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SnRK1 Phosphorylates and Destabilizes WRKY3 to Enhance Barley Immunity to Powdery Mildew

Plant Communications 2020年第4期1卷 115-128页

作者： Xinyun Han Ling Zhang Lifang Zhao Pengya xue Ting Qi Chunlei Zhang hongbo Yuan Lixun Zhou Daowen Wang Jinlong Qiuand Qian-Hua Shen State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of SciencesInnovation Academy for Seed DesignBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Plant Genomics Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Plants recognize pathogens and activate immune responses,which usually involve massive transcriptional *** evolutionarily conserved kinase,Sucrose non-fermenting-related kinase 1(SnRK1),functions as a metabolic regulator that is essential for plant growth and stress ***,we identify barley SnRK1 and a WRKY3 transcription factor by screening a cDNA ***1 interacts with WRKY3 in yeast,as confirmed by pull-down and luciferase complementation assays.Förster resonance energy transfer combined with noninvasive fluorescence lifetime imaging analysis indicates that the interaction occurs in the barley *** expression and virus-induced gene silencing analyses indicate that WRKY3 acts as a repressor of disease resistance to the Bgh *** plants overexpressing WRKY3 have enhanced fungal microcolony formation and *** assays show that SnRK1 phosphorylates WRKY3 mainly at Ser83 and Ser112 to destabilize the repressor,and WRKY3 non-phosphorylation-null mutants at these two sites are more stable than the wild-type ***1-overexpressing barley plants display enhanced disease resistance to *** expression of SnRK1 reduces fungal haustorium formation in barley cells,which probably requires SnRK1 nuclear localization and kinase ***,these findings suggest that SnRK1 is directly involved in plant immunity through phosphorylation and destabilization of the WRKY3 repressor,revealing a new regulatory mechanism of immune derepression in plants.

关键词： SnRK1 phosphorylation WRKY transcription factor immunity powdery mildew fungus

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Revealing Functional Significance of Interleukin-2 Glycopro-teoforms Enabled by Expressed Serine Ligation

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Chinese Journal of Chemistry 2022年第7期40卷 787-793页

作者： Jie Zhao Jiazhi Liu Xinnan Liu Qi Cao hongbo Zhao Lizhen Liu Farong Ye Can Wang Hong Shao Dongxiang xue Houchao Tao Bin Li Biao Yu Ping Wang Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs School of Chemistry and Chemical EngineeringShanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China Shanghai Institute of Immunology Department of Immunology and MicrobiologyShanghai Jiao Tong University School of Medicine280 S.Chongqing RoadShanghai 200025China Obstetrics and Gynecology Hospital of Fudan University Shanghai 200011China Shanghai Institute for Food and Drug Control NMPA Key Laboratory for Quality Control of Therapeutic Monoclonal AntibodiesShanghai 201203China iHuman Institute ShanghaiTech UniversityHaike Road 230Shanghai 200032China State Key Laboratory of Bioorganic and Natural Products Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryChinese Academy of Sciences345 Lingling RoadShanghai 200032

Naturally occurring interleukin-2(IL-2)is a pleiotropic glycoprotein that regulates immune responses by controlling the differentia-tion and homeostasis of T ***-glycosylated IL-2 has been used in clinical settings for three ***,the function of the O-glycan of native IL-2 remains ***,to stress this issue,we report a highly efficient semi-synthesis of homogeneous glycosylated IL-2 with various glycoproteoforms on a multi-milligram *** glycopeptide fragment was prepared by chemical synthesis and then merged with recombinant fragment via a serine ligation to generate the desired glycoprotein in a single *** evaluation of the homogenous glycoprotein library reveals that the activity of IL-2 in activating individual T cell subset is glycan dependent,thus highlighting the possibility of further improving current clinical medicine.

