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Medicine in Novel Technology and Devices 2024年第1期21卷 110-119页

作者： Yaojia Zhang hongchi yu Li Deng Zhe Hou Jie Yang Fei Fang Michael ZMiao Wenjun Li Xin Shen Dongyun Hao Xiaoyi Ma Lifeng Zhou Fugui He Xiaoheng Liu a1Institute of Biomedical Engineering West China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu610041China Division of Oral&Craniofacial Health Sciences Adams School of DentistryUniversity of North Carolina at Chapel HillNC27599USA Beijing Key Laboratory of Cardiac Drug Device Technology and Evidence Based Medicine Beijing100021China

The limitations of current drug-eluting stent technologies in selectively inhibiting vascular smooth muscle cell proliferation,which often leads to inflammation,call for innovative approaches in coronary artery disease *** the present work,we propose a revolutionary solution:a three-in-one platform for vascular stents,combining arsenic trioxide(ATO)and tacrolimus(TAC)to address anti-proliferation,pro-endothelialization,and anti-inflammation *** findings demonstrate that the synergistic action of ATO and TAC effectively suppresses aberrant vascular smooth muscle cell proliferation and mitigates endothelial cell ***,the combination treatment of TAC/ATO enhances endothelial cell migration and adhesion ***,our TAC/ATO-eluting stent exhibits superior re-endothelialization and anti-restenosis effects in a rabbit and porcine stent implantation *** in vitro and in vivo results solidify the notion that the TAC/ATO-eluting stent ensures rapid re-endothelialization and significantly reduces the incidence of in-stent ***,this study represents a promising and novel multifunctional platform with immense potential in the therapy of coronary artery disease.

关键词： Tacrolimus Arsenic trioxide Drug-eluting stent

The biological responses and mechanisms of endothelial cells to magnesium alloy

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Regenerative Biomaterials 2021年第3期8卷 57-69页

作者： Zhe Hou Maolong Xiang Nuoya Chen Xiao Cai Bo Zhang Rifang Luo Li Yang Xiaoyi Ma Lifeng Zhou Fugui He hongchi yu yunbing Wang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610064China College of Life Sciences Sichuan UniversityChengdu 610064China The Fourth People’s Hospital of Chengdu Chengdu 610036China Beijing Key Laboratory of Cardiac Drug Device Technology and Evidence Based Medicine Beijing 100021China Institute of Biomedical Engineering West China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu 610041China

Due to its good biocompatibility and degradability,magnesium alloy(Mg alloy)has shown great promise in cardiovascular stent *** stent re-endothelialization is derived from migrated and adhered endothelial cells(ECs),which is an effective way to reduce late thrombosis and inhibit ***,fundamental questions regarding Mg alloy affecting migration and adhesion of ECs are not fully ***,we evaluated the effects of Mg alloy on the ECs proliferation,adhesion and migration.A global gene expression profiling of ECs co-culturing with Mg alloy was conducted,and the adhesion-and migration-related genes were *** found that Mg alloy had no adverse effects on ECs viability but significantly affected ECs migration and ***-cultured with Mg alloy extract,ECs showed contractive adhesion morphology and decreased motility,which was supported by the down-regulation of adhesion-related genes(Paxillin and Vinculin)and migration-related genes(RAC 1,Rho A and CDC 42).Accordingly,the re-endothelialization of Mg alloy stent was inhibited in *** results may provide new inspiration for improving the broad application of Mg alloy stents.

关键词： magnesium alloy endothelial cells migration adhesion

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长白山天池火山监测工作进展

岩石学报 2006年第6期22卷 1491-1493页

作者：刘国明于洪茌谭雨文吉林省地震局长白山天池火山监测站延吉133613 吉林省地震局合隆地震台长春130022 吉林省地震局丰满地震台吉林132000

长白山天池火山是我国最具有潜在喷发危险的活火山。本文介绍了天池火山监测系统建设的基本情况,报道了近些年在火山地震监测、大地形变监测以及地球化学监测等方面的工作进展。

关键词：天池火山火山监测系统火山监测工作进展

Yes-associated protein contributes to magnesium alloy-derivedinflammation in endothelial cells

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Regenerative Biomaterials 2022年第1期9卷 130-142页

作者： hongchi yu Zhe Hou Nuoya Chen Rifang Luo Li Yang Michael Miao Xiaoyi Ma Lifeng Zhou Fugui He Yang Shen Xiaoheng Liu yunbing Wang National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610065China Institute of Biomedical Engineering West China School of Basic Medical Sciences&Forensic MedicineSichuan UniversityChengdu 610041China Division of Oral&Craniofacial Health Sciences University of North Carolina Adams School of DentistryChapel HillNC 27599USA Beijing Key Laboratory of Cardiac Drug Device Technology and Evidence Based Medicine Beijing 100021China

Magnesium alloy(Mg alloy)has attracted massive attention in the potential applications of cardiovascular stents because of its good biocompatibility and ***,whether and how the Mg alloy induces inflammation in endothelial cells remains *** the present work,we investigated the activation of Yes-associated protein(YAP)upon Mg alloy stimuli and unveiled the transcriptional function in Mg alloy-induced *** RT–PCR,western blotting and immunofluorescence staining showed that Mg alloy inhibited the Hippo pathway to facilitate nuclear shuttling and activation of YAP in human coronary artery endothelial cells(HCAECs).Chromatin immunoprecipitation followed sequencing was carried out to explore the transcriptional function of YAP in Mg alloy-derived *** led to the observation that nuclear YAP further bonded to the promoter region of inflammation transcription factors and co-transcription *** binding event activated their transcription and modified mRNA methylation of inflammation-related genes through regulating the expression of N6-methyladenosine modulators(METTL3,METTL14,FTO and WTAP).This then promoted inflammation-related gene expression and aggravated inflammation in *** YAP deficiency cells,Mg alloy-induced inflammation was ***,our data suggest that YAP contributes to the Mg alloy-derived inflammation in HCAECs and may provide a potential therapeutic target that alleviates inflammation after Mg alloy stent implantation.

