less frequently observed at 60−70°S magnetic latitude and 90−240°E ***,the troughs related to ion temperature(Ti)maximums were observed at relatively higher latitudes,occurring more frequently in *** addition,the troughs related to ion velocity(Vi)maximums could be observed in all *** troughs with the maximum-Ti and maximum-Vi were located closer to the equatorward boundary of the auroral oval at the nightside,and in both *** implies that enhanced ion drift velocity contributes to increased collisional frictional heating and enhanced ion temperatures,resulting in a density depletion within the trough region.

关键词： topside ionosphere mid-latitude trough ionospheric main trough auroral oval boundary temperature maximum