关键词： Oligosaccharide Glycoprotein Serine ligation Interleukin-2 Glycopeptides

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CD38 deficiency alleviates Ang II-induced vascular remodeling by inhibiting small extracellular vesicle-mediated vascular smooth muscle cell senescence in mice

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Signal Transduction and Targeted Therapy 2021年第7期6卷 2172-2185页

作者： Lu Gan Demin Liu Jing Liu Erya Chen Chan Chen Lian Liu Hang Hu Xiaohui Guan Wen Ma Yanzi Zhang Yarong He Bofu Liu Songling Tang Wei Jiang Jianxin xue hongbo Xin Research Laboratory of Emergency Medicine Department of Emergency MedicineNational Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduPeopled Republic of China Cardiology Department The Second Hospital of Hebei Medical UniversityShijiazhuangPeopled Republic of China Department of Endocrinology The Second Hospital of Shanxi Medical UniversityTaiyuanPeople’s Republic of China Department of Anesthesiology Laboratory of Anesthesia and Critical Care MedicineTranslational Neuroscience CenterWest China HospitalSichuan UniversityChengduPeople's Republic of China The National Engineering Research Center for Bioengineering Drugs and the Technologies Institute of Translational MedicineNanchang UniversityNanchangPeople's Republic of China State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengduPeopled Republic of China Department of Thoracic Oncology Cancer CenterWest China HospitalSichuan UniversityChengduPeople’s Republic of China

CD38 is the main enzyme for nicotinamide adenine dinucleotide(NAD)degradation in mammalian *** NAD levels are closely related to metabolic syndromes and aging-related *** study showed that CD38 deficiency significantly alleviated angiotensin II(Ang ll)-induced vascular remodeling in mice,as shown by decreased blood pressures;reduced vascular media thickness,media-to-lumen ratio,and collagen deposition;and restored elastin ***,our bone marrow transplantation assay showed that CD38 deficiency in lymphocytes led to lack of protection against Ang ll-induced vascular remodeling,suggesting that the effects of CD38 on Ang ll-induced vascular remodeling might rely primarily on vascular smooth muscle cells(VSMCs),not *** addition,we observed that CD38 deficiency or NAD supplementation remarkably mitigated Ang ll-induced vascular senescence by suppressing the biogenesis,secretion,and internalization of senescence-associated small extracellular vesicles(SA-sEVs),which facilitated the senescence of neighboring non-damaged ***,we found that the protective effects of CD38 deficiency on VSMC senescence were related to restoration of lysosome dysfunction,particularly with respect to the maintenance of sirtuin-mediated mitochondrial homeostasis and activation of the mitochondria-lysosomal axis in *** conclusion,our findings demonstrated that CD38 and its associated intracellular NAD decline are critical for Ang ll-induced VSMC senescence and vascular remodeling.

关键词： CD38 Ang remodeling

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High-Performance H_(2) Photosynthesis from Pure Water over Ru−S Charge Transfer Channels

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Precision Chemistry 2024年第9期2卷 471-479页

作者： Huiping Peng Mingzi Sun Fei xue Xiaozhi Liu Shangheng Liu Tang Yang Lin Sun hongbo Geng Dong Su Bolong Huang Yong Xu Xiaoqing Huang State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityKowloonHong Kong SAR 999077China Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Materials Engineering Changshu Institute of TechnologyChangshu 215500China i-lab Suzhou Institute of Nano-Tech and Nano-Bionics(SINANO)Chinese Academy of Sciences(CAS)Suzhou 215123China

As a versatile energy carrier,H_(2) is considered as one of the most promising sources of clean energy to tackle the current energy crisis and environmental concerns,which can be produced from photocatalytic water ***,solar-driven photocatalytic H_(2) production from pure water in the absence of sacrificial reagents remains a great ***,we demonstrate that the incorporation of Ru single atoms(SAs)into ZnIn_(2)S_(4)(Ru-ZIS)can enhance the light absorption,reduce the energy barriers for water dissociation,and construct a channel(Ru-S)for separating photogenerated electron−hole pairs,as a result of a significantly enhanced photocatalytic water splitting ***,the productivity of H_(2) reaches 735.2μmol g^(-1) h^(-1) under visible light irradiation in the absence of sacrificial *** apparent quantum efficiency(AQE)for H_(2) evolution reaches 7.5% at 420 nm,with a solarto-hydrogen(STH)efficiency of 0.58%,which is much higher than the value of natural synthetic plants(~0.10%).Moreover,Ru-ZIS exhibits steady productivity of H_(2) even after exposure to ambient conditions for 330 *** work provides a unique strategy for constructing charge transfer channels to promote the separation of photogenerated electron−hole pairs,which may motivate the fundamental researches on catalyst design for photocatalysis and beyond.