关键词： magnesium alloy Yes-associated protein inflammation

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长春地磁台天文方位角测量及精度估计

东北地震研究 2009年第2期25卷 67-70页

作者：于洪池吴江星吕晗长春地磁台吉林长春130022 吉林省地震局吉林长春130117

本文论述了长春地磁台天文方位角的测量方法、原理及测量结果,同时做了测量精度估计,通过计算方位角理论最大误差为3.7″,实际观测最大误差为2.5″,能满足地磁偏角6″的精度要求。

关键词：长春地磁台天文方位角测量精度估计

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油耗监控系统的介绍和应用

港口科技 2010年第7期 20-22页

作者：于洪池王柯许升元大连集发港口技术服务有限公司辽宁大连116601

为加强对港口机械燃油管理,降低燃油损耗,介绍了一种车辆油耗监测系统。该系统可以实时记录油量的剩余值,并通过PC软件可以看出油量变化情况,以确定每辆车燃油的使用情况是否正常。能有效控制司机及其车辆的油耗变化及其管理,可在港口... 详细信息

为加强对港口机械燃油管理,降低燃油损耗,介绍了一种车辆油耗监测系统。该系统可以实时记录油量的剩余值,并通过PC软件可以看出油量变化情况,以确定每辆车燃油的使用情况是否正常。能有效控制司机及其车辆的油耗变化及其管理,可在港口行业内推广。

关键词：车辆油耗监控

三氧化二砷对肝癌细胞HepG2迁移、侵袭和凋亡的影响

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生物医学工程学杂志 2020年第1期37卷 105-111页

作者：何佳许博闻高文博苏冠月余泓池沈阳刘肖珩四川大学华西基础医学与法医学院生物医学工程研究室成都610041 四川大学生物材料工程研究中心成都610065

本文旨在探究三氧化二砷(As2O3)对肝癌细胞HepG2作用的最佳浓度,以及此浓度As2O3对HepG2细胞迁移、侵袭和凋亡的影响。本研究采用CCK-8法检验0、1、2、4、8、16、32μmol/L As2O3处理后HepG2细胞活力,计算半抑制浓度(IC50),并且观察IC5... 详细信息

本文旨在探究三氧化二砷(As2O3)对肝癌细胞HepG2作用的最佳浓度,以及此浓度As2O3对HepG2细胞迁移、侵袭和凋亡的影响。本研究采用CCK-8法检验0、1、2、4、8、16、32μmol/L As2O3处理后HepG2细胞活力,计算半抑制浓度(IC50),并且观察IC50浓度As2O3作用12、24、48 h后HepG2细胞形态变化。通过伤口愈合实验和Transwell侵袭实验验证As2O3对细胞迁移侵袭能力的影响。Western blot和qRT-PCR实验检测As2O3对细胞迁移、侵袭及凋亡相关蛋白和基因表达水平的影响。结果显示,与对照组相比,HepG2细胞活力随As2O3处理浓度的升高而降低,呈现剂量依懒性,其IC50为7.3μmol/L;8μmol/L As2O3处理24 h后,HepG2细胞发生明显凋亡,且其迁移和侵袭能力显著降低;此外,细胞中RhoA、Cdc42、Rac1、基质金属蛋白酶-9(MMP-9)蛋白表达水平下调,抑凋亡基因Bcl-2的蛋白和mRNA表达水平显著下调,而促凋亡基因Bax、Caspase-3的蛋白和mRNA表达水平显著上调。以上结果说明一定浓度的As2O3能够抑制肝癌细胞迁移和侵袭,促进肝癌细胞凋亡。

关键词：三氧化二砷 HepG2细胞迁移侵袭凋亡

Mathematical Modeling and Design of RIS Deployment in a RIS-Assisted Metal Cuboid for WAIC Systems

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China Communications 2023年第4期20卷 86-101页

作者： hongchi Lin Qiyue yu Communication Research Center Harbin Institute of TechnologyHarbin 150000China

Wireless avionics intra-communications(WAIC)is an emergent research topic,since it can improve fuel efficiency and enhance aircraft safety ***,there are numerous baffles in an aircraft,e.g.,seats and cabin bulkheads,resulting in serious blockage and even destroying wireless ***,this paper focuses on the reconfigurable intelligent surface(RIS)deployment issue of RIS-assisted WAIC systems,to solve the blockage problem caused by *** first propose the mirror-symmetric imaging principle for mathematically analyzing electromagnetic(EM)wave propagation in a metal cuboid,which is a typical structure of WAIC *** on the mirror-symmetric imaging principle,the mathematical channel model in a metal cuboid is deduced in *** addition,we develop an objective function of RIS's location and deduce the optimal RIS deployment location based on the geometric center optimization lemma.A two-dimensional gravity center search algorithm is then *** results show that the designed RIS deployment can greatly increase the received power and efficiently solve the blockage problem in the aircraft.

关键词： wireless avionics intra-communications(WAIC) reconfigurable intelligent surface(RIS) channel modeling deployment optimization