关键词： Ru single atom charge channel ZnIn_(2)S_(4) photocatalytic pure water splitting

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Overlooked uneven progress across sustainable development goals at the global scale: Challenges and opportunities

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The Innovation 2024年第2期5卷 42-50页

作者： Yali Liu Jianqing Du Yanfen Wang Xiaoyong Cui Jichang Dong Pan Gu Yanbin Hao Kai xue hongbo Duan Anquan Xia Yi Hu Zhi Dong Bingfang Wu Jüurgen P.Kropp Bojie Fu School of Grassland Science Beijing Forestry UniversityBeijing 100083China Beijing Yanshan Earth Critical Zone National Research Station University of Chinese Academy of SciencesBeijing 101408China College of Resources and Environment University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Tibetan Plateau Earth System Environment and ResourcesChinese Academy of SciencesBeijing 100101China College of Life Sciences University of Chinese Academy of SciencesBeijing 100049China School of Economics and Management University of Chinese Academy of SciencesBeijing 100190China School of Humanities University of Chinese Academy of SciencesBeijing 100049China Key Laboratory of Adaptation and Evolution of Plateau Biota Northwest Institute of Plateau BiologyChinese Academy of SciencesXining 810001China School of Innovation and Entrepreneurship University of Chinese Academy of SciencesBeijing 100190China State Key Laboratory of Remote Sensing Science Aerospace Information Research InstituteChinese Academy of SciencesBeijing 100101China Potsdam Institute for Climate Impact Research 14412 PotsdamGermany Institute for Environmental Science and Geography University of Potsdam14412 PotsdamGermany State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China

Differences in progress across sustainable development goals(SDGs)are widespread globally;meanwhile,the rising call for prioritizing specific SDGs may exacerbate such ***,how these progress differences would influence global sustainable development has been long ***,we present the first quantitative assessment of SDGs’progress differences globally by adopting the SDGs progress evenness *** results highlight that the uneven progress across SDGs has been a hindrance to sustainable development because(1)it is strongly associated with many public health risks(e.g.,air pollution),social inequalities(e.g.,gender inequality,modern slavery,wealth gap),and a reduction in life expectancy;(2)it is also associated with deforestation and habitat loss in terrestrial and marine ecosystems,increasing the challenges related to biodiversity conservation;(3)most countries with low average SDGs performance show lower progress evenness,which further hinders their fulfillment of SDGs;and(4)many countries with high average SDGs performance also showcase stagnation or even retrogression in progress evenness,which is partly ascribed to the antagonism between climate actions and other *** findings highlight that while setting SDGs priorities may be more realistic under the constraints of multiple global stressors,caution must be exercised to avoid new problems from intensifying uneven progress across ***,our study reveals that the urgent needs regarding SDGs of different regions seem complementary,emphasizing that regional collaborations(e.g.,demand-oriented carbon trading between SDGs poorly performed and well-performed countries)may promote sustainable development achievements at the global scale.

关键词： globally priori inequality

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CD20^(+)T淋巴细胞在多发性硬化中的作用及机制研究

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中华神经科杂志 2024年第1期57卷 92-97页

作者：薛龙星刘洪波郑州大学第一附属医院神经内科郑州450052

CD20是一种经典的B细胞标志物,但近年来有研究发现,除B细胞外,部分CD3^(+)T淋巴细胞亚型也微弱表达CD20分子,并且在多发性硬化(MS)的发病机制中发挥重要的促炎作用,抗CD20药物选择性清除CD20^(+)T细胞后,可有效抑制炎性疾病活动。虽然CD... 详细信息

CD20是一种经典的B细胞标志物,但近年来有研究发现,除B细胞外,部分CD3^(+)T淋巴细胞亚型也微弱表达CD20分子,并且在多发性硬化(MS)的发病机制中发挥重要的促炎作用,抗CD20药物选择性清除CD20^(+)T细胞后,可有效抑制炎性疾病活动。虽然CD20^(+)T细胞受到越来越多的关注,但目前人们对其的理解仍处于起步阶段,文中就该细胞亚群的最新研究进展及其在MS中的作用作一综述。

关键词：多发性硬化 CD20^(+)T细胞 B细胞 T细胞

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氧化石墨烯(GO)及复合物制备及其对汞吸附特性的研究

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工程热物理学报 2017年第9期38卷 2018-2024页

作者：田冲 Yuxi Liu 余学海 hongbo Zeng 赵永椿张军营武汉大学动力与机械学院武汉430072 华中科技大学煤燃烧国家重点实验室武汉430074 Department of Chemical and Material Engineering University of Alberta 神华集团国华(北京)电力研究院有限公司北京100025

以石墨粉(G)为原料,通过化学方法制备了氧化石墨烯(GO)、纳米Fe_3O_4负载石墨烯复合材料(MGO)、纳米Ag颗粒修饰磁性氧化石墨烯(GO-Ag/MGO-Ag)四种吸附材料,对材料进行了表征并考察了氧化石墨烯及其复合物对烟气中汞的吸附作用。研究表... 详细信息

以石墨粉(G)为原料,通过化学方法制备了氧化石墨烯(GO)、纳米Fe_3O_4负载石墨烯复合材料(MGO)、纳米Ag颗粒修饰磁性氧化石墨烯(GO-Ag/MGO-Ag)四种吸附材料,对材料进行了表征并考察了氧化石墨烯及其复合物对烟气中汞的吸附作用。研究表明四种石墨烯基吸附剂可被成功合成和表征;GO在100-150℃时对Hg^0表现出优异的吸附性能,Ag-NPs修饰GO能有效提升吸附剂对汞的吸附能力,MGO-Ag复合吸附剂对汞的吸附能力最佳;MGOAg在150~200℃时表现出优异的汞吸附能力,在反复循环之后吸附性能几乎不变;以MGO-Ag为代表的可再生磁性石墨烯基复合吸附剂在中低温条件下对Hg^0具有优异的吸附性能,且能有效与飞灰进行分离,具有良好的工业应用前景。

关键词：氧化石墨烯汞吸附磁性纳米银颗粒再生循环

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Impacts of Different Weeding Methods on Weeds Control in Tobacco Fields in Anshun City

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Plant Diseases and Pests 2021年第3期12卷 4-8页

作者： Fei Dai hongbo Wan Huijuan Dai Xiquan Li Yuan xue Quan Zhang Anshun Branch of Guizhou Provincial Tobacco Company Anshun 561000China China Tobacco Hebei Industry Co. Ltd.Shijiazhuang 050000China

[Objective] The paper was to explore weed control measures in tobacco fields in Anshun City. [Method] Different treatments on weed control were conducted in tobacco fields in Anshun City, Guizhou Province, from 2017 to 2019. [Result] Various treatments had no negative effect on tobacco plant growth in the field, and had different degrees of control effects on five dominant weeds, including Digitaria sanguinalis, Setaria viridis, Fagopyrum dibotrys, Commelina communis and Chenopodium album. White mulching film and 50% butralin·clomazone EC 160 m L/667 m^(2) + white mulching film had the worst performance, which had extremely significant or significant differences with other treatments. There was no sig-nificant difference among most treatments, and the overall effects were comprehensive(multi-factor) treatment > double factor treatment > single factor treatment. [Conclusion] Combination control is recommended in practical tobacco production.

关键词： Tobacco field Weed Control effect Impact

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Silica Nanoparticles with Virus-Mimetic Spikes Enable Efficient siRNA Delivery In Vitro and In Vivo

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Research 2023年第3期2022卷 281-294页

作者： Jianye Fu Wenwei Han xue Zhang Yutong Sun Rajendra Bhadane Bo Wei Li Li Liangmin Yu Jinbo Yang Jessica MRosenholm Outi MHSalo-Ahen Taojian Fan Bin Zhang Wageh Swelm Ahmed AAl-Ghamdi Lin Xia Han Zhang Meng Qiu hongbo Zhang Xin Wang Key Laboratory of Marine Drugs Chinese Ministry of EducationSchool of Medicine and PharmacyOcean University of ChinaQingdao 266003China Collaborative Innovation Center for Optoelectronic Science&Technology International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology of Ministry of EducationInstitute of Microscale OptoelectronicsCollege of Physics and Optoelectronic EngineeringShenzhen UniversityShenzhen 518060China Key Laboratory of Marine Chemistry Theory and Technology(Ocean University of China) Ministry of EducationQingdao 266100China College of Chemistry and Chemical Engineering China University of PetroleumQingdao 266555China. Pharmaceutical Sciences Laboratory Åbo Akademi University20520 TurkuFinland Structural Bioinformatics Laboratory BiochemistryÅbo Akademi University20520 TurkuFinland. Center for Innovation Marine Drug Screening&Evaluation Pilot National Laboratory for Marine Science and Technology(Qingdao)Qingdao 266237China Marine Biomedical Research Institute of Qingdao Qingdao 266100China Department of Physics Faculty of ScienceKing Abdulaziz UniversityJeddah 21589Saudi Arabia Hangzhou No.14 High School Hangzhou 310000China Turku Bioscience Centre University of Turku andÅbo Akademi University20520 TurkuFinland

Oligonucleotide-based therapy has experienced remarkable development in the past 2 decades,but its broad applications are severely hampered by delivery *** used viral vectors and lipid nanovectors are suffering from immune clearance after repeating usage or requiring refrigerated transportation and storage,*** this work,amino-modified virus-mimetic spike silica nanoparticles(NH_(2)-SSNs)were fabricated using a 1-pot surfactant-free approach with controlled spike lengths,which were demonstrated with excellent delivery performance and biosafety in nearly all cell types and *** indicated that NH2-SSNs entered cells by spike-dependent cell membrane docking and dynamin-dependent *** positively charged spikes with proper length on the surface can facilitate the efficient encapsulation of RNAs,protect the loaded RNAs from degradation,and trigger an early endosome escape during intracellular trafficking,similarly to the cellular internalization mechanism of *** the fantastic properties of NH_(2)-SSNs in nucleic acid delivery,it revealed that nanoparticles with solid spikes on the surface would be excellent vehicles for gene therapy,presenting self-evident advantages in storage,transportation,modification,and quality control in large-scale production compared to lipid nanovectors.

关键词： surfactant loaded transportation

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Highly regular nitrogen doped anatase TiO2 nanotube

Highly regular nitrogen doped anatase TiO2 nanotube

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第九届全国表面工程大会暨第四届全国青年表面工程论坛

作者： Li hongbo Li Jinlong Wang Yongxin Wang Liping xue Qunji Ningbo Key laboratory of Marine Protection Materials Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences

Nitrogen-doped TiO2 nanotubes(N-TNTs) are fabricated on titanium foil via anodic oxidation followed by annealing at NH3 environment. Highly ordered nanotubes, roughly 150 nm in the diameter and 20 μm in the length, form on the titanium foil surfaces. By controlling oxidation voltage, the thick TiO2 nanotubes can peel off the titanium substrate. In one step of annealing at NH3 environment, not only nitrogen, which replaced oxygen, was doped into TiO2, but anatase phase was formed.

关键词： Titanium foil anodic oxidation TiO2 nanotubes nitrogen doping